Sedentary BehaviorCHAINNCT06377254
Multi-organ Responses to CHronic Physical Activity and INactivity
A study testing Decreased Physical Activity and Increased Physical activity in people with Sedentary Behavior and Metabolic Syndrome, run by University of Nottingham at 1 site in United Kingdom.
Trial summary
Life expectancy has been increasing for the last 150 years, but the maintenance of health has not kept pace with increased lifespan, and on average, UK adults spend the last decade of life in poor-health, with major consequences for society and the individual. Read more about this study
- Who is it for?
- Ages 50 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Sedentary Behavior, Metabolic Syndrome, Age-related Cognitive Decline
- What is being tested?
- Decreased Physical Activity and Increased Physical activity
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 12 Mar 2024to 31 Oct 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Group 1 ('non-sedentary') self-reporting <6 sedentary hrs/day, not actively involved in exercise training or a regular physical activity regimen (>8,000 steps/day).
- Group 2 ('sedentary') self-reporting ≥8 waking hrs/day in sedentary activities and/or ≤5,000 steps/day.
- Aged 50-65y.
- Overweight (BMI 25-35 kg/m2).
- Waist circumference ≥94cm (males) and ≥80cm (females).
- Willing to alter physical activity levels as instructed for 6 months
- Without neurological or psychiatric diseases, motor or cognitive restrictions
- Ability to give informed consent
Who cannot join
- Regular medication use that could interfere with measures
- A history, or evidence, of chronic cardiovascular, metabolic, musculoskeletal, renal or respiratory diseases.
- Experiencing 'long-COVID', inflammatory bowel disease or malignancy.
- Uncontrolled hypertension. Stage 1 hypertension (BP ≤160/100mmHg) with no other signs of cardiovascular disease, and blood pressure (BP) managed by routine medication will not be an exclusion.
- People employed in jobs that would preclude reducing step count and night-shift workers.
- Females who are pre/peri-menopausal, (due to effect of oestrogen fluctuations on primary outcomes and the longitudinal study design), but individuals stable on hormone replacement therapy are eligible.
- Contraindications for MRI.
- Allergy or sensitivity to local anaesthesia, or dressing adhesive
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Melanie Tooley (participant recruitment), BSc contact
United Kingdom1 site, 1 recruiting
- Recruiting
David Greenfield Human Physiology Unit
Nottingham, Notts, NG72UH
Sara Brown, +44(0)115 8230434, sara.brown@nottingham.ac.uk
Joanne Mallinson, PhD, +44(0)1158230434, joanne.mallinson@nottingham.ac.uk
About this study
Official title: Concurrent Multi-organ Responses to CHronic Physical Activity and INactivity Intervention, to Increase Research Discovery in Human Health and Wellbeing
Life expectancy has been increasing for the last 150 years, but the maintenance of health has not kept pace with increased lifespan, and on average, UK adults spend the last decade of life in poor-health, with major consequences for society and the individual.
Persistent physical inactivity is thought to be a key contributing factor to the risk of poor health and functional decline occurring in middle-aged and older adults. It is therefore concerning that most middle-aged adults spend >8hrs/day being sedentary, with average step count of 3000-4000 steps/day.
Read more
To be able to holistically assess the effectiveness of future strategies to address age-related decline in health, and devise public health messages to help individuals reach older age in better health, it is essential that the complex physiological effects that activity and inactivity have across biological systems are characterised.
The goal of this intervention study is to compare the impact of physical activity and inactivity on body functioning. Twenty moderately active participants will decrease their physical activity for three months to match the average amount carried out by middle-aged people in the UK. They will then undertake 3-months of reconditioning training to restore their fitness. In addition, twenty sedentary participants will increase their physical activity to UK recommended levels for six months.
Before and at points during the intervention period, participants will be asked to make some measurements at home and attend the University of Nottingham to have multiple assessments made. These include;
- fitness, muscle strength and function tests,
- completion of questionnaires and computer-based brain puzzles
- having muscle and fat tissue biopsies and blood samples taken.
- The study also involves having MRI scans.
This 5-year study will commence in January 2024, with participant recruitment starting in March 2024 and finishing in May 2027.
Read the detailed description
This is a parallel design study comparing the impact of physical activity and inactivity on the way the body functions, to understand the mechanisms (including the inter-relationship between tissues and organs) by which lifestyle behaviours may effect health and wellbeing in later life. In particular, the mechanisms by which inactivity results in long term poor health is not well understood, and has rarely been studied in an integrated way in people. However, initial research indicates that the physiology of being inactive is not simply the reverse of being active. To enable effective treatments and public health advice to be devised so that more adults reach old age in better health, and maintain a good quality of life for a greater proportion of their older age, it is important that the impact of physical inactivity on the way the body functions is better understood. Therefore, twenty participants who are moderately, but not highly active will be asked to decrease their physical activity for three months to match the average exercise levels of middle-aged people in the United Kingdom (UK). This will require them to increase their daily sitting time to 7 hours a day and reduce their step count to <4500 steps per day. At the end of the 3-months they will undertake 3-months of supervised reconditioning training by attending the Medical School at Queen's Medical Centre, Nottingham, three times a week.
In addition, twenty participants who currently have low physical activity levels will be asked to increase their physical activity to UK recommended levels by attending the Medical School at Queen's Medical Centre, Nottingham, three times a week for six months to undertake a supervised exercise program.
Before and during the 6-month period (at weeks 6, 12, 18 and 24) participants will be asked to make some measurements at home (physical activity levels, dietary intake) and attend the University of Nottingham over 4 days to have multiple assessments made. These include: height; weight; body composition (body fat and lean tissue); blood pressure; fitness, muscle strength and function; sleep quality, quality of life and wellbeing (questionnaires). The rate of muscle protein breakdown and muscle protein synthesis, blood sugar regulation, and biochemistry of the blood, fat tissue and muscles will be assessed, and to enable this muscle and fat tissue biopsies will be collected and blood samples taken. The study also involves having MRI scans to study the structure and function of the brain and heart, and to determine liver and muscle fat content.
- Conditions
- Sedentary Behavior, Metabolic Syndrome, Age-related Cognitive Decline, Age-Related Sarcopenia
- Being tested
- Decreased Physical Activity, Increased Physical activity
- Keywords
- Physical activity, middle-age, Physical inactivity, overweight, lifestyle
- Medical subject headings
- Sedentary Behavior, Metabolic Syndrome, Motor Activity, Overweight
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Decreased Physical ActivityBehavioural
Physical activity levels will be decreased
Increased Physical activityBehavioural
Physical activity levels will be increased
| Study group | Role | What they receive |
|---|---|---|
| Inactivity | Experimental | Participants in this group will reduce their physical activity (increase sitting time to 7hrs/day and decrease step count to <4500/day) for 3 months, then increase their activity for 3 months, through attending 3x 45 min supervised exercise sessions/week. Receives: Behavioral: Decreased Physical Activity |
| Activity | Experimental | Participants in this group will have moderate intensity physical activity levels increased for 6 months, through attending 3x 45 min supervised exercise sessions/week. Receives: Behavioral: Increased Physical activity |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Cardiorespiratory fitness (VO2 max)
change in maximal oxygen uptake (continuous incremental bicycle ergometer exercise test with on-line gas analysis) measured every 6 weeks
Measured: 12 weeks
Secondary outcomes (30)
Change in Isometric leg strength
Change in Isometric leg strength measured every 6 weeks using CYBEX dynamometer
Measured: 24 weeks
Change in time to leg fatigue
Change in time taken to induce muscle fatigue measured every 6 weeks using isokinetic knee extensions on a CYBEX dynamometer
Measured: 24 weeks
Change in incremental area under the curve (iAUC) for blood glucose concentration
Change in 180 minute blood glucose concentration incremental area under the curve measured every 6 weeks during an oral glucose tolerance test.
Measured: 24 weeks
Change in iAUC for serum insulin concentration
Change in 180-minute serum insulin concentration incremental area under the curve measured every 6 weeks during an oral glucose tolerance test
Measured: 24 weeks
Change in fasting glucose oxidation rate
Change in glucose oxidation rate (when fasted), measured every 6 weeks using ventilated hood indirect calorimetry
Measured: 24 weeks
Change in 'fed' glucose oxidation rate
Change in glucose oxidation rate (in the insulin-stimulated 'fed' state), measured every 6 weeks using ventilated hood indirect calorimetry during an oral glucose tolerance test
Measured: 24 weeks
Change in Short Form Health Survey (SF36) Questionnaire aggregated normalised 'physical' score
Change in 'SF36' Questionnaire aggregated 'physical' score (normalised to UK population) calculated according to standard procedures (min 0, max 100), with higher score indicating better physical wellbeing measured every 6 weeks
Measured: 24 weeks
Change in Short Form Health Survey (SF36) Questionnaire aggregated and normalised 'mental' score
Change in 'SF36' Questionnaire aggregated 'mental' score (normalised to UK population) calculated according to standard procedures (min 0, max 100), with higher score indicating better mental wellbeing, measured every 6 weeks
Measured: 24 weeks
Change in World Health Organisation Quality of Life (WHOQoL) score
Change in World Health Organisation Quality of Life Score (measured using the WHOQoL-Bref questionnaire every 6 weeks), (min score 0, max 100), with higher score indicating a better state of health.
Measured: 24 weeks
Change in Pittsburgh Sleep Quality Index (PSQI)
Change in PSQI score (min score 0, max 21), measured every 6 weeks, with higher score indicating poorer sleep quality
Measured: 24 weeks
Change in Stroop test; % Accuracy
Change in the percentage of accurate responses, measured every 6 weeks, with higher score indicating better cognitive performance. Minimum value 0%, maximum value 100%
Measured: 24 weeks
Change in Stroop test; reaction time
Change in the reaction time for responses, measured every 6 weeks, with higher score indicating slower cognitive performance. No minimum or maximum value defined.
Measured: 24 weeks
Change in four-choice reaction time test; % Accuracy
Change in the percentage of accurate responses, measured every 6 weeks, with higher score indicating better cognitive performance. Minimum value 0%, maximum value 100%
Measured: 24 weeks
Change in four-choice reaction time test; reaction time
Change in the reaction time for responses, measured every 6 weeks, with higher score indicating slower cognitive performance. No minimum or maximum value defined.
Measured: 24 weeks
Change in card sort test; % Accuracy
Change in the percentage of accurate responses, measured every 6 weeks, with higher score indicating better cognitive performance. Minimum value 0%, maximum value 100%
Measured: 24 weeks
Change in card sort test; reaction time
Change in the reaction time for responses, measured every 6 weeks, with higher score indicating slower cognitive performance. No minimum or maximum value defined.
Measured: 24 weeks
Change in Logical reasoning test; % accuracy
Change in the accuracy of responses, measured every 6 weeks, with higher score indicating better cognitive performance. Minimum value 0%, maximum value 100%
Measured: 24 weeks
Change in Logical reasoning test; reaction time
Change in the reaction time for responses, measured every 6 weeks, with higher score indicating slower cognitive performance. No minimum or maximum value defined.
Measured: 24 weeks
Change in serial subtractions test; number of responses in 2 minutes
Change in the number of responses, measured every 6 weeks, with higher score indicating better cognitive performance. minimum number is 0, maximum number is variable dependent on starting value (800-999; randomly selected by computer program) and speed of response.
Measured: 24 weeks
Change in Corsi blocks test; score
Change in the test score, measured every 6 weeks, with higher score indicating better cognitive performance.Minimum score is 0 and maximum is 15.
Measured: 24 weeks
Change in Muscle protein synthesis rate
Muscle synthesis protein rate calculated from deuterium incorporation into muscle tissue
Measured: 24 weeks
Change in Muscle protein breakdown rate
Muscle protein breakdown rate calculated every 6 weeks using 3-methylhistidine tracer
Measured: 24 weeks
Change in whole body fat volumes
Change in the amount of fat within the body, measured every 6 weeks using magnetic resonance imaging (MRI)
Measured: 24 weeks
Change in liver fat volumes
Change in the amount of fat within the liver, measured every 6 weeks using magnetic resonance imaging (MRI)
Measured: 24 weeks
Change in thigh muscle fat volumes
Change in the amount of fat within the vastus lateralis thigh muscle, measured every 6 weeks using magnetic resonance imaging (MRI)
Measured: 24 weeks
Change in whole body muscle volumes
Change in the amount of muscle within the body, measured every 6 weeks using magnetic resonance imaging (MRI)
Measured: 24 weeks
Change in muscle phosphocreatine synthesis rate
Change in the rate of phosphocreatine synthesis, measured every 6 weeks using magnetic resonance spectroscopy
Measured: 24 weeks
Change in cerebral volume
Change in the volume of brain tissue, measured every 6 weeks using magnetic resonance imaging (MRI)
Measured: 24 weeks
Change in cortical thickness
Change in the thickness of the brain cortex, measured every 6 weeks using magnetic resonance imaging (MRI)
Measured: 24 weeks
Change in plasma metabolome
change in untargeted plasma metabolome profile measured every 6 weeks
Measured: 24 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Apr 2024
- Study start12 Mar 2024
- Primary completion17 Dec 2027 (estimated)
- Study completion31 Oct 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Sedentary BehaviorStudies of the same condition, open and under way.
- More trials run by University of NottinghamThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Non-randomised, parallel design lifestyle intervention
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Nottingham
- Sponsor type
- University, hospital or other
- Collaborators
- Biotechnology and Biological Sciences Research Council
- Responsible party
- Principal investigator, Paul Greenhaff, University of Nottingham
- Investigators
- Paul L Greenhaff, PhD, Principal investigator, University of Nottingham
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06377254
- Sponsor's protocol ID
- BB/X015173/1
- Acronym
- CHAIN
- Status last verified
- Nov 2025
- First submitted
- 11 Apr 2024
- Last updated
- 4 Dec 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Anonymised dataset will be made available to other researchers on request after study aims have been analysed and published. No patient identifiable data will be shared
Study at a glance
From the registry record, last updated by the sponsor on 4 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Concurrent Multi-organ Responses to CHronic Physical Activity and INactivity Intervention, to Increase Research Discovery in Human Health and Wellbeing
- ClinicalTrials.gov ID
- NCT06377254
- Acronym / sponsor ID
- CHAIN / BB/X015173/1
- Conditions
- Sedentary Behavior, Metabolic Syndrome, Age-related Cognitive Decline, Age-Related Sarcopenia
- Keywords
- Physical activity, middle-age, Physical inactivity, overweight, lifestyle
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- University of NottinghamUniversity, hospital or other
- Collaborators
- Biotechnology and Biological Sciences Research Council
- Study start
- 12 Mar 2024 (actual)
- Primary completion
- 17 Dec 2027 (estimated)
- Study completion
- 31 Oct 2028 (estimated)
- First posted
- 22 Apr 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Life expectancy has been increasing for the last 150 years, but the maintenance of health has not kept pace with increased lifespan, and on average, UK adults spend the last decade of life in poor-health, with major consequences for society and the individual.
Persistent physical inactivity is thought to be a key contributing factor to the risk of poor health and functional decline occurring in middle-aged and older adults. It is therefore concerning that most middle-aged adults spend >8hrs/day being sedentary, with average step count of 3000-4000 steps/day.
To be able to holistically assess the effectiveness of future strategies to address age-related decline in health, and devise public health messages to help individuals reach older age in better health, it is essential that the complex physiological effects that activity and inactivity have across biological systems are characterised.
The goal of this intervention study is to compare the impact of physical activity and inactivity on body functioning. Twenty moderately active participants will decrease their physical activity for three months to match the average amount carried out by middle-aged people in the UK. They will then undertake 3-months of reconditioning training to restore their fitness. In addition, twenty sedentary participants will increase their physical activity to UK recommended levels for six months.
Before and at points during the intervention period, participants will be asked to make some measurements at home and attend the University of Nottingham to have multiple assessments made. These include;
- fitness, muscle strength and function tests,
- completion of questionnaires and computer-based brain puzzles
- having muscle and fat tissue biopsies and blood samples taken.
- The study also involves having MRI scans.
This 5-year study will commence in January 2024, with participant recruitment starting in March 2024 and finishing in May 2027.
Detailed description
This is a parallel design study comparing the impact of physical activity and inactivity on the way the body functions, to understand the mechanisms (including the inter-relationship between tissues and organs) by which lifestyle behaviours may effect health and wellbeing in later life. In particular, the mechanisms by which inactivity results in long term poor health is not well understood, and has rarely been studied in an integrated way in people. However, initial research indicates that the physiology of being inactive is not simply the reverse of being active. To enable effective treatments and public health advice to be devised so that more adults reach old age in better health, and maintain a good quality of life for a greater proportion of their older age, it is important that the impact of physical inactivity on the way the body functions is better understood. Therefore, twenty participants who are moderately, but not highly active will be asked to decrease their physical activity for three months to match the average exercise levels of middle-aged people in the United Kingdom (UK). This will require them to increase their daily sitting time to 7 hours a day and reduce their step count to <4500 steps per day. At the end of the 3-months they will undertake 3-months of supervised reconditioning training by attending the Medical School at Queen's Medical Centre, Nottingham, three times a week.
In addition, twenty participants who currently have low physical activity levels will be asked to increase their physical activity to UK recommended levels by attending the Medical School at Queen's Medical Centre, Nottingham, three times a week for six months to undertake a supervised exercise program.
Before and during the 6-month period (at weeks 6, 12, 18 and 24) participants will be asked to make some measurements at home (physical activity levels, dietary intake) and attend the University of Nottingham over 4 days to have multiple assessments made. These include: height; weight; body composition (body fat and lean tissue); blood pressure; fitness, muscle strength and function; sleep quality, quality of life and wellbeing (questionnaires). The rate of muscle protein breakdown and muscle protein synthesis, blood sugar regulation, and biochemistry of the blood, fat tissue and muscles will be assessed, and to enable this muscle and fat tissue biopsies will be collected and blood samples taken. The study also involves having MRI scans to study the structure and function of the brain and heart, and to determine liver and muscle fat content.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Non-randomised, parallel design lifestyle intervention
| Arm | Type | Receives |
|---|---|---|
| Inactivity | Experimental | Behavioral: Decreased Physical ActivityParticipants in this group will reduce their physical activity (increase sitting time to 7hrs/day and decrease step count to <4500/day) for 3 months, then increase their activity for 3 months, through attending 3x 45 min supervised exercise sessions/week. |
| Activity | Experimental | Behavioral: Increased Physical activityParticipants in this group will have moderate intensity physical activity levels increased for 6 months, through attending 3x 45 min supervised exercise sessions/week. |
Who may qualify
- Ages
- 50 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Group 1 ('non-sedentary') self-reporting <6 sedentary hrs/day, not actively involved in exercise training or a regular physical activity regimen (>8,000 steps/day).
- Group 2 ('sedentary') self-reporting ≥8 waking hrs/day in sedentary activities and/or ≤5,000 steps/day.
- Aged 50-65y.
- Overweight (BMI 25-35 kg/m2).
- Waist circumference ≥94cm (males) and ≥80cm (females).
Key exclusion criteria (8 listed)
- Regular medication use that could interfere with measures
- A history, or evidence, of chronic cardiovascular, metabolic, musculoskeletal, renal or respiratory diseases.
- Experiencing 'long-COVID', inflammatory bowel disease or malignancy.
- Uncontrolled hypertension. Stage 1 hypertension (BP ≤160/100mmHg) with no other signs of cardiovascular disease, and blood pressure (BP) managed by routine medication will not be an exclusion.
- People employed in jobs that would preclude reducing step count and night-shift workers.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Decreased Physical ActivityPhysical activity levels will be decreased | Behavioural | Inactivity |
| Increased Physical activityPhysical activity levels will be increased | Behavioural | Activity |
Primary outcome
Change in Cardiorespiratory fitness (VO2 max)
Time frame: 12 weeks
change in maximal oxygen uptake (continuous incremental bicycle ergometer exercise test with on-line gas analysis) measured every 6 weeks
30 secondary outcomes
Change in Isometric leg strength
Time frame: 24 weeks
Change in time to leg fatigue
Time frame: 24 weeks
Change in incremental area under the curve (iAUC) for blood glucose concentration
Time frame: 24 weeks
Change in iAUC for serum insulin concentration
Time frame: 24 weeks
Change in fasting glucose oxidation rate
Time frame: 24 weeks
Change in 'fed' glucose oxidation rate
Time frame: 24 weeks
Change in Short Form Health Survey (SF36) Questionnaire aggregated normalised 'physical' score
Time frame: 24 weeks
Change in Short Form Health Survey (SF36) Questionnaire aggregated and normalised 'mental' score
Time frame: 24 weeks
Change in World Health Organisation Quality of Life (WHOQoL) score
Time frame: 24 weeks
Change in Pittsburgh Sleep Quality Index (PSQI)
Time frame: 24 weeks
Change in Stroop test; % Accuracy
Time frame: 24 weeks
Change in Stroop test; reaction time
Time frame: 24 weeks
Change in four-choice reaction time test; % Accuracy
Time frame: 24 weeks
Change in four-choice reaction time test; reaction time
Time frame: 24 weeks
Change in card sort test; % Accuracy
Time frame: 24 weeks
Change in card sort test; reaction time
Time frame: 24 weeks
Change in Logical reasoning test; % accuracy
Time frame: 24 weeks
Change in Logical reasoning test; reaction time
Time frame: 24 weeks
Change in serial subtractions test; number of responses in 2 minutes
Time frame: 24 weeks
Change in Corsi blocks test; score
Time frame: 24 weeks
Change in Muscle protein synthesis rate
Time frame: 24 weeks
Change in Muscle protein breakdown rate
Time frame: 24 weeks
Change in whole body fat volumes
Time frame: 24 weeks
Change in liver fat volumes
Time frame: 24 weeks
Change in thigh muscle fat volumes
Time frame: 24 weeks
Change in whole body muscle volumes
Time frame: 24 weeks
Change in muscle phosphocreatine synthesis rate
Time frame: 24 weeks
Change in cerebral volume
Time frame: 24 weeks
Change in cortical thickness
Time frame: 24 weeks
Change in plasma metabolome
Time frame: 24 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Dec 2025.
- Individual participant dataSharing planned: Yes. Anonymised dataset will be made available to other researchers on request after study aims have been analysed and published. No patient identifiable data will be shared
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Melanie Tooley (participant recruitment), BSc contact
Paul L Greenhaff, PhD principal investigator
University of Nottingham
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Decreased Physical Activity and Increased Physical activity in people with Sedentary Behavior and Metabolic Syndrome, run by University of Nottingham at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Paul L Greenhaff (PI), PhD (+44 (0) 1158230133, paul.greenhaff@nottingham.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Cardiorespiratory fitness (VO2 max) (time frame: 12 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Dec 2025.