ExerciseNCT06378762
Interference of Endurance Training on Strength Development and Neuromuscular Adaptations
A study testing Endurance Exercise, Strength Exercise and Concurrent Exercise in people with Exercise, run by University of Lisbon at 1 site in Portugal.
Trial summary
This study aims to find out if performing combined strength and endurance exercise in the same program (called concurrent training-CT) leads to similar long-term improvements in neuromuscular function as doing each type of exercise separately. Read more about this study
- Who is it for?
- Ages 18 to 30 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Exercise
- What is being tested?
- Endurance Exercise, Strength Exercise and Concurrent Exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 sitePortugal
- Study dates
- 1 Apr 2022to 30 Jul 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Active training status (strength and endurance (running) exercise at least 2 times per week over the last three months prior to inclusion in the study)
Who cannot join
- Active smoking status
- Orthopedic injuries
- On medication
- Known cardiovascular or respiratory disease
Trial locations and contacts
1 site in 1 country.
Portugal1 site
Faculdade de Motricidade Humana - Universidade de Lisboa
Lisbon, Cruz Quebrada - Dafundo, 1499-002
About this study
This study aims to find out if performing combined strength and endurance exercise in the same program (called concurrent training-CT) leads to similar long-term improvements in neuromuscular function as doing each type of exercise separately. The main questions it seeks to answer are:
Does performing CT result in similar improvements in strength and power as doing just strength training? Does performing CT result in similar improvements in cardiorespiratory fitness as doing just endurance training? Are neuromuscular adaptations similar between CT and just strength training? Researchers will compare the results between three groups: the CT group, the endurance training group (E), and the strength training group (S) to answer these questions.
Read the detailed description
This study looks at how different types of exercise affect neuromuscular and cardiorespiratory improvements over time. It aims to see how combining strength and endurance training (concurrent training - CT) affects neuromuscular and cardiorespiratory adaptations compared to doing just strength or endurance training. Participants who regularly do both types of exercise will be split into three groups: Concurrent training (CT), endurance training (E), or strength training (S) and will be involved in 11 weeks of supervised training, three days a week:
Endurance training involves 30 minutes of continuous running, three days a week, at an intensity corresponding to the heavy domain (between the first and second ventilatory threshold) Strength training includes weightlifting three days a week, focusing on building both strength and power.
Concurrent training incorporates both strength and endurance exercises in the same session, three days a week, with strength training being executed prior to endurance training.
Researchers will collect data at three time-points during the 11 weeks: before starting the program (Baseline), at the end of week 5 (Week 5), and at the end of the program (Week 11). Measurements include lower-body strength and power, aerobic capacity, nerve evoked responses, and muscle structure if the quadriceps femoris.
Researchers will then compare the CT, E, and S groups at each measurement point to see which type of training elicited the best adaptations for the different neuromuscular and cardiorespiratory outcomes.
- Conditions
- Exercise
- Being tested
- Endurance Exercise, Strength Exercise, Concurrent Exercise
- Keywords
- Neuromuscular adaptations, Concurrent training, Interference effect, Endurance, Strength
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Endurance ExerciseBehavioural
30 minutes of running at an intensity corresponding to the heavy-domain (between the first and second ventilatory thresholds)
Strength ExerciseBehavioural
Combination of strength and power exercises Weeks 1-5 focus on building maximal strength Weeks 6-11 focus on maintaining maximal strength and improve muscle power
Concurrent ExerciseBehavioural
Combining both strength and endurance training programs, with strength preceding endurance, incorporating a 20-min rest period between each modality
| Study group | Role | What they receive |
|---|---|---|
| Endurance | Experimental | Not described Receives: Behavioral: Endurance Exercise |
| Strength | Experimental | Not described Receives: Behavioral: Strength Exercise |
| Concurrent | Experimental | Not described Receives: Behavioral: Concurrent Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Maximal Isometric Strength
Maximal voluntary isometric strength of the plantarflexors and leg press exercise in Newtons
Measured: Baseline, Week 5, Week 11
Maximal Dynamic Strength
Maximal dynamic strength on the back squat exercise in kilograms lifted
Measured: Baseline, Week 5, Week 11
Surface EMG
Using surface electromyography (EMG), the muscle activation of the plantarflexors muscles will me assessed, as well as the quadriceps femoris during the leg press and back squat exercise
Measured: Baseline, Week 5, Week 11
H-reflex excitability
Using percutaneous electrostimulation of the tibial nerve, spinal reflex excitability will be explored by assessing H-reflex evoked responses
Measured: Baseline, Week 5, Week 11
V-wave
Using percutaneous electrostimulation of the tibial nerve, neural drive to the active muscle will be assessed by measuring V-wave amplitudes
Measured: Baseline, Week 5, Week 11
Lower Body Muscle Power
Lower body muscle power in watts will be assessed during countermovement jumps
Measured: Baseline, Week 5, Week 11
Muscle fascicle length
Fascicle length of the vastus lateralis muscles in centimeters
Measured: Baseline, Week 5, Week 11
Muscle fascicle pennation angle
Pennation angle of the vastus laterais fascicles, in degrees
Measured: Baseline, Week 5, Week 11
Muscle thickenss
Muscle thickenss of the vastus lateralis, in centimeters
Measured: Baseline, Week 5, Week 11
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Apr 2024
- Study start1 Apr 2022
- Primary completion30 Jul 2024
- Study completion30 Jul 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ExerciseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Lisbon
- Sponsor type
- University, hospital or other
- Collaborators
- Fundação para a Ciência e a Tecnologia
- Responsible party
- Principal investigator, Miguel Gomes, University of Lisbon
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06378762
- Sponsor's protocol ID
- 6/2021
- Status last verified
- Nov 2024
- First submitted
- 8 Apr 2024
- Last updated
- 3 Dec 2024
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Gomes M, Costa M, Pezarat-Correia P, Mendonca GV. Lower-Body Strength and Hypertrophy Adaptations in Response to Concurrent Training in Trained Young Males. J Strength Cond Res. 2026 Oct 28. doi: 10.1519/JSC.0000000000005698. Online ahead of print.
PubMed 42949799
Study at a glance
From the registry record, last updated by the sponsor on 3 Dec 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Interference of Endurance Training on Strength Development and Neuromuscular Adaptations
- ClinicalTrials.gov ID
- NCT06378762
- Acronym / sponsor ID
- 6/2021
- Conditions
- Exercise
- Keywords
- Neuromuscular adaptations, Concurrent training, Interference effect, Endurance, Strength
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 30 participants (actual)
- Lead sponsor
- University of LisbonUniversity, hospital or other
- Collaborators
- Fundação para a Ciência e a Tecnologia
- Study start
- 1 Apr 2022 (actual)
- Primary completion
- 30 Jul 2024 (actual)
- Study completion
- 30 Jul 2025 (estimated)
- First posted
- 22 Apr 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to find out if performing combined strength and endurance exercise in the same program (called concurrent training-CT) leads to similar long-term improvements in neuromuscular function as doing each type of exercise separately. The main questions it seeks to answer are:
Does performing CT result in similar improvements in strength and power as doing just strength training? Does performing CT result in similar improvements in cardiorespiratory fitness as doing just endurance training? Are neuromuscular adaptations similar between CT and just strength training? Researchers will compare the results between three groups: the CT group, the endurance training group (E), and the strength training group (S) to answer these questions.
Detailed description
This study looks at how different types of exercise affect neuromuscular and cardiorespiratory improvements over time. It aims to see how combining strength and endurance training (concurrent training - CT) affects neuromuscular and cardiorespiratory adaptations compared to doing just strength or endurance training. Participants who regularly do both types of exercise will be split into three groups: Concurrent training (CT), endurance training (E), or strength training (S) and will be involved in 11 weeks of supervised training, three days a week:
Endurance training involves 30 minutes of continuous running, three days a week, at an intensity corresponding to the heavy domain (between the first and second ventilatory threshold) Strength training includes weightlifting three days a week, focusing on building both strength and power.
Concurrent training incorporates both strength and endurance exercises in the same session, three days a week, with strength training being executed prior to endurance training.
Researchers will collect data at three time-points during the 11 weeks: before starting the program (Baseline), at the end of week 5 (Week 5), and at the end of the program (Week 11). Measurements include lower-body strength and power, aerobic capacity, nerve evoked responses, and muscle structure if the quadriceps femoris.
Researchers will then compare the CT, E, and S groups at each measurement point to see which type of training elicited the best adaptations for the different neuromuscular and cardiorespiratory outcomes.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Endurance | Experimental | Behavioral: Endurance Exercise |
| Strength | Experimental | Behavioral: Strength Exercise |
| Concurrent | Experimental | Behavioral: Concurrent Exercise |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Active training status (strength and endurance (running) exercise at least 2 times per week over the last three months prior to inclusion in the study)
Key exclusion criteria (4 listed)
- Active smoking status
- Orthopedic injuries
- On medication
- Known cardiovascular or respiratory disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Endurance Exercise30 minutes of running at an intensity corresponding to the heavy-domain (between the first and second ventilatory thresholds) | Behavioural | Endurance |
| Strength ExerciseCombination of strength and power exercises Weeks 1-5 focus on building maximal strength Weeks 6-11 focus on maintaining maximal strength and improve muscle power | Behavioural | Strength |
| Concurrent ExerciseCombining both strength and endurance training programs, with strength preceding endurance, incorporating a 20-min rest period between each modality | Behavioural | Concurrent |
Primary outcome
Maximal Isometric Strength
Time frame: Baseline, Week 5, Week 11
Maximal voluntary isometric strength of the plantarflexors and leg press exercise in Newtons
Maximal Dynamic Strength
Time frame: Baseline, Week 5, Week 11
Maximal dynamic strength on the back squat exercise in kilograms lifted
Surface EMG
Time frame: Baseline, Week 5, Week 11
Using surface electromyography (EMG), the muscle activation of the plantarflexors muscles will me assessed, as well as the quadriceps femoris during the leg press and back squat exercise
H-reflex excitability
Time frame: Baseline, Week 5, Week 11
Using percutaneous electrostimulation of the tibial nerve, spinal reflex excitability will be explored by assessing H-reflex evoked responses
V-wave
Time frame: Baseline, Week 5, Week 11
Using percutaneous electrostimulation of the tibial nerve, neural drive to the active muscle will be assessed by measuring V-wave amplitudes
Lower Body Muscle Power
Time frame: Baseline, Week 5, Week 11
Lower body muscle power in watts will be assessed during countermovement jumps
Muscle fascicle length
Time frame: Baseline, Week 5, Week 11
Fascicle length of the vastus lateralis muscles in centimeters
Muscle fascicle pennation angle
Time frame: Baseline, Week 5, Week 11
Pennation angle of the vastus laterais fascicles, in degrees
Muscle thickenss
Time frame: Baseline, Week 5, Week 11
Muscle thickenss of the vastus lateralis, in centimeters
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Dec 2024.
- Derived from this study: PubMed 42949799Gomes M, Costa M, Pezarat-Correia P, Mendonca GV. Lower-Body Strength and Hypertrophy Adaptations in Response to Concurrent Training in Trained Young Males. J Strength Cond Res. 2026 Oct 28. doi: 10.1519/JSC.0000000000005698. Online ahead of print.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Endurance Exercise, Strength Exercise and Concurrent Exercise in people with Exercise, run by University of Lisbon at 1 site in Portugal.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 3 Dec 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Portugal. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maximal Isometric Strength (time frame: Baseline, Week 5, Week 11). The study lists 9 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06378762, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Dec 2024.