Neck PainNCT06407479
Comparison of Eccentric Muscle Training and Proprioceptive Neuromuscular Facilitation Techniques in Neck Pain
A study testing proprioceptive neuromuscular facilitation technique group and eccentric muscle training technique application group in people with Neck Pain and Musculoskeletal Pain, run by Uskudar University at 1 site in Turkey (Türkiye).
Trial summary
This trial compared eccentric exercise training and the proprioceptive neuromuscular facilitation (PNF) technique, each added to a common cervical stretching and stabilisation programme, in individuals with non-specific neck pain. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Neck Pain, Musculoskeletal Pain
- What is being tested?
- proprioceptive neuromuscular facilitation technique group and eccentric muscle training technique application group
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 9 May 2024to 10 Jan 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Being between the ages of 18-65
- Deep cervical flexor endurance time of less than 60 seconds on the modified craniocervical flexor endurance test at screening. Candidates able to hold the test position for 60 seconds or longer were considered to have sufficient deep cervical flexor endurance and were not enrolled.
- History of neck pain that has persisted for at least 7 days
- Agreeing to participate in the study
- Having the ability to read and write Turkish. EXCLUSION CRITERIA
- Radiculopathy and structural disorder in the cervical region,
Show all 17Show fewer
- Surgery to the cervical region,
- Inflammatory disease,
- Severe psychological illness,
- Presence of infection in the bone and soft tissue in the cervical spine,
- Malignancy,
- Advanced osteoporosis,
- Those with upper extremity pathologies,
- Having a neurological disease that will prevent treatment
- Having previously undergone cervical region and spine surgery
- Having been included in a physiotherapy program for the neck and back area in the last 6 months,
- It was defined as the administration of drugs such as NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) and opioids in the last 24 hours.
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison of Eccentric Muscle Training and Proprioceptive Neuromuscular Facilitation Techniques in Individuals With Non-specific Neck Pain
This trial compared eccentric exercise training and the proprioceptive neuromuscular facilitation (PNF) technique, each added to a common cervical stretching and stabilisation programme, in individuals with non-specific neck pain. Outcomes were neck-related disability, multidimensional pain, cervical range of motion, deep cervical flexor endurance, kinesiophobia and health-related quality of life, assessed at baseline and after 6 weeks.
Read the detailed description
The study was planned as a quantitative study. Volunteer individuals with nonspecific neck pain between the ages of 18-65 will be included in the study, and the participants will be randomly distributed into 3 groups. Control group (n=15), proprioceptive neuromuscular facilitation technique application group (n=15), eccentric muscle training technique application group (n=15). People included in the study will be explained in detail and will be asked to sign a voluntary consent form approved by the ethics committee. Demographic information of individuals in all three groups will be recorded first. Participants in all three groups will be evaluated at the beginning and end of the applications. In our study, participants were evaluated with the McGill Pain Questionnaire to evaluate the character and character of pain, their physical fitness with the Deep Neck Flexor Endurance Test, their functionality related to daily living activities with the Neck Disability Index (NDI, and their quality of life with the World Health Organization Short Form of Quality of Life (WHOQOL-BREF) Tampa Kinesiophobia Scale and a goniometer for Cervical Region Joint Range of Motion Measurement will be used to evaluate kinesiophobia, which is the fear of pain and re-injury, as well as anxiety towards activity and physical movement. This study will be planned five times a week for six weeks. Stretching and stabilization exercises will be applied to the control group in 3 sets of 10 repetitions.
- Conditions
- Neck Pain, Musculoskeletal Pain
- Being tested
- proprioceptive neuromuscular facilitation technique group, eccentric muscle training technique application group, Control
- Medical subject headings
- Neck Pain, Musculoskeletal Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
proprioceptive neuromuscular facilitation technique groupOther
Proprioceptive Neuromuscular Facilitation Technique group; In addition to the exercises applied to the participants and the control group, combined isotonic contractions and dynamic stabilization will be used as facilitation techniques, and hold-relax technique will be used as an inhibition technique.
eccentric muscle training technique application groupOther
Eccentric Muscle Training Technique: Participants will receive eccentric muscle training in addition to the exercises given to the control group. Before the application, 5-minute warm-up exercises will be given to the neck area. Eccentric muscle training will be applied to the muscles of the participants in the cervical region. Eccentric exercise will be strengthened in the cervical region muscles in the direction of movement in each plane, that is, flexion / extension and lateral flexion. The movements will first be explained and demonstrated to the patient.
ControlOther
Cervical stretching and stabilisation exercise programme. Stretching was applied in flexion, extension, rotation and lateral flexion (30-second hold, 10 repetitions). Stabilisation exercises were performed with the participant applying self-resistance from a seated position (10-second contraction, 15-second rest). Both components were performed in 3 sets of 10 repetitions with 1-minute rest between sets, in 45-minute sessions, 5 days per week for 6 weeks. This programme was also delivered as the base programme to both experimental groups.
| Study group | Role | What they receive |
|---|---|---|
| proprioceptive | Experimental | proprioceptive neuromuscular facilitation technique application Receives: Other: proprioceptive neuromuscular facilitation technique group |
| eccentric | Experimental | eccentric muscle training technique application Receives: Other: eccentric muscle training technique application group |
| Control | Active comparator | Participants performed a cervical stretching and stabilisation exercise programme only, without any additional technique. Receives: Other: Control |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cervical Deep Flexor Muscle Endurance Test
Patients were asked to lie in a supine position with knees flexed at 90° and hands on the abdomen in a hook position. A 0.5 kilogram (kg) weight was placed on the forehead with the help of a band passed over the ears. The patients were asked to first perform cervical retraction and then 10° cervical flexion, and the degree of flexion was determined with the help of a goniometer. The patients were asked to maintain this position and the time was determined with a stopwatch and recorded in seconds. Patients must be able to maintain this position for 60 seconds (sec) in order to have sufficient muscle endurance. Those below this period have insufficient muscle endurance. Cervical flexion for 60 seconds. Patients holding it above were considered to have sufficient endurance and were not included in the study.
Measured: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period). No further follow-up.
World Health Organization Quality of Life Survey Short Form
The scale measures 28 general health, physical, psychological, social and environmental well-being and consists of 26 questions. Turkey version consists of 27 questions. The 27th question is the national question that determines the Environmental Score. Since each domain expresses the quality of life in its own field independently of each other, domain scores are calculated between 4-20. As the score increases, the quality of life increases.
Measured: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period). No further follow-up.
Neck Disability Index
Neck Disability Index will be used to evaluate the disability specific to neck pain. The Neck Disability Index has been modified from the Oswestry Disability Index. It consists of 10 sections: pain intensity, personal care, weight bearing, reading, headache, concentration, working, driving, sleep and recreational activities. Each section consists of 6 answers and is scored from 0, no disability, to 5, representing total disability. According to total score; 0-4: no limitation, 5-14: mild limitation, 15-24: moderate limitation, 25-34: severe limitation, 34 and above: completely limited.
Measured: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period). No further follow-up.
Tampa Kinesiophobia Scale
Tampa Kinesiophobia Scale was used to evaluate kinesiophobia, which is a state of anxiety that develops against activity and physical movement due to fear of pain and re-injury. It was developed to differentiate between non-excessive fear and phobia in patients with chronic musculoskeletal pain. It is frequently used in the literature to evaluate movement-related fear and anxiety. The scale is a 17-item scale that includes parameters of injury, re-injury and fear-avoidance in work-related activities. As the score increases, it is accepted that the kinesiophobia of the individual with pain increases.Results consist of a total raw score (range between 17 and 68) A low score indicates low kinesiophobia.
Measured: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period). No further follow-up.
Cervical joint goniometric measurements
Goniometric measurements in the neck are methods used to evaluate and record neck joint range of motion. These measurements are important to evaluate the patient's condition during the treatment process, follow the progress and create the treatment plan.
Measured: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period). No further follow-up.
Secondary outcomes (1)
McGill Pain Questionnaire (long form)
The long-form McGill Pain Questionnaire was used to characterise the multidimensional quality of pain, including pain localisation, the sensory, affective and evaluative word-descriptor dimensions, the number of words chosen, the pain-time relationship, and present pain intensity. Higher scores indicate greater pain.
Measured: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 May 2024
- Study start9 May 2024
- Primary completion30 Jul 2024
- Study completion10 Jan 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Neck PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- Uskudar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Doç.Dr.Ömer Şevgin, Uskudar University
- Investigators
- Büşra SÖKMEN YILDIRIM, Study chair, Uskudar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06407479
- Sponsor's protocol ID
- Uskudar4
- Status last verified
- Aug 2026
- First submitted
- 6 May 2024
- Last updated
- 14 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Holmgren T, Bjornsson Hallgren H, Oberg B, Adolfsson L, Johansson K. Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study. BMJ. 2012 Feb 20;344:e787. doi: 10.1136/bmj.e787.
PubMed 22349588Heredia-Rizo AM, Petersen KK, Madeleine P, Arendt-Nielsen L. Clinical Outcomes and Central Pain Mechanisms are Improved After Upper Trapezius Eccentric Training in Female Computer Users With Chronic Neck/Shoulder Pain. Clin J Pain. 2019 Jan;35(1):65-76. doi: 10.1097/AJP.0000000000000656.
PubMed 30222615Espi-Lopez GV, Aguilar-Rodriguez M, Zarzoso M, Serra-Ano P, Martinez DE LA Fuente JM, Ingles M, Marques-Sule E. Efficacy of a proprioceptive exercise program in patients with nonspecific neck pain: a randomized controlled trial. Eur J Phys Rehabil Med. 2021 Jun;57(3):397-405. doi: 10.23736/S1973-9087.20.06302-9. Epub 2020 Oct 13.
PubMed 33047944Hidalgo B, Hall T, Bossert J, Dugeny A, Cagnie B, Pitance L. The efficacy of manual therapy and exercise for treating non-specific neck pain: A systematic review. J Back Musculoskelet Rehabil. 2017 Nov 6;30(6):1149-1169. doi: 10.3233/BMR-169615.
PubMed 28826164Gillani SN, Ain Q-, Rehman SU, Masood T. Effects of eccentric muscle energy technique versus static stretching exercises in the management of cervical dysfunction in upper cross syndrome: a randomized control trial. J Pak Med Assoc. 2020 Mar;70(3):394-398. doi: 10.5455/JPMA.300417.
PubMed 32207413
Study at a glance
From the registry record, last updated by the sponsor on 14 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Eccentric Muscle Training and Proprioceptive Neuromuscular Facilitation Techniques in Individuals With Non-specific Neck Pain
- ClinicalTrials.gov ID
- NCT06407479
- Acronym / sponsor ID
- Uskudar4
- Conditions
- Neck Pain, Musculoskeletal Pain
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- Uskudar UniversityUniversity, hospital or other
- Study start
- 9 May 2024 (actual)
- Primary completion
- 30 Jul 2024 (actual)
- Study completion
- 10 Jan 2025 (actual)
- First posted
- 9 May 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This trial compared eccentric exercise training and the proprioceptive neuromuscular facilitation (PNF) technique, each added to a common cervical stretching and stabilisation programme, in individuals with non-specific neck pain. Outcomes were neck-related disability, multidimensional pain, cervical range of motion, deep cervical flexor endurance, kinesiophobia and health-related quality of life, assessed at baseline and after 6 weeks.
Detailed description
The study was planned as a quantitative study. Volunteer individuals with nonspecific neck pain between the ages of 18-65 will be included in the study, and the participants will be randomly distributed into 3 groups. Control group (n=15), proprioceptive neuromuscular facilitation technique application group (n=15), eccentric muscle training technique application group (n=15). People included in the study will be explained in detail and will be asked to sign a voluntary consent form approved by the ethics committee. Demographic information of individuals in all three groups will be recorded first. Participants in all three groups will be evaluated at the beginning and end of the applications. In our study, participants were evaluated with the McGill Pain Questionnaire to evaluate the character and character of pain, their physical fitness with the Deep Neck Flexor Endurance Test, their functionality related to daily living activities with the Neck Disability Index (NDI, and their quality of life with the World Health Organization Short Form of Quality of Life (WHOQOL-BREF) Tampa Kinesiophobia Scale and a goniometer for Cervical Region Joint Range of Motion Measurement will be used to evaluate kinesiophobia, which is the fear of pain and re-injury, as well as anxiety towards activity and physical movement. This study will be planned five times a week for six weeks. Stretching and stabilization exercises will be applied to the control group in 3 sets of 10 repetitions.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| proprioceptive | Experimental | Other: proprioceptive neuromuscular facilitation technique groupproprioceptive neuromuscular facilitation technique application |
| eccentric | Experimental | Other: eccentric muscle training technique application groupeccentric muscle training technique application |
| Control | Active comparator | Other: ControlParticipants performed a cervical stretching and stabilisation exercise programme only, without any additional technique. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (17 listed)
- Being between the ages of 18-65
- Deep cervical flexor endurance time of less than 60 seconds on the modified craniocervical flexor endurance test at screening. Candidates able to hold the test position for 60 seconds or longer were considered to have sufficient deep cervical flexor endurance and were not enrolled.
- History of neck pain that has persisted for at least 7 days
- Agreeing to participate in the study
- Having the ability to read and write Turkish. EXCLUSION CRITERIA
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| proprioceptive neuromuscular facilitation technique groupProprioceptive Neuromuscular Facilitation Technique group; In addition to the exercises applied to the participants and the control group, combined isotonic contractions and dynamic stabilization will be used as facilitation techniques, and hold-relax technique will be used as an inhibition technique. | Other | proprioceptive |
| eccentric muscle training technique application groupEccentric Muscle Training Technique: Participants will receive eccentric muscle training in addition to the exercises given to the control group. Before the application, 5-minute warm-up exercises will be given to the neck area. Eccentric muscle training will be applied to the muscles of the participants in the cervical region. Eccentric exercise will be strengthened in the cervical region muscles in the direction of movement in each plane, that is, flexion / extension and lateral flexion. The movements will first be explained and demonstrated to the patient. | Other | eccentric |
| ControlCervical stretching and stabilisation exercise programme. Stretching was applied in flexion, extension, rotation and lateral flexion (30-second hold, 10 repetitions). Stabilisation exercises were performed with the participant applying self-resistance from a seated position (10-second contraction, 15-second rest). Both components were performed in 3 sets of 10 repetitions with 1-minute rest between sets, in 45-minute sessions, 5 days per week for 6 weeks. This programme was also delivered as the base programme to both experimental groups. | Other | Control |
Primary outcome
Cervical Deep Flexor Muscle Endurance Test
Time frame: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period). No further follow-up.
Patients were asked to lie in a supine position with knees flexed at 90° and hands on the abdomen in a hook position. A 0.5 kilogram (kg) weight was placed on the forehead with the help of a band passed over the ears. The patients were asked to first perform cervical retraction and then 10° cervical flexion, and the degree of flexion was determined with the help of a goniometer. The patients were asked to maintain this position and the time was determined with a stopwatch and recorded in seconds. Patients must be able to maintain this position for 60 seconds (sec) in order to have sufficient muscle endurance. Those below this period have insufficient muscle endurance. Cervical flexion for 60 seconds. Patients holding it above were considered to have sufficient endurance and were not included in the study.
World Health Organization Quality of Life Survey Short Form
Time frame: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period). No further follow-up.
The scale measures 28 general health, physical, psychological, social and environmental well-being and consists of 26 questions. Turkey version consists of 27 questions. The 27th question is the national question that determines the Environmental Score. Since each domain expresses the quality of life in its own field independently of each other, domain scores are calculated between 4-20. As the score increases, the quality of life increases.
Neck Disability Index
Time frame: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period). No further follow-up.
Neck Disability Index will be used to evaluate the disability specific to neck pain. The Neck Disability Index has been modified from the Oswestry Disability Index. It consists of 10 sections: pain intensity, personal care, weight bearing, reading, headache, concentration, working, driving, sleep and recreational activities. Each section consists of 6 answers and is scored from 0, no disability, to 5, representing total disability. According to total score; 0-4: no limitation, 5-14: mild limitation, 15-24: moderate limitation, 25-34: severe limitation, 34 and above: completely limited.
Tampa Kinesiophobia Scale
Time frame: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period). No further follow-up.
Tampa Kinesiophobia Scale was used to evaluate kinesiophobia, which is a state of anxiety that develops against activity and physical movement due to fear of pain and re-injury. It was developed to differentiate between non-excessive fear and phobia in patients with chronic musculoskeletal pain. It is frequently used in the literature to evaluate movement-related fear and anxiety. The scale is a 17-item scale that includes parameters of injury, re-injury and fear-avoidance in work-related activities. As the score increases, it is accepted that the kinesiophobia of the individual with pain increases.Results consist of a total raw score (range between 17 and 68) A low score indicates low kinesiophobia.
Cervical joint goniometric measurements
Time frame: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period). No further follow-up.
Goniometric measurements in the neck are methods used to evaluate and record neck joint range of motion. These measurements are important to evaluate the patient's condition during the treatment process, follow the progress and create the treatment plan.
1 secondary outcome
McGill Pain Questionnaire (long form)
Time frame: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Aug 2026.
- Background: PubMed 22349588Holmgren T, Bjornsson Hallgren H, Oberg B, Adolfsson L, Johansson K. Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study. BMJ. 2012 Feb 20;344:e787. doi: 10.1136/bmj.e787.
- Background: PubMed 30222615Heredia-Rizo AM, Petersen KK, Madeleine P, Arendt-Nielsen L. Clinical Outcomes and Central Pain Mechanisms are Improved After Upper Trapezius Eccentric Training in Female Computer Users With Chronic Neck/Shoulder Pain. Clin J Pain. 2019 Jan;35(1):65-76. doi: 10.1097/AJP.0000000000000656.
- Background: PubMed 33047944Espi-Lopez GV, Aguilar-Rodriguez M, Zarzoso M, Serra-Ano P, Martinez DE LA Fuente JM, Ingles M, Marques-Sule E. Efficacy of a proprioceptive exercise program in patients with nonspecific neck pain: a randomized controlled trial. Eur J Phys Rehabil Med. 2021 Jun;57(3):397-405. doi: 10.23736/S1973-9087.20.06302-9. Epub 2020 Oct 13.
- Background: PubMed 28826164Hidalgo B, Hall T, Bossert J, Dugeny A, Cagnie B, Pitance L. The efficacy of manual therapy and exercise for treating non-specific neck pain: A systematic review. J Back Musculoskelet Rehabil. 2017 Nov 6;30(6):1149-1169. doi: 10.3233/BMR-169615.
- Background: PubMed 32207413Gillani SN, Ain Q-, Rehman SU, Masood T. Effects of eccentric muscle energy technique versus static stretching exercises in the management of cervical dysfunction in upper cross syndrome: a randomized control trial. J Pak Med Assoc. 2020 Mar;70(3):394-398. doi: 10.5455/JPMA.300417.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Büşra SÖKMEN YILDIRIM study chair
Uskudar University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing proprioceptive neuromuscular facilitation technique group and eccentric muscle training technique application group in people with Neck Pain and Musculoskeletal Pain, run by Uskudar University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 17 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 14 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cervical Deep Flexor Muscle Endurance Test (time frame: Baseline (before the first session) and 6 weeks (immediately after the final session of the intervention period). No further follow-up.). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06407479, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Aug 2026.