AsthmaNCT06426849
Effects of Liuzijue Exercise Versus Tai Chi Chuan Exercise in Asthma
A study testing Liuzijue Exercise and Tai Chi Chuan Exercise in people with Asthma, run by Riphah International University at 1 site in Pakistan.
Trial summary
To analyze either Liuzijue exercise or Tai Chi Chuan exercise is effective in improving dyspnea index and pulmonary function in patients with asthma. In the general population, the rate of asthma is increasing day by day because of environmental and occupational risk factors which is becoming a burden. Read more about this study
- Who is it for?
- Ages 20 to 40 years
- Conditions the study is for
- Asthma
- What is being tested?
- Liuzijue Exercise and Tai Chi Chuan Exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 sitePakistan
- Study dates
- 15 Feb 2024to 15 Aug 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Diagnosed case of Asthma for last 6 months
- Patients with mild to moderate asthma
- On spirometry FEV1/FVC ratio less than 70%
- MRC- Grade 2 and 3
Who cannot join
- Refusal to consent.
- Unstable vitals.
- Diagnosed with any lung disease.
- Uncontrolled Hypertension.
- Diagnosed Tumor.
- Patient with Stroke and other neurological conditions.
- Patient with active Tuberculosis or other infectious disease.
- Patients with history of heart failure or any other cardiovascular condition
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Tehsil Headquarter Hospital
Chichawatni, Punjab Province, 57200
About this study
Official title: Effects of Liuzijue Exercise Versus Tai Chi Chuan Exercise in Improving Dyspnea Index and Pulmonary Function in Patients With Asthma
To analyze either Liuzijue exercise or Tai Chi Chuan exercise is effective in improving dyspnea index and pulmonary function in patients with asthma. In the general population, the rate of asthma is increasing day by day because of environmental and occupational risk factors which is becoming a burden. It causes shortness of breath, decreases lung volume, and disturbs quality of life. This study aims to improve dyspnea index, lung volume and quality of life of the patients with asthma.
Read the detailed description
Liuzijue Exercise is the most popular exercise in ancient Chinese literature which is compiled by the Chinese Qigong Management Centre. Liuzijue exercise includes inhalation and exhalation through various mouth patterns to manage and control the rise and fall of the breath in the body. It is performed by delivering 6 distinct sounds, ("xū", "hē", "hū", "sī", "chuī", and "xī") through termination along with comparing body activities. It is very helpful to improve pulmonary functions, exercise capacity, and quality of life of patients with pulmonary disease.
Liuzijue exercise takes on the backward abdominal breathing technique joined with physical exercises, which can practice the diaphragm and chest auxiliary respiratory muscles. Hence, the patient's breathing time is extended, and the breathing profundity increments. To accomplish the reason for expanding the gas exchange rate of the lungs and enhancing the lung capacity. Tai Chi Chuan is a traditional Chinese Exercise that is significant in improving the pulmonary functions of asthmatic patients.
Tai Chi (10 forms of yang style ) significantly improves the exercise capacity of patients with lung disease. Tai Chi seems to have physiologic and psychosocial benefits and appears to be protected and viable in advancing balance control, adaptability, and cardiovascular fitness for older adults.
- Conditions
- Asthma
- Being tested
- Liuzijue Exercise, Tai Chi Chuan Exercise
- Keywords
- Liuzijue exercise, Tai Chi Chuan exercise, Dyspnea Index, Pulmonary Function, Asthma
- Medical subject headings
- Asthma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Liuzijue ExerciseOther
LiuzijueExercise includes inhalation and exhalation through various mouth patterns to manage and control the rise and fall of the breath in the body. It is performed by delivering 6 distinct sounds, (xū,hē, hū sī, chuī, and xī) through termination along with comparing body activities.
The following are 6-8 vital parts of body movements:
- Swaying and twisting
- Hip rotations
- Arm movements
- Knee bends
- Foot pivots
- Spine elongation
- Hand gestures
- Breath synchronization Frequency: 1 session per day for a week Intensity:In first week 1 set of Luizijue exercise will be performed then progressively increase to 4 sets till 6th week .
Total Time for Session; 40 minutes Warm-up Time: 10 minutes with pursed lip breathing Cool Down Time: 10 minutes with upper body gentle stretching. Exercise Duration: 20 minutes for Luizijue Exercise.
Tai Chi Chuan ExerciseOther
Tai Chi Chuan Exercise combines deep diaphragmatic breathing and relaxation with many fundamental postures.
Names of the 10 Movements in Sequence
- Commencing Form
- Repulsing the Monkey
- Brush Knee
- Parting the Horse's Mane
- Cloud Hands
- Golden Cockerel Standing on the Left, then the Right
- Kick Out Right, Kick Out Left
- Grasping the Bird's Tail
- Cross Hands or Embrace the Tiger
- Closing Form Frequency: 3 sessions / week Intensity: Initially each posture will be performed 3 times then progressively leads to 6 or 10 reps according to patient tolorance.
Total Time for Session; 40 minutes Warm-up Time: 10 minutes with pursed lip breathing Cool Down Time: 10 minutes with upper body gentle stretching. Exercise Duration: 20 minutes for Tai Chi Chuan Exercise.
| Study group | Role | What they receive |
|---|---|---|
| GROUP A | Experimental | LiuzijueExercise will be performed by delivering 6 distinct sounds,("xū", "hē", "hū", "sī", "chuī", and "xī") through termination along with comparing body activities. Receives: Other: Liuzijue Exercise |
| GROUP B | Experimental | 10 FORM OF YANG NG STYLE Tai Chi Chuan Exercise that combines deep diaphragmatic breathing and relaxation with many fundamental postures. Receives: Other: Tai Chi Chuan Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Dyspnea index
From baseline till 2nd, 4th, and 6th week measured throug Modified Medical Research Council (mMRC) dyspnoea scale. It is a self-rating scale to quantify the level of incapacity that breathlessness presents on everyday activity on a scale from Grade 0 to 4.
Grade 0: No shortness of breath besides on exhausting activity Grade1: Breathlessness while hustling fair and square or strolling along a slight slope Grade 2: Strolls more slow than individuals of same age fair and square in light of shortness of breath or needs to stop to take breath while strolling at their own speed fair and square Grade 3: Stop for breath subsequent to strolling ∼100 m or following couple of moments fair and square.
Grade 4: Excessively breathless to take off from the house, or breathless while dressing or stripping down
Measured: 6 weeks
Forced Expiratory Volume in 1 second (FEV1)
Changes from the Baseline, the digital spirometer is used in the clinical setting to analyze
Measured: 6 weeks
Secondary outcomes (1)
Asthma Quality of life
From baseline till 6th week measured through Asthma Control Questionnaire that individuals answer in regards to the recurrence of asthma symptoms over 6 weeks.
Each answer has a numeric value. The asthmatic individual adds their score to decide their degree of asthma symptoms control. Score ranges from 5 to 25. A score 20 to 25 indicate well controlled asthma while score ranges between 5 to 6 indicated poor controlled asthma.
Measured: 6 Weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 May 2024
- Study start15 Feb 2024
- Primary completion15 Aug 2024
- Study completion15 Aug 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AsthmaStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Mehwish Waseem, MSPT-CPPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06426849
- Sponsor's protocol ID
- Rec/01815 Maria Akbar
- Status last verified
- Sep 2024
- First submitted
- 19 May 2024
- Last updated
- 4 Sep 2024
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Sep 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Liuzijue Exercise Versus Tai Chi Chuan Exercise in Improving Dyspnea Index and Pulmonary Function in Patients With Asthma
- ClinicalTrials.gov ID
- NCT06426849
- Acronym / sponsor ID
- Rec/01815 Maria Akbar
- Conditions
- Asthma
- Keywords
- Liuzijue exercise, Tai Chi Chuan exercise, Dyspnea Index, Pulmonary Function, Asthma
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 15 Feb 2024 (actual)
- Primary completion
- 15 Aug 2024 (actual)
- Study completion
- 15 Aug 2024 (actual)
- First posted
- 23 May 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To analyze either Liuzijue exercise or Tai Chi Chuan exercise is effective in improving dyspnea index and pulmonary function in patients with asthma. In the general population, the rate of asthma is increasing day by day because of environmental and occupational risk factors which is becoming a burden. It causes shortness of breath, decreases lung volume, and disturbs quality of life. This study aims to improve dyspnea index, lung volume and quality of life of the patients with asthma.
Detailed description
Liuzijue Exercise is the most popular exercise in ancient Chinese literature which is compiled by the Chinese Qigong Management Centre. Liuzijue exercise includes inhalation and exhalation through various mouth patterns to manage and control the rise and fall of the breath in the body. It is performed by delivering 6 distinct sounds, ("xū", "hē", "hū", "sī", "chuī", and "xī") through termination along with comparing body activities. It is very helpful to improve pulmonary functions, exercise capacity, and quality of life of patients with pulmonary disease.
Liuzijue exercise takes on the backward abdominal breathing technique joined with physical exercises, which can practice the diaphragm and chest auxiliary respiratory muscles. Hence, the patient's breathing time is extended, and the breathing profundity increments. To accomplish the reason for expanding the gas exchange rate of the lungs and enhancing the lung capacity. Tai Chi Chuan is a traditional Chinese Exercise that is significant in improving the pulmonary functions of asthmatic patients.
Tai Chi (10 forms of yang style ) significantly improves the exercise capacity of patients with lung disease. Tai Chi seems to have physiologic and psychosocial benefits and appears to be protected and viable in advancing balance control, adaptability, and cardiovascular fitness for older adults.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| GROUP A | Experimental | Other: Liuzijue ExerciseLiuzijueExercise will be performed by delivering 6 distinct sounds,("xū", "hē", "hū", "sī", "chuī", and "xī") through termination along with comparing body activities. |
| GROUP B | Experimental | Other: Tai Chi Chuan Exercise10 FORM OF YANG NG STYLE Tai Chi Chuan Exercise that combines deep diaphragmatic breathing and relaxation with many fundamental postures. |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Diagnosed case of Asthma for last 6 months
- Patients with mild to moderate asthma
- On spirometry FEV1/FVC ratio less than 70%
- MRC- Grade 2 and 3
Key exclusion criteria (8 listed)
- Refusal to consent.
- Unstable vitals.
- Diagnosed with any lung disease.
- Uncontrolled Hypertension.
- Diagnosed Tumor.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Liuzijue ExerciseLiuzijueExercise includes inhalation and exhalation through various mouth patterns to manage and control the rise and fall of the breath in the body. It is performed by delivering 6 distinct sounds, (xū,hē, hū sī, chuī, and xī) through termination along with comparing body activities. The following are 6-8 vital parts of body movements: 1. Swaying and twisting 2. Hip rotations 3. Arm movements 4. Knee bends 5. Foot pivots 6. Spine elongation 7. Hand gestures 8. Breath synchronization Frequency: 1 session per day for a week Intensity:In first week 1 set of Luizijue exercise will be performed then progressively increase to 4 sets till 6th week . Total Time for Session; 40 minutes Warm-up Time: 10 minutes with pursed lip breathing Cool Down Time: 10 minutes with upper body gentle stretching. Exercise Duration: 20 minutes for Luizijue Exercise. | Other | GROUP A |
| Tai Chi Chuan ExerciseTai Chi Chuan Exercise combines deep diaphragmatic breathing and relaxation with many fundamental postures. Names of the 10 Movements in Sequence 1. Commencing Form 2. Repulsing the Monkey 3. Brush Knee 4. Parting the Horse's Mane 5. Cloud Hands 6. Golden Cockerel Standing on the Left, then the Right 7. Kick Out Right, Kick Out Left 8. Grasping the Bird's Tail 9. Cross Hands or Embrace the Tiger 10. Closing Form Frequency: 3 sessions / week Intensity: Initially each posture will be performed 3 times then progressively leads to 6 or 10 reps according to patient tolorance. Total Time for Session; 40 minutes Warm-up Time: 10 minutes with pursed lip breathing Cool Down Time: 10 minutes with upper body gentle stretching. Exercise Duration: 20 minutes for Tai Chi Chuan Exercise. | Other | GROUP B |
Primary outcome
Dyspnea index
Time frame: 6 weeks
From baseline till 2nd, 4th, and 6th week measured throug Modified Medical Research Council (mMRC) dyspnoea scale. It is a self-rating scale to quantify the level of incapacity that breathlessness presents on everyday activity on a scale from Grade 0 to 4. Grade 0: No shortness of breath besides on exhausting activity Grade1: Breathlessness while hustling fair and square or strolling along a slight slope Grade 2: Strolls more slow than individuals of same age fair and square in light of shortness of breath or needs to stop to take breath while strolling at their own speed fair and square Grade 3: Stop for breath subsequent to strolling ∼100 m or following couple of moments fair and square. Grade 4: Excessively breathless to take off from the house, or breathless while dressing or stripping down
Forced Expiratory Volume in 1 second (FEV1)
Time frame: 6 weeks
Changes from the Baseline, the digital spirometer is used in the clinical setting to analyze
1 secondary outcome
Asthma Quality of life
Time frame: 6 Weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Sep 2024.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mehwish Waseem, MSPT-CPPT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Liuzijue Exercise and Tai Chi Chuan Exercise in people with Asthma, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Sep 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Dyspnea index (time frame: 6 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Sep 2024.