MeaslesBFMMRHCWNCT06456788
Barriers and Facilitators to MMR Vaccination Among Healthcare Workers
An observational study of Measles, run by King's College London at 1 site in United Kingdom.
Trial summary
Measles is a highly contagious disease which can result in severe complications in some patients. Healthcare workers have a higher risk of getting measles than the general population because of their increased risk of exposure from patients with measles attending hospitals. Read more about this study
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Adult, Older adult
Study population: Participants will be recruited from a population of hospital-based healthcare workers, including doctors, nurses, health assistants, etc. Healthcare workers will be recruited from one site only (KCH).
Who may be able to join
- Are aged 18 and over
- Currently work as a healthcare worker at the Trust
- Have direct contact with patients
- Don't know if they have had measles and don't know if they have been vaccinated
- Or: Have not had measles and have not received the MMR vaccine
- Or: Have only received 1 dose of the MMR vaccine
- Or: Received the MMR vaccine after joining the Trust
Who cannot join
- Are aged <18 years old
- Work in a role at the Trust that does not involve direct contact with patients (e.g., administrative or business staff)
- Are sure and/or have evidence that they have had measles in the past or both doses of the MMR vaccine before joining the Trust
- Are not able to give informed consent
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Exploring Barriers and Facilitators to Uptake of the MMR Vaccine Among Healthcare Workers at King's College Hospital NHS Foundation Trust
Measles is a highly contagious disease which can result in severe complications in some patients. Healthcare workers have a higher risk of getting measles than the general population because of their increased risk of exposure from patients with measles attending hospitals. Having had measles in the past or at least one dose of the measles, mumps and rubella (MMR) vaccine provides protection (immunity) against measles. UK government guidelines therefore recommend that healthcare workers and non-clinical staff with direct patient contact are fully vaccinated or have other evidence of immunity. Yet, evidence from recent measles outbreaks suggests that some healthcare workers are not immune or do not know if they are immune, with implications for containment efforts, cost and transmission. The purpose of this study is to identify barriers and facilitators to uptake of the MMR vaccine among healthcare workers at King's College Hospital NHS Foundation Trust (KCH). KCH healthcare workers will be eligible to take part in the study if they are aged 18 and over and have direct contact with patients. In addition, the research will focus on four subgroups of healthcare workers at KCH: those who are not immune, those who have not completed the full vaccination schedule, those who don't know their immunity status, those received the vaccine only after joining KCH. The latter may provide insights into facilitators to vaccine uptake. Measles immunity forms part of the occupational health screening at KCH. A series of semi structured interviews lasting approximately 1 hour will explore participants' experiences of the occupational health vaccine screening process and measles vaccine campaigns at KCH; why they are unvaccinated/not fully vaccinated/do not know if they are immune/decided to be vaccinated after joining KCH; and what measures or interventions may help healthcare workers when deciding whether to get the MMR vaccine.
- Conditions
- Measles
- Being tested
- MMR vaccination
- Medical subject headings
- Measles
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MMR vaccinationBiological
MMR vaccination status
| Study group | Role | What they receive |
|---|---|---|
| Healthcare workers | Healthcare workers at one Trust who have direct patient contact and fall within one of four groups: 1) they are not immune to measles (have not had measles in the past and have not been vaccinated with both doses of the MMR vaccine), 2) they have not completed the full vaccination schedule (they have received only 1 dose of the MMR vaccine), 3) they do not know their immunity status, and 4) they received the MMR vaccine after joining the Trust. Receives: Biological: MMR vaccination |
What is being measured
The primary outcome is the main question the study is designed to answer.
Barriers to MMR vaccination
Barriers to MMR vaccination will be explored in the qualitative interview
Measured: Collected at one timepoint 1 day during qualitative interview
Facilitators to MMR vaccination
Facilitators to MMR vaccination will be explored in the qualitative interview
Measured: Collected at one timepoint 1 day during qualitative interview
Reasons for not knowing immunity status
Reasons for not knowing immunity status will be explored in the qualitative interview
Measured: Collected at one timepoint 1 day during qualitative interview
Secondary outcomes (1)
Experiences of the occupational health vaccine screening process at KCH
Experiences of the occupational health vaccine screening process at the Trust will be explored in the qualitative interview
Measured: Collected at one timepoint 1 day during qualitative interview
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Jun 2024
- Study start12 Sep 2024
- Primary completion19 Dec 2024
- Study completion19 Dec 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MeaslesStudies of the same condition, open and under way.
- More trials run by King's College LondonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 23 participants (actual)
Sponsor and investigators
- Lead sponsor
- King's College London
- Sponsor type
- University, hospital or other
- Collaborators
- King's College Hospital NHS Trust, UK Health Security Agency
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06456788
- Sponsor's protocol ID
- 344919
- Acronym
- BFMMRHCW
- Status last verified
- Apr 2025
- First submitted
- 30 May 2024
- Last updated
- 6 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Pseudonymised interview transcripts will be uploaded onto the King's College London Open Research Data System with the participant's consent.
Study at a glance
From the registry record, last updated by the sponsor on 6 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Exploring Barriers and Facilitators to Uptake of the MMR Vaccine Among Healthcare Workers at King's College Hospital NHS Foundation Trust
- ClinicalTrials.gov ID
- NCT06456788
- Acronym / sponsor ID
- BFMMRHCW / 344919
- Conditions
- Measles
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 23 participants (actual)
- Lead sponsor
- King's College LondonUniversity, hospital or other
- Collaborators
- King's College Hospital NHS Trust, UK Health Security Agency
- Study start
- 12 Sep 2024 (actual)
- Primary completion
- 19 Dec 2024 (actual)
- Study completion
- 19 Dec 2024 (actual)
- First posted
- 13 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Measles is a highly contagious disease which can result in severe complications in some patients. Healthcare workers have a higher risk of getting measles than the general population because of their increased risk of exposure from patients with measles attending hospitals. Having had measles in the past or at least one dose of the measles, mumps and rubella (MMR) vaccine provides protection (immunity) against measles. UK government guidelines therefore recommend that healthcare workers and non-clinical staff with direct patient contact are fully vaccinated or have other evidence of immunity. Yet, evidence from recent measles outbreaks suggests that some healthcare workers are not immune or do not know if they are immune, with implications for containment efforts, cost and transmission. The purpose of this study is to identify barriers and facilitators to uptake of the MMR vaccine among healthcare workers at King's College Hospital NHS Foundation Trust (KCH). KCH healthcare workers will be eligible to take part in the study if they are aged 18 and over and have direct contact with patients. In addition, the research will focus on four subgroups of healthcare workers at KCH: those who are not immune, those who have not completed the full vaccination schedule, those who don't know their immunity status, those received the vaccine only after joining KCH. The latter may provide insights into facilitators to vaccine uptake. Measles immunity forms part of the occupational health screening at KCH. A series of semi structured interviews lasting approximately 1 hour will explore participants' experiences of the occupational health vaccine screening process and measles vaccine campaigns at KCH; why they are unvaccinated/not fully vaccinated/do not know if they are immune/decided to be vaccinated after joining KCH; and what measures or interventions may help healthcare workers when deciding whether to get the MMR vaccine.
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Healthcare workers | – | Biological: MMR vaccinationHealthcare workers at one Trust who have direct patient contact and fall within one of four groups: 1) they are not immune to measles (have not had measles in the past and have not been vaccinated with both doses of the MMR vaccine), 2) they have not completed the full vaccination schedule (they have received only 1 dose of the MMR vaccine), 3) they do not know their immunity status, and 4) they received the MMR vaccine after joining the Trust. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- Participants will be recruited from a population of hospital-based healthcare workers, including doctors, nurses, health assistants, etc. Healthcare workers will be recruited from one site only (KCH).
Key inclusion criteria (7 listed)
- Are aged 18 and over
- Currently work as a healthcare worker at the Trust
- Have direct contact with patients
- Don't know if they have had measles and don't know if they have been vaccinated
- Or: Have not had measles and have not received the MMR vaccine
Key exclusion criteria (4 listed)
- Are aged <18 years old
- Work in a role at the Trust that does not involve direct contact with patients (e.g., administrative or business staff)
- Are sure and/or have evidence that they have had measles in the past or both doses of the MMR vaccine before joining the Trust
- Are not able to give informed consent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MMR vaccinationMMR vaccination status | Biological | Healthcare workers |
Primary outcome
Barriers to MMR vaccination
Time frame: Collected at one timepoint 1 day during qualitative interview
Barriers to MMR vaccination will be explored in the qualitative interview
Facilitators to MMR vaccination
Time frame: Collected at one timepoint 1 day during qualitative interview
Facilitators to MMR vaccination will be explored in the qualitative interview
Reasons for not knowing immunity status
Time frame: Collected at one timepoint 1 day during qualitative interview
Reasons for not knowing immunity status will be explored in the qualitative interview
1 secondary outcome
Experiences of the occupational health vaccine screening process at KCH
Time frame: Collected at one timepoint 1 day during qualitative interview
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 May 2025.
- Individual participant dataSharing planned: Undecided. Pseudonymised interview transcripts will be uploaded onto the King's College London Open Research Data System with the participant's consent.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Measles, run by King's College London at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Barriers to MMR vaccination (time frame: Collected at one timepoint 1 day during qualitative interview). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 May 2025.