ExerciseCOPDNCT06466213
Acute Effects of Three Different Types Single Leg Exercise in Copd
A study testing single exercise bout about one-leg exercise in people with Exercise, run by Hacettepe University at 1 site in Turkey (Türkiye).
Trial summary
COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and muscle oxygenation are observed in COPD. Read more about this study
- Who is it for?
- Ages 40 years and older
- Conditions the study is for
- Exercise
- What is being tested?
- single exercise bout about one-leg exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 26 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 20 Feb 2024to 28 Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- COPD patients that applied to physiotherapy
- cooperate to test
- no severe ortopedical and neurological disease no severe cardiovascular disease volunteer to study
Who cannot join
- have an acute exacerbation
- hypoxemia [PaO2] <55 mmHg
- no cooperated to test no volunteer to study having ortophedical and neurological diesase that affecting of tests having severe cardiovascular disease
Trial locations and contacts
1 site in 1 country.
About this study
COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and muscle oxygenation are observed in COPD. One leg exercise result is not enough to highlight these parameters.
Read the detailed description
Acute Effects of Three Different Types Single Leg Exercise in Copd
single bout high intensity interval training
single bout continuous exercise training single bout resistance training
- Conditions
- Exercise
- Being tested
- single exercise bout about one-leg exercise
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
single exercise bout about one-leg exerciseOther
cycle exercise includes single leg
| Study group | Role | What they receive |
|---|---|---|
| single session one leg exercise intervantion in COPD | Experimental | first session: single session leg Continuous exercise intervantion will be applied to COPD. Unilaterally single leg continuous exercise will be performed as only one session
second session : single session leg high intensity interval exercise intervantion will be applied to COPD. Unilaterally single leg hııt exercise will be performed as only one session
third sessionsingle session leg resistance exercise intervantion will be applied to COPD. Respirocally leg strength (knee extantion ) exercise will be performed Receives: Other: single exercise bout about one-leg exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
six minute walk test
six minute walk test in meter
Measured: beginning, day 1
Secondary outcomes (10)
cardiopulmonary exercise test
VO2 max will be recorded as ml/kg/min will be recorded from incremental cycle cpet test
Measured: beginning, day 2
single leg extremity test
VO2 max will be recorded as ml/kg/min will be recorded from incremental cycle cpet test
Measured: beginning, day 3
lung function
FVC in % , FEV1 in %, FEV1/FVC ratio, PEF in % and FEF 25-75 in %
Measured: beginning, day 1
muscle strength (isometric)
quadriceps isometric muscle strength will be recorded as kilogram
Measured: beginning day 1
muscle strength (10 repeated max)
quadriceps 10 repeated max muscle strength will be recorded as kilogram
Measured: beginning, day 1
continous exercise acute (single leg)
VO2 max will be recorded as ml/kg/min will be performed from incremental cycle exercise at single session
Measured: beginning day 4
high intensity interval training acute exercise (single leg)
VO2 max will be recorded as ml/kg/min will be performed from incremental cycle exercise at single session
Measured: beginning day 5
strength training acute exercise (single leg)
VO2 max will be recorded as ml/kg/min will be performed from incremental cycle exercise at single session
Measured: beginning day 4,5,6
muscle oxygenation
minumum muscle oxygenation level will be presented as percentage
Measured: beginning day 4,5,6
arterial stifness
Aıx@75 in %
Measured: beginning day 2,3, 4,5,6
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jun 2024
- Study start20 Feb 2024
- Primary completion28 Mar 2025
- Study completion28 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ExerciseStudies of the same condition, open and under way.
- More trials run by Hacettepe UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hacettepe University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Elif Kocaaga, Hacettepe University
- Investigators
- elif kocaaga, ms, Principal investigator, Hacettepe University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06466213
- Sponsor's protocol ID
- GO23-193
- Acronym
- COPD
- Status last verified
- Nov 2025
- First submitted
- 17 May 2024
- Last updated
- 4 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Evans RA, Dolmage TE, Mangovski-Alzamora S, Romano J, O'Brien L, Brooks D, Goldstein RS. One-Legged Cycle Training for Chronic Obstructive Pulmonary Disease. A Pragmatic Study of Implementation to Pulmonary Rehabilitation. Ann Am Thorac Soc. 2015 Oct;12(10):1490-7. doi: 10.1513/AnnalsATS.201504-231OC.
PubMed 26291542
Study at a glance
From the registry record, last updated by the sponsor on 4 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of Three Different Types Single Leg Exercise in Copd
- ClinicalTrials.gov ID
- NCT06466213
- Acronym / sponsor ID
- COPD / GO23-193
- Conditions
- Exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- Hacettepe UniversityUniversity, hospital or other
- Study start
- 20 Feb 2024 (actual)
- Primary completion
- 28 Mar 2025 (actual)
- Study completion
- 28 Mar 2025 (actual)
- First posted
- 20 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and muscle oxygenation are observed in COPD. One leg exercise result is not enough to highlight these parameters.
Detailed description
Acute Effects of Three Different Types Single Leg Exercise in Copd
single bout high intensity interval training
single bout continuous exercise training single bout resistance training
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| single session one leg exercise intervantion in COPD | Experimental | Other: single exercise bout about one-leg exercisefirst session: single session leg Continuous exercise intervantion will be applied to COPD. Unilaterally single leg continuous exercise will be performed as only one session second session : single session leg high intensity interval exercise intervantion will be applied to COPD. Unilaterally single leg hııt exercise will be performed as only one session third sessionsingle session leg resistance exercise intervantion will be applied to COPD. Respirocally leg strength (knee extantion ) exercise will be performed |
Who may qualify
- Ages
- 40 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- COPD patients that applied to physiotherapy
- cooperate to test
- no severe ortopedical and neurological disease no severe cardiovascular disease volunteer to study
Key exclusion criteria (3 listed)
- have an acute exacerbation
- hypoxemia [PaO2] <55 mmHg
- no cooperated to test no volunteer to study having ortophedical and neurological diesase that affecting of tests having severe cardiovascular disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| single exercise bout about one-leg exercisecycle exercise includes single leg | Other | single session one leg exercise intervantion in COPD |
Primary outcome
six minute walk test
Time frame: beginning, day 1
six minute walk test in meter
10 secondary outcomes
cardiopulmonary exercise test
Time frame: beginning, day 2
single leg extremity test
Time frame: beginning, day 3
lung function
Time frame: beginning, day 1
muscle strength (isometric)
Time frame: beginning day 1
muscle strength (10 repeated max)
Time frame: beginning, day 1
continous exercise acute (single leg)
Time frame: beginning day 4
high intensity interval training acute exercise (single leg)
Time frame: beginning day 5
strength training acute exercise (single leg)
Time frame: beginning day 4,5,6
muscle oxygenation
Time frame: beginning day 4,5,6
arterial stifness
Time frame: beginning day 2,3, 4,5,6
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Dec 2025.
- Background: PubMed 26291542Evans RA, Dolmage TE, Mangovski-Alzamora S, Romano J, O'Brien L, Brooks D, Goldstein RS. One-Legged Cycle Training for Chronic Obstructive Pulmonary Disease. A Pragmatic Study of Implementation to Pulmonary Rehabilitation. Ann Am Thorac Soc. 2015 Oct;12(10):1490-7. doi: 10.1513/AnnalsATS.201504-231OC.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
elif kocaaga, ms principal investigator
Hacettepe University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing single exercise bout about one-leg exercise in people with Exercise, run by Hacettepe University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
six minute walk test (time frame: beginning, day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06466213, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Dec 2025.