Corticospinal ExcitabilityLAMINCT06478303
LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension
An observational study of Corticospinal Excitability and Cortical Activation, run by University Hospital, Grenoble at 2 sites in France.
Trial summary
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Corticospinal Excitability, Cortical Activation
- What is being tested?
- Motor imagery, Action reading and Motor localizer
- How many people
- 105 participants
- Where
- 2 sitesFrance
- Study dates
- 27 Jul 2024to 26 Jul 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: Subjects will be aged between 18 and 40, reading and understanding French, with no neurological or psychiatric disorders, no uncorrected vision deficits, and meeting all MRI or TMS examination criteria. they were recruited at the University of Burgundy (TMS measures only) and the University of Grenoble Alpes (fMRI measures only).
Who may be able to join
- persons who have given written consent,
- healthy subjects
- subjects reading and understanding French
- right-handed,
- affiliated with a social security system,
- between 18 and 40 years old,
- had completed the TMS inclusion questionnaire or had undergone a medical examination prior to participation in the MRI study.
Who cannot join
- Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
- Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
- Characterized psychiatric pathology,
- Ingestion of alcohol prior to the examination,
- Persons covered by articles L1121-5 to L1121-8 of the CSP,
- Presence of contraindications to MRI or TMS.
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
France2 sites, 2 recruiting
- Recruiting
Université de Bourgogne
Dijon
Florent LEBON, +33 (0)3 80 39 67 54, Florent.Lebon@u-bourgogne.fr
William DUPONT, +33 (0)6 67 76 00 99, william.dupont@univ-grenoble-alpes.fr
- Recruiting
CHU Grenoble Alpes
Grenoble, Grenob, 38043
Laurent VERCUEIL, +33 (0)4 76 76 55 61, LVercueil@chu-grenoble.fr
William DUPONT, +33 (0)6 67 76 00 99, william.dupont@univ-grenoble-alpes.fr
About this study
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.
- Conditions
- Corticospinal Excitability, Cortical Activation
- Being tested
- Motor imagery, Action reading, Motor localizer
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Motor imageryOther
Participants were asked to imagine arm or foot movements.
Action readingOther
Participants were asked to read sentences involving arm or foot movements
Motor localizerOther
Participants were asked to perform arm or foot movements
| Study group | Role | What they receive |
|---|---|---|
| TMS Experimental group | Not described Receives: Other: Motor imagery; Other: Action reading | |
| fMRI Experimental group | Not described Receives: Other: Motor imagery; Other: Action reading; Other: Motor localizer | |
| Experimental ccPAS group | Not described Receives: Other: Motor imagery; Other: Action reading | |
| Sham ccPAS group | Not described Receives: Other: Motor imagery; Other: Action reading | |
| control group | Not described Receives: Other: Motor imagery; Other: Action reading |
What is being measured
The primary outcome is the main question the study is designed to answer.
Level of corticospinal excitability
this is a physiological response obtained by transcranial magnetic pulses (TMS). This is an indicator of the excitability of the motor system, which can be used at rest or during various cognitive tasks (motor imagery or action reading).
Measured: 1 hour and 30 minutes
Cortical activation (BOLD signal)
this is a cortical response obtained via a fMRI. This is an indicator of the brain activity, which can be used at rest or during motor and cognitive tasks (motor imagery or action reading).
Measured: 1 hour
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jun 2024
- Study start27 Jul 2024
- Primary completion26 Jul 2027 (estimated)
- Study completion26 Jul 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Corticospinal ExcitabilityStudies of the same condition, open and under way.
- More trials run by University Hospital, GrenobleThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 105 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Grenoble
- Sponsor type
- University, hospital or other
- Collaborators
- University of Burgundy
- Responsible party
- Sponsor
- Investigators
- Laurent VERCUEIL, Principal investigator, CHU Grenoble Alpes
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06478303
- Sponsor's protocol ID
- 38RC23.0349
- Other IDs
- 2023-A02322-43
- Acronym
- LAMI
- Status last verified
- Sep 2026
- First submitted
- 13 Jun 2024
- Last updated
- 2 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension
- ClinicalTrials.gov ID
- NCT06478303
- Acronym / sponsor ID
- LAMI / 38RC23.0349
- Conditions
- Corticospinal Excitability, Cortical Activation
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 105 participants (estimated)
- Lead sponsor
- University Hospital, GrenobleUniversity, hospital or other
- Collaborators
- University of Burgundy
- Study start
- 27 Jul 2024 (actual)
- Primary completion
- 26 Jul 2027 (estimated)
- Study completion
- 26 Jul 2028 (estimated)
- First posted
- 27 Jun 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 5
| Arm | Type | Receives |
|---|---|---|
| TMS Experimental group | – | Other: Motor imagery, Other: Action reading |
| fMRI Experimental group | – | Other: Motor imagery, Other: Action reading, Other: Motor localizer |
| Experimental ccPAS group | – | Other: Motor imagery, Other: Action reading |
| Sham ccPAS group | – | Other: Motor imagery, Other: Action reading |
| control group | – | Other: Motor imagery, Other: Action reading |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Subjects will be aged between 18 and 40, reading and understanding French, with no neurological or psychiatric disorders, no uncorrected vision deficits, and meeting all MRI or TMS examination criteria. they were recruited at the University of Burgundy (TMS measures only) and the University of Grenoble Alpes (fMRI measures only).
Key inclusion criteria (7 listed)
- persons who have given written consent,
- healthy subjects
- subjects reading and understanding French
- right-handed,
- affiliated with a social security system,
Key exclusion criteria (6 listed)
- Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
- Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
- Characterized psychiatric pathology,
- Ingestion of alcohol prior to the examination,
- Persons covered by articles L1121-5 to L1121-8 of the CSP,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Motor imageryParticipants were asked to imagine arm or foot movements. | Other | Experimental ccPAS group, Sham ccPAS group, TMS Experimental group, control group, fMRI Experimental group |
| Action readingParticipants were asked to read sentences involving arm or foot movements | Other | Experimental ccPAS group, Sham ccPAS group, TMS Experimental group, control group, fMRI Experimental group |
| Motor localizerParticipants were asked to perform arm or foot movements | Other | fMRI Experimental group |
Primary outcome
Level of corticospinal excitability
Time frame: 1 hour and 30 minutes
this is a physiological response obtained by transcranial magnetic pulses (TMS). This is an indicator of the excitability of the motor system, which can be used at rest or during various cognitive tasks (motor imagery or action reading).
Cortical activation (BOLD signal)
Time frame: 1 hour
this is a cortical response obtained via a fMRI. This is an indicator of the brain activity, which can be used at rest or during motor and cognitive tasks (motor imagery or action reading).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Laurent VERCUEIL principal investigator
CHU Grenoble Alpes
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Corticospinal Excitability and Cortical Activation, run by University Hospital, Grenoble at 2 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 2 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Laurent VERCUEIL (0476765561, LVercueil@chu-grenoble.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Level of corticospinal excitability (time frame: 1 hour and 30 minutes). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2026.