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Parkinson DiseaseNCT06483126

The Benefits of Nature for Mood and Cognition in Persons With and Without Parkinson's Disease

An observational study of Parkinson Disease and Mood, run by Boston University Charles River Campus at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This online study aims to explore the benefits of nature for mood and cognition in persons with and without Parkinson's disease. For the purpose of this survey, "natural environment" refers to places that primarily consist of natural elements, such as vegetation, water bodies, and landscapes. Read more about this study

Who is it for?
Ages 40 to 100 yearsHealthy volunteers can take part
Conditions the study is for
Parkinson Disease, Mood, Cognition
How many people
97 participants
Where
1 siteUnited States
Study dates
12 Aug 2024to 31 Jul 2025
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 40 to 100 years
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Study population: Persons with and without Parkinson's disease volunteering for an online study

Who may be able to join

  • For persons with Parkinson's disease:
  • Participants must be at least 40 years old
  • Have a diagnosis of idiopathic PD
  • Be proficient English speakers
  • Have functional vision
  • Have internet access, and access to a smartphone/laptop/desktop
Show all 12Show fewer
  • For persons without Parkinson's disease:
  • Participants must be healthy middle-aged and older adults, with no diagnosis of neurological/neurodegenerative conditions
  • Participants must be at least 40 years old
  • Be proficient English speakers
  • Have functional vision
  • Have internet access, and access to a smartphone/laptop/desktop

Who cannot join

  • Diagnosis of dementia
  • Poor vision (non-functional range)
  • Lack of access to internet or to a smartphone/ laptop/desktop computer.

Trial locations and contacts

1 site in 1 country.

United States1 site

  • Vision and Cognition Laboratory, Boston University

    Boston, Massachusetts, 02215

Other trials in United States

About this study

This online study aims to explore the benefits of nature for mood and cognition in persons with and without Parkinson's disease. For the purpose of this survey, "natural environment" refers to places that primarily consist of natural elements, such as vegetation, water bodies, and landscapes. This includes greenspaces (such as parks, gardens, neighborhood streets lined with trees, forests, or nature reserves) bluespaces (such as next to beaches, lakes, rivers, ponds, or waterfronts), and desert regions, among others.

Read the detailed description

To participate in this online study, you will need an email address, and a smartphone or laptop/desktop with internet access. If you are eligible to participate, you will be sent a link to an online survey (Qualtrics). We will ask questions about demographic and health information, followed by questions about exercise habits, exposure to natural environments (including greenspaces and bluespaces, among others), and questionnaires assessing mood, motivation, cognition, sleep, stress, quality of life, and related functions. The survey should take roughly 20-25 minutes to complete. This is an observational study only, and not an interventional study.

Compensation: A $15 Amazon gift card will be offered to those who complete the survey all the way through with good effort.

Keywords
Nature, Natural Environments
Medical subject headings
Parkinson Disease

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT06483126
Study groupRoleWhat they receive
Persons with Parkinson's disease (PwPD)Individuals with a diagnosis of Parkinson's disease
Persons without Parkinson's diseaseHealthy middle-aged and older adults

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Nature Connection Index

    Assesses the extent to which people feel connected to nature.

    Measured: Baseline

  2. Perceived Restorativeness Scale

    Assesses the extent to which particular environments have restorative qualities. Higher scores indicate greater perceived restorativeness.

    Measured: Baseline

  3. Center for Epidemiological Studies Depression (CES-D)

    Assesses depressive symptoms in the general population. Maximum score:60. Higher scores indicate more severe depression.

    Measured: Baseline

  4. Parkinson's Disease Sleep Scale-2

    Assesses sleep and nocturnal disturbances in Parkinson's disease. Maximum score: 60. Higher scores indicate more frequent sleep disturbances.

    Measured: Baseline

  5. Parkinson's Disease Questionnaire - 8 (PDQ-8)

    Assesses Parkinson's disease-specific health-related quality of life. Maximum Score: 32. Higher scores indicate worse quality of life.

    Measured: Baseline

  6. Perceived Stress Scale

    Assesses how different situations affect feelings and perception of stress. Maximum score: 40. Higher scores indicate higher perceived stress.

    Measured: Baseline

  7. NIH NeuroQoL measures

    Assesses health-related quality of life in adults with neurological disorders. Higher scores on the sub-scales indicate worse outcomes.

    Measured: Baseline

  8. Parkinson's Anxiety Scale (PAS)

    Assesses the severity of anxiety symptoms in persons with Parkinson's disease. Maximum score:48. Higher scores indicate more severe anxiety.

    Measured: Baseline

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted3 Jul 2024
  2. Study start12 Aug 2024
  3. Primary completion31 Jul 2025
  4. Study completion31 Jul 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Case only
Time perspective
Cross-sectional
Enrolment
97 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06483126
Sponsor's protocol ID
7175E
Status last verified
Aug 2024
First submitted
26 Jun 2024
Last updated
19 Sep 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Alcock I, White MP, Wheeler BW, Fleming LE, Depledge MH. Longitudinal effects on mental health of moving to greener and less green urban areas. Environ Sci Technol. 2014 Jan 21;48(2):1247-55. doi: 10.1021/es403688w. Epub 2014 Jan 7.

    PubMed 24320055

  • Gascon M, Triguero-Mas M, Martinez D, Dadvand P, Forns J, Plasencia A, Nieuwenhuijsen MJ. Mental health benefits of long-term exposure to residential green and blue spaces: a systematic review. Int J Environ Res Public Health. 2015 Apr 22;12(4):4354-79. doi: 10.3390/ijerph120404354.

    PubMed 25913182

  • Hartig T, Mitchell R, de Vries S, Frumkin H. Nature and health. Annu Rev Public Health. 2014;35:207-28. doi: 10.1146/annurev-publhealth-032013-182443. Epub 2014 Jan 2.

    PubMed 24387090

  • Rigolon A, Browning MHEM, McAnirlin O, Yoon HV. Green Space and Health Equity: A Systematic Review on the Potential of Green Space to Reduce Health Disparities. Int J Environ Res Public Health. 2021 Mar 4;18(5):2563. doi: 10.3390/ijerph18052563.

    PubMed 33806546

  • Rodriguez-Loureiro L, Casas L, Bauwelinck M, Lefebvre W, Vanpoucke C, Vanroelen C, Gadeyne S. Social inequalities in the associations between urban green spaces, self-perceived health and mortality in Brussels: Results from a census-based cohort study. Health Place. 2021 Jul;70:102603. doi: 10.1016/j.healthplace.2021.102603. Epub 2021 Jun 21.

    PubMed 34166885

  • Miller IN, Neargarder S, Risi MM, Cronin-Golomb A. Frontal and posterior subtypes of neuropsychological deficit in Parkinson's disease. Behav Neurosci. 2013 Apr;127(2):175-183. doi: 10.1037/a0031357. Epub 2013 Feb 11.

    PubMed 23398433

  • Cerin E, Barnett A, Shaw JE, Martino E, Knibbs LD, Tham R, Wheeler AJ, Anstey KJ. From urban neighbourhood environments to cognitive health: a cross-sectional analysis of the role of physical activity and sedentary behaviours. BMC Public Health. 2021 Dec 23;21(1):2320. doi: 10.1186/s12889-021-12375-3.

    PubMed 34949175

  • Cerin E, Barnett A, Shaw JE, Martino E, Knibbs LD, Tham R, Wheeler AJ, Anstey KJ. Urban Neighbourhood Environments, Cardiometabolic Health and Cognitive Function: A National Cross-Sectional Study of Middle-Aged and Older Adults in Australia. Toxics. 2022 Jan 7;10(1):23. doi: 10.3390/toxics10010023.

    PubMed 35051065

Questions about this trial

What is this clinical trial studying?

An observational study of Parkinson Disease and Mood, run by Boston University Charles River Campus at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 12 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 19 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Nature Connection Index (time frame: Baseline). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06483126, which also lists 8 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Sep 2025.

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