Emergency Service, HospitalNCT06491290
Modelling of Correlation Between Emergency Department Admissions and Location-specific Air Quality and Weather in the Florence Urban Area
An observational study of Emergency Service, Hospital and Air Pollution, run by Azienda Ospedaliero-Universitaria Careggi at 1 site in Italy.
Trial summary
The goal of this observational study is to evaluate the impact of primary air pollutants and weather parameters on emergency department (ED) visits in the metropolitan area of Florence. Read more about this study
- Who is it for?
- Ages 14 years and older
- Conditions the study is for
- Emergency Service, Hospital, Air Pollution, Weather
- How many people
- 480,000 participants
- Where
- 1 siteItaly
- Study dates
- 1 Jan 2024to 31 Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 14 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: The study population consists of consecutive patients presenting to the Emergency Departments (ED) of the participating hospital.
Who may be able to join
- Consecutive emergency department visits within the study period
Who cannot join
- Patients resident outside the metropolitan area investigated
- Patients admitted to the emergency department for traumatic injuries
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Italy1 site, 1 recruiting
- Recruiting
SOD Medicina e Chirurgia d'Urgenza ed Accettazione, Azienda Ospedaliera-Universitaria Careggi
Florence, 50134
Peiman Nazerian, nazerianp@aou-careggi.toscana.it
About this study
The goal of this observational study is to evaluate the impact of primary air pollutants and weather parameters on emergency department (ED) visits in the metropolitan area of Florence.
Read the detailed description
This is a retrospective, single-center, observational cohort study aimed at investigate the impact of primary air pollutant concentrations and weather parameters on emergency department (ED) visits in the metropolitan area of Florence.
Anonymous data for each individual ED visit is retrieved from the hospital medical record. The daily concentrations of PM2.5, PM10, NO2, SO2 and O3 and the levels of atmospheric pressure, humidity and temperature are recorded by stations of the dedicated local agencies. The relationship between ED daily visits and pollutant concentrations or weather parameters are investigated.
- Conditions
- Emergency Service, Hospital, Air Pollution, Weather
- Being tested
- No intervention administered
- Medical subject headings
- Emergencies
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
No intervention administeredOther
NA (not applicable)
| Study group | Role | What they receive |
|---|---|---|
| Study cohort | Not described Receives: Other: No intervention administered |
What is being measured
The primary outcome is the main question the study is designed to answer.
number of daily emergency department visits
Total number of emergency department visits on a given day
Measured: through study completion, 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jul 2024
- Study start1 Jan 2024
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Emergency Service, HospitalStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Retrospective
- Enrolment
- 480,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Azienda Ospedaliero-Universitaria Careggi
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Peiman Nazerian, Azienda Ospedaliero-Universitaria Careggi
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06491290
- Sponsor's protocol ID
- 24192_oss
- Status last verified
- Jul 2024
- First submitted
- 21 Jun 2024
- Last updated
- 9 Jul 2024
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Gnerucci A, Rossetto A, Faraoni P, Ranaldi F, Cavallaro G, Tonietti B, Santosuosso U, Bonaccorsi L, Nazerian P; SIMEU Study Group. Particulate matter concentration is associated with increased utilization of the emergency department: a single-centre time-series analysis. Intern Emerg Med. 2026 Apr;21(3):1097-1107. doi: 10.1007/s11739-025-04013-2. Epub 2025 Jun 19.
PubMed 40537710
Study at a glance
From the registry record, last updated by the sponsor on 9 Jul 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Modelling of Correlation Between Emergency Department Admissions and Location-specific Air Quality and Weather in the Florence Urban Area
- ClinicalTrials.gov ID
- NCT06491290
- Acronym / sponsor ID
- 24192_oss
- Conditions
- Emergency Service, Hospital, Air Pollution, Weather
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 480,000 participants (estimated)
- Lead sponsor
- Azienda Ospedaliero-Universitaria CareggiUniversity, hospital or other
- Study start
- 1 Jan 2024 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 9 Jul 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to evaluate the impact of primary air pollutants and weather parameters on emergency department (ED) visits in the metropolitan area of Florence.
Detailed description
This is a retrospective, single-center, observational cohort study aimed at investigate the impact of primary air pollutant concentrations and weather parameters on emergency department (ED) visits in the metropolitan area of Florence.
Anonymous data for each individual ED visit is retrieved from the hospital medical record. The daily concentrations of PM2.5, PM10, NO2, SO2 and O3 and the levels of atmospheric pressure, humidity and temperature are recorded by stations of the dedicated local agencies. The relationship between ED daily visits and pollutant concentrations or weather parameters are investigated.
Study design
- Observational model
- Case-control
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Study cohort | – | Other: No intervention administered |
Who may qualify
- Ages
- 14 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- The study population consists of consecutive patients presenting to the Emergency Departments (ED) of the participating hospital.
Key inclusion criteria (1 listed)
- Consecutive emergency department visits within the study period
Key exclusion criteria (2 listed)
- Patients resident outside the metropolitan area investigated
- Patients admitted to the emergency department for traumatic injuries
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| No intervention administeredNA (not applicable) | Other | Study cohort |
Primary outcome
number of daily emergency department visits
Time frame: through study completion, 1 year
Total number of emergency department visits on a given day
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jul 2024.
- Derived from this study: PubMed 40537710Gnerucci A, Rossetto A, Faraoni P, Ranaldi F, Cavallaro G, Tonietti B, Santosuosso U, Bonaccorsi L, Nazerian P; SIMEU Study Group. Particulate matter concentration is associated with increased utilization of the emergency department: a single-centre time-series analysis. Intern Emerg Med. 2026 Apr;21(3):1097-1107. doi: 10.1007/s11739-025-04013-2. Epub 2025 Jun 19.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Emergency Service, Hospital and Air Pollution, run by Azienda Ospedaliero-Universitaria Careggi at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 9 Jul 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Peiman Nazerian (+39 3396122448, nazerianp@aou-careggi.toscana.it), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
number of daily emergency department visits (time frame: through study completion, 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06491290, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jul 2024.