AzTrials
AzTrials

Breast CancerPhase 3ELEGANTNCT06492616

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

A Phase 3 study testing Elacestrant, Anastrozole and Letrozole in people with Breast Cancer, run by Stemline Therapeutics, Inc. at 555 sites in 28 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

The primary goal of this study is to evaluate the effectiveness of elacestrant versus standard endocrine therapy in participants with node-positive, Estrogen Receptor-positive (ER+), Human Epidermal Growth Factor-2 negative (HER2-) early breast cancer with high risk of recurrence. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Breast Cancer
What is being tested?
Elacestrant, Anastrozole and Letrozole
Type of treatment
Pill or oral medicine
Could I receive a placebo?
No, everyone receives an active treatment
How many people
4,556 participants
Where
555 sitesin 28 countries
Study dates
27 Sep 2024to Oct 2032
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Histopathologically or cytologically confirmed ER+ (≥10% by immunohistochemistry [IHC]), HER2- (tumors with an IHC score of 0, 1+, or 2+ with in situ hybridization [ISH]-negative [not amplified]). ISH-negative without IHC testing will also be eligible on tumor biopsy or final surgical pathology specimen early stage resected invasive breast cancer without evidence of recurrence or distant metastases, per local laboratory, according to the American Society of Clinical Oncology/College of American Pathologists guidelines.
  • Participants must be node positive (microscopic and macroscopic tumor involvement are allowed) and fulfill one of the following criteria:
  • ≥4 positive axillary lymph nodes or
  • 1-3 positive axillary lymph nodes and
  • Histologic grade 3 disease and/or
  • Tumor size ≥5 centimeters and/or
Show all 9Show fewer
  • High genomic risk (identified by Oncotype, MammaPrint, EndoPredict, PAM50)
  • Participants who are currently taking endocrine therapy (aromatase inhibitors or tamoxifen) and have received at least 24 months but not more than 60 months of endocrine therapy at the time of randomization (Cycle 1 Day 1 [C1D1]) with or without a CDK 4 and CKD 6 inhibitor (CDK4/6i) and with or without a luteinizing hormone-releasing hormone agonist.
  • Participants who received prior CDK4/6i or a poly adenosine diphosphate-ribose polymerase inhibitor must have already completed or discontinued these treatments.

Who cannot join

  • Participants with inflammatory breast cancer.
  • History of any prior (ipsilateral and/or contralateral) invasive breast cancer.
  • Participant with history of non-breast malignancy within 3 years of the date of randomization, except for adequately treated basal or squamous cell skin cancer, superficial bladder cancer or carcinoma in situ of the cervix.
  • Participants who have had more than a 6-month continuous interruption of prior SoC adjuvant endocrine therapy or who are off current adjuvant endocrine therapy more than 6 months prior to randomization.
  • Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Trial locations and contacts

555 sites in 28 countries.

555 sites in 28 countries

United States170 sites

  • Hendrick Cancer Center

    Abilene, Texas, 79601

  • Mayo Clinic Health System - Albert Lea

    Albert Lea, Minnesota, 56007

  • Exigent Research LLC/New Mexico Oncology Hematology Consultants Ltd.

    Albuquerque, New Mexico, 87109

  • Lehigh Valley Health Network - Cedar Crest

    Allen, Pennsylvania, 18103

  • Texas Oncology-Northeast Texas

    Allen, Texas, 75013

  • Illinois Cancer Specialists

    Arlington Heights, Illinois, 60005

  • University Blood & Cancer Center, LLC

    Athens, Georgia, 30607

  • Winship Cancer Institute

    Atlanta, Georgia, 30322

  • Northside Hospital

    Atlanta, Georgia, 30341

  • Mercy Medical Center

    Baltimore, Maryland, 21202

  • Ascension St. Agnes Hospital

    Baltimore, Maryland, 21229

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    Baltimore, Maryland, 21287

  • UCSF Cancer Center Berkeley

    Berkeley, California, 94702

  • Cedars-Sinai Cancer Beverly Hills

    Beverly Hills, California, 90211

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114

  • Boston Medical Center

    Boston, Massachusetts, 02118

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215

  • Kings County Hospital Center

    Brooklyn, New York, 11203

  • Consultants In Medical Oncology and Hematology, P.C.

    Broomall, Pennsylvania, 19008

  • University of Vermont Medical Center

    Burlington, Vermont, 05401

  • MD Anderson Cancer Center at Cooper

    Camden, New Jersey, 08103

  • Miami Valley Hospital South

    Centerville, Ohio, 45459

  • Ironwood Cancer and Research Centers

    Chandler, Arizona, 85224

  • Hollings Cancer Center

    Charleston, South Carolina, 29425

  • Northwestern Memorial Hospital

    Chicago, Illinois, 60611

  • RUSH MD Anderson Cancer Center

    Chicago, Illinois, 60612-3841

  • MetroHealth

    Cleveland, Ohio, 44109

  • Cleveland Clinic

    Cleveland, Ohio, 44195

  • Maryland Oncology Hematology, P.A.

    Columbia, Maryland, 21044

  • Texas Oncology - DFW

    Dallas, Texas, 75246

  • Mass General North Shore Cancer Center

    Danvers, Massachusetts, 01923-3623

  • Southern Cancer Center, PC

    Daphne, Alabama, 36526

  • St. Joseph Hospital-Cancer Centers of Colorado

    Denver, Colorado, 80218-1122

  • Mission Cancer and Blood

    Des Moines, Iowa, 50309

  • City of Hope National Medical Center

    Duarte, California, 91010

  • Duke Cancer Institute

    Durham, North Carolina, 27710

  • Northwest Cancer Centers, PC

    Dyer, Indiana, 46311

  • Hematology Oncology Associates of Central New York, PC

    East Syracuse, New York, 13057

  • Mayo Clinic Health System - Eau Claire

    Eau Claire, Wisconsin, 54703

  • Swedish Cancer Institute - Edmonds

    Edmonds, Washington, 98206

  • Inova Schar Cancer Institute

    Fairfax, Virginia, 22031

  • Virginia Cancer Specialists

    Fairfax, Virginia, 22031

  • Oncology Hematology Care Clinical Trials, LLC

    Fairfield, Ohio, 45014

  • Cape Fear Valley Medical Center

    Fayetteville, North Carolina, 28304

  • Summit Medical Group

    Florham Park, New Jersey, 07932

  • Florida Cancer Specialists

    Fort Myers, Florida, 33901

  • Dana Farber Cancer Institute at Foxborough

    Foxborough, Massachusetts, 02035

  • UCSF Wash Cancer CNTR

    Fremont, California, 94538

  • Banner MD Anderson Cancer Center

    Gilbert, Arizona, 85234-2165

  • The Cancer & Hematology Centers

    Grand Rapids, Michigan, 49503

  • Cone Health Cancer Center at Wesley Long

    Greensboro, North Carolina, 27403

  • John Theurer Ctr-Hackensack UMC

    Hackensack, New Jersey, 07601

  • Penn State Milton S. Hershey Medical Center

    Hershey, Pennsylvania, 17033

  • Kaiser Permanente Hawaii Moanalua Medical Center

    Honolulu, Hawaii, 96819

  • Oncology Consultants, P.A.

    Houston, Texas, 77024

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030-4009

  • Harris Health System - Smith Clinic

    Houston, Texas, 77054

  • O'Quinn Medical Tower - McNair Campus

    Houston, Texas, 77054

  • City of Hope at Irvine Lennar

    Irvine, California, 92618

  • Swedish Cancer Institute - Issaquah

    Issaquah, Washington, 98029

  • Cayuga Medical Center

    Ithaca, New York, 14850

  • Mayo Clinic

    Jacksonville, Florida, 32224

  • Fred Hutch CC at Evergreen HMC

    Kirkland, Washington, 98034

  • Mayo Clinic Health System - La Crosse

    La Crosse, Wisconsin, 54601

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92037

  • NHO Revive Research Institute LLC

    Lincoln, Nebraska, 68506

  • Rocky Mountain Cancer Centers, LLP

    Lone Tree, Colorado, 80124

  • Helios Clinical Research

    Long Beach, California, 90805

  • Cancer and Blood Research Center, LLC

    Los Alamitos, California, 90720

  • USC/Norris Comprehensive Cancer Center

    Los Angeles, California, 90033

  • UCLA Department of Medicine - Hematology/Oncology

    Los Angeles, California, 90095

  • UofL Health Brown Cancer Center

    Louisville, Kentucky, 40202

  • Covenant Children's Hospital- Joe Arrington Cancer Research and Treatment Center

    Lubbock, Texas, 79410

  • University of Wisconsin Carbone Cancer Center- University Hospital

    Madison, Wisconsin, 53792

  • Mayo Clinic - Mankato

    Mankato, Minnesota, 56001-4752

  • Holy Redeemer Hospital And Medical Center

    Meadowbrook, Pennsylvania, 19046

  • Alliance Cancer Specialists, PC

    Media, Pennsylvania, 19044-1134

  • Baptist Cancer Center

    Memphis, Tennessee, 38120

  • Dana Farber Cancer Institute - Merrimack Valley

    Methuen, Massachusetts, 01844

  • Miami Cancer Institute at Baptist Health Inc.

    Miami, Florida, 33176

  • University of Miami

    Miami, Florida, 33176

  • Dana-Farber Cancer Institute at Milford Regional

    Milford, Massachusetts, 01757

  • Froedtert Hospital & the Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226

  • NYU Langone Hospital-Long Island

    Mineola, New York, 11501

  • Allina Health Cancer Institute - Abbott Northwestern Hospital

    Minneapolis, Minnesota, 55407

  • Pacific Cancer Care - Oncology

    Monterey, California, 93940

  • SCRI Oncology Partners

    Nashville, Tennessee, 37203

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37203

  • Henry - Joyce Cancer Clinic

    Nashville, Tennessee, 37232

  • Texas Oncology - San Antonio

    New Braunfels, Texas, 78130

  • Rutgers Cancer Institute

    New Brunswick, New Jersey, 08903

  • Yale New Haven Hospital- Yale Cancer Center

    New Haven, Connecticut, 06510

  • University Medical Center-New Orleans

    New Orleans, Louisiana, 70112

  • The Blavatnik Family - Chelsea Medical Center at Mount Sinai

    New York, New York, 10011

  • Laura and Isaac Perlmutter Cancer Center/NYU Langone Health

    New York, New York, 10016

  • Mount Sinai West

    New York, New York, 10019

  • Icahn School of Medicine Mount Sinai

    New York, New York, 10029

  • Columbia University Medical Center

    New York, New York, 10032-3729

  • Hoag Memorial Hospital Presbyterian

    Newport Beach, California, 92663

  • Virginia Oncology Associates

    Newport News, Virginia, 23606

  • Mass General Cancer Center at Newton-Wellesley Hospital's Vernon Cancer Center

    Newton, Massachusetts, 02462

  • Vista Oncology

    Olympia, Washington, 98506

  • Oncology Hematology West, PC dba Nebraska Cancer Specialists - Legacy

    Omaha, Nebraska, 68130

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198

  • UC Irvine Health, Chao Family Comprehensive Cancer Center

    Orange, California, 92868-3201

  • AdventHealth Orlando Infusion Center

    Orlando, Florida, 32804

  • Baptist Clinical Research Institution

    Oxford, Mississippi, 38655

  • Cancer Care Centers of Brevard (CCCB) - Palm Bay

    Palm Bay, Florida, 32909

  • Stanford Women's Cancer Center

    Palo Alto, California, 94304

  • AHMG Hematology and Oncology

    Parker, Colorado, 80138

  • Texas Oncology-Gulf Coast

    Pearland, Texas, 77584

  • Memorial Healthcare System

    Pembroke Pines, Florida, 33026

  • Ascension Sacred Heart

    Pensacola, Florida, 32504

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111

  • Banner University Medical Center - Phoenix Campus (Banner Good Samaritan Medical Center)

    Phoenix, Arizona, 85006

  • Avera St. Mary's Hospital

    Pierre, South Dakota, 57501

  • Miami Cancer Institute at Plantation

    Plantation, Florida, 33324

  • Providence Cancer Institute Franz Clinic

    Portland, Oregon, 97213

  • Providence Cancer Institute Franz Clinic

    Portland, Oregon, 97225

  • Rhode Island Hospital

    Providence, Rhode Island, 02903

  • Virginia Cancer Institute

    Richmond, Virginia, 23229

  • Mayo Clinic

    Rochester, Minnesota, 01842

  • University of Rochester Medical

    Rochester, New York, 14642

  • Dignity Health dba Health Research Institute

    Sacramento, California, 95816

  • Sutter Institute for Medical Research

    Sacramento, California, 95816

  • Metro-MN Comm. Onc. Res Consortium

    Saint Louis Park, Minnesota, 55416

  • Oregon Oncology Specialists

    Salem, Oregon, 97301

  • Utah Cancer Specialists

    Salt Lake City, Utah, 84106

  • Huntsman Cancer Institute, University of Utah

    Salt Lake City, Utah, 84112

  • Mays Cancer Center

    San Antonio, Texas, 78229

  • UCSF Zuckerberg SF General

    San Francisco, California, 94143

  • University of California, San Francisco (UCSF)

    San Francisco, California, 94158

  • Southern California Kaiser Medical Center-San Marcos Medical

    San Marcos, California, 92069

  • UCSF Cancer Center San Mateo

    San Mateo, California, 94402

  • Mayo Clinic

    Scottsdale, Arizona, 85259-5452

  • Virginia Mason Medical Center

    Seattle, Washington, 98101

  • Swedish Cancer Institute

    Seattle, Washington, 98104

  • Fred Hutchinson Cancer Center

    Seattle, Washington, 98109

  • Fred Hutch CC at UWMC-Northwest

    Seattle, Washington, 98133

  • Avera Cancer Institute

    Sioux Falls, South Dakota, 57105

  • Sansum Clinic

    Solvang, California, 93463

  • Dana-Farber/Brigham and Women's Cancer Center (DF/BWCC) in Clinical Affiliation with South Shore Hospital

    South Weymouth, Massachusetts, 02190

  • MultiCare Deaconess Hospital

    Spokane, Washington, 99204

  • Cancer Care Northwest

    Spokane Valley, Washington, 99216

  • Highlands Oncology Group, PA

    Springdale, Arkansas, 72762

  • Siteman Cancer Center

    St Louis, Missouri, 63108

  • Florida Cancer Specialists

    St. Petersburg, Florida, 33705

  • Comprehensive Hematology Oncology

    St. Petersburg, Florida, 33709

  • Stony Brook University Cancer Center

    Stony Brook, New York, 11794

  • MultiCare Cancer Institute - Tacoma

    Tacoma, Washington, 98405

  • Northwest Medical Specialties PLLC

    Tacoma, Washington, 98405

  • Moffitt Cancer Center

    Tampa, Florida, 33612

  • Northwest Cancer Specialists, P.C.

    Tigard, Oregon, 97223

  • Torrance Memorial Physician Network- Cancer Care

    Torrance, California, 90505

  • Arizona Clinical Research Center, Inc.

    Tucson, Arizona, 85715

  • University of Arizona Cancer Center

    Tucson, Arizona, 85719

  • Oklahoma Cancer Specialists and Research Institute (OCSRI) - Tulsa Cancer Center

    Tulsa, Oklahoma, 74146

  • Mass General - North Shore Cancer Center

    Waltham, Massachusetts, 02451

  • Georgetown University Medical Center

    Washington D.C., District of Columbia, 20007

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010-3017

  • Sibley Memorial Hospital

    Washington D.C., District of Columbia, 20016

  • The George Washington Medical Faculty Associates

    Washington D.C., District of Columbia, 20037

  • Texas Oncology- Central South

    Weslaco, Texas, 78596

  • Florida Cancer Specialists

    West Palm Beach, Florida, 33401

  • Clinical Research Alliance, Inc.

    Westbury, New York, 11590

  • Cleveland Clinic Florida

    Weston, Florida, 33331-3609

  • Cancer Center of Kansas

    Wichita, Kansas, 67214

  • Lankenau Medical Center

    Wynnewood, Pennsylvania, 19096

  • Oncology & Hematology Associates of Southwest Virginia, Inc

    Wytheville, Virginia, 24382

  • Cancer Care Associates of York, Inc.

    York, Pennsylvania, 17403

Other trials in United States

Italy39 sites

  • Centro di Riferimento Oncologico, IRCCS

    Aviano, Pordenone, 33081

  • SSD Oncologia Medica Zamagni, IRCCS Azienda Ospedaliero- Universitaria di Bologna, Policlinico di Sant'Orsola

    Bologna, Emilia-Romagna, 40138

  • Divisione di Oncologia Medica ASST Spedali Civili di Brescia

    Brescia, 25123

  • Fond. Piemonte per l'Oncologia - Istituto di Candiolo IRCCS

    Candiolo, Torino, 10060

  • Ospedale di Cremona, ASST Cremona

    Cremona, 26100

  • SOD Radioterapia Oncologica, AOU Careggi

    Florence, 50134

  • Azienda Sanitaria Locale Napoli 2 Nord

    Frattamaggiore, Napoli, 80027

  • Ospedale San Martino IRCCS

    Genova, 16132

  • Azienda Unità Sanitaria Locale Toscana Nord Ovest

    Livorno, 57124

  • IRST Dino Amadori IRCCS

    Meldola, Forli-Cesena, 47014

  • Ospedale San Raffaele, IRCCS - Oncologia Medica

    Milan, 20132

  • Istituto Nazionale dei Tumori,IRCCS

    Milan, 20133

  • Istituto Europeo di Oncologia IRCCS

    Milan, 20141

  • S. C. Oncologia, Centro Oncologico Modenese (COM) - A.O.U. di Modena -Policlinico di Modena

    Modena, 41124

  • AOU Cagliari

    Monserrato, Cagliari, 9042

  • IRCCS San Gerardo dei Tintori

    Monza, Monza E Brianza, 20900

  • Azienda Ospedaliera Universitaria Federico II

    Naples, 80131

  • IRCCS Istituto Nazionale Tumori Fondazione Pascale

    Naples, 80131

  • UOC Oncologia - A.O.R.N. "A. Cardarelli"

    Naples, 80131

  • AOU Maggiore della Carità - Oncologia

    Novara, 28100

  • Istituto Oncologico Veneto

    Padova, 35128

  • IRCCS ICS Maugeri

    Pavia, 27100

  • IRCCS Policlinico San Matteo, Università degli studi di Pavia

    Pavia, 27100

  • Ospedale Santa Maria Della Misericordia

    Perugia, 06129

  • PO S.Chiara, AOU Pisana

    Pisa, 56126

  • PO S Carlo, Azienda Ospedaliera Regionale San Carlo - Oncologia

    Potenza, 85100

  • Azienda USL Toscana Centro

    Prato, 59100

  • Ospedale Generale Provinciale di Macerata

    Province of Macerata, 62100

  • Azienda Unita Sanitaria Locale della Romagna

    Rimini, 47923

  • Irccs Crob

    Rionero in Vulture, 85028

  • Fondazione PU Campus Biomedico

    Roma, 00128

  • U.O. Ginecologia Oncologica - Fondazione Policlinico A. Gemelli

    Roma, 00136

  • IRCCS Istituto Nazionale Tumori Regina Elena,UOSD Sperimentazioni di fase IV

    Roma, 00144

  • Ospedale Casa Sollievo della Sofferen IRCCS, Opera di San Pio da Pietrelcina

    San Giovanni Rotondo, Apulia, 71013

  • Azienda Ospedaliero Universitaria Di Sassari

    Sassari, 07100

  • Azienda Ospedaliera Universitaria Senese

    Siena, 53100

  • SOC Oncologia - P.O. "Santa Maria della Misericordia"

    Udine, 33100

  • Ospedale Sacro cuore Don Calabria- Negrar di Valpolicella

    Verona, 37024

  • Ist.Oncologico del Mediterraneo

    Viagrande, Catania, 039021

Other trials in Italy

Spain35 sites

  • Complexo Hospitalario Universitario A Coruña

    A Coruña, 15006

  • ICO Badalona-Hospital Germans Trias i Pujol

    Badalona, Barcelona, 08916

  • Hospital Universitari Vall D Hebron

    Barcelona, 08035

  • Hospital Clinic De Barcelona - Oncología Médica

    Barcelona, 08036

  • Hospital de La Santa Creu i Sant Pau

    Barcelona, 08041

  • Caceres Hospital Complex - San Pedro de Alcantara General Hospital

    Cáceres, Extremadura, 10002

  • Hospital Universitario Reina Sofia

    Córdoba, 14004

  • Hospital Clínico Universitario Virgen De La Arrixaca

    El Palmar, Murcia, 30120

  • Hospital Universitario de Jaén

    Jaén, 23007

  • H.U. Insular Gran Canaria

    Las Palmas de Gran Canaria, 35010

  • H.U Arnau De Vilanova Lleida

    Lleida, 25198

  • Hospital Universitario Lucus Augusti

    Lugo, 27003

  • Hospital Universitario De La Princesa - Oncología Médica

    Madrid, 28006

  • Hospital Beata Maria Ana

    Madrid, 28007

  • Hospital General Universitario Gregorio Marañón - Oncology

    Madrid, 28009

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034

  • Hospital Clínico San Carlos

    Madrid, 28040

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040

  • Hospital Universitario 12 de Octubre

    Madrid, 28041

  • Hospital Universitario La Paz

    Madrid, 28046

  • Hospital Universitario Virgen De La Victoria

    Málaga, 29010

  • Hospital Regional Universitario de Málaga (Hospital Civil)

    Málaga, 29011

  • Hospital Universitario Rey Juan Carlos

    Móstoles, Madrid, 28935

  • Hospital Universitario de Canarias

    San Cristóbal de La Laguna, Canary Islands, 38320

  • Hospital Universitari General de Catalunya

    Sant Cugat del Vallès, Barcelona, 08195

  • Hospital de Sant Joan Despi Moises Broggi

    Sant Joan Despí, Barcelona, 08970

  • Hospital Universitario de Santiago

    Santiago de Compostela, 15706

  • Hospital Universitario Virgen del Rocío

    Seville, Andalusia, 41013

  • H. Virgen de Valme

    Seville, Andalusia, 41014

  • Hospital Universitario Virgen de la Macarena - Oncología Médica

    Seville, 41009

  • Fundación Instituto Valenciano Oncologia

    Valencia, Navarre, 46009

  • Hospital Clinico Universitario De Valencia

    Valencia, 46010

  • Hospital Quironsalud Valencia

    Valencia, 46010

  • Hospital Alvaro Cunqueiro

    Vigo, A Coruña, 36312

  • Hospital Clínico Universitario Lozano Blesa - Oncología Médica

    Zaragoza, 50009

Other trials in Spain

Brazil30 sites

  • Fundação Pio XII - Hospital de Amor de Barretos

    Barretos, São Paulo, 14784-400

  • Instituto do Cancer do Estado de Sao Paulo (ICESP)

    Barueri, São Paulo, 01246-000

  • CTO Centro de Tratamento Oncologico LTDA

    Belém, Pará, 66073-005

  • CETUS Oncologia S.A

    Belo Horizonte, Minas Gerais, 30150-270

  • Impar Servicos Hospitalares S/A - Hospital Brasília

    Brasília, Federal District, 71635-580

  • Centro de Pesquisas Clínicas em Oncologia

    Cachoeiro de Itapemirim, Espírito Santo, 29308-014

  • Hospital Santa Cruz Sociedade Anonima

    Curitiba, Paraná, 80420-090

  • Centro Integrado Oncologia Curitiba

    Curitiba, Paraná, 80810-050

  • Centro de Pesquisas Oncologicas - CEPON

    Florianópolis, Santa Catarina, 88034000

  • Instituto D'Or de Pesquisa e Ensino (Oncocentro Servicos Medicos e Hospitalares LTDA)

    Fortaleza, Ceará, 61160-070

  • Hospital Araujo Jorge

    Goiânia, Goiás, 74605-070

  • Clinica de Neoplasias Litoral

    Itajaí, Santa Catarina, 88301-220

  • Sociedade Beneficência e Caridade de Lajeado (Hospital Bruno Born)

    Lajeado, Rio Grande do Sul, 95900-000

  • Instituto de Câncer de Londrina

    Londrina, Paraná, 86015-520

  • Futtura Oncologia

    Porto Alegre, Rio Grande do Sul, 055026

  • Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa - Hospital Mae de Deus

    Porto Alegre, Rio Grande do Sul, 90110-270

  • PUCRS - Hospital São Lucas

    Porto Alegre, 90610-000

  • Fundação PIO XII - Hospital de Amor Amazônia

    Porto Velho, Rondônia, 76834-899

  • Universidade de Sao Paulo (USP) - Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto (HCFMRP)

    Ribeirão Preto, São Paulo, 14048-900

  • Instituto Nacional do Cancer - INCA-HC III

    Rio de Janeiro, 20560-120

  • Instituto de Educacao, Pesquisa e Gestao em Saude

    Rio de Janeiro, 22775-001

  • Hospital de Base de São José do Rio Preto - CIP

    São José do Rio Preto, São Paulo, 15090-000

  • Instituto Brasileiro de Controle do Cancer - ibcc - Hematology / Oncology

    São Paulo, São Paulo, 03102-002

  • Clínica de Pesquisas e Centro de Estudos em Oncologia Ginecológica e Mamária Ltda

    São Paulo, 01317-904

  • A.C.Camargo Cancer Center

    São Paulo, 01509-010

  • Instituto de Assistencia Medica ao Servidor Publico Estadual (IAMSPE)

    São Paulo, 04039-901

  • Onco Star SP Oncologia LTDA (Onco Star)

    São Paulo, 04062-001

  • Hospital Universitario y Politecnico La Fe - Oncología Médica

    Valência, 46026

  • CEDOES - Centro de Pesquisa Clinica e Diagnostico do Espirito Santo LTDA

    Vitória, Espírito Santo, 29.055-450

  • Hospital da Fundacao Oswaldo Aranha

    Volta Redonda, Rio de Janeiro, 27251-260

Other trials in Brazil

Germany30 sites

  • Hämatologie-Onkologie Zentrum MVZ

    Augsburg, Bavaria, 049017

  • Universitätsklinikum Augsburg

    Augsburg, Bavaria, 86156

  • Praxisklinik Krebsheilkunde

    Berlin, 10367

  • Helios Klinikum Berlin-Buch

    Berlin, 13125

  • Charite-Universitaetsmedizin Berlin - Campus Charite Mitte (CCM)

    Berlin

  • Marienhospital Bottrop gGmbH

    Bottrop, North Rhine-Westphalia, 46236

  • 'Schwerpunktpraxis Fuer Gynaekologie und Onkologie

    Brandenburg, Fuerstenwalde /Spree, 15517

  • Staedtisches Klinikum Dessau

    Dessau, 06847

  • Gemeinschaftspraxis Haematologie - Onkologie

    Dresden, Saxony, 01307

  • GynOnco Duesseldorf

    Düsseldorf, North Rhine-Westphalia, 40235

  • Studienzentrale für das MVZ e.K

    Eggenfelden, Bavaria, 84307

  • Universitaetsklinikum Erlangen

    Erlangen, Bavaria, 91054

  • Evang. Kliniken Essen-Mitte

    Essen, North Rhine-Westphalia, 45136

  • 'Klinikum Esslingen GmbH

    Esslingen am Neckar, Esslingen a.N., 73730

  • Agaplesion Markus Krankenhaus - Klinik fuer Gynaekologie und Geburtshilfe

    Frankfurt am Main, Hesse, 60431

  • Klinikum Frankfurt Höchst GmbH

    Frankfurt am Main, Hesse, 65929

  • Mammazentrum Hamburg MVZ GbR

    Hamburg, 20357

  • Universitätsklinikum des Saarlandes

    Homburg/Saar, Saarland, 66421

  • University Hospital Of Leipzig - Frauen- und Kindermedizin

    Leipzig, Saxony, 04103

  • Universitätsklinikum Schleswig-Holstein, Campus Lübeck

    Lübeck, Schleswig-Holstein, 23538

  • Praxisklinik am Rosengarten

    Mannheim, Baden-Wurttemberg, 68165

  • Universitätsmedizin Mannheim (UMM)

    Mannheim, Baden-Wurttemberg, 68167

  • Evangelisches Krankenhaus Bethesda

    Mönchengladbach, North Rhine-Westphalia, 41061

  • LMU - Klinikum Innenstadt

    München, Bavaria, 80336

  • Klinikum rechts der Isar, TUM München

    München, Bavaria, 81675

  • Caritas-Krankenhaus St. Josef - Frauenheilkunde und Geburtshilfe

    Regensburg, Bavaria, 93053

  • Immanuel Klinik Rüdersdorf

    Rüdersdorf, Brandenburg, 15562

  • universitaet Hospital Of Ulm

    Ulm, Baden-Wurttemberg, 89075

  • Marien Hospital Witten

    Witten, North Rhine-Westphalia, 58452

  • Klinikum Worms gGmbH

    Worms, Rhineland-Palatinate, 67550

Other trials in Germany

Turkey (Türkiye)27 sites

  • Baskent Universitesi Adana Uygulama ve Arastirma Merkezi

    Adana, Adana/ Yuregir, 01250

  • Medical Park Seyhan Hospital

    Adana, Seyhan/Adana, 01140

  • Adana Sehir Egitim ve Arastirma Hastanesi

    Adana, Yüregir, 1220

  • Dr Abdurrahman Yurtaslan EAH

    Ankara, Ankara/ Yenimahalle, 06200

  • Memorial Ankara Hastanesi

    Ankara, Ankara/Cankaya, 06520

  • Ankara City Hospital - Medical Oncology

    Ankara, Cankaya/Ankara, 06800

  • Gazi Uni Hast

    Ankara, Yenimahalle/Ankara, 06560

  • Ankara Etlik Sehir Hastanesi - Tıbbi Onkoloji

    Ankara, 06170

  • Hacettepe University Medical Faculty - Medical Oncology

    Ankara, 06230

  • Gulhane Training and Research Hospital

    Ankara, 6010

  • Ankara Universitesi Tip Fakultesi Cebeci Arastirma Ve Uygulama Hastanesi

    Ankara, 6590

  • Adnan Menderes Universitesi - Uygulama ve Arastirma Hastanesi

    Aydin, 9010

  • Dokuz Eylul Universitesi - Tip Fakultesi

    Balçova, İzmir, 35330

  • Dicle Universitesi Hastanesi

    Diyarbakır, 21280

  • Gaziantep University Sahinbey Practise and Research Hospital - Internal Medicine- Endocrinology and Metobolism

    Gaziantep, 27310

  • Medipol Mega Hospital - Medical Oncology

    Istanbul, Samsun, 34214

  • Acibadem Maslak Hospital

    Istanbul, Samsun, 34457

  • Acibadem Atasehir Hospital

    Istanbul, Samsun, 34758

  • Medical Park Florya Hastanesi

    Istanbul, 34295

  • Acibadem Altunizade Hospital

    Istanbul, 34662

  • Medical Point Izmir Hospital

    Izmir, 35575

  • Kocaeli Uni Egt ve Uyg Hast

    İzmit, Kocaeli, 41001

  • Prof. Dr. Suleyman Yalcin Sehir Hastanesi

    Kadıköy, Istanbul, 34722

  • Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi

    Konya, Meram/Konya, 42080

  • VM Medical Park Mersin Hastanesi

    Mersin, Mersin/Mezitli, 33200

  • Sakarya Egit ve Aras Hast

    Sakarya, Adapazari, 54100

  • VM Medical Park Samsun Hospital - Medical oncology

    Samsun, 55000

Other trials in Turkey (Türkiye)

Australia25 sites

  • Cancer Research SA

    Adelaide, South Australia, 5000

  • Royal Adelaide Hospital - Oncology

    Adelaide, South Australia, 5000

  • Icon Cancer Centre Wesley

    Auchenflower, Queensland, 4066

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042

  • Box Hill Hospital

    Box Hill, Victoria, 3128

  • Monash Medical Centre

    Clayton, Victoria, 3168

  • St Vincent's Hospital Sydney

    Darlinghurst, New South Wales, 2010

  • Northern Hospital

    Epping, Victoria, 3076

  • Lake Macquarie Private Hospital - Oncology

    Gateshead, New South Wales, 2290

  • Austin Health

    Heidelberg, VIC 3084

  • Icon Cancer Centre Hobart

    Hobart, 7000

  • Icon Cancer Centre Townsville

    Hyde Park, Queensland, 4812

  • St George Hospital - Medical Oncology

    Kogarah, New South Wales, 2217

  • Icon Cancer Centre Kurralta Park

    Kurralta Park, South Australia, 5037

  • Launceston General Hospital - Medical Oncology

    Launceston, Tasmania, 7250

  • Lismore Base Hospital - Cancer Care , Haematology Unit

    Lismore, New South Wales, 2480

  • Macquarie University

    Macquarie Park, New South Wales, 2109

  • Maroondah Hospitals - Medical Oncology

    Melbourne, Victoria, 3135

  • Breast Cancer Research Centre

    Nedlands, Western Australia, 6009

  • Mater Hospital Sydney

    North Sydney, New South Wales, 2060

  • Mid North Coast Cancer Institute

    Port Macquarie, 2444

  • Goulburn Valley Health

    Shepparton, Victoria, 3630

  • Icon Cancer Centre Southport

    Southport, Queensland, 4215

  • Westmead Hospital

    Westmead, New South Wales, 2145

  • The Queen Elizabeth Hospital

    Woodville, South Australia, 5011

Other trials in Australia

France21 sites

  • CHU Amiens - Picardie Site Sud

    Amiens, Somme, 80000

  • Institut Sainte Catherine

    Avignon, Vaucluse, 84000

  • ICONE

    Bezannes, Marne, 51430

  • Ct Oncologie Radiotherapie CORT 37

    Chambray-lès-Tours, Indre-et-Loire, 37170

  • Centre Jean Perrin

    Clermont-Ferrand, Puy-de-Dôme, 63011

  • Institut de Cancerologie Bourgogne

    Dijon, Saône-et-Loire, 21000

  • CHI De Fréjus / Saint-Raphael

    Fréjus, Var, 83600

  • CHU de Grenoble

    Grenoble, Auvergne-Rhône-Alpes, 38043

  • Polyclinique de Blois

    La Chaussée-Saint-Victor, Loir-et-Cher, 41260

  • CHD Vendee

    La Roche-sur-Yon, Vendée, 85925

  • Hopital Universitaire Dupuytren

    Limoges, Limousin, 87000

  • Centre de Cancérologie du Grand Montpellier

    Montpellier, Hérault, 34070

  • Hopital Tenon

    Paris, Île-de-France Region, 75970

  • Centre Hospitalier De Pau

    Pau, Pyrénées-Atlantiques, 64046

  • Centre Hospitalier Universitaire De Poitiers - Pôle Régional de Cancérologie

    Poitiers, 86000

  • CRLCC Jean Godinot

    Reims, Marne, 51100

  • Institut de Cancerologie de l'Ouest - Oncology

    Saint-Herblain, Loire-Atlantique, 44805

  • Inst Cancerologie Strasbourg Europe

    Strasbourg, Alsace, 67200

  • Centre de cancerologie Les Dentellieres

    Valenciennes, Hauts-de-France, 59300

  • Institut de Cancérologie de Lorraine

    Vandœuvre-lès-Nancy, 54511

  • Institut Gustave Roussy

    Villejuif, Val-de-Marne, 94805

Other trials in France

South Korea16 sites

  • Inje University Haeundae Paik Hospital

    Busan, 48108

  • Chungbuk National University Hospital

    Cheongju-si, Chungcheongbugdo [Ch'ungch'ongbuk-do], 28644

  • Kyungpook National University Chilgok Hospital

    Daegu, 41404

  • National Cancer Center

    Gyeonggi-do, 10408

  • Ajou University Hospital

    Gyeonggi-do, 16499

  • Gachon University Gil Medical Center

    Incheon, Incheon Gwang'yeogsi [Inch'n-Kwangyokshi], 21565

  • CHA Bundang Medical Center, CHA University

    Seongnam-si, Gyeonggido, 13496

  • Severance Hospital, Yonsei University Health System

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 03722

  • Asan Medical Center

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 05505

  • Gangnam Severance Hospital - Oncology

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 06273

  • Korea University Guro Hospital

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 08308

  • Korea University Anam Hospital

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 2841

  • Ewha Womans University Mokdong Hospital

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 7985

  • Seoul National University Hospital

    Seoul, 03080

  • The Catholic University of Korea, Seoul St. Mary's Hospital

    Seoul, 06591

  • Ulsan University Hospital

    Ulsan, 44033

Other trials in South Korea

United Kingdom16 sites

  • Blackpool Victoria Hospital

    Blackpool, Lancashire, FY3 8NR

  • University Hospitals Sussex NHS Foundation Trust - Royal Sussex County Hospital

    Brighton, East Sussex, BN2 5BE

  • Cheltenham General Hospital

    Cheltenham, Gloucestershire, GL53 7AN

  • Western General Hospital

    Edinburgh, EH4 2XU

  • Leeds Cancer Centre

    Leeds, LS9 7TF

  • St John's Hospital - NHS Lothian

    Livingston, Scotland, EH54 6PP

  • Whittington Health NHS Trust - Whittington Hospital

    London, England, N19 5NF

  • University College London Hospitals

    London, London, City of, NW1 2PG

  • The Royal Marsden NHS Foundation Trust - The Royal Marsden Hospital Fulham Road

    London, London, City of, SW3 6JJ

  • St Bartholomew's Hospital

    London, EC1A 7BE

  • Maidstone Hospital Kent Oncology Centre

    Maidstone, ME16 9QQ

  • Mount Vernon Cancer Centre - Main Site

    Northwood, Greater London, HA6 2RN

  • Royal Preston Hospital

    Preston, Lancashire, PR2 9HT

  • The Royal Marsden NHS Foundation Trust - The Royal Marsden Sutton

    Sutton, Surrey, SM2 5PT

  • Musgrove Park Hospital

    Taunton, Somerset, TA1 5DA

  • Royal Cornwall Hospital (RCH) - Sunrise Centre

    Truro, Cornwall, TR1 3LJ

Other trials in United Kingdom

Belgium13 sites

  • Edith Cavell Inter-regional Hospital Centre (CHIREC) - Delta Hospital

    Aalst, Brussels Capital, 1160

  • Algemeen Ziekenhuis Klina

    Brasschaat, Antwerpen, 2930

  • CHU Saint-Pierre

    Brussels, Brussels Capital, 1000

  • Association Hospitaliere De Bruxelles Et De Schaerbeek - Centre Hospitalier Universitaire Brugmann

    Brussels, Brussels Capital, 1020

  • Institut Jules Bordet

    Brussels, 1070

  • Grand Hopital de Charleroi - Site Les Viviers

    Charleroi, Hainaut, 6060

  • Jessa Ziekenhuis - Campus Virga Jesse - Medische Oncologie

    Hasselt, Limburg, 3500

  • UZ Leuven

    Leuven, Vlaams Brabant, 3000

  • CHU De Liège - Oncologie Médicale

    Liège, 04000

  • CHC - Oncologie - Hémato-Immunopatho

    Liège, 4000

  • CHU UCL Namur - Site Ste Elisabeth - Oncologie

    Namur, 5000

  • Clnique Saint Pierre Ottignies - Oncologie-Hématologie

    Ottignies, Brabant Wallon, 1340

  • VITAZ Campus Sint-Niklaas Moerland

    Sint-Niklaas, Oost-Vlaanderen, 9100

Other trials in Belgium

Portugal13 sites

  • CHUC - Centro Hospitalar e Universitário de Coimbra

    Coimbra, 3000-075

  • Unidade Local de Saúde do Algarve, E. P. E.

    Faro, 8000-386

  • Instituto Portugues de Oncologia de Lisboa Francisco Gentil - Oncologia Medica

    Lisbon, 1099-023

  • ULS Lisboa Ocidental (ULSLO)

    Lisbon, 1449-005

  • Hospital CUF Descobertas

    Lisbon, 1998-018

  • Hospital Beatriz Ângelo. Hospital de Loures - Oncologia Medica

    Loures, Lisbon District, 2674-514

  • IPO Porto FG, EPE

    Porto, Madeira, 4200-072

  • Unidade Local De Saude De Santo Antonio E.P.E.

    Porto, 4099-001

  • Hospital da Luz de Setubal

    Setúbal, 2900-722

  • Unidade Local de Saúde de Arrábida

    Setúbal, 2910-446

  • Hospital De Vila Franca De Xira E.P.E.

    Vila Franca de Xira, Lisbon District, 2600-009

  • C.H. de Vila Nova de Gaia/Espinho - Oftalmologia

    Vila Nova de Gaia, Porto District, 4434-502

  • Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE

    Vila Real, 5000-508

Other trials in Portugal

Malaysia12 sites

  • Hospital Pulau Pinang - Rheumatology

    George Town, Pulau Pinang

  • Hospital Raja Permaisuri Bainun

    Ipoh, Perak, 30990

  • Hospital Sultan Ismail

    Johor Bahru, 81100

  • Institut Perubatan & Pergigian Termaju (IPPT) - USM (Kepala Batas, Pulau Pinang)

    Kepala Batas, Pulau Pinang, 13200

  • Universiti Sains Malaysia /ID# 200101

    Kota Bharu, Kelantan, 16150

  • Pantai Hospital Kuala Lumpur

    Kuala Lumpur, Kuala Lumpur, 50603

  • UKM Medical Centre

    Kuala Lumpur, Kuala Lumpur, 56000

  • Beacon Hospital

    Kuala Lumpur, Kuala Lumpur, 59100

  • Universiti Malaya Medical Centre

    Kuala Lumpur, Kuala Lumpur, 59100

  • Hospital Kuala Lumpur

    Kuala Lumpur, 50000

  • Mahkota Medical Center

    Malacca

  • Institut Kanser Negara

    Putrajaya, Kuala Lumpur, 62250

Other trials in Malaysia

Switzerland12 sites

  • Tumor Zentrum Aarau

    Aarau, Aargau (de), 5000

  • Kantonsspital Badenv

    Baden, Aargau (de), 5404

  • Universitätsspital Basel

    Basel, Basel-Stadt (de), 4031

  • Inselspital, Universitätsspital Bern

    Bern, 3010

  • Hopitaux Universitaires de Geneve (HUG) - Hopital Cantonal

    Geneva, 1211

  • Centre Hospitalier Universitaire Vaudois (CHUV)Département d'oncologie

    Lausanne, Vaud (fr), CH-1011

  • Kantonsspital Baselland

    Liestal, Basel-Landschaft (de), 4410

  • HOCH Health Ostschweiz - Kantonsspital St.Gallen

    Sankt Gallen, Sankt Gallen (de), 9007

  • Spitaeler Schaffhausen Kantonspital

    Schaffhausen, 8208

  • Kantonsspital Winterthur

    Winterthur, Zürich (de), CH-8401

  • Brust-Zentrum AG Zurich

    Zurich, Zürich (de), 8008

  • Universitätsspital Zürich

    Zurich, 8091

Other trials in Switzerland

Taiwan12 sites

  • Changhua Christian Medical Foundation Changhua Christian Hospital

    Changhua, 500209

  • Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

    New Taipei City, Taipei, 231020

  • Taipei Medical University - Shuang Ho Hospital Ministry of Health and Welfare - Hematology & Oncology

    New Taipei City, Taipei, 235041

  • Kuang Tien General Hospital - Shalu Xiangshang Division - Hemato-Oncology

    Taichung, Taichung, 433004

  • China Medical University Hospital - Breast Surgery

    Taichung, 404327

  • National Cheng Kung University Hospital

    Tainan, 704302

  • Chi Mei Medical Center - Liouying - Oncology

    Tainan, 736402

  • Koo Foundation Sun Yat-Sen Cancer Center - Hematology

    Taipei, Taoyuan, 112019

  • National Taiwan University Hospital - Surgery

    Taipei, 100225

  • Taipei Veterans General Hospital - Hematology

    Taipei City, Taipei, 112201

  • National Defense Medical Center (NDMC) - Tri-Service General Hospital - Neihu Branch

    Taipei City, Taipei, 114202

  • Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital - Breast Surgery

    Taiyuan, Taoyuan, 333423

Other trials in Taiwan

Argentina11 sites

  • (COIBA)Centro de Oncologia e Investigacion Buenos Aires

    Berazategui, Buenos Aires, B1884BBF

  • Fundacion Respirar

    Buenos Aires, Buenos Aires F.D., 1426

  • Organizacion Medica de Investigacion (OMI)

    Buenos Aires, Buenos Aires F.D., C1015ABO

  • Clinica Adventista Belgrano

    Buenos Aires, Tucumán Province, 1430

  • Instituto Argentino de Diagnostico y Tratamiento

    Buenos Aires, 054002

  • Centro de Investigación CIPREC

    C.a.b.a., Buenos Aires F.D., 1061

  • Centro Oncológico Korben

    CABA, Buenos Aires F.D., C1426AGE

  • Centro Medico Privado CEMAIC

    Córdoba, Córdoba Province, X5008HHW

  • Inst Med Fund Estudios Clinicos

    Rosario, Santa Fe Province, S2000DEJ

  • Instituto de Oncologia de Rosario

    Rosario, Santa Fe Province, S2000KZE

  • Centro Oncologico de Excelencia

    San Juan, J5400

Other trials in Argentina

Romania11 sites

  • Spitalul Clinic Filantropia

    Bucharest, 011171

  • Spitalul Clinic CF Nr 2 Bucuresti

    Bucharest, 011464

  • Spitalul Clinic Colentina - Policlinica Dr Grozovici - Medical Oncology

    Bucharest, 021106

  • Memorial Healthcare International

    Bucharest, 13823

  • Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca

    Cluj-Napoca, Cluj, 400015

  • Oncolab - Medical Oncology

    Craiova, Dolj, 200385

  • Onco Clinic Consult - Ambulatory

    Craiova, Dolj, 200508

  • Centrul de Oncologie Sf. Nectarie

    Craiova, Dolj, 200746

  • Radiotherapy Center Cluj

    Floreşti, 407280

  • Institutul Regional de Oncologie Iasi - Medical Oncology

    Iași, 700483

  • Oncomed - Medical Oncology

    Timișoara, Timiș County, 300239

Other trials in Romania

Canada10 sites

  • Royal Victoria Regional Health Centre; c/o Oncology Clinical Trials

    Barrie, Ontario, L4M 6M2

  • London Health Sciences Centre

    London, Ontario, N6A 4G5

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2

  • Hôpital du Saint-Sacrement

    Québec, G1S 4L8

  • Centre hospitalier régional de Lanaudière

    Saint-Charles-Borromée, Quebec, J6E 6J2

  • Regional Hospital Saint-Jerome

    Saint-Jérôme, Quebec, J7Z 5T3

  • BC Cancer -Surrey

    Surrey, British Columbia, V3V 1Z2

  • St. Michaels Hospital

    Toronto, Ontario, M5B 1W8

  • Mount Sinai Hospital - Study Supplies

    Toronto, Ontario, M5G 1X5

  • BC Cancer Agency

    Vancouver, British Columbia, V5Z 4E6

Other trials in Canada

Hungary8 sites

  • Észak-Pesti Centrumkórház - Honvédkórház

    Budapest, 1062

  • Budapesti Uzsoki Utcai Korhaz

    Budapest, H-1145

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, Hajdú-Bihar, 4032

  • Békés Megyei Központi Kórház Pándy Kálmán Tagkórház - Oncology

    Gyula, Bekes County, 5700

  • Bacs-Kiskun Varmegyei Oktatakorhaz

    Kecskemét, Bács-Kiskun county, H-6000

  • University Of Pécs - Oncology dept.

    Pécs, Baranya, 7624

  • Nograd Varmegyei Szent Lazar Korhaz

    Salgótarján, Szabolcs-Szatmár-Bereg, 3100

  • Zala Vármegyei Szent Rafael Korhaz - Onkologiai Osztaly

    Zalaegerszeg, Zala County, H-8900

Other trials in Hungary

Georgia7 sites

  • LTD "High technology hospital MEDCENTER"

    Batumi, Adjara, 6000

  • LTD Brothers

    Batumi, Adjara, 6010

  • LTD "Israel-Georgian Medical Research Clinic Healthycore"

    Tbilisi, 0112

  • "Pineo Medical Ecosystem" LTD

    Tbilisi, 0114

  • LLC "Todua Clinic"

    Tbilisi, 0119

  • LTD Institute of Clinical Oncology

    Tbilisi, 0159

  • LLC "Caucasus Medical Center"

    Tbilisi, 0186

Other trials in Georgia

Poland7 sites

  • Szpitale Pomorskie Sp. z o.o. Oddzial Onkologii Klinicznej

    Gdynia, Pomeranian Voivodeship, 81-519

  • IP Clinic Sp. z o.o.

    Lodz, Łódź Voivodeship, 90-752

  • Centrum Onkologii Ziemi Lubelskiej im. sw. Jana z Dukli - I Oddzial Onkologii Klinicznej

    Lublin, Lubusz Voivodeship, 20-090

  • Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina - Oddział Onkologii Klinicznej

    Otwock, Masovian Voivodeship, 05-400

  • Wielkopolskie Centrum Onkologii Oddzial Onkologii Klinicznej i Immunoonkologii

    Poznan, Greater Poland Voivodeship, 61-866

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy

    Warsaw, Masovian Voivodeship, 02-781

  • Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii - Oddzial Onkologii Klinicznej/Chemioterapii

    Wroclaw, Lower Silesian Voivodeship, 53-413

Other trials in Poland

Austria6 sites

  • Medizinische Universität Graz

    Graz, Styria, 8010

  • Universitätsklinikum Krems

    Krems, Lower Austria, 3500

  • LKH Hochsteiermark

    Leoben, Styria, 8700

  • Universitatsklinikum St. Polten

    Sankt Pölten, Lower Austria, 3100

  • Hanusch Krankenhaus

    Vienna, 1140

  • Brustgesundheitszentrum Süd

    Weiz, Styria, 8160

Other trials in Austria

Finland6 sites

  • Docrates Mehiläinen Syöpäsairaala, Mehiläinen Oy

    Helsinki, Etelä-Suomen Lääni, 00180

  • Helsinki University Central Hospital (HUCH) - Meilahden Sair

    Helsinki, Länsi-Suomen Lääni, 00290

  • Kuopio University Hospital, Pohjois-Savon hyvinvointialue

    Kuopio, Northern Savonia, 70211

  • Tampere University Hospital

    Tampere, Etelä-Suomen Lääni, 33520

  • Turku University Hospital

    Turku, Etelä-Suomen Lääni, 20520

  • Vaasa Central Hospital

    Vaasa, Länsi-Suomen Lääni, 65130

Other trials in Finland

Hong Kong4 sites

  • Hong Kong Sanatorium & Hospital (HKSH)

    Happy Valley

  • Pamela Youde Nethersole Eastern Hospital

    Hong Kong

  • Queen Mary Hospital - Clinical Oncology

    Hong Kong

  • Prince of Wales Hospital (PWH) - The Chinese University of Hong Kong (CUHK) - Clinical Oncology

    Shatin

Other trials in Hong Kong

Netherlands4 sites

  • Albert Schweitzer Ziekenhuis Locatie Dordwijk

    Dordrecht, South Holland, 3318 AT

  • Catharina Ziekenhuis

    Eindhoven, 5623 EJ

  • Haga Ziekenhuis - Internal Medicine

    The Hague, South Holland, 2545 AA

  • Elisabeth-TweeSteden Ziekenhuis

    Tilburg, North Brabant, 5022 GC

Other trials in Netherlands

Singapore4 sites

  • National University Hospital

    Singapore, Central Singapore, 119074

  • OncoCare Cancer Centre

    Singapore, North East, 258499

  • Raffles Hospital

    Singapore, 065001

  • Curie Oncology (Farrer)

    Singapore, 217562

Other trials in Singapore

Czechia3 sites

  • Masarykuv onkologicky ustav - Klinika komplexni onkol. pece

    Brno, Brno-město, 656 53

  • Multiscan s.r.o.

    Hořovice, Stredoceský Kraj, 268 31

  • Fakultni Thomayerova nemocnice - Onkologicka klinika

    Prague, 140 59

Other trials in Czechia

Denmark3 sites

  • Hillerod Hospital

    Hillerød, Capital, 3400

  • Odense Universitetshospital - Oncology

    Odense, Region Syddanmark, 5000

  • Soenderborg Sygehus

    Sønderborg, Region Syddanmark, 6400

Other trials in Denmark

About this study

Official title: Elacestrant Versus Standard Endocrine Therapy in Women and Men With Node-positive, Estrogen Receptor-positive, HER2-negative, Early Breast Cancer With High Risk of Recurrence-A Global, Multicenter, Randomized, Open-label Phase 3 Study

The primary goal of this study is to evaluate the effectiveness of elacestrant versus standard endocrine therapy in participants with node-positive, Estrogen Receptor-positive (ER+), Human Epidermal Growth Factor-2 negative (HER2-) early breast cancer with high risk of recurrence.

Conditions
Breast Cancer
Being tested
Elacestrant, Anastrozole, Letrozole, Exemestane, Tamoxifen
Keywords
ELEGANT, Breast Cancer Stage II, Breast Cancer Stage III, Breast Cancer Female, Breast Cancer, Male, High-Risk Breast Cancer, High Risk Breast Carcinoma, ER-positive Breast Cancer, ER-positive HER-2 Negative Breast Cancer, ER Positive/HER2 Low Breast Cancer, Breast Cancer, ER+, HER2-, Adjuvant, Adjuvant Therapy
Medical subject headings
Breast Neoplasms, Breast Neoplasms, Male

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • ElacestrantDrug

    Administered as oral tablets

  • AnastrozoleDrug

    Administered as oral tablets

  • LetrozoleDrug

    Administered as oral tablets

  • ExemestaneDrug

    Administered as oral tablets

  • TamoxifenDrug

    Administered as oral tablets

Study groups in NCT06492616
Study groupRoleWhat they receive
ElacestrantExperimentalParticipants will receive 345 milligrams (mg) elacestrant once daily (QD) for 5 years.
Receives: Drug: Elacestrant
Standard of Care (SoC) Endocrine TherapyExperimentalParticipants will receive the SoC endocrine therapy that was used prior to randomization: * AI (anastrozole 1 mg QD, letrozole 2.5 mg QD, or exemestane 25 mg QD); or * Tamoxifen 20 mg QD
Receives: Drug: Anastrozole; Drug: Letrozole; Drug: Exemestane; Drug: Tamoxifen

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Invasive Breast Cancer-Free Survival (IBCFS)

    Assessed by the time from date of randomization to the date of first occurrence of:

    • Ipsilateral invasive breast tumor recurrence
    • Local/regional invasive breast cancer recurrence
    • Distant recurrence
    • Contralateral invasive breast cancer, or
    • Death attributable to any cause

    Measured: Up to 5 years

Secondary outcomes (10)

  1. Distant Relapse-Free Survival (DRFS)

    Assessed by the time from date of randomization to the date of first occurrence of:

    • Distant recurrence, or
    • Death attributable to any cause

    Measured: Up to 5 years

  2. Overall Survival (OS)

    Measured: Up to 5 years

  3. Invasive Disease-Free Survival (IDFS)

    Assessed by the time from date of randomization to the date of first occurrence of:

    • Local/regional recurrence
    • Contralateral recurrence
    • Second primary non-breast invasive cancer
    • Distant recurrence, or
    • Death attributable to any cause

    Measured: Up to 5 years

  4. Number of Participants With Adverse Events (AEs)

    Measured: Up to 5 years plus 28 days

  5. Change from Baseline in Global Health Status Quality of Life Scale score, as Assessed by the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30)

    Measured: Baseline, Month 6, Annually at Years 1, 2, 3, 4, 5

  6. Change from Baseline in the Physical Functioning Sub-Scale Score as Assessed by EORTC QLQ-C30

    Measured: Baseline, Month 6, Annually at Years 1, 2, 3, 4, 5

  7. Change From Baseline in the Breast Cancer Endocrine Therapy Symptoms Sub-Scale Score, as Assessed by the EORTC Quality of Life Breast Cancer Questionnaire module (EORTC QLQ-BR42)

    Measured: Baseline, Month 6, Annually at Years 1, 2, 3, 4, 5

  8. Change From Baseline in Side Effects, as Assessed by the Question 168 of the European Organization for the Research and Treatment of Cancer Question Library (EORTC Q168)

    Measured: Baseline, Month 6, Annually at Years 1, 2, 3, 4, 5

  9. Area Under the Plasma Concentration Versus Time Curve at Steady State (AUCss) of Elacestrant

    Measured: Predose up to 4 hours postdose

  10. Maximum Plasma Concentration at Steady State (Cmaxss) of Elacestrant

    Measured: Predose up to 4 hours postdose

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted9 Jul 2024
  2. Study start27 Sep 2024
  3. Primary completionAug 2029 (estimated)
  4. Study completionOct 2032 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
4,556 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06492616
Sponsor's protocol ID
STML-ELA-0422
Other IDs
2024-515445-42-00
Acronym
ELEGANT
Status last verified
Nov 2026
First submitted
1 Jul 2024
Last updated
4 Nov 2026
Results posted
No
FDA-regulated drug
Yes
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Elacestrant, Anastrozole and Letrozole in people with Breast Cancer, run by Stemline Therapeutics, Inc. at 555 sites in 28 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 9 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 555 sites in United States, Italy, Spain, Brazil, Germany and 23 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Invasive Breast Cancer-Free Survival (IBCFS) (time frame: Up to 5 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06492616.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.

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