Mild Cognitive ImpairmentNCT06493422
Online Interplay Between Deciding and Acting With Mild Cognitive Impairment
A study testing Reaching Movements in people with Mild Cognitive Impairment, run by University of Delaware at 1 site in United States.
Trial summary
The investigators aim to understand the interplay and neural structures involved with decision--making and movement for participants with mild cognitive impairment. Rapidly deciding and acting becomes bottlenecked with mild cognitive impairment and Alzheimer's, leading to detrimental outcomes such as falling and car… Read more about this study
- Who is it for?
- Ages 45 to 90 yearsHealthy volunteers can take part
- Conditions the study is for
- Mild Cognitive Impairment
- What is being tested?
- Reaching Movements
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 41 participants
- Where
- 1 siteUnited States
- Study dates
- 28 Jan 2025to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 90 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- age 45 - 90 years
- Perfect or corrected vision
- Ability to reach
- Neurotypical Age-Matched control participants - No history of neurological disorders or injury.
- Mild Cognitive Impairment participants - clinical diagnosis of amnestic mild cognitive impairment.
Who cannot join
- Any injury or condition that impacts reaching
- Traumatic brain injury, such as concussion, in the last 6 months.
- Neurotypical Age-Matched control participants: Modified Telephone Interview for Cognitive Status (TICS-m) score < 34
- Mild Cognitive Impairment participants: Modified Telephone Interview for Cognitive Status (TICS-m) score > 34
- Mild Cognitive Impairment participants: Mini-Mental State Examination Second Edition (MMSE-2) score < 21.
Trial locations and contacts
1 site in 1 country.
About this study
The investigators aim to understand the interplay and neural structures involved with decision--making and movement for participants with mild cognitive impairment. Rapidly deciding and acting becomes bottlenecked with mild cognitive impairment and Alzheimer's, leading to detrimental outcomes such as falling and car crashes. The investigators work will have a tangible impact by discovering sensitive biomarkers to detect disease onset and pave the way for informed and effective neurorehabilitation.
Read the detailed description
Mild cognitive impairment leads not only to impaired decision making, but also movement deficits that predict the development of Alzheimer's disease. Recent behavioral work has suggested a common mechanism that throttles the speed of both decisions and reaching movements, which is supported by converging neural evidence that finds an interac-tion between decision making and movement (motor) circuits. Yet it remains unknown how the interplay between decision making and motor neural circuits becomes impaired and impedes rapid responses for those with mild cognitive impairment. Here the investigators test the central hypothesis that there is an impaired interaction between decision making and motor neural circuits with mild cognitive impairment.
First, the investigators will use human reaching experiments to establish that mild cognitive impairment disrupts the interplay of decision making and motor control. Second, the investigators will use Magnetic resonance elastography to elucidate whether brain stiffness in decision making and motor brain regions are related to altered movement behavior. The expected outcome is a mechanistic understanding of how impaired decision making and motor neural circuits impact movement for those with mild cognitive impairment.
- Conditions
- Mild Cognitive Impairment
- Being tested
- Reaching Movements
- Keywords
- Reaching, Brain, Decisions
- Medical subject headings
- Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Reaching MovementsBehavioural
participants will perform a perceptual decision making task while moving their hand.
| Study group | Role | What they receive |
|---|---|---|
| Reaching task | Experimental | Mild cognitive impairment participants will make decisions while moving Receives: Behavioral: Reaching Movements |
| Reaching Task | Active comparator | Age-match control participants will make decision while moving Receives: Behavioral: Reaching Movements |
What is being measured
The primary outcome is the main question the study is designed to answer.
Reaching Movements
Hand position will be recorded throughout each trial during the behavioral task
Measured: through study completion, an average of 1 year
Change in brain mechanical properties
Investigators are assessing change in brain structure through mechanical properties
Measured: through study completion, an average of 1 year
Secondary outcomes (1)
Decision Time
Decision time will be calculated on each trial during the behavioral task
Measured: through study completion, an average of 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Jul 2024
- Study start28 Jan 2025
- Primary completion30 Jun 2026
- Study completion30 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Mild Cognitive ImpairmentStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 41 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Delaware
- Sponsor type
- University, hospital or other
- Collaborators
- National Institutes of Health (NIH), National Institute of General Medical Sciences (NIGMS)
- Responsible party
- Principal investigator, Joshua Cashaback, University of Delaware
- Investigators
- Josh Cashaback, Principal investigator, University of Delaware
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06493422
- Sponsor's protocol ID
- 2026374-5
- Other IDs
- U54GM104941
- Status last verified
- Jul 2026
- First submitted
- 18 Jun 2024
- Last updated
- 6 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Online Interplay Between Deciding and Acting With Mild Cognitive Impairment
- ClinicalTrials.gov ID
- NCT06493422
- Acronym / sponsor ID
- 2026374-5
- Conditions
- Mild Cognitive Impairment
- Keywords
- Reaching, Brain, Decisions
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 41 participants (actual)
- Lead sponsor
- University of DelawareUniversity, hospital or other
- Collaborators
- National Institutes of Health (NIH), National Institute of General Medical Sciences (NIGMS)
- Study start
- 28 Jan 2025 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 30 Jun 2026 (actual)
- First posted
- 10 Jul 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The investigators aim to understand the interplay and neural structures involved with decision--making and movement for participants with mild cognitive impairment. Rapidly deciding and acting becomes bottlenecked with mild cognitive impairment and Alzheimer's, leading to detrimental outcomes such as falling and car crashes. The investigators work will have a tangible impact by discovering sensitive biomarkers to detect disease onset and pave the way for informed and effective neurorehabilitation.
Detailed description
Mild cognitive impairment leads not only to impaired decision making, but also movement deficits that predict the development of Alzheimer's disease. Recent behavioral work has suggested a common mechanism that throttles the speed of both decisions and reaching movements, which is supported by converging neural evidence that finds an interac-tion between decision making and movement (motor) circuits. Yet it remains unknown how the interplay between decision making and motor neural circuits becomes impaired and impedes rapid responses for those with mild cognitive impairment. Here the investigators test the central hypothesis that there is an impaired interaction between decision making and motor neural circuits with mild cognitive impairment.
First, the investigators will use human reaching experiments to establish that mild cognitive impairment disrupts the interplay of decision making and motor control. Second, the investigators will use Magnetic resonance elastography to elucidate whether brain stiffness in decision making and motor brain regions are related to altered movement behavior. The expected outcome is a mechanistic understanding of how impaired decision making and motor neural circuits impact movement for those with mild cognitive impairment.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Reaching task | Experimental | Behavioral: Reaching MovementsMild cognitive impairment participants will make decisions while moving |
| Reaching Task | Active comparator | Behavioral: Reaching MovementsAge-match control participants will make decision while moving |
Who may qualify
- Ages
- 45 to 90 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- age 45 - 90 years
- Perfect or corrected vision
- Ability to reach
- Neurotypical Age-Matched control participants - No history of neurological disorders or injury.
- Mild Cognitive Impairment participants - clinical diagnosis of amnestic mild cognitive impairment.
Key exclusion criteria (5 listed)
- Any injury or condition that impacts reaching
- Traumatic brain injury, such as concussion, in the last 6 months.
- Neurotypical Age-Matched control participants: Modified Telephone Interview for Cognitive Status (TICS-m) score < 34
- Mild Cognitive Impairment participants: Modified Telephone Interview for Cognitive Status (TICS-m) score > 34
- Mild Cognitive Impairment participants: Mini-Mental State Examination Second Edition (MMSE-2) score < 21.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Reaching Movementsparticipants will perform a perceptual decision making task while moving their hand. | Behavioural | Reaching Task, Reaching task |
Primary outcome
Reaching Movements
Time frame: through study completion, an average of 1 year
Hand position will be recorded throughout each trial during the behavioral task
Change in brain mechanical properties
Time frame: through study completion, an average of 1 year
Investigators are assessing change in brain structure through mechanical properties
1 secondary outcome
Decision Time
Time frame: through study completion, an average of 1 year
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jul 2026.
- Individual participant dataSharing planned: No
Related trials for Mild Cognitive Impairment
Recruiting
Telehealth-Adapted Compensatory Training and Intervention for Cognition
MCI, Mild Cognitive Impairment
RecruitingPhase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
Alzheimer s Disease, Mild Cognitive Impairment
Recruiting
Treating Insomnia in Mild Cognitive Impairment
Mild Cognitive Impairment (MCI), Insomnia
Not yet recruitingObservational study
Prospective Research on Identification of Dementia in Early Stages (P.R.I.D.E)
Mild Cognitive Impairment, Memory Disorders
Enrolling by invitation
Mild Cognitive Impairment and Neuromodulation
Mild Cognitive Impairment (MCI)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Josh Cashaback principal investigator
University of Delaware
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Reaching Movements in people with Mild Cognitive Impairment, run by University of Delaware at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Reaching Movements (time frame: through study completion, an average of 1 year). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jul 2026.