AgingNCT06501547
Association of Leucocyte Telomere Length With DPAS Score in Skin Aging
An observational study of Aging and Skin Laxity, run by Dr.dr.Irma Bernadette, SpKK (K) at 3 sites in Indonesia.
Trial summary
The goal is to know the profile of photoaging based on clinical examination, Dermoscopic Photoaging Scale and leucocyte telomere length The main questions of Research are: what is the profile of photoaging based on clinical examination results in skin aging what is the profile of photoaging based on DPAS Score in skin… Read more about this study
- Who is it for?
- Ages 29 to 61 yearsHealthy volunteers can take part
- Conditions the study is for
- Aging, Skin Laxity
- What is being tested?
- Leucocyte Telomere Length from blood draw
- How many people
- 20 participants
- Where
- 3 sitesIndonesia
- Study dates
- 1 Oct 2023to 1 Sep 2024
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 29 to 61 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: The study population consisted of eligible male and female participants within the prespecified age ranges who provided written informed consent. Participants were excluded if they were pregnant or breastfeeding or had a history of relevant diseases or genetic disorders. All participants provided written informed consent for participation in the study.
Who may be able to join
- Female and Male (age 29-31 years old and 59-61 years old
- signs of aging
Who cannot join
- pregnant or breastfeeding
- have disease or genetic problem
Trial locations and contacts
3 sites in 1 country.
Indonesia3 sites
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital
Jakarta Pusat, DKI Jakarta, 10430
Department of Dermatology and Venereology, Faculty of Medicine, University of Sam Ratulangi, Prof. RD Kandou Central General Hospital
Manado, North Sulawesi, 95115
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Andalas, Dr. M Djamil Central General Hospital
Padang, West Sumatra, 25171
About this study
Official title: Association of Leucocyte Telomere Length With Clinical Examination and Dermoscopic Photoaging Scale (DPAS) Score in Skin Aging: a Pilot Study
The goal is to know the profile of photoaging based on clinical examination, Dermoscopic Photoaging Scale and leucocyte telomere length
The main questions of Research are:
Read more
- what is the profile of photoaging based on clinical examination results in skin aging
- what is the profile of photoaging based on DPAS Score in skin aging
- what is the profile of leucocyte telomere length in skin aging
Participants are female and male with the age of 29-31 years old and 59-61 years old. They will be examined by dermatovenereologist and will be photographed in 5 positions, they will get dermocopy on forehead, right cheek , left cheek, and chin, and their blood will be drawn about 10 mL in order to get the profile of leucocyte telomere length
Read the detailed description
Skin aging is a process of deterioration in the physiological structure and function of the skin that significantly increases in the 4th and 5th decades of life. Skin aging is a combination of physiological and pathological aging. Physiological change cannot be avoided and mandatory for everyone, pathological aging ir extrinsic aging is an abnormal skin condition caused by cigarettes, pollution and ultraviolet (UV). In general, the clinical characteristics of skin aging consist of pigmentation changes, hydration disorders, the appearance of wrinkles and skin tumors. The photoaging assessment was first proposed in 1996 by Dr. Richard Glogau, The Glogau scale assesses photoaging based on clinical assessment grouped into 4 categories, namely types I, II, III, and IV,where each type is graded by the severity of wrinkles, namely from mild, moderate, advanced, and severe. Isik et al. developed an instrument for quantitative skin aging assessment using dermoscopy. This examination is non-invasive and is expected to provide a more objective assessment. There are four facial regions assessed in the DPAS score calculation: forehead, right cheek, left cheek, and chin. The sum of the scores of the four regions is assessed based on 11 parameters, with a maximum final score of 44. Telomeres are repetitive DNA-Protein complexes located at the ends of chromosomes of eukarotic cells, and their function is to maintain chromosome stability during cell division, by protecting chromosomes from degradation and fusion. Many factors affect telomere length, such as body mass index, hormonal therapy, antioxidant intake, chronic diseases, and gender. Research by son et al. found that telomere length shortening was validated to increase the odds of skin aging (OR=0.96, 95% CI: 0.9332-0.99566, P= 0.03) Telomeres are closely linked to cellular aging, especially in dermal cells and telomere shortening in skin fibroblasts may lead to epidermal aging and barrier function defectcs.
- Conditions
- Aging, Skin Laxity
- Being tested
- Leucocyte Telomere Length from blood draw
- Keywords
- Dermoscopy, Dermoscopic photoaging scale (DPAS), Glogau scale, Leucocyte telomere length (LTL), Photoaging, Skin aging, Telomere, Ultraviolet (UV)
- Medical subject headings
- Cutis Laxa
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Leucocyte Telomere Length from blood drawGenetic
blood draw, PCR method to see leucocyte telomere length
| Study group | Role | What they receive |
|---|---|---|
| lifestyle counseling | patient will be asked about the mean of sun exposure per week Receives: Genetic: Leucocyte Telomere Length from blood draw | |
| Clinical examination | patients's face were assessed by the doctor by using Glogau scale and the doctor will perform dermoscopic tes to assess dermoscopic photoaging scale (DPAS) score to obtain the score of skin aging Receives: Genetic: Leucocyte Telomere Length from blood draw |
What is being measured
The primary outcome is the main question the study is designed to answer.
profile of leucocyte telomere length
profile of leucocyte telomere length in skin aging
Measured: 1 year
Profile of skin examination from Glogau scale
Glogau type 1 (mild) is without wrinkles (Age of 28-35 years), type II (moderate) is wrinkles in motion (age of 35-50 years), III (advanced) with wrinkles at rest (age of 50-65 years), type IV (severe) is wrinkles all over the face (age of 60-75)
Measured: 1 year
profile of skin examination with dermoscopic photoaging scale (DPAS)
skin aging is assessed from dermoscopic photoaging scale on dermoscopic images, looking at pigmentary changes, vascular changes, telangiectasis, wrinkles, actinic keratoses, and blackheads. There are four facial regions assessed in the DPAS score calculation, namely the forehead, right cheek, left cheek, and chin. The sum of the scores of the four regions is assessed based on 11 parameters, with a maximum final score of 44.
The greater the score, the higher marks of skin aging
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jul 2024
- Study start1 Oct 2023
- Primary completion30 Apr 2024
- Study completion1 Sep 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Ecologic or community
- Time perspective
- Cross-sectional
- Enrolment
- 20 participants (actual)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
- Sponsor type
- University, hospital or other
- Collaborators
- Indonesia Medical Education and Research Institute
- Responsible party
- Sponsor-investigator, Dr.dr.Irma Bernadette, SpKK (K), Universitas Indonesia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06501547
- Sponsor's protocol ID
- tes
- Status last verified
- Jul 2024
- First submitted
- 2 Jun 2024
- Last updated
- 30 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: provide positive impact for Cipto Mangunkusumo National Hospital and worldwide
Study at a glance
From the registry record, last updated by the sponsor on 30 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association of Leucocyte Telomere Length With Clinical Examination and Dermoscopic Photoaging Scale (DPAS) Score in Skin Aging: a Pilot Study
- ClinicalTrials.gov ID
- NCT06501547
- Acronym / sponsor ID
- tes
- Conditions
- Aging, Skin Laxity
- Keywords
- Dermoscopy, Dermoscopic photoaging scale (DPAS), Glogau scale, Leucocyte telomere length (LTL), Photoaging, Skin aging, Telomere, Ultraviolet (UV)
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Dr.dr.Irma Bernadette, SpKK (K)University, hospital or other
- Collaborators
- Indonesia Medical Education and Research Institute
- Study start
- 1 Oct 2023 (actual)
- Primary completion
- 30 Apr 2024 (actual)
- Study completion
- 1 Sep 2024 (actual)
- First posted
- 15 Jul 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal is to know the profile of photoaging based on clinical examination, Dermoscopic Photoaging Scale and leucocyte telomere length
The main questions of Research are:
- what is the profile of photoaging based on clinical examination results in skin aging
- what is the profile of photoaging based on DPAS Score in skin aging
- what is the profile of leucocyte telomere length in skin aging
Participants are female and male with the age of 29-31 years old and 59-61 years old. They will be examined by dermatovenereologist and will be photographed in 5 positions, they will get dermocopy on forehead, right cheek , left cheek, and chin, and their blood will be drawn about 10 mL in order to get the profile of leucocyte telomere length
Detailed description
Skin aging is a process of deterioration in the physiological structure and function of the skin that significantly increases in the 4th and 5th decades of life. Skin aging is a combination of physiological and pathological aging. Physiological change cannot be avoided and mandatory for everyone, pathological aging ir extrinsic aging is an abnormal skin condition caused by cigarettes, pollution and ultraviolet (UV). In general, the clinical characteristics of skin aging consist of pigmentation changes, hydration disorders, the appearance of wrinkles and skin tumors. The photoaging assessment was first proposed in 1996 by Dr. Richard Glogau, The Glogau scale assesses photoaging based on clinical assessment grouped into 4 categories, namely types I, II, III, and IV,where each type is graded by the severity of wrinkles, namely from mild, moderate, advanced, and severe. Isik et al. developed an instrument for quantitative skin aging assessment using dermoscopy. This examination is non-invasive and is expected to provide a more objective assessment. There are four facial regions assessed in the DPAS score calculation: forehead, right cheek, left cheek, and chin. The sum of the scores of the four regions is assessed based on 11 parameters, with a maximum final score of 44. Telomeres are repetitive DNA-Protein complexes located at the ends of chromosomes of eukarotic cells, and their function is to maintain chromosome stability during cell division, by protecting chromosomes from degradation and fusion. Many factors affect telomere length, such as body mass index, hormonal therapy, antioxidant intake, chronic diseases, and gender. Research by son et al. found that telomere length shortening was validated to increase the odds of skin aging (OR=0.96, 95% CI: 0.9332-0.99566, P= 0.03) Telomeres are closely linked to cellular aging, especially in dermal cells and telomere shortening in skin fibroblasts may lead to epidermal aging and barrier function defectcs.
Study design
- Observational model
- Ecologic or community
- Time perspective
- Cross-sectional
- Target follow-up
- 1 Day
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| lifestyle counseling | – | Genetic: Leucocyte Telomere Length from blood drawpatient will be asked about the mean of sun exposure per week |
| Clinical examination | – | Genetic: Leucocyte Telomere Length from blood drawpatients's face were assessed by the doctor by using Glogau scale and the doctor will perform dermoscopic tes to assess dermoscopic photoaging scale (DPAS) score to obtain the score of skin aging |
Who may qualify
- Ages
- 29 to 61 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- The study population consisted of eligible male and female participants within the prespecified age ranges who provided written informed consent. Participants were excluded if they were pregnant or breastfeeding or had a history of relevant diseases or genetic disorders. All participants provided written informed consent for participation in the study.
Key inclusion criteria (2 listed)
- Female and Male (age 29-31 years old and 59-61 years old
- signs of aging
Key exclusion criteria (2 listed)
- pregnant or breastfeeding
- have disease or genetic problem
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Leucocyte Telomere Length from blood drawblood draw, PCR method to see leucocyte telomere length | Genetic | Clinical examination, lifestyle counseling |
Primary outcome
profile of leucocyte telomere length
Time frame: 1 year
profile of leucocyte telomere length in skin aging
Profile of skin examination from Glogau scale
Time frame: 1 year
Glogau type 1 (mild) is without wrinkles (Age of 28-35 years), type II (moderate) is wrinkles in motion (age of 35-50 years), III (advanced) with wrinkles at rest (age of 50-65 years), type IV (severe) is wrinkles all over the face (age of 60-75)
profile of skin examination with dermoscopic photoaging scale (DPAS)
Time frame: 1 year
skin aging is assessed from dermoscopic photoaging scale on dermoscopic images, looking at pigmentary changes, vascular changes, telangiectasis, wrinkles, actinic keratoses, and blackheads. There are four facial regions assessed in the DPAS score calculation, namely the forehead, right cheek, left cheek, and chin. The sum of the scores of the four regions is assessed based on 11 parameters, with a maximum final score of 44. The greater the score, the higher marks of skin aging
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Oct 2026.
- Individual participant dataSharing planned: Yes. provide positive impact for Cipto Mangunkusumo National Hospital and worldwide
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
3 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Aging and Skin Laxity, run by Dr.dr.Irma Bernadette, SpKK (K) at 3 sites in Indonesia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 3 sites in Indonesia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
profile of leucocyte telomere length (time frame: 1 year). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Oct 2026.