Cardiac Magnetic ResonanceNCT06502899
CMR in Myocardial Infarction with Nonobstructive Coronary Arteries
An observational study of Cardiac Magnetic Resonance and Myocardial Infarction with Nonobstructive Coronary Arteries, run by The Affiliated Hospital of Xuzhou Medical University at 1 site in China.
Trial summary
MINOCA is accompanied by a worse prognosis, which is related to the inability to clarify the etiology.CMR has been explicitly recommended by guidelines as an etiologic diagnostic tool for MINOCA. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Cardiac Magnetic Resonance, Myocardial Infarction with Nonobstructive Coronary Arteries, Strain
- What is being tested?
- Cardiac MRI
- How many people
- 387 participants
- Where
- 1 siteChina
- Study dates
- 1 Jan 2019to 9 Jul 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: We consecutively selected patients who were suspected of myocardial infarction with concomitant CAG from January 2019 to June 2024 at the Affiliated Hospital of Xuzhou Medical University. All patients completed CMR during hospitalization. hsTnT peak was above the 99th percentile and CAG less than 50% in all patients.
Who may be able to join
- Complete CMR during hospitalization;
- CAG results suggesting coronary stenosis of less than 50%;
- peak hsTnT above the 99th percentile.
Who cannot join
- CMR image sequences are missing or of poor quality.
Trial locations and contacts
1 site in 1 country.
China1 site
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, 221002
About this study
Official title: Prognostic Value of CMR-related Parameters in Patients with MINOCA
MINOCA is accompanied by a worse prognosis, which is related to the inability to clarify the etiology.CMR has been explicitly recommended by guidelines as an etiologic diagnostic tool for MINOCA. Although CMR-related parameters, such as strain and ECV, have been shown to be associated with prognosis in patients with myocardial infarction. However, the relationship between CMR-strain or ECV and MINOCA is unclear. The aim of this study was to investigate the characterization of CMR-strain or ECV in patients with MINOCA and the relationship with prognosis.
- Conditions
- Cardiac Magnetic Resonance, Myocardial Infarction with Nonobstructive Coronary Arteries, Strain, Extracellular Volume
- Being tested
- Cardiac MRI
- Medical subject headings
- MINOCA, Sprains and Strains
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cardiac MRIOther
Patients with a diagnosis of MINOCA and completed CMR were included in this study
| Study group | Role | What they receive |
|---|---|---|
| diagnosed with MINOCA and completed with cardiac magnetic resonance | Not described Receives: Other: Cardiac MRI |
What is being measured
The primary outcome is the main question the study is designed to answer.
Primary endpoint events included any cause, non-fatal infarction, stroke, or cardiac readmission.
Measured: All patients were followed until June 30, 2024
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jul 2024
- Study start1 Jan 2019
- Primary completion30 Jun 2024
- Study completion9 Jul 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Cardiac Magnetic ResonanceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 387 participants (actual)
Sponsor and investigators
- Lead sponsor
- The Affiliated Hospital of Xuzhou Medical University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06502899
- Sponsor's protocol ID
- CMR in MINOCA
- Status last verified
- Jul 2024
- First submitted
- 9 Jul 2024
- Last updated
- 16 Jul 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Considering the patient's privacy and the next steps in our research program
Publications
Abdu FA, Chen L, Qiu B, Liu L, Mohammed AQ, Lv X, Yin G, Zhang W, Alifu J, Chen W, Lu Y, Che W. Prognostic Impact of Infarct Size and Coronary Microvascular Function Via Cardiovascular Magnetic Resonance and Coronary Angiography-Derived Index of Microcirculatory Resistance in Myocardial Infarction With Nonobstructive Coronary Arteries. J Am Heart Assoc. 2026 Jan 6;15(1):e043169. doi: 10.1161/JAHA.125.043169. Epub 2025 Dec 18.
PubMed 41413401Chen L, Ge L, Abdu FA, Du X, Liu J, Chen W, Lu Y, Che W. Prognostic value of CMR-derived extracellular volume in myocardial infarction with non-obstructive coronary arteries. Int J Cardiol. 2025 Oct 15;437:133528. doi: 10.1016/j.ijcard.2025.133528. Epub 2025 Jun 18.
PubMed 40541789Chen L, Qiu B, Abdu FA, Liu L, Zhang W, Wang C, Alifu J, Qi P, Che W, Lu Y. Prognostic Value of Strain by Tissue Tracking Cardiac Magnetic Resonance in Myocardial Infarction With Nonobstructive Coronary Arteries. J Am Heart Assoc. 2025 Apr 15;14(8):e039395. doi: 10.1161/JAHA.124.039395. Epub 2025 Apr 7.
PubMed 40194976
Study at a glance
From the registry record, last updated by the sponsor on 16 Jul 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prognostic Value of CMR-related Parameters in Patients with MINOCA
- ClinicalTrials.gov ID
- NCT06502899
- Acronym / sponsor ID
- CMR in MINOCA
- Conditions
- Cardiac Magnetic Resonance, Myocardial Infarction with Nonobstructive Coronary Arteries, Strain, Extracellular Volume
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 387 participants (actual)
- Lead sponsor
- The Affiliated Hospital of Xuzhou Medical UniversityUniversity, hospital or other
- Study start
- 1 Jan 2019 (actual)
- Primary completion
- 30 Jun 2024 (actual)
- Study completion
- 9 Jul 2024 (actual)
- First posted
- 16 Jul 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
MINOCA is accompanied by a worse prognosis, which is related to the inability to clarify the etiology.CMR has been explicitly recommended by guidelines as an etiologic diagnostic tool for MINOCA. Although CMR-related parameters, such as strain and ECV, have been shown to be associated with prognosis in patients with myocardial infarction. However, the relationship between CMR-strain or ECV and MINOCA is unclear. The aim of this study was to investigate the characterization of CMR-strain or ECV in patients with MINOCA and the relationship with prognosis.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| diagnosed with MINOCA and completed with cardiac magnetic resonance | – | Other: Cardiac MRI |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- We consecutively selected patients who were suspected of myocardial infarction with concomitant CAG from January 2019 to June 2024 at the Affiliated Hospital of Xuzhou Medical University. All patients completed CMR during hospitalization. hsTnT peak was above the 99th percentile and CAG less than 50% in all patients.
Key inclusion criteria (3 listed)
- Complete CMR during hospitalization;
- CAG results suggesting coronary stenosis of less than 50%;
- peak hsTnT above the 99th percentile.
Key exclusion criteria (1 listed)
- CMR image sequences are missing or of poor quality.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cardiac MRIPatients with a diagnosis of MINOCA and completed CMR were included in this study | Other | diagnosed with MINOCA and completed with cardiac magnetic resonance |
Primary outcome
Primary endpoint events included any cause, non-fatal infarction, stroke, or cardiac readmission.
Time frame: All patients were followed until June 30, 2024
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jul 2024.
- Derived from this study: PubMed 41413401Abdu FA, Chen L, Qiu B, Liu L, Mohammed AQ, Lv X, Yin G, Zhang W, Alifu J, Chen W, Lu Y, Che W. Prognostic Impact of Infarct Size and Coronary Microvascular Function Via Cardiovascular Magnetic Resonance and Coronary Angiography-Derived Index of Microcirculatory Resistance in Myocardial Infarction With Nonobstructive Coronary Arteries. J Am Heart Assoc. 2026 Jan 6;15(1):e043169. doi: 10.1161/JAHA.125.043169. Epub 2025 Dec 18.
- Derived from this study: PubMed 40541789Chen L, Ge L, Abdu FA, Du X, Liu J, Chen W, Lu Y, Che W. Prognostic value of CMR-derived extracellular volume in myocardial infarction with non-obstructive coronary arteries. Int J Cardiol. 2025 Oct 15;437:133528. doi: 10.1016/j.ijcard.2025.133528. Epub 2025 Jun 18.
- Derived from this study: PubMed 40194976Chen L, Qiu B, Abdu FA, Liu L, Zhang W, Wang C, Alifu J, Qi P, Che W, Lu Y. Prognostic Value of Strain by Tissue Tracking Cardiac Magnetic Resonance in Myocardial Infarction With Nonobstructive Coronary Arteries. J Am Heart Assoc. 2025 Apr 15;14(8):e039395. doi: 10.1161/JAHA.124.039395. Epub 2025 Apr 7.
- Individual participant dataSharing planned: Undecided. Considering the patient's privacy and the next steps in our research program
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiac Magnetic Resonance and Myocardial Infarction with Nonobstructive Coronary Arteries, run by The Affiliated Hospital of Xuzhou Medical University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Jul 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Primary endpoint events included any cause, non-fatal infarction, stroke, or cardiac readmission. (time frame: All patients were followed until June 30, 2024). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06502899, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jul 2024.