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StrokeTeleRehab DSSNCT06534164

Telerehabilitation of Balance Clinical and Economic Decision Support System

A study testing Full/High Tech Telerehabilitation decision support system, Basic/Low Tech Telerehabilitation decision support system and OTAGO Home exercise program in people with Stroke and Mild Cognitive Impairment, run by University College, London at 5 sites in 5 countries.

Not yet recruiting

Opening soon. The study is approved but enrolment has not started yet. Sites may already take enquiries.

Sites and contacts
Official record

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Trial summary

This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real time by the hologram prompts based on performance monitoring via sensors. Read more about this study

Who is it for?
Ages 40 to 80 years
What is being tested?
Full/High Tech Telerehabilitation decision support system, Basic/Low Tech Telerehabilitation decision support system and OTAGO Home exercise program
Could I receive a placebo?
No, everyone receives an active treatment
How many people
460 participants
Where
5 sitesin 5 countries
Study dates
1 Sep 2025to 31 Aug 2026
Phase
Interventional

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 40 to 80 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

None listed.

Who cannot join

  • Outside of the stated age bracket
  • Unable to walk independently (even with use of a walking stick)
  • MOCA score <23
  • Score of 10 or higher on depression subscale of HADS
  • Unwilling to comply with study procedures, proposed training and testing regime
  • No capacity to consent
Show all 17Show fewer
  • Significant visual impairment or homonymous hemianopia (stroke cohort only) (self-reported)
  • Orthostatic hypotension or uncontrolled hypertension
  • Other neurological problem (e.g. Parkingson's disease, Multiple Sclerosis etc.)
  • Language and communication deficits impairing ability to express thoughts (e.g. Aphasia)
  • Has participated in a clinical drug trial in the past 6 months.
  • Acute musculoskeletal injury that prevents participation in a structured exercise programme (e.g. lower limb fracture).
  • Has an implanted medical device or cardiac pacemaker.
  • Diagnosis of unstable Meniere's or with more than 4 migraines/month at the time of participating in the study
  • Not fulfilling the inclusion criteria for one of the sub-groups (such as criteria for Stroke group, or MCI group, or chronic vestibular disorder group, or long-Covid group), as outlined above.
  • Unable to provide a clinical letter confirming diagnosis.
  • For those with stroke, no visual spatial neglect.

Trial locations and contacts

5 sites in 5 countries. Contact the study team or a site near you to ask about taking part.

Doris-Eva Bamiou, PhD contact

7813716768

d.bamiou@ucl.ac.uk

Brooke Nairn, MSc. contact

7538640838

b.nairn@ucl.ac.uk

5 sites in 5 countries

Germany1 site
  • University Medical Center Freiberg Neurocenter (UKLFR)

    Freiberg

    Isabelle Walz, MSc., nez.ag-maurer@uniklinik-freiburg.de

Other trials in Germany

Greece1 site
  • National and Kapodistrian University of Athens

    Athens

    Christos Nikitas, PhD, xnikitas@hotmail.com

Other trials in Greece

Portugal1 site
  • Secretaria Regional de Saúde e Proteção Civil da Região Autónoma da Madeira

    Madeirã

    Andreia Pimenta

Other trials in Portugal

Thailand1 site
  • King Chulalongeorn Memorial Hospital (KMCH)

    Bangkok

    Nattawan Utoomprurkporn, PhD, nattawan.u@chula.ac.th

Other trials in Thailand

United Kingdom1 site
  • University College London

    London, WC1N 3BG

    Doris-Eva Bamiou, PhD, d.bamiou@ucl.ac.uk

    Brooke Nairn, MSc., b.nairn@ucl.ac.uk

Other trials in United Kingdom

About this study

This study follows the successfully completed HOLOBalance project which was funded by the EU Horizon 2020 scheme. TheHOLOBalance platform delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real time by the hologram prompts based on performance monitoring via sensors. Further information is available at: https://holobalance.eu/. HOLOBalance was developed as a comprehensive rehabilitation protocol for individualised remote (tele)rehabilitation balance physiotherapy programme. It includes different multisensory balance and gait exercises, physical activity and memory training and exergames (video games which are also exercises) to improve balance function in older adults. The system can thus assess and remotely monitor how users are performing the exercises.

This multisite randomised control trial (TeleRehab DSS, short for TeleRehabilitation Decision Support System) aims to (i) determine the system's safety, acceptability, and feasibility explore effectiveness of running such programme in comparison with the current standard care for middle-age/older adults with balance disorders/falls due to MCI, vestibular disorders, stroke or long Covid. This study also aims to (ii) assess if balance function, gait, cognitive function, balance confidence, and wellbeing can improve more compared to standard intervention and (iii) provide preliminary data for a definitive randomised controlled trial.

This study involves human participants, and each clinical site has applied for appropriate ethical approval.

Read the detailed description

This is an assessor-blinded (researchers assessing the participants will not know what study group participants will be in), randomised (participants will join different study groups randomly) controlled study. Participants will be randomised using an online platform to undergo a home-based exercise programmes, into either the intervention group (IG) or control group (CG). Participants will not be able to choose their preferred group and must be willing to participate in the assigned group.

All study participants will attend two sessions at UCL. The first assessment will be within one week prior to starting the programme, and the second will be within one week of completing the programme. Participants will be asked to complete a questionnaire set, walking/balance tests and a cognitive test.

Participants will receive telephone calls each week to monitor their progress. Participants will also receive remote program reviews at weeks 3, 6 and 9, from a member of the research team to assess and change exercises as required. Participants will be advised to contact the research team by email or by telephone during working hours if they have concerns or questions about their rehabilitation program or the TeleRehab DSS system. The research team will judge whether an additional home visit is required. If a patient does not complete their exercises for three consecutive days, a flag/warning will appear on the patients dashboard as a priority patient to follow up with, within 24 hours.

Intervention Group (IG): TeleRehab DSS The intervention (TeleRehaB DSS) group participants will be visited by a research team member to install the TeleRehab DSS system in their home and taught how to use the system, with a practice session. The system comprises a depth camera, lightweight augmented reality headset that displays the hologram, body-worn sensors that record movements and a heart rate sensor. Participants will be required to wear all the equipment when performing the prescribed exercises. A demo-video (including equipment and hologram) is available at www.holobalance.eu. Exercise progressions will be suggested by the AI-supported TeleRehaB DSS and approved by the clinicians at weeks 3, 6, and 9, which will be loaded into the participant's programme. At the end of the study, participants will be invited to take part in an interview to discuss their experience with using the TeleRehab DSS system.

The IG will receive the TeleRehaB DSS supported, prescribed, progressed and delivered intervention. In the TeleRehaB DSS IG, the platform will suggest two possible management strategies, on an individualized basis, based on patient profiles and expected benefit: 1)The high-tech, full TeleRehaB DSS with all components of the intervention consisting of TeleRehaB DSS AI-progressed multisensory balance exercises with the use of the AR avatar, real time feedback, AR gamified intervention, sensor monitored exercise performance and additional cognitive training, 2) the low-tech, basic version of TeleRehaB DSS, with depth camera, sensors and tablet - multisensory balance exercises, real time feedback, sensor monitored exercise performance and cognitive games, with no exergames, no smartwatch, and no mobile phone. The clinician can override the TeleRehab DSS group allocation decision if it is deemed unsafe. The intervention will be delivered as a daily (5 days per week, 12 weeks long) home-based exercise programme prescribed by non-experts (junior physiotherapist without vestibular expertise or non physio) with DSS support and coaching.

Control group (CG):

Control group participants will receive standard balance rehabilitation. Stroke and mild cognitive impairment (MCI) participants will receive the OTAGO home exercise program, while vestibular dysfunction and long covid-19 participants will receive the Meniere's Dizziness Booklet program.

  1. OTAGO Home Exercise Programme (HEP), a balance exercise programme developed by a research group at University of Otago, New Zealand. The OTAGO HEP will be provided to all individuals in the control arm who report falls/are at risk of falls. The OTAGO group participants will receive a pamphlet with instructions for home exercises within the programme, resistance bands and an exercise diary. The OTAGO HEP booklet is available at https://www.livestronger.org.nz/assets/Uploads/acc1162-otago-exercise-manual.pdf
  2. Vestibular rehabilitation programme - for participants with problems chronic (lasting >3 months) dizziness/imbalance due to chronic vestibular disorder (affecting the vestibular /balance system) or due to long Covid). The vestibular rehabilitation group participants will receive a booklet with vestibular exercises which have been individualised based on the assessment by the research team member. The exercise booklet is a validated and widely used intervention for vestibular disorder. This will be provided to all individuals in the control arm with chronic dizziness/imbalance (>3 months) without falls/risk of falls (FGA>22). The booklet has descriptions and diagrams of the exercises and instructions on how to progress these as well as an exercise log, available at: https://www.menieres.org.uk/files/pdfs/balance-retraining-2012.pdf
Being tested
Full/High Tech Telerehabilitation decision support system, Basic/Low Tech Telerehabilitation decision support system, OTAGO Home exercise program, Vestibular rehabilitation program
Keywords
vestibular, rehabilitation, falls, balance, exercise, artificial intelligence, telerehabilitation, physiotherapy, cognitive
Medical subject headings
Stroke, Cognitive Dysfunction, Vestibular Diseases, Post-Acute COVID-19 Syndrome, Motor Activity

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Full/High Tech Telerehabilitation decision support systemDevice

    The TeleRehaB DSS intervention includes balance rehabilitation programme delivered via an augmented reality hologram of a virtual physiotherapist. The system delivers exercises demonstrated via a hologram of the physiotherapist and corrected in real time by the hologram prompts based on performance monitoring via sensors. It includes different multisensory balance and gait exercises, physical activity and memory training and exergames (video games which are also exercises) to improve balance function in older adults. The system can thus assess and remotely monitor how users are performing the exercises.

    Exercise progressions will be suggested by the AI-supported TeleRehaB DSS and approved by the clinicians, which will be loaded into the participant's programme.

  • Basic/Low Tech Telerehabilitation decision support systemDevice

    The basic system does not inlcude exergames, a smartwatch, or a mobile phone for activity tracking.

    It includes different multisensory balance and gait exercise, cognitive training and real-time feedback from motion sensors.

    Exercise progressions will be suggested by the AI-supported TeleRehaB DSS and approved by the clinicians, which will be loaded into the participant's programme.

  • OTAGO Home exercise programProcedure or surgery

    balance rehabilitation program

  • Vestibular rehabilitation programProcedure or surgery

    Also called Meniere's Dizziness Booklet

    vestibular rehabilitation and dizziness program

Study groups in NCT06534164
Study groupRoleWhat they receive
Full/High-tech TeleRehab DSSExperimental5x/week x 9 weeks All TeleRehab DSS components: multisensory balance exercises, AR avatar, real-time feedback, AR gamified activities, sensor-monitored exercise performance and additional cognitive training.
Receives: Device: Full/High Tech Telerehabilitation decision support system
Basic/Low-tech TeleRehab DSSExperimental5x/week x 9 weeks With depth camera, motion sensors and tablet for multisensory balance exercises, real time feedback, sensor monitored exercise performance and cognitive games. No exergames, no smartwatch, no mobile phone.
Receives: Device: Basic/Low Tech Telerehabilitation decision support system
OTAGO Home Exercise programmeActive comparator9-week balance exercise programme developed by a research group at University of Otago, New Zealand [12]. The OTAGO HEP will be provided to all individuals in the control arm who report falls/are at risk of falls. The OTAGO group participants will receive a pamphlet with instructions for home exercises within the programme, resistance bands and an exercise diary. The OTAGO HEP booklet is available at https://www.livestronger.org.nz/assets/Uploads/acc1162-otago-exercise-manual.pdf
Receives: Procedure: OTAGO Home exercise program
Vestibular rehabilitation programmeActive comparatorDaily x 9 weeks For participants with problems chronic (lasting >3 months) dizziness/imbalance due to chronic vestibular disorder (affecting the vestibular /balance system) or due to long Covid). The vestibular rehabilitation group participants will receive a booklet with vestibular exercises which have been individualised based on the assessment by the research team member. The exercise booklet is a validated and widely used intervention for vestibular disorder [17]. This will be provided to all individuals in the control arm with chronic dizziness/imbalance (>3 months) without falls/risk of falls (FGA>22). The booklet has descriptions and diagrams of the exercises and instructions on how to progress these as well as an exercise log, available at: https://www.menieres.org.uk/files/pdfs/balance-retraining-2012.pdf
Receives: Procedure: Vestibular rehabilitation program

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Recruitment Rate (acceptability)

    percentage of recruited participants that were eligible

    Measured: Baseline (week 0) through to post-intervention at week 10

  2. Incidence of Treatment-Emergent Adverse Events (safety)

    Participants will be monitored for adverse events during telephone or face-to-face contacts as part of the intervention phase and during follow-up assessments. Any adverse events related to the treatment will be reported via an adverse events form on the system database. Falls diaries will be collected weekly from participants during the intervention and monthly for up to 6 months after completion of the intervention.

    Measured: Baseline (week 0) through to post-intervention at week 10

  3. Feasibility (protocol deviations/problems)

    Incidence of protocol deviation and/or implementation problems reported during the intervention.

    Measured: Baseline (Week 0) through to post-intervention at week 10

  4. Participants experience using the system (usability)

    Participants experience using the system (perceived benefits) via via weekly check in on frustration levels, technical troubleshooting and any other usability considerations, as well as during exit interviews for all TeleRehab DSS group completers.

    Measured: weekly and post-intervention at week 10

  5. Adherence to Intervention

    percentage of prescribed sessions completed throughout the intervention

    Measured: Week 1 through to completion at week 9

  6. Drop-out rate (acceptability)

    Percentage of enrolled participants that were loss to follow-up or drop-outs

    Measured: Baseline (week 0) through to post-intervention at week 10

Secondary outcomes (19)
  1. Mini Balance Evaluation Systems Test (Mini-BESTest)

    a 14-item test that assesses dynamic balance, on a scale of 0 (indicating severe balance impairment) to 28 (representing normal balance with a total score of 28 points.

    Measured: Baseline (week 0) & post intervention (Week 10)

  2. Functional Gait Assessment (FGA)

    test that assesses complex gait tasks (e.g. walking with head turns or stopping and turning, 5 minutes).

    Measured: Baseline (week 0) & post intervention (Week 10)

  3. Incremental cost-effectiveness ratio (ICER)

    Cost-effectiveness, by dividing the difference in mean QALYs; The Incremental Cost-Effectiveness Ratio (ICER) is calculated as the difference in cost (ΔC) divided by the difference in effectiveness (ΔE) between two interventions. Lower ICER values indicate better cost-effectiveness, while higher values suggest greater cost per unit of effectiveness gained. An intervention is considered cost-effective if its ICER falls below a predefined willingness-to-pay (WTP) threshold

    Measured: 1 year before study to 1 year after the end of the intervention

  4. EuroQol five dimensional descriptive system (EQ-5D-5L)

    Measure of quality-adjusted life years (QALYs). EQ-5D-5L is a standardized, valid and reliable simple, generic measure of health status for clinical and economic appraisal. The respondent is asked to rate their health status on these five dimensions from 1 to 5 respectively as no problems, slight problems, moderate problems, severe problems, and extreme problems. The EQ VAS (Visual Analogue Scale) records the respondent's self-rated health on a 20 cm vertical, visual analogue scale with endpoints labelled 'the best health you can imagine' and 'the worst health you can imagine'. The respondent is asked to mark an X on the scale to indicate "how your health is TODAY" with a higher score indicating better health-related quality of life .

    Measured: Baseline (week 0) & post intervention (Week 10)

  5. Montreal Cognitive Assessment (MoCA)

    includes sections on visuospatial/executive function, naming, attention, language, abstraction, memory and orientation to time and place (6 questions) with a scor range from 0-30, with a higher score indicating better cognitive function.

    Measured: Baseline (week 0) & post intervention (Week 10)

  6. Rapid Assessment of Physical Activity (RAPA)

    The 9-item self-administered Rapid Assessment of Physical Activity (RAPA) is a questionnaire that assesses levels of a wide range of physical activity level in adults older than 50 years, with a score range 1-7 and a higher score indicating ihgher levels of physical activity.

    Measured: Baseline (week 0) & post-intervention (Week 10)

  7. Dizziness Handicap Inventory (DHI)

    The 25-item self-report Dizziness Handicap inventory (DHI) validated questionnaire that assesses functional, emotional and physical domains. Responses are graded 0 (no), 2 (sometimes) or 4 (yes) with higher scores indicating greater impact of dizziness maximum and maximum score of 100 points (15 minutes).

    Measured: Baseline (week 0) & post intervention (Week 10)

  8. The Activities-specific balance confidence scale (ABC)

    The Activities-specific Balance Confidence Scale (ABC) that assesses patient's perceived confidence for 16-activities of daily living without losing balance .Score range from 0-100 with higher schore indicating greater balance confidence and scores ≤67/100% indicate increased falls risk.

    Measured: Baseline (week 0) & post intervention (Week 10)

  9. The Hospital Anxiety and Depression Scale (HADS-d) depression subscale

    a 14-item scale which assesses non-somatic anxiety (HAD-A) and depression (HAD-D) symptoms. Scores range from 0-21 for each subscale, with higher scores indicating worse outcomes (greater anxiety or depression).

    Measured: Baseline (week 0) & post intervention (Week 10)

  10. Fatigue Severity Scale (FFS)

    a 9-item instrument designed to assess fatigue as a symptom of a variety of different chronic conditions and disorders. The scale addresses fatigue's effects on daily functioning, querying its relationship to motivation, physical activity, work, family, and social life, and asking respondents to rate the ease with which they are fatigued and the degree to which the symptom poses a problem for them. Sca;e 9-63 with higher score indicating greater fatigue.

    Measured: Baseline (week 0) & post intervention (Week 10)

  11. Warwick-Edingburgh Mental Wellbeing Scale (WEMWBS)

    developed to enable the measuring of mental wellbeing in the general population and the evaluation of projects, programmes and policies which aim to improve mental wellbeing. The 14-item scale WEMWBS has 5 response categories, summed to provide a single score. The items are all worded positively and cover both feeling and functioning aspects of mental wellbeing, thereby making the concept more accessible. The scale has been widely used nationally and internationally for monitoring, evaluating projects and programmes and investigating the determinants of mental wellbeing. Scale 14-70 with higher score indicating better mental wellbeing.

    Measured: Baseline (week 0) & post intervention (Week 10)

  12. Situational Vertigo Questionnaire(SVQ):

    The SVQ is 20-item questionnaire designed to assess discomfort in situations of intense visual salience of visual-vestibular conflict. It was originally developed as a measure of space and motion discomfort. The questions are graded on a scale from 0 (not at all) to 4 (very much), with a higher score indicating greater vertigo severity.

    Measured: Baseline (week 0) & post intervention (Week 10)

  13. The system Usability Scale (SUS)

    The System Usability Scale (SUS) scale 1-5 rated on 10 aspects, with a total possible score of 0-100, with a higher score indicated better usability.

    Measured: post-intervention (week 10)

  14. User experience questionnaire (UEQ)

    The User Experience Questionnaire (UEQ; scale 1-7 on 26 dimensions of attractiveness, perspicuity, efficiency, dependability, stimulation and novelty with a score range of -3 (worst) to +3 (best) with a higher score indicating a more positive user experience.

    Measured: Baseline (week 0), Week 8 & post intervention (Week 10)

  15. Falls

    Falls diary collected (self-reported)

    Measured: collected weekly for the duration of the 9-week intervention and up to 6 months after completing the intervention

  16. System performance

    We will also compare the TeleRehaB DSS predicted versus observed patient outcomes on the EQ-5D-5L, and secondary outcome measures, to assess the system performance

    Measured: post-intervention (week 10)

  17. eHealth Literacy Assessment (eHEALS)

    a 10-item likert scale questionnaire that evaluate's patients' skills in finding, evaluating and applying electronic health information. Responses range from 1 (strongly disagree, to 65 (strong agree), with total scores indicating levels of eHealth literacy. This will be used to help validate the AI-model in terms of participant allocation into the high-tech versus low-tech solution.

    Measured: Baseline (week 0)

  18. The Senior technology acceptance & adoption model (STAM)

    is a 38-item questionnaire, with items rated on a 1-10 Likert scale to measure factors influencing technology acceptance among older adults, with a higher scores indicating greater perceived digital literacy.

    Measured: Baseline (week 0)

  19. Mobile Device Proficiency Questionnaire - short (MDPQ-s)

    is a 16-question version of the full MDPQ-16. The MDPQ, its subscales, and the MDPQ-16 were found to be highly reliable and valid measures of mobile device proficiency in a large sample. We conclude that the MDPQ and MDPQ-16 may serve as useful tools for facilitating mobile device training of older adults and measuring mobile device proficiency for research purposes.

    Measured: Baseline (week 0)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted2 Aug 2024
  2. Study start1 Sep 2025 (estimated)
  3. Primary completion30 Jun 2026 (estimated)
  4. Study completion31 Aug 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Model description
This is an assessor-blinded, parallel, randomised controlled study. Participants will be block randomised by condition (stroke, MCI, long covid-19, vestibular disorders) using an online platform into either the intervention group (IG) or control group (CG). Within the IG, participants will be randomised into one of two groups; 1) High tech TeleRehab DSS system, 2) Low tech TeleRehab DSS system. Participants will not be able to choose their preferred group and must be willing to participate in the assigned group.
Masking
Double blind
Who is masked
Participant, Outcomes assessor
Enrolment
460 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06534164
Sponsor's protocol ID
UCLondon 101057747
Other IDs
101057747
Acronym
TeleRehab DSS
Status last verified
Jul 2025
First submitted
29 Jul 2024
Last updated
10 Jul 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: Anonymised data collected willl be analysed, and a Final Study Report prepared. with results published in academic journals and disseminated in relevant clinical/scientific peer-reviewed literature and conferences. No participant identifiable data will be included in the final study reports or in the process of dissemination of the study results. The participants will be guided to where they can access the final result publication(s). The study protocol and study report will be published. Anonymised data will be uploaded to the Zenodo data repository and will be available to other researchers in line with open science principles. The research data collected in the course of the study will be retained by UCL and other clinical partners in their capacity as a sponsor for 20 years after the research study has ended. The data will be then securely destroyed.

Publications

  • Nairn B, Walz ID, Nikitas C, Kaski D, Utoomprurkporn N, Maurer C, Kikidis D, Tsakanikas V, Fotiadis D, Pavlou M, Bamiou DE. Investigating the feasibility and acceptability of the TeleRehabilitation of balance clinical and economic Decision Support System (TeleRehaB DSS) in adults at risk of falls: study protocol for a multicentre clinical trial. BMJ Open. 2026 Jun 25;16(6):e108821. doi: 10.1136/bmjopen-2025-108821.

    PubMed 42350021

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