ObesityDSWNCT06574854
Effects of Descending Stair Walking
A study testing DSW and ASW in people with Obesity, run by Universiti Sains Malaysia at 1 site in Malaysia.
Trial summary
The global rise in the prevalence of physical inactivity is major public health concern. Lifestyle-related activities, such as stairs walking, has important public health implications and may represent an alternative approach for those who have difficulty adhering to conventional exercise programs. Read more about this study
- Who is it for?
- Ages 18 to 50 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Obesity
- What is being tested?
- DSW and ASW
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteMalaysia
- Study dates
- 1 May 2023to 15 Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Women
- age 18-50-year-old
- BMI 25.0 - 39.9 kg/m2,
- body fat percentage > 30%
- no lower limb orthopaedic injuries
- sedentary lifestyle (regular exercise <1 h per week).
Who cannot join
- smokers
- taking supplements or medication known to affect REE (such as oral contraceptives),
- severe medical conditions affecting their physical or mental health
- individuals with implanted medical device
- suffer from alcohol or drug abuse and
- trying to conceive/ pregnant or breastfeeding
Trial locations and contacts
1 site in 1 country.
Malaysia1 site
Wellness Hub Timur Laut, Pulau Pinang
Ayer Itam, Pulau Pinang, 11500
About this study
Official title: Effects of Descending Stair Walking on Cardiometabolic Adaptations Among Obese, Untrained Women
The global rise in the prevalence of physical inactivity is major public health concern. Lifestyle-related activities, such as stairs walking, has important public health implications and may represent an alternative approach for those who have difficulty adhering to conventional exercise programs. This two-armed, parallel-group, randomized controlled trial (RCT) aims to assess and compare the effects between the descending stair walking (DSW) and ascending stair walking (ASW) on cardiometabolic health markers, cardiopulmonary capacity, body composition and muscular strength.
This RCT will recruit 16 obese inactive and sedentary females will be randomized using permuted block randomization into two arms: intervention arm, DSW and active comparator arm: ASW in a 1:1 allocation ratio. The participants in the DSW and ASW arms will undergo twice a week stair walking intervention session for 8 weeks. The exercise volume will be gradually increased over 8 weeks by increasing the number of repetitions by two every week for both arms. Borg's scale of perceived exertion (RPE) and visual analogue scale (VAS) will be used to assess subjective intensity of stair walking and pain intensity immediately after each repetition. Assessments will be carried out through two time points, pre-intervention assessment (T0) and immediately after completion of the intervention at 8 weeks (T1). During each assessment, the primary outcome to be assessed includes the cardiometabolic health markers and cardiopulmonary capacity, while the secondary outcomes to be assessed are the body composition and muscular strength. Whereas during the intervention, continuous heart rate and gas consumption will be monitored at week 1 (W1), week 4 (W4) and week 8 (W8) to monitor the intensity of the exercise.
Read the detailed description
1.2 Research Objectives
1.2.1 General Objective (i) The study compares the impact of the 8-week descending stair walking (DSW) and ascending stair walking (ASW) on cardiometabolic health in obese, untrained women.
1.2.2 Specific Objective
To compare the effect of DSW \& ASW on:
(i) cardiometabolic health (fasting plasma glucose, lipid profile, renal profile, cardiorespiratory fitness, resting blood pressure, resting energy expenditure, resting heart rate) (ii) body composition (fat mass, lean body mass, waist circumference, hip circumference, thigh circumference) (iii) muscular fitness \& functional capacity (back and leg strength \& 6-min walking test)
1.3 Research Design This randomized controlled trial (RCT) is a single-centre, two-armed, parallel-group.
1.4 Research Location This RCT is expected to run for 1 year in the Wellness Hub Timur Laut, Klinik Kesihatan Jalan Angsana Pulau Pinang. Wellness Hub Timur Laut is located in the primary healthcare facility of the Ministry of Health and receives approximately 1,000 clients annually for health screening.
1.5 Sampling Method The sampling method used in this study for recruitment of participants is by purposive sampling. Overweight \& obese clients of Wellness Hub Jalan Angsana, Klinik Kesihatan Jalan Angsana Pulau Pinang
1.6 Sample Size Calculation The sample size is estimated based on an effect size of 1.91, an α-level of 0.05, and a power (1-β) of 0.08. A priori sample size analysis (G∗Power 3.1; Düsseldorf, Germany) indicated that 6 participants/ group were necessary. Considering a possible dropout rate of 50%, a sample size of 12 participants/ group is anticipated making it a total of 24 participants.
1.7 Data Collection Procedure Permission to conduct the study in Wellness Hub Timur Laut (WHTL), Pulau Pinang, will be sought. Clients will be recruited from WHLA after agreeing to participate in the study.
1.7.1 Data Collection Technique The researcher will interview and assess participants face-to-face at baseline and 8th weeks and the end of the intervention. Participants will be randomly assigned to the stair-walking intervention. At baseline, a background information questionnaire will be used to obtain respondents' sociodemographic characteristics, occupation, health problems and health-related fitness as part of wellness hub health screening. Body composition, metabolic risk factors and selected physical fitness will be assessed before and after the 8th week of intervention.
1.7.2 Daily Energy Balance Monitoring A logbook will be provided for all participants to record daily calorie intake and physical activity. Two weekdays and one-weekend food logs will be retrieved from the logbook, and the total weekly calorie intake and macronutrients will be calculated using Nutritionist Pro software.
1.7.3 Stair Walking Intervention All participants must complete progressive exercise training using stairs in WHLA over 8 weeks, twice a week. The participants in the DSW arm will ride an elevator from level 1 to level 6, eliminating the concentric impact of walking upstairs. Whereas for the ASW arm, participants will ride an elevator from level 6 to level 1 to eliminate the eccentric impact of walking downstairs. The number of stairs from the first to the sixth floor was 120 (five floors, 24 stairs per floor), and the height of each stair was 18 cm. The walking tempo is approximately 1s per step, thus to descend or ascend 120 stairs, it takes about 2 min 30 sec including steps at the landing. The exercise volume will be gradually increased over 8 weeks by increasing the number of repetitions by two repetitions weekly for both arms (first week, 2 repetitions/ session; 8th week, 16 repetitions/ session; 1 repetition,120 stairs).
This protocol assumes that symptoms of muscle damage, such as delayed-onset muscle soreness (DOMS) and prolonged decreases in muscle function, would be minimal after any sessions. It took approximately 5 min to perform one repetition, including the time used for waiting for and riding on an elevator, and the time taken to perform 16 repetitions was approximately 80 min. Lower limb stretching exercises will be included in the workout's general warming-up and cooling-down phases. Over the 16 sessions, each participant will walk up or down 720 floors, thus 17,424 stairs.
- Conditions
- Obesity
- Being tested
- DSW, ASW
- Keywords
- body composition, cardiometabolic, stair walking, obesity
- Medical subject headings
- Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
DSWOther
Also called Eccentric Training
Descending Stair Walking
ASWOther
Also called Concentric Training
Ascending Stair Walking
| Study group | Role | What they receive |
|---|---|---|
| DSW | Experimental | Descending Stair Walking Receives: Other: DSW |
| ASW | Active comparator | Ascending Stair Walking Receives: Other: ASW |
What is being measured
The primary outcome is the main question the study is designed to answer.
Total Cholesterol
Changes in Total Cholesterol (mmol/L) from baseline
Measured: 8 weeks
Low-Density Lipoprotein Cholesterol
Changes in Low-Density Lipoprotein Cholesterol (mmol/L) from baseline
Measured: 8 weeks
High-Density Lipoprotein Cholesterol
Changes in High-Density Lipoprotein Cholesterol (mmol/L) from baseline
Measured: 8 weeks
Trigliceride
Changes in Trigliceride (mmol/L) from baseline
Measured: 8 weeks
Fasting Plasma Glucose
Changes in Fasting Plasma Glucose (mmol/L) from baseline
Measured: 8 weeks
Resting Heart Rate
Changes in Resting Heart Rate (beat.min) from baseline
Measured: 8 weeks
Resting Blood Pressure
Changes in Resting Diastolic and Systolic Blood Pressure (mm/Hg) from baseline
Measured: 8 weeks
Resting Energy Expenditure
Changes in Resting Energy Expenditure (kcal/day) from baseline
Measured: 8 weeks
Alanine Aminotransferase
Changes in Alanine Aminotransferase (U/L) from baseline
Measured: 8 weeks
Alanine Aspartate transaminase
Changes in Alanine Aspartate transaminase (U/L) from baseline
Measured: 8 weeks
Resting energy oxidation
Changes in fat and charbohydrate oxidation from baseline
Measured: 8 weeks
Secondary outcomes (9)
Body Mass
Changes in body mass (kg)from baseline
Measured: 8 weeks
Body Mass Index (BMI)
Changes in BMI (kg/m2)from baseline
Measured: 8 weeks
Percentage body fat
Changes in percentage body fat (%) from baseline
Measured: 8 weeks
Lean Body Mass
Changes in lean body mass (kg) from baseline
Measured: 8 weeks
Waist Circumference
Changes in waist circumference (cm) from baseline
Measured: 8 weeks
Hip Circumference
Changes in hip circumference (cm) from baseline
Measured: 8 weeks
Isometric Muscular Strength
Changes in back \& leg isometric (kg) from baseline
Measured: 8 weeks
Cardiorespiratory Capacity-6 Minute Walking Test
Changes in distance (m) covered from baseline
Measured: 8 weeks
Training substrate oxidation
Changes in substrate oxidation from week 1 to 8
Measured: 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Aug 2024
- Study start1 May 2023
- Primary completion1 Mar 2025
- Study completion15 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (11)Papers the sponsor has linked to this study.
- Other trials for ObesityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universiti Sains Malaysia
- Sponsor type
- University, hospital or other
- Collaborators
- Ministry of Health, Malaysia
- Responsible party
- Principal investigator, Nazirah Gulam Mohamed, Universiti Sains Malaysia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06574854
- Sponsor's protocol ID
- USM/JEPeM/PP/23070582
- Acronym
- DSW
- Status last verified
- Feb 2026
- First submitted
- 14 Aug 2024
- Last updated
- 5 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Chen TC, Hsieh CC, Tseng KW, Ho CC, Nosaka K. Effects of Descending Stair Walking on Health and Fitness of Elderly Obese Women. Med Sci Sports Exerc. 2017 Aug;49(8):1614-1622. doi: 10.1249/MSS.0000000000001267.
PubMed 28291022Regnersgaard S, Knudsen AK, Lindskov FO, Mratinkovic M, Pressel E, Ingersen A, Dela F. Down stair walking: A simple method to increase muscle mass and performance in 65+ year healthy people. Eur J Sport Sci. 2022 Feb;22(2):279-288. doi: 10.1080/17461391.2020.1856936. Epub 2021 Apr 24.
PubMed 33241972Chen TC, Huang TH, Tseng WC, Tseng KW, Hsieh CC, Chen MY, Chou TY, Huang YC, Chen HL, Nosaka K. Changes in plasma C1q, apelin and adropin concentrations in older adults after descending and ascending stair walking intervention. Sci Rep. 2021 Sep 3;11(1):17644. doi: 10.1038/s41598-021-96631-x.
PubMed 34480035Theodorou AA, Panayiotou G, Paschalis V, Nikolaidis MG, Kyparos A, Mademli L, Grivas GV, Vrabas IS. Stair descending exercise increases muscle strength in elderly males with chronic heart failure. BMC Res Notes. 2013 Mar 8;6:87. doi: 10.1186/1756-0500-6-87.
PubMed 23510560Chow BC, Li S, Zhu X, Jiao J, Quach B, Baker JS, Zhang H. Effects of descending or ascending stair exercise on body composition, insulin sensitivity, and inflammatory markers in young Chinese women with obesity: A randomized controlled trial. J Sports Sci. 2021 Mar;39(5):496-502. doi: 10.1080/02640414.2020.1829362. Epub 2020 Oct 4.
PubMed 33012244Ainsworth BE, Haskell WL, Herrmann SD, Meckes N, Bassett DR Jr, Tudor-Locke C, Greer JL, Vezina J, Whitt-Glover MC, Leon AS. 2011 Compendium of Physical Activities: a second update of codes and MET values. Med Sci Sports Exerc. 2011 Aug;43(8):1575-81. doi: 10.1249/MSS.0b013e31821ece12.
PubMed 21681120Bassett DR, Vachon JA, Kirkland AO, Howley ET, Duncan GE, Johnson KR. Energy cost of stair climbing and descending on the college alumnus questionnaire. Med Sci Sports Exerc. 1997 Sep;29(9):1250-4. doi: 10.1097/00005768-199709000-00019.
PubMed 9309638Paschalis V, Theodorou AA, Panayiotou G, Kyparos A, Patikas D, Grivas GV, Nikolaidis MG, Vrabas IS. Stair descending exercise using a novel automatic escalator: effects on muscle performance and health-related parameters. PLoS One. 2013;8(2):e56218. doi: 10.1371/journal.pone.0056218. Epub 2013 Feb 21.
PubMed 23437093Chen TC, Tseng WC, Huang GL, Chen HL, Tseng KW, Nosaka K. Superior Effects of Eccentric to Concentric Knee Extensor Resistance Training on Physical Fitness, Insulin Sensitivity and Lipid Profiles of Elderly Men. Front Physiol. 2017 Apr 10;8:209. doi: 10.3389/fphys.2017.00209. eCollection 2017.
PubMed 28443029Ansari M, Hardcastle S, Myers S, Williams AD. The Health and Functional Benefits of Eccentric versus Concentric Exercise Training: A Systematic Review and Meta-Analysis. J Sports Sci Med. 2023 Jun 1;22(2):288-309. doi: 10.52082/jssm.2023.288. eCollection 2023 Jun.
PubMed 37293426Touron J, Maisonnave L, Rigaudiere JP, Montaurier C, De Antonio M, Perrault H, Richard R, Capel F. Eccentric and concentric exercises induce different adaptions in adipose tissue biology. J Physiol Biochem. 2023 May;79(2):441-450. doi: 10.1007/s13105-023-00956-2. Epub 2023 Mar 24.
PubMed 36961725
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Descending Stair Walking on Cardiometabolic Adaptations Among Obese, Untrained Women
- ClinicalTrials.gov ID
- NCT06574854
- Acronym / sponsor ID
- DSW / USM/JEPeM/PP/23070582
- Conditions
- Obesity
- Keywords
- body composition, cardiometabolic, stair walking, obesity
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Universiti Sains MalaysiaUniversity, hospital or other
- Collaborators
- Ministry of Health, Malaysia
- Study start
- 1 May 2023 (actual)
- Primary completion
- 1 Mar 2025 (actual)
- Study completion
- 15 Mar 2025 (actual)
- First posted
- 28 Aug 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The global rise in the prevalence of physical inactivity is major public health concern. Lifestyle-related activities, such as stairs walking, has important public health implications and may represent an alternative approach for those who have difficulty adhering to conventional exercise programs. This two-armed, parallel-group, randomized controlled trial (RCT) aims to assess and compare the effects between the descending stair walking (DSW) and ascending stair walking (ASW) on cardiometabolic health markers, cardiopulmonary capacity, body composition and muscular strength.
This RCT will recruit 16 obese inactive and sedentary females will be randomized using permuted block randomization into two arms: intervention arm, DSW and active comparator arm: ASW in a 1:1 allocation ratio. The participants in the DSW and ASW arms will undergo twice a week stair walking intervention session for 8 weeks. The exercise volume will be gradually increased over 8 weeks by increasing the number of repetitions by two every week for both arms. Borg's scale of perceived exertion (RPE) and visual analogue scale (VAS) will be used to assess subjective intensity of stair walking and pain intensity immediately after each repetition. Assessments will be carried out through two time points, pre-intervention assessment (T0) and immediately after completion of the intervention at 8 weeks (T1). During each assessment, the primary outcome to be assessed includes the cardiometabolic health markers and cardiopulmonary capacity, while the secondary outcomes to be assessed are the body composition and muscular strength. Whereas during the intervention, continuous heart rate and gas consumption will be monitored at week 1 (W1), week 4 (W4) and week 8 (W8) to monitor the intensity of the exercise.
Detailed description
1.2 Research Objectives
1.2.1 General Objective (i) The study compares the impact of the 8-week descending stair walking (DSW) and ascending stair walking (ASW) on cardiometabolic health in obese, untrained women.
1.2.2 Specific Objective
To compare the effect of DSW \& ASW on:
(i) cardiometabolic health (fasting plasma glucose, lipid profile, renal profile, cardiorespiratory fitness, resting blood pressure, resting energy expenditure, resting heart rate) (ii) body composition (fat mass, lean body mass, waist circumference, hip circumference, thigh circumference) (iii) muscular fitness \& functional capacity (back and leg strength \& 6-min walking test)
1.3 Research Design This randomized controlled trial (RCT) is a single-centre, two-armed, parallel-group.
1.4 Research Location This RCT is expected to run for 1 year in the Wellness Hub Timur Laut, Klinik Kesihatan Jalan Angsana Pulau Pinang. Wellness Hub Timur Laut is located in the primary healthcare facility of the Ministry of Health and receives approximately 1,000 clients annually for health screening.
1.5 Sampling Method The sampling method used in this study for recruitment of participants is by purposive sampling. Overweight \& obese clients of Wellness Hub Jalan Angsana, Klinik Kesihatan Jalan Angsana Pulau Pinang
1.6 Sample Size Calculation The sample size is estimated based on an effect size of 1.91, an α-level of 0.05, and a power (1-β) of 0.08. A priori sample size analysis (G∗Power 3.1; Düsseldorf, Germany) indicated that 6 participants/ group were necessary. Considering a possible dropout rate of 50%, a sample size of 12 participants/ group is anticipated making it a total of 24 participants.
1.7 Data Collection Procedure Permission to conduct the study in Wellness Hub Timur Laut (WHTL), Pulau Pinang, will be sought. Clients will be recruited from WHLA after agreeing to participate in the study.
1.7.1 Data Collection Technique The researcher will interview and assess participants face-to-face at baseline and 8th weeks and the end of the intervention. Participants will be randomly assigned to the stair-walking intervention. At baseline, a background information questionnaire will be used to obtain respondents' sociodemographic characteristics, occupation, health problems and health-related fitness as part of wellness hub health screening. Body composition, metabolic risk factors and selected physical fitness will be assessed before and after the 8th week of intervention.
1.7.2 Daily Energy Balance Monitoring A logbook will be provided for all participants to record daily calorie intake and physical activity. Two weekdays and one-weekend food logs will be retrieved from the logbook, and the total weekly calorie intake and macronutrients will be calculated using Nutritionist Pro software.
1.7.3 Stair Walking Intervention All participants must complete progressive exercise training using stairs in WHLA over 8 weeks, twice a week. The participants in the DSW arm will ride an elevator from level 1 to level 6, eliminating the concentric impact of walking upstairs. Whereas for the ASW arm, participants will ride an elevator from level 6 to level 1 to eliminate the eccentric impact of walking downstairs. The number of stairs from the first to the sixth floor was 120 (five floors, 24 stairs per floor), and the height of each stair was 18 cm. The walking tempo is approximately 1s per step, thus to descend or ascend 120 stairs, it takes about 2 min 30 sec including steps at the landing. The exercise volume will be gradually increased over 8 weeks by increasing the number of repetitions by two repetitions weekly for both arms (first week, 2 repetitions/ session; 8th week, 16 repetitions/ session; 1 repetition,120 stairs).
This protocol assumes that symptoms of muscle damage, such as delayed-onset muscle soreness (DOMS) and prolonged decreases in muscle function, would be minimal after any sessions. It took approximately 5 min to perform one repetition, including the time used for waiting for and riding on an elevator, and the time taken to perform 16 repetitions was approximately 80 min. Lower limb stretching exercises will be included in the workout's general warming-up and cooling-down phases. Over the 16 sessions, each participant will walk up or down 720 floors, thus 17,424 stairs.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| DSW | Experimental | Other: DSWDescending Stair Walking |
| ASW | Active comparator | Other: ASWAscending Stair Walking |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Women
- age 18-50-year-old
- BMI 25.0 - 39.9 kg/m2,
- body fat percentage > 30%
- no lower limb orthopaedic injuries
Key exclusion criteria (6 listed)
- smokers
- taking supplements or medication known to affect REE (such as oral contraceptives),
- severe medical conditions affecting their physical or mental health
- individuals with implanted medical device
- suffer from alcohol or drug abuse and
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| DSWAlso: Eccentric TrainingDescending Stair Walking | Other | DSW |
| ASWAlso: Concentric TrainingAscending Stair Walking | Other | ASW |
Primary outcome
Total Cholesterol
Time frame: 8 weeks
Changes in Total Cholesterol (mmol/L) from baseline
Low-Density Lipoprotein Cholesterol
Time frame: 8 weeks
Changes in Low-Density Lipoprotein Cholesterol (mmol/L) from baseline
High-Density Lipoprotein Cholesterol
Time frame: 8 weeks
Changes in High-Density Lipoprotein Cholesterol (mmol/L) from baseline
Trigliceride
Time frame: 8 weeks
Changes in Trigliceride (mmol/L) from baseline
Fasting Plasma Glucose
Time frame: 8 weeks
Changes in Fasting Plasma Glucose (mmol/L) from baseline
Resting Heart Rate
Time frame: 8 weeks
Changes in Resting Heart Rate (beat.min) from baseline
Resting Blood Pressure
Time frame: 8 weeks
Changes in Resting Diastolic and Systolic Blood Pressure (mm/Hg) from baseline
Resting Energy Expenditure
Time frame: 8 weeks
Changes in Resting Energy Expenditure (kcal/day) from baseline
Alanine Aminotransferase
Time frame: 8 weeks
Changes in Alanine Aminotransferase (U/L) from baseline
Alanine Aspartate transaminase
Time frame: 8 weeks
Changes in Alanine Aspartate transaminase (U/L) from baseline
Resting energy oxidation
Time frame: 8 weeks
Changes in fat and charbohydrate oxidation from baseline
9 secondary outcomes
Body Mass
Time frame: 8 weeks
Body Mass Index (BMI)
Time frame: 8 weeks
Percentage body fat
Time frame: 8 weeks
Lean Body Mass
Time frame: 8 weeks
Waist Circumference
Time frame: 8 weeks
Hip Circumference
Time frame: 8 weeks
Isometric Muscular Strength
Time frame: 8 weeks
Cardiorespiratory Capacity-6 Minute Walking Test
Time frame: 8 weeks
Training substrate oxidation
Time frame: 8 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2026.
- Background: PubMed 28291022Chen TC, Hsieh CC, Tseng KW, Ho CC, Nosaka K. Effects of Descending Stair Walking on Health and Fitness of Elderly Obese Women. Med Sci Sports Exerc. 2017 Aug;49(8):1614-1622. doi: 10.1249/MSS.0000000000001267.
- Background: PubMed 33241972Regnersgaard S, Knudsen AK, Lindskov FO, Mratinkovic M, Pressel E, Ingersen A, Dela F. Down stair walking: A simple method to increase muscle mass and performance in 65+ year healthy people. Eur J Sport Sci. 2022 Feb;22(2):279-288. doi: 10.1080/17461391.2020.1856936. Epub 2021 Apr 24.
- Background: PubMed 34480035Chen TC, Huang TH, Tseng WC, Tseng KW, Hsieh CC, Chen MY, Chou TY, Huang YC, Chen HL, Nosaka K. Changes in plasma C1q, apelin and adropin concentrations in older adults after descending and ascending stair walking intervention. Sci Rep. 2021 Sep 3;11(1):17644. doi: 10.1038/s41598-021-96631-x.
- Background: PubMed 23510560Theodorou AA, Panayiotou G, Paschalis V, Nikolaidis MG, Kyparos A, Mademli L, Grivas GV, Vrabas IS. Stair descending exercise increases muscle strength in elderly males with chronic heart failure. BMC Res Notes. 2013 Mar 8;6:87. doi: 10.1186/1756-0500-6-87.
- Background: PubMed 33012244Chow BC, Li S, Zhu X, Jiao J, Quach B, Baker JS, Zhang H. Effects of descending or ascending stair exercise on body composition, insulin sensitivity, and inflammatory markers in young Chinese women with obesity: A randomized controlled trial. J Sports Sci. 2021 Mar;39(5):496-502. doi: 10.1080/02640414.2020.1829362. Epub 2020 Oct 4.
- Background: PubMed 21681120Ainsworth BE, Haskell WL, Herrmann SD, Meckes N, Bassett DR Jr, Tudor-Locke C, Greer JL, Vezina J, Whitt-Glover MC, Leon AS. 2011 Compendium of Physical Activities: a second update of codes and MET values. Med Sci Sports Exerc. 2011 Aug;43(8):1575-81. doi: 10.1249/MSS.0b013e31821ece12.
- Background: PubMed 9309638Bassett DR, Vachon JA, Kirkland AO, Howley ET, Duncan GE, Johnson KR. Energy cost of stair climbing and descending on the college alumnus questionnaire. Med Sci Sports Exerc. 1997 Sep;29(9):1250-4. doi: 10.1097/00005768-199709000-00019.
- Background: PubMed 23437093Paschalis V, Theodorou AA, Panayiotou G, Kyparos A, Patikas D, Grivas GV, Nikolaidis MG, Vrabas IS. Stair descending exercise using a novel automatic escalator: effects on muscle performance and health-related parameters. PLoS One. 2013;8(2):e56218. doi: 10.1371/journal.pone.0056218. Epub 2013 Feb 21.
- Background: PubMed 28443029Chen TC, Tseng WC, Huang GL, Chen HL, Tseng KW, Nosaka K. Superior Effects of Eccentric to Concentric Knee Extensor Resistance Training on Physical Fitness, Insulin Sensitivity and Lipid Profiles of Elderly Men. Front Physiol. 2017 Apr 10;8:209. doi: 10.3389/fphys.2017.00209. eCollection 2017.
- Background: PubMed 37293426Ansari M, Hardcastle S, Myers S, Williams AD. The Health and Functional Benefits of Eccentric versus Concentric Exercise Training: A Systematic Review and Meta-Analysis. J Sports Sci Med. 2023 Jun 1;22(2):288-309. doi: 10.52082/jssm.2023.288. eCollection 2023 Jun.
- Background: PubMed 36961725Touron J, Maisonnave L, Rigaudiere JP, Montaurier C, De Antonio M, Perrault H, Richard R, Capel F. Eccentric and concentric exercises induce different adaptions in adipose tissue biology. J Physiol Biochem. 2023 May;79(2):441-450. doi: 10.1007/s13105-023-00956-2. Epub 2023 Mar 24.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing DSW and ASW in people with Obesity, run by Universiti Sains Malaysia at 1 site in Malaysia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Malaysia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Total Cholesterol (time frame: 8 weeks). The study lists 11 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06574854, which also lists 11 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2026.