Parkinson DiseaseNCT06576817
High-intensity Interval Circuit Training in People With Parkinson Disease
A study testing High intensity circuit exercise class - Lower and upper extremity and High intensity circuit exercise class - Lower extremity alone in people with Parkinson Disease, run by Pacific Northwest University of Health Sciences at 1 site in United States.
Trial summary
The goal of the study is to compare different types of high intensity circuit exercises over an 8-class training series in people with Parkinson disease. The main question it aims to answer is: -Does including arm and hand exercises with leg exercises improve reaction time, balance, functional measures, gait speed and… Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Parkinson Disease
- What is being tested?
- High intensity circuit exercise class - Lower and upper extremity and High intensity circuit exercise class - Lower extremity alone
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 64 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Feb 2024to 30 Nov 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- diagnosis of Parkinson's disease
- Hoehn and Yahr level of 1 to 3
- ability to walk independently with or without an assistive device
- obtain medical clearance to participate in moderate or vigorous exercise.
Who cannot join
- diagnosis of any neurological disease other than PD (including but not limited to stroke, dementia, and multiple sclerosis; mild cognitive impairment is not excluded)
- bone instability (non-consolidated fractures, unstable spinal column, severe osteoporosis)
- muscle or ligament tears
- uncontrolled hypertension
- uncontrolled diabetes
- severe cardiovascular disease that impairs walking or exercise
- a major change in medication during the study training period (pre-test to post-test)
Trial locations and contacts
1 site in 1 country.
United States1 site
Pacific Northwest University of Health Sciences
Yakima, Washington, 98901
About this study
Official title: Comparison of High-intensity Interval Circuit Training With Upper Extremity and Lower Extremity Training Versus Lower Extremity Training Alone in People With Parkinson Disease
The goal of the study is to compare different types of high intensity circuit exercises over an 8-class training series in people with Parkinson disease. The main question it aims to answer is:
-Does including arm and hand exercises with leg exercises improve reaction time, balance, functional measures, gait speed and quality of life? This group will be compared to a group that only does leg exercises. Participants will be asked to participate in 8 high intensity circuit exercise classes.
Read the detailed description
People with Parkinson disease will be recruited from the community and randomized into 2 equal groups: high intensity interval circuit training with lower extremity (LE) and lower and upper extremity (LEUE) training. The study will be composed of a baseline assessment, 8 group class sessions, and a post-intervention assessment. The baseline assessment will include demographics, disease and fall history and outcome measure collection. Group class sessions will include concurrent group warmup, followed by an 8-station circuit performed with high intensity intervals, and a cool-down. The circuit will include 4 stations performed by both the LE and LEUE groups and 4 stations specific to each intervention group, including 4 additional LE exercise stations for the LE group and 4 UE specific stations for the LEUE group. The stations that differ will not be adjacent to one another nor specifically indicated as different. The stations that differ will mirror similar aspects of function (ie, strength, reaction time, etc.) for the UE and LE stations. Participants will be told exercise stations may vary within-session and week to week but will not be informed that only one group has UE exercise interventions. After conclusion of the class series, post-intervention balance and stepping outcomes will be reassessed.
- Conditions
- Parkinson Disease
- Being tested
- High intensity circuit exercise class - Lower and upper extremity, High intensity circuit exercise class - Lower extremity alone
- Keywords
- exercise
- Medical subject headings
- Parkinson Disease, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High intensity circuit exercise class - Lower and upper extremityOther
Exercises performed at high intensity effort in the circuit (8 total) will focus on both the lower extremity (4) and upper extremity (4)
High intensity circuit exercise class - Lower extremity aloneOther
All exercises performed at high intensity effort in the circuit (8 total) will focus on the lower extremity alone
| Study group | Role | What they receive |
|---|---|---|
| Lower extremity and upper extremity exercise | Experimental | Exercises in the circuit (8 total) will focus on the lower extremity (4) and upper extremity (4) Receives: Other: High intensity circuit exercise class - Lower and upper extremity |
| Lower extremity exercise | Active comparator | Exercises in the circuit (8 total) will focus on the lower extremity (4) alone. Receives: Other: High intensity circuit exercise class - Lower extremity alone |
What is being measured
The primary outcome is the main question the study is designed to answer.
Trail making Test Parts A and B (timed, higher scores mean worse outcome)
Cognitive and fine motor skills
Measured: 8-10 weeks
Activity-specific Balance Confidence Scale (0-100%, higher scores mean better outcome)
Balance confidence self-report
Measured: 8-10 weeks
Timed Up and Go
Balance and function
Measured: 8-10 weeks
10 meter Walk Test
Gait Speed
Measured: 8-10 weeks
6 minute walk test
endurance
Measured: 8-10 weeks
9-hole peg test (timed, higher scores mean worse outcome)
fine motor
Measured: 8-10 weeks
Parkinson's Disease Questionnaire - Short Form (8) (Score 0-32, higher scores mean worse outcome)
Quality of Life
Measured: 8-10 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Aug 2024
- Study start15 Feb 2024
- Primary completion30 Nov 2025
- Study completion30 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parkinson DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Single center, two arm, pre-test post-test parallel design with up to 4 cohorts of class participants.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 64 participants (actual)
Sponsor and investigators
- Lead sponsor
- Pacific Northwest University of Health Sciences
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Tiffany B Salido, DPT, PhD, Principal investigator, Pacific Northwest University of Health Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06576817
- Sponsor's protocol ID
- 24-003
- Status last verified
- Mar 2026
- First submitted
- 12 Jul 2024
- Last updated
- 27 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of High-intensity Interval Circuit Training With Upper Extremity and Lower Extremity Training Versus Lower Extremity Training Alone in People With Parkinson Disease
- ClinicalTrials.gov ID
- NCT06576817
- Acronym / sponsor ID
- 24-003
- Conditions
- Parkinson Disease
- Keywords
- exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 64 participants (actual)
- Lead sponsor
- Pacific Northwest University of Health SciencesUniversity, hospital or other
- Study start
- 15 Feb 2024 (actual)
- Primary completion
- 30 Nov 2025 (actual)
- Study completion
- 30 Nov 2025 (actual)
- First posted
- 29 Aug 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of the study is to compare different types of high intensity circuit exercises over an 8-class training series in people with Parkinson disease. The main question it aims to answer is:
-Does including arm and hand exercises with leg exercises improve reaction time, balance, functional measures, gait speed and quality of life? This group will be compared to a group that only does leg exercises. Participants will be asked to participate in 8 high intensity circuit exercise classes.
Detailed description
People with Parkinson disease will be recruited from the community and randomized into 2 equal groups: high intensity interval circuit training with lower extremity (LE) and lower and upper extremity (LEUE) training. The study will be composed of a baseline assessment, 8 group class sessions, and a post-intervention assessment. The baseline assessment will include demographics, disease and fall history and outcome measure collection. Group class sessions will include concurrent group warmup, followed by an 8-station circuit performed with high intensity intervals, and a cool-down. The circuit will include 4 stations performed by both the LE and LEUE groups and 4 stations specific to each intervention group, including 4 additional LE exercise stations for the LE group and 4 UE specific stations for the LEUE group. The stations that differ will not be adjacent to one another nor specifically indicated as different. The stations that differ will mirror similar aspects of function (ie, strength, reaction time, etc.) for the UE and LE stations. Participants will be told exercise stations may vary within-session and week to week but will not be informed that only one group has UE exercise interventions. After conclusion of the class series, post-intervention balance and stepping outcomes will be reassessed.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- Single center, two arm, pre-test post-test parallel design with up to 4 cohorts of class participants.
| Arm | Type | Receives |
|---|---|---|
| Lower extremity and upper extremity exercise | Experimental | Other: High intensity circuit exercise class - Lower and upper extremityExercises in the circuit (8 total) will focus on the lower extremity (4) and upper extremity (4) |
| Lower extremity exercise | Active comparator | Other: High intensity circuit exercise class - Lower extremity aloneExercises in the circuit (8 total) will focus on the lower extremity (4) alone. |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (4 listed)
- diagnosis of Parkinson's disease
- Hoehn and Yahr level of 1 to 3
- ability to walk independently with or without an assistive device
- obtain medical clearance to participate in moderate or vigorous exercise.
Key exclusion criteria (7 listed)
- diagnosis of any neurological disease other than PD (including but not limited to stroke, dementia, and multiple sclerosis; mild cognitive impairment is not excluded)
- bone instability (non-consolidated fractures, unstable spinal column, severe osteoporosis)
- muscle or ligament tears
- uncontrolled hypertension
- uncontrolled diabetes
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High intensity circuit exercise class - Lower and upper extremityExercises performed at high intensity effort in the circuit (8 total) will focus on both the lower extremity (4) and upper extremity (4) | Other | Lower extremity and upper extremity exercise |
| High intensity circuit exercise class - Lower extremity aloneAll exercises performed at high intensity effort in the circuit (8 total) will focus on the lower extremity alone | Other | Lower extremity exercise |
Primary outcome
Trail making Test Parts A and B (timed, higher scores mean worse outcome)
Time frame: 8-10 weeks
Cognitive and fine motor skills
Activity-specific Balance Confidence Scale (0-100%, higher scores mean better outcome)
Time frame: 8-10 weeks
Balance confidence self-report
Timed Up and Go
Time frame: 8-10 weeks
Balance and function
10 meter Walk Test
Time frame: 8-10 weeks
Gait Speed
6 minute walk test
Time frame: 8-10 weeks
endurance
9-hole peg test (timed, higher scores mean worse outcome)
Time frame: 8-10 weeks
fine motor
Parkinson's Disease Questionnaire - Short Form (8) (Score 0-32, higher scores mean worse outcome)
Time frame: 8-10 weeks
Quality of Life
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Tiffany B Salido, DPT, PhD principal investigator
Pacific Northwest University of Health Sciences
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High intensity circuit exercise class - Lower and upper extremity and High intensity circuit exercise class - Lower extremity alone in people with Parkinson Disease, run by Pacific Northwest University of Health Sciences at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Trail making Test Parts A and B (timed, higher scores mean worse outcome) (time frame: 8-10 weeks). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Mar 2026.