IVFNCT06577181
Effect of HCG on Endometrial Preparation in Frozen Embryo Transfer
An observational study of IVF, run by Assiut University at 1 site in Egypt.
Trial summary
Intramuscular injection of HCG to prepare endometrium for frozen embryo transfer Read more about this study
- Who is it for?
- Any age, women only
- Conditions the study is for
- IVF
- What is being tested?
- hCG + estradiol and Observation arm
- Type of treatment
- Injection or infusion
- How many people
- 50 participants
- Where
- 1 siteEgypt
- Study dates
- 10 May 2024to 10 May 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Women only
- No healthy volunteers
- Child, Adult, Older adult
Study population: Reproductive age female
Who may be able to join
- Infertile women being prepared for frozen embryo transfer (FET) in an ART program
Who cannot join
- (1) Use of preimplantation genetic test.
- History of recurrent spontaneous abortion.
- Presence of congenital uterine malformations.
- Use of sequential embryo transfer.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Intramuscular Injection of Human Chorionic Gonadotropins on Endometrial Preparation for Frozen Embryo Transfer
Intramuscular injection of HCG to prepare endometrium for frozen embryo transfer
Read the detailed description
This study is to compare the effectiveness of intramuscular injections of Human chorionic gonadotropins in preparing the endometrium for frozen embryo transfer compared to the control group who did not receive the injection
- Conditions
- IVF
- Being tested
- hCG + estradiol, Observation arm
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
hCG + estradiolDrug
Human chorionic gonadotropins
Observation armOther
estradiol only wuithout giving hcg
| Study group | Role | What they receive |
|---|---|---|
| Women undergoing preparation for Embryo transfer | Group who received intramuscular injection of HCG before embryo transfer Receives: Drug: hCG + estradiol | |
| Women undergoing preparation for Embryo transfer 1 | Group who did not receive intramuscular injection of HCG before embryo transfer Receives: Other: Observation arm |
What is being measured
The primary outcome is the main question the study is designed to answer.
Clinical pregnancy
Presence of at least one gestational sac inside the uterus 28 days after embryo transfer
Measured: 2months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Aug 2024
- Study start10 May 2024
- Primary completion10 May 2025 (estimated)
- Study completion10 May 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for IVFStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Collaborators
- Banon fertility center
- Responsible party
- Principal investigator, Omar Ahmed Mohamed Aly Ahmed Nasr, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06577181
- Sponsor's protocol ID
- Omar Nasr OBGYN
- Status last verified
- Sep 2024
- First submitted
- 27 Aug 2024
- Last updated
- 19 Sep 2024
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Eftekhar M, Rahmani E, Eftekhar T. Effect of adding human chorionic gonadotropin to the endometrial preparation protocol in frozen embryo transfer cycles. Int J Fertil Steril. 2012 Oct;6(3):175-8. Epub 2012 Dec 17.
PubMed 24520435
Study at a glance
From the registry record, last updated by the sponsor on 19 Sep 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Intramuscular Injection of Human Chorionic Gonadotropins on Endometrial Preparation for Frozen Embryo Transfer
- ClinicalTrials.gov ID
- NCT06577181
- Acronym / sponsor ID
- Omar Nasr OBGYN
- Conditions
- IVF
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Collaborators
- Banon fertility center
- Study start
- 10 May 2024 (actual)
- Primary completion
- 10 May 2025 (estimated)
- Study completion
- 10 May 2026 (estimated)
- First posted
- 29 Aug 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Intramuscular injection of HCG to prepare endometrium for frozen embryo transfer
Detailed description
This study is to compare the effectiveness of intramuscular injections of Human chorionic gonadotropins in preparing the endometrium for frozen embryo transfer compared to the control group who did not receive the injection
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Women undergoing preparation for Embryo transfer | – | Drug: hCG + estradiolGroup who received intramuscular injection of HCG before embryo transfer |
| Women undergoing preparation for Embryo transfer 1 | – | Other: Observation armGroup who did not receive intramuscular injection of HCG before embryo transfer |
Who may qualify
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Reproductive age female
Key inclusion criteria (1 listed)
- Infertile women being prepared for frozen embryo transfer (FET) in an ART program
Key exclusion criteria (4 listed)
- History of recurrent spontaneous abortion.
- Presence of congenital uterine malformations.
- Use of sequential embryo transfer.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| hCG + estradiolHuman chorionic gonadotropins | Drug | Women undergoing preparation for Embryo transfer |
| Observation armestradiol only wuithout giving hcg | Other | Women undergoing preparation for Embryo transfer 1 |
Primary outcome
Clinical pregnancy
Time frame: 2months
Presence of at least one gestational sac inside the uterus 28 days after embryo transfer
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Sep 2024.
- Background: PubMed 24520435Eftekhar M, Rahmani E, Eftekhar T. Effect of adding human chorionic gonadotropin to the endometrial preparation protocol in frozen embryo transfer cycles. Int J Fertil Steril. 2012 Oct;6(3):175-8. Epub 2012 Dec 17.
- Individual participant dataSharing planned: Undecided
Related trials for IVF
RecruitingObservational study
International Pilot Study for Dual Non-invasive Assesment of Embryo Development
Infertility
RecruitingObservational study
Pilot Study of Discarded Blastocysts
Infertility (IVF Patients)
Active, not recruitingPhase 3
Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.
Infertility (IVF Patients)
RecruitingPhase 2
Ubiquinone vs. Ubiquinol Supplementation
IVF
Active, not recruitingPhase 1/2
Opt-IVF for Personalized Medicine for Normal Responders
Ivf
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of IVF, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 19 Sep 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Clinical pregnancy (time frame: 2months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06577181, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Sep 2024.