Post-menopauseBEETBOOSTNCT06598488
Beetroot Juice: A Natural Boost for Cardiovascular Health in Postmenopausal Women?
A study testing Beetroot juice in people with Post-menopause, run by Western Norway University of Applied Sciences at 1 site in Norway.
Trial summary
This study aims to explore the effects of short-term beetroot juice (BRJ) supplementation on cardiovascular health in post-menopausal women. The primary focus is to determine whether BRJ, rich in nitrates that increase nitric oxide (NO) bioavailability, can reduce blood pressure at rest and during exercise, as well as… Read more about this study
- Who is it for?
- Ages Up to 65 years, women only
- Conditions the study is for
- Post-menopause
- What is being tested?
- Beetroot juice
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 14 participants
- Where
- 1 siteNorway
- Study dates
- 9 Sep 2025to 16 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 65 years
- Women only
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Females under the age of 65
- Self-reported absence of menstrual cycle for \>1 year
- BMI \<30 kg/m2.
- Able to walk on a treadmill and cycle on a stationary bike without problems.
- Proficient in Norwegian and able to provide informed consent.
Who cannot join
- Current or recent (last 5 years) regular smoker or user of nicotine products
- Addictions to alcohol or illegal drugs
- Allergy or intolerance (s) to nitrate or BRJ supplement.
- Diagnosed with cardiovascular disease (e.g., previous acute myocardial infarction or stroke, peripheral artery disease, heart failure), renal, or respiratory (e.g., asthma, sleep apnea).
- Regular usage of nitrate supplements, including beetroot juice
- Hormone replacement therapy.
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- Uncontrolled high blood pressure (e.g., resting systolic and diastolic blood pressure \&gt;160/110 mmHg)
- Problems with very low blood pressure (e.g., severe dizziness upon standing)
- Diagnosed with diabetes (type 1 or type 2).
- Using blood pressure or glucose-lowering medications
- Close family (parents, siblings, children) history of sudden cardiac death at an early age (\&lt;55 for men, \&lt;65 for women)
- Judgment by a medical provider that exercise poses an undue burden or risk.
- Cognitive or psychiatric impairment
- Lack of proficiency in Norwegian language oral or writing skills that will hamper the ability to participate in the interventions and fill out questionnaires.
Trial locations and contacts
1 site in 1 country.
About this study
This study aims to explore the effects of short-term beetroot juice (BRJ) supplementation on cardiovascular health in post-menopausal women. The primary focus is to determine whether BRJ, rich in nitrates that increase nitric oxide (NO) bioavailability, can reduce blood pressure at rest and during exercise, as well as improve oxygen uptake during maximal exercise. Given the increased cardiovascular risk in post-menopausal women due to the loss of estrogen's protective effects, this research seeks to provide a novel, non-pharmacological intervention to enhance cardiovascular function during exercise in this population.
Read the detailed description
This study aims to evaluate the short-term effects of beetroot juice (BRJ) supplementation on blood pressure and oxygen uptake during exercise in post-menopausal women. Post-menopausal women are at increased risk of cardiovascular disease due to the loss of estrogen, which plays a critical role in nitric oxide (NO) production, a key regulator of blood vessel function and blood pressure. BRJ, rich in dietary nitrates, is converted into NO in the body and may offer a natural means to improve cardiovascular health.
The primary objective is to investigate whether short-term BRJ supplementation can reduce resting and exercise blood pressure and enhance oxygen uptake during maximal exercise, compared to a placebo. The study will also explore the relationship between these cardiovascular responses and blood biomarkers, including nitrate/nitrite levels and inflammatory cytokines.
The study design is a randomized, double-blind, placebo-controlled crossover trial. Post-menopausal women will be randomized into either the BRJ or placebo group, consuming BRJ or nitrate-depleted juice for 4 days, followed by a 7-day washout period before switching to the alternate group. Participants will undergo testing to measure blood pressure and oxygen uptake at rest and during exercise at baseline and after each intervention.
This research is novel and clinically significant, as it explores a non-pharmacological approach to mitigate cardiovascular risks in post-menopausal women. By improving cardiovascular function, this study aims to offer a new strategy for addressing age- and menopause-related increases in blood pressure and declines in exercise capacity.
- Conditions
- Post-menopause
- Being tested
- Beetroot juice, Beetroot juice placebo
- Keywords
- Beetroot juice
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Beetroot juiceDietary supplement
Beetroot juice will be consumed 2 times a day for 4 days before testing plus one shot on experimental testing day 1,5 hours before arrival.
Beetroot juice placeboDietary supplement
Beetroot juice will be consumed 2 times a day for 4 days before testing plus one shot on experimental testing day 1,5 hours before arrival.
| Study group | Role | What they receive |
|---|---|---|
| Nitrate rich beetroot juice | Experimental | 4 days of nitrate rich beetroot juice ingestion (Beet it) Receives: Dietary Supplement: Beetroot juice |
| Nitrate depleted beetroot juice | Placebo comparator | 4 days of nitrate depleted beetroot juice ingestion (Beet it) Receives: Dietary Supplement: Beetroot juice placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood pressure
Measured: After 4 days of intervention
Blood pressure reactivity
Measured: After 4 days of intervention
Maximal oxygen consumption
Measured: After 4 days of intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Sep 2024
- Study start9 Sep 2025
- Primary completion16 Dec 2025
- Study completion16 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post-menopauseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 14 participants (actual)
Sponsor and investigators
- Lead sponsor
- Western Norway University of Applied Sciences
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ann-Katrin Grotle, Western Norway University of Applied Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06598488
- Sponsor's protocol ID
- 730456
- Other IDs
- 730456
- Acronym
- BEETBOOST
- Status last verified
- Mar 2026
- First submitted
- 13 Sep 2024
- Last updated
- 10 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Beetroot Juice: A Natural Boost for Cardiovascular Health in Postmenopausal Women?
- ClinicalTrials.gov ID
- NCT06598488
- Acronym / sponsor ID
- BEETBOOST / 730456
- Conditions
- Post-menopause
- Keywords
- Beetroot juice
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 14 participants (actual)
- Lead sponsor
- Western Norway University of Applied SciencesUniversity, hospital or other
- Study start
- 9 Sep 2025 (actual)
- Primary completion
- 16 Dec 2025 (actual)
- Study completion
- 16 Dec 2025 (actual)
- First posted
- 19 Sep 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to explore the effects of short-term beetroot juice (BRJ) supplementation on cardiovascular health in post-menopausal women. The primary focus is to determine whether BRJ, rich in nitrates that increase nitric oxide (NO) bioavailability, can reduce blood pressure at rest and during exercise, as well as improve oxygen uptake during maximal exercise. Given the increased cardiovascular risk in post-menopausal women due to the loss of estrogen's protective effects, this research seeks to provide a novel, non-pharmacological intervention to enhance cardiovascular function during exercise in this population.
Detailed description
This study aims to evaluate the short-term effects of beetroot juice (BRJ) supplementation on blood pressure and oxygen uptake during exercise in post-menopausal women. Post-menopausal women are at increased risk of cardiovascular disease due to the loss of estrogen, which plays a critical role in nitric oxide (NO) production, a key regulator of blood vessel function and blood pressure. BRJ, rich in dietary nitrates, is converted into NO in the body and may offer a natural means to improve cardiovascular health.
The primary objective is to investigate whether short-term BRJ supplementation can reduce resting and exercise blood pressure and enhance oxygen uptake during maximal exercise, compared to a placebo. The study will also explore the relationship between these cardiovascular responses and blood biomarkers, including nitrate/nitrite levels and inflammatory cytokines.
The study design is a randomized, double-blind, placebo-controlled crossover trial. Post-menopausal women will be randomized into either the BRJ or placebo group, consuming BRJ or nitrate-depleted juice for 4 days, followed by a 7-day washout period before switching to the alternate group. Participants will undergo testing to measure blood pressure and oxygen uptake at rest and during exercise at baseline and after each intervention.
This research is novel and clinically significant, as it explores a non-pharmacological approach to mitigate cardiovascular risks in post-menopausal women. By improving cardiovascular function, this study aims to offer a new strategy for addressing age- and menopause-related increases in blood pressure and declines in exercise capacity.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Nitrate rich beetroot juice | Experimental | Dietary Supplement: Beetroot juice4 days of nitrate rich beetroot juice ingestion (Beet it) |
| Nitrate depleted beetroot juice | Placebo comparator | Dietary Supplement: Beetroot juice placebo4 days of nitrate depleted beetroot juice ingestion (Beet it) |
Who may qualify
- Ages
- Up to 65 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (5 listed)
- Females under the age of 65
- Self-reported absence of menstrual cycle for \&gt;1 year
- BMI \<30 kg/m2.
- Able to walk on a treadmill and cycle on a stationary bike without problems.
- Proficient in Norwegian and able to provide informed consent.
Key exclusion criteria (14 listed)
- Current or recent (last 5 years) regular smoker or user of nicotine products
- Addictions to alcohol or illegal drugs
- Allergy or intolerance (s) to nitrate or BRJ supplement.
- Diagnosed with cardiovascular disease (e.g., previous acute myocardial infarction or stroke, peripheral artery disease, heart failure), renal, or respiratory (e.g., asthma, sleep apnea).
- Regular usage of nitrate supplements, including beetroot juice
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Beetroot juiceBeetroot juice will be consumed 2 times a day for 4 days before testing plus one shot on experimental testing day 1,5 hours before arrival. | Dietary supplement | Nitrate rich beetroot juice |
| Beetroot juice placeboBeetroot juice will be consumed 2 times a day for 4 days before testing plus one shot on experimental testing day 1,5 hours before arrival. | Dietary supplement | Nitrate depleted beetroot juice |
Primary outcome
Blood pressure
Time frame: After 4 days of intervention
Blood pressure reactivity
Time frame: After 4 days of intervention
Maximal oxygen consumption
Time frame: After 4 days of intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Beetroot juice in people with Post-menopause, run by Western Norway University of Applied Sciences at 1 site in Norway.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 14 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Norway. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood pressure (time frame: After 4 days of intervention). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Mar 2026.