Dental Implant FailureNCT06599320
Variables for Long-term Success in Implant Dentistry
An observational study of Dental Implant Failure, run by University of Bern at 1 site in Switzerland.
Trial summary
The aims of the present retrospective 25-year study of a sample of 459 patients with 753 sandblasted and acid-etched (SLA) titanium oral implants are: to assess the clinical parameters at SLA implants after 25 years in function to assess the crestal bone levels at SLA implants after 25 years in function to assess and… Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Dental Implant Failure
- What is being tested?
- Oral rehabilitation with dental implants
- Type of treatment
- Pill or oral medicine
- How many people
- 160 participants
- Where
- 1 siteSwitzerland
- Study dates
- 9 Sep 2024to 31 Dec 2025
- How long will I take part?
- 25 Years
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: Out of the pool of patients from the Departments of Oral Surgery and Periodontology and Fixed Prosthodontics at the University of Bern, Switzerland, all patients having received at least one dental implant will be recruited for a comprehensive evaluation 25 years after implant installation and delivery of the reconstruction. The patients had been treated according to a comprehensive treatment strategy prior to the installation of implants and incorporation of reconstructions. All patients were offered maintenance care that was provided either in the School of Dental Medicine, University of Bern, Switzerland, or in the dental practices of the referring dentists at intervals between 3 and 6 months. All the implants installed were solid screws (SS) with a diameter of 3.3, 4.1 or 4.8 mm, a length between 6-14 mm and a sandblasted and acid-etched surface (SLA) (Straumann® Dental Implant System, Institute Straumann AG, Basel, Switzerland).
Who may be able to join
- All patients rehabilitated with oral dental implants supporting fixed partial dental prostheses and followed up for at least 20-years.
Who cannot join
- None
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Variables for Long-term Success in Implant Dentistry: A Retrospective Cross-sectional Study With a 25 Year Follow-up or More
The aims of the present retrospective 25-year study of a sample of 459 patients with 753 sandblasted and acid-etched (SLA) titanium oral implants are:
- to assess the clinical parameters at SLA implants after 25 years in function
- to assess the crestal bone levels at SLA implants after 25 years in function
- to assess and compare the microbiological conditions at SLA implants and their adjacent teeth after 25 years of function
- to assess the periodontal conditions in patients having received SLA implants 25 years ago
- to establish a baseline data set for future prospective studies on patients having received SLA implants 25 years ago
- to assess the incidence rates of biological, technical, traumatic failures / complications with SLA implants
- to assess the incidence rates of technical failures / complications with prosthetic components on SLA implants
- to assess the incidence rates of biological, technical, mechanical, esthetic failures / complications with prosthetic reconstructions on SLA implants
- to find potential risk factors for biological failures / complications with SLA implants; i.e. patients having lost their teeth due to different reasons (e.g. partial anodontia, caries, periodontitis, endodontic failure, trauma, vertical root fracture), (ii) to calculate the success rates using different thresholds set as success criteria, (iii) to evaluate the influence of medical conditions and tobacco smoking on the long-term prognosis of titanium oral implants, and (iv) to assess the frequency and quality of maintenance
- to find potential risk factors for mechanical, technical, esthetic failures/complications with reconstructions seated on SLA implants
- to assess the treatment need and utility of implant therapy after 25 years in patients having received SLA implants
Read the detailed description
Specific aims
The aims of the present retrospective 25-year study of a sample of 459 patients with 753 sandblasted and acid-etched (SLA) titanium oral implants are:
- to assess the clinical parameters at SLA implants after 25 years in function
- to assess the crestal bone levels at SLA implants after 25 years in function
- to assess and compare the microbiological conditions at SLA implants and their adjacent teeth after 25 years of function
- to assess the periodontal conditions in patients having received SLA implants 25 years ago
- to establish a baseline data set for future prospective studies on patients having received SLA implants 25 years ago
- to assess the incidence rates of biological, technical, traumatic failures / complications with SLA implants
- to assess the incidence rates of technical failures / complications with prosthetic components on SLA implants
- to assess the incidence rates of biological, technical, mechanical, esthetic failures / complications with prosthetic reconstructions on SLA implants
- to find potential risk factors for biological failures / complications with SLA implants; i.e. patients having lost their teeth due to different reasons (e.g. partial anodontia, caries, periodontitis, endodontic failure, trauma, vertical root fracture), (ii) to calculate the success rates using different thresholds set as success criteria, (iii) to evaluate the influence of medical conditions and tobacco smoking on the long-term prognosis of titanium oral implants, and (iv) to assess the frequency and quality of maintenance
- to find potential risk factors for mechanical, technical, esthetic failures/complications with reconstructions seated on SLA implants
- to assess the treatment need and utility of implant therapy after 25 years in patients having received SLA implants
Material and methods Out of the pool of patients from the Departments of Oral Surgery and Periodontology and Fixed Prosthodontics at the University of Bern, Switzerland, all patients having received at least one dental implant will be recruited for a comprehensive evaluation 25 years after implant installation and delivery of the reconstruction. The patients had been treated according to a comprehensive treatment strategy prior to the installation of implants and incorporation of reconstructions. All patients were offered maintenance care that was provided either in the School of Dental Medicine, University of Bern, Switzerland, or in the dental practices of the referring dentists at intervals between 3 and 6 months.
All the implants installed were solid screws (SS) with a diameter of 3.3, 4.1 or 4.8 mm, a length between 6-14 mm and a sandblasted and acid-etched surface (SLA) (Straumann® Dental Implant System, Institute Straumann AG, Basel, Switzerland). The implants were placed according to the manufacturer's instructions. The reconstructions were either cemented or screw-retained and consisted of single-unit crowns (SCs) or short-span fixed dental prostheses (FDPs) with or without cantilever extension(s).
- Conditions
- Dental Implant Failure
- Being tested
- Oral rehabilitation with dental implants
- Keywords
- dental implant, complications
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Oral rehabilitation with dental implantsOther
Patients rehabilitated with implant-supported fixed partial dental prostheses
| Study group | Role | What they receive |
|---|---|---|
| Partial edentulous patients rehabilitated with at least one dental implant | Partial edentulous patients rehabilitated with at least one dental implant in function for at least 20-years Receives: Other: Oral rehabilitation with dental implants |
What is being measured
The primary outcome is the main question the study is designed to answer.
Implant survival rate
percentage of implants in-situ
Measured: 25 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Sep 2024
- Study start9 Sep 2024
- Primary completion30 Jul 2025
- Study completion31 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Dental Implant FailureStudies of the same condition, open and under way.
- More trials run by University of BernThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 160 participants (actual)
- Target duration
- 25 Years
Sponsor and investigators
- Lead sponsor
- University of Bern
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Martin Schimmel, Study chair, University of Bern
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06599320
- Sponsor's protocol ID
- 2023-02279
- Other IDs
- ITI n 1574_2021, 2023
- Status last verified
- Jan 2026
- First submitted
- 5 Sep 2024
- Last updated
- 23 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Buser D, Janner SF, Wittneben JG, Bragger U, Ramseier CA, Salvi GE. 10-year survival and success rates of 511 titanium implants with a sandblasted and acid-etched surface: a retrospective study in 303 partially edentulous patients. Clin Implant Dent Relat Res. 2012 Dec;14(6):839-51. doi: 10.1111/j.1708-8208.2012.00456.x.
PubMed 22897683
Study at a glance
From the registry record, last updated by the sponsor on 23 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Variables for Long-term Success in Implant Dentistry: A Retrospective Cross-sectional Study With a 25 Year Follow-up or More
- ClinicalTrials.gov ID
- NCT06599320
- Acronym / sponsor ID
- 2023-02279
- Conditions
- Dental Implant Failure
- Keywords
- dental implant, complications
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 160 participants (actual)
- Lead sponsor
- University of BernUniversity, hospital or other
- Study start
- 9 Sep 2024 (actual)
- Primary completion
- 30 Jul 2025 (actual)
- Study completion
- 31 Dec 2025 (actual)
- First posted
- 19 Sep 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aims of the present retrospective 25-year study of a sample of 459 patients with 753 sandblasted and acid-etched (SLA) titanium oral implants are:
- to assess the clinical parameters at SLA implants after 25 years in function
- to assess the crestal bone levels at SLA implants after 25 years in function
- to assess and compare the microbiological conditions at SLA implants and their adjacent teeth after 25 years of function
- to assess the periodontal conditions in patients having received SLA implants 25 years ago
- to establish a baseline data set for future prospective studies on patients having received SLA implants 25 years ago
- to assess the incidence rates of biological, technical, traumatic failures / complications with SLA implants
- to assess the incidence rates of technical failures / complications with prosthetic components on SLA implants
- to assess the incidence rates of biological, technical, mechanical, esthetic failures / complications with prosthetic reconstructions on SLA implants
- to find potential risk factors for biological failures / complications with SLA implants; i.e. patients having lost their teeth due to different reasons (e.g. partial anodontia, caries, periodontitis, endodontic failure, trauma, vertical root fracture), (ii) to calculate the success rates using different thresholds set as success criteria, (iii) to evaluate the influence of medical conditions and tobacco smoking on the long-term prognosis of titanium oral implants, and (iv) to assess the frequency and quality of maintenance
- to find potential risk factors for mechanical, technical, esthetic failures/complications with reconstructions seated on SLA implants
- to assess the treatment need and utility of implant therapy after 25 years in patients having received SLA implants
Detailed description
Specific aims
The aims of the present retrospective 25-year study of a sample of 459 patients with 753 sandblasted and acid-etched (SLA) titanium oral implants are:
- to assess the clinical parameters at SLA implants after 25 years in function
- to assess the crestal bone levels at SLA implants after 25 years in function
- to assess and compare the microbiological conditions at SLA implants and their adjacent teeth after 25 years of function
- to assess the periodontal conditions in patients having received SLA implants 25 years ago
- to establish a baseline data set for future prospective studies on patients having received SLA implants 25 years ago
- to assess the incidence rates of biological, technical, traumatic failures / complications with SLA implants
- to assess the incidence rates of technical failures / complications with prosthetic components on SLA implants
- to assess the incidence rates of biological, technical, mechanical, esthetic failures / complications with prosthetic reconstructions on SLA implants
- to find potential risk factors for biological failures / complications with SLA implants; i.e. patients having lost their teeth due to different reasons (e.g. partial anodontia, caries, periodontitis, endodontic failure, trauma, vertical root fracture), (ii) to calculate the success rates using different thresholds set as success criteria, (iii) to evaluate the influence of medical conditions and tobacco smoking on the long-term prognosis of titanium oral implants, and (iv) to assess the frequency and quality of maintenance
- to find potential risk factors for mechanical, technical, esthetic failures/complications with reconstructions seated on SLA implants
- to assess the treatment need and utility of implant therapy after 25 years in patients having received SLA implants
Material and methods Out of the pool of patients from the Departments of Oral Surgery and Periodontology and Fixed Prosthodontics at the University of Bern, Switzerland, all patients having received at least one dental implant will be recruited for a comprehensive evaluation 25 years after implant installation and delivery of the reconstruction. The patients had been treated according to a comprehensive treatment strategy prior to the installation of implants and incorporation of reconstructions. All patients were offered maintenance care that was provided either in the School of Dental Medicine, University of Bern, Switzerland, or in the dental practices of the referring dentists at intervals between 3 and 6 months.
All the implants installed were solid screws (SS) with a diameter of 3.3, 4.1 or 4.8 mm, a length between 6-14 mm and a sandblasted and acid-etched surface (SLA) (Straumann® Dental Implant System, Institute Straumann AG, Basel, Switzerland). The implants were placed according to the manufacturer's instructions. The reconstructions were either cemented or screw-retained and consisted of single-unit crowns (SCs) or short-span fixed dental prostheses (FDPs) with or without cantilever extension(s).
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Target follow-up
- 25 Years
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Partial edentulous patients rehabilitated with at least one dental implant | – | Other: Oral rehabilitation with dental implantsPartial edentulous patients rehabilitated with at least one dental implant in function for at least 20-years |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Out of the pool of patients from the Departments of Oral Surgery and Periodontology and Fixed Prosthodontics at the University of Bern, Switzerland, all patients having received at least one dental implant will be recruited for a comprehensive evaluation 25 years after implant installation and delivery of the reconstruction. The patients had been treated according to a comprehensive treatment strategy prior to the installation of implants and incorporation of reconstructions. All patients were offered maintenance care that was provided either in the School of Dental Medicine, University of Bern, Switzerland, or in the dental practices of the referring dentists at intervals between 3 and 6 months. All the implants installed were solid screws (SS) with a diameter of 3.3, 4.1 or 4.8 mm, a length between 6-14 mm and a sandblasted and acid-etched surface (SLA) (Straumann® Dental Implant System, Institute Straumann AG, Basel, Switzerland).
Key inclusion criteria (1 listed)
- All patients rehabilitated with oral dental implants supporting fixed partial dental prostheses and followed up for at least 20-years.
Key exclusion criteria (1 listed)
- None
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Oral rehabilitation with dental implantsPatients rehabilitated with implant-supported fixed partial dental prostheses | Other | Partial edentulous patients rehabilitated with at least one dental implant |
Primary outcome
Implant survival rate
Time frame: 25 years
percentage of implants in-situ
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jan 2026.
- Results publication: PubMed 22897683Buser D, Janner SF, Wittneben JG, Bragger U, Ramseier CA, Salvi GE. 10-year survival and success rates of 511 titanium implants with a sandblasted and acid-etched surface: a retrospective study in 303 partially edentulous patients. Clin Implant Dent Relat Res. 2012 Dec;14(6):839-51. doi: 10.1111/j.1708-8208.2012.00456.x.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Martin Schimmel study chair
University of Bern
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Dental Implant Failure, run by University of Bern at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Implant survival rate (time frame: 25 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06599320, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jan 2026.