Caffeine and Resistance TrainingNCT06618261
Caffeine and Resistance Training in Older Adults
A study testing Caffeine + Resistance exercise in people with Caffeine and Resistance Training, run by Alberto Pérez-López at 1 site in Spain.
Trial summary
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effects of this supplement on neuromuscular adaptations to strength training. Read more about this study
- Who is it for?
- Ages 55 years and olderHealthy volunteers can take part
- Conditions the study is for
- Caffeine and Resistance Training
- What is being tested?
- Caffeine + Resistance exercise
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 48 participants
- Where
- 1 siteSpain
- Study dates
- 14 Jan 2024to 30 Jul 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 55 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age between ≥ 55
- Body mass index (BMI) ≥ 30 kg/m².
- Physically active subjects (\>150 min/week of moderate exercise).
- Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
- Participants capable of performing the tests.
Who cannot join
- History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
- Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
- Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
- Performing strenuous exercise within 48 hours prior to the tests.
- Failing to replicate the same food intake on the two experimental days.
- Consuming caffeine after 6 PM on the day prior to training or testing.
Trial locations and contacts
1 site in 1 country.
Spain1 site
Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá
Alcalá de Henares, 28805
About this study
Official title: Effects of Acute and Prolonged Caffeine Intake on Neuromuscular Adaptations to Resistance Training in Older Adults
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effects of this supplement on neuromuscular adaptations to strength training.
Objectives: The present study aims to analyze the effects of acute and chronic caffeine intake on neuromuscular adaptations to strength training, according to sex (men vs. women) and type of exercise (bench press vs. squat), as well as fatigue perception, mood state, and potential side effects in older adults.
- Conditions
- Caffeine and Resistance Training
- Being tested
- Caffeine + Resistance exercise, Placebo + Resistance exercise
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Caffeine + Resistance exerciseDietary supplement
Acute caffeine intake (3 mg/kg) prior each resistance training session of a 8 weeks training program.
Placebo + Resistance exerciseDietary supplement
Acute placeb intake (3 mg/kg of maltodextrin) prior each resistance training session of a 8 weeks training program.
| Study group | Role | What they receive |
|---|---|---|
| Caffeine - Males | Experimental | Not described Receives: Dietary Supplement: Caffeine + Resistance exercise |
| Placebo - Males | Placebo comparator | Not described Receives: Dietary Supplement: Placebo + Resistance exercise |
| Caffeine - Females | Experimental | Not described Receives: Dietary Supplement: Caffeine + Resistance exercise |
| Placebo - Females | Placebo comparator | Not described Receives: Dietary Supplement: Placebo + Resistance exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean velocity at different %1RM
Measuring bar mean velocity desplacement during bench press and back squat exercises.
Measured: Through study completion, an average of 12 weeks
Peak velocity at different %1RM
Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.
Measured: Through study completion, an average of 12 weeks
Mean power output at different %1RM
Measuring during bench press and back squat exercises.
Measured: Through study completion, an average of 12 weeks
Peak power output and time to reach peak power output at different %1RM
Measuring during bench press and back squat exercises.
Measured: Through study completion, an average of 12 weeks
Number of repetitions performed at 65%1RM until task failure
In bench press and back squat exercises
Measured: Through study completion, an average of 12 weeks
Bar velocity deplacement performed in 1 set at 65%1RM until task failure
In bench press and back squat exercises
Measured: Through study completion, an average of 12 weeks
Power output generated in 1 set at 65%1RM until task failure
In bench press and back squat exercise
Measured: Through study completion, an average of 12 weeks
Resting Metabolic Rate (RMR)
Kcal at rest (RMR) using a metabolic chart.
Measured: Through study completion, an average of 12 weeks
Maximal Fat Oxidation Rate (MFO)
g/min (MFO) using a metabolic chart.
Measured: Through study completion, an average of 12 weeks
Secondary outcomes (6)
Fat mass
Using electrical bioimpedance and untrasound in the quadriceps muscle
Measured: Through study completion, an average of 12 weeks
Fat-free mass
Using electrical bioimpedance and untrasound in the quadriceps muscle
Measured: Through study completion, an average of 12 weeks
Physical activity (METs-min/wk)
Using IPAQ
Measured: Through study completion, an average of 12 weeks
Dietary (g/kg of macronutrients)
Using a 24-total recall
Measured: Through study completion, an average of 12 weeks
Mood state
Mood. Participants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question;How do you feel at this moment?; to assess six scales: tension, depression, anger, vigor, fatigue and confusion.
Measured: Through study completion, an average of 12 weeks
Adverse effects
Adverse effects. perception of power, endurance, energy and exertion, as well as heart, muscular and gastrointestinal discomfort.
Measured: Through study completion, an average of 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Oct 2024
- Study start14 Jan 2024
- Primary completion30 Jul 2026 (estimated)
- Study completion30 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Caffeine and Resistance TrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized controlled trial
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 48 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Alberto Pérez-López
- Sponsor type
- University, hospital or other
- Collaborators
- University of Alcala
- Responsible party
- Sponsor-investigator, Alberto Pérez-López, University of Alcala
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06618261
- Sponsor's protocol ID
- CEIP/2022/3/055
- Status last verified
- Apr 2026
- First submitted
- 9 Sep 2024
- Last updated
- 6 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 6 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Acute and Prolonged Caffeine Intake on Neuromuscular Adaptations to Resistance Training in Older Adults
- ClinicalTrials.gov ID
- NCT06618261
- Acronym / sponsor ID
- CEIP/2022/3/055
- Conditions
- Caffeine and Resistance Training
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 48 participants (estimated)
- Lead sponsor
- Alberto Pérez-LópezUniversity, hospital or other
- Collaborators
- University of Alcala
- Study start
- 14 Jan 2024 (actual)
- Primary completion
- 30 Jul 2026 (estimated)
- Study completion
- 30 Jul 2026 (estimated)
- First posted
- 1 Oct 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, little is known about the prolonged effects of this supplement on neuromuscular adaptations to strength training.
Objectives: The present study aims to analyze the effects of acute and chronic caffeine intake on neuromuscular adaptations to strength training, according to sex (men vs. women) and type of exercise (bench press vs. squat), as well as fatigue perception, mood state, and potential side effects in older adults.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 4
- Model description
- Randomized controlled trial
| Arm | Type | Receives |
|---|---|---|
| Caffeine - Males | Experimental | Dietary Supplement: Caffeine + Resistance exercise |
| Placebo - Males | Placebo comparator | Dietary Supplement: Placebo + Resistance exercise |
| Caffeine - Females | Experimental | Dietary Supplement: Caffeine + Resistance exercise |
| Placebo - Females | Placebo comparator | Dietary Supplement: Placebo + Resistance exercise |
Who may qualify
- Ages
- 55 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age between ≥ 55
- Body mass index (BMI) ≥ 30 kg/m².
- Physically active subjects (\>150 min/week of moderate exercise).
- Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
- Participants capable of performing the tests.
Key exclusion criteria (6 listed)
- History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
- Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
- Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
- Performing strenuous exercise within 48 hours prior to the tests.
- Failing to replicate the same food intake on the two experimental days.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Caffeine + Resistance exerciseAcute caffeine intake (3 mg/kg) prior each resistance training session of a 8 weeks training program. | Dietary supplement | Caffeine - Females, Caffeine - Males |
| Placebo + Resistance exerciseAcute placeb intake (3 mg/kg of maltodextrin) prior each resistance training session of a 8 weeks training program. | Dietary supplement | Placebo - Females, Placebo - Males |
Primary outcome
Mean velocity at different %1RM
Time frame: Through study completion, an average of 12 weeks
Measuring bar mean velocity desplacement during bench press and back squat exercises.
Peak velocity at different %1RM
Time frame: Through study completion, an average of 12 weeks
Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.
Mean power output at different %1RM
Time frame: Through study completion, an average of 12 weeks
Measuring during bench press and back squat exercises.
Peak power output and time to reach peak power output at different %1RM
Time frame: Through study completion, an average of 12 weeks
Measuring during bench press and back squat exercises.
Number of repetitions performed at 65%1RM until task failure
Time frame: Through study completion, an average of 12 weeks
In bench press and back squat exercises
Bar velocity deplacement performed in 1 set at 65%1RM until task failure
Time frame: Through study completion, an average of 12 weeks
In bench press and back squat exercises
Power output generated in 1 set at 65%1RM until task failure
Time frame: Through study completion, an average of 12 weeks
In bench press and back squat exercise
Resting Metabolic Rate (RMR)
Time frame: Through study completion, an average of 12 weeks
Kcal at rest (RMR) using a metabolic chart.
Maximal Fat Oxidation Rate (MFO)
Time frame: Through study completion, an average of 12 weeks
g/min (MFO) using a metabolic chart.
6 secondary outcomes
Fat mass
Time frame: Through study completion, an average of 12 weeks
Fat-free mass
Time frame: Through study completion, an average of 12 weeks
Physical activity (METs-min/wk)
Time frame: Through study completion, an average of 12 weeks
Dietary (g/kg of macronutrients)
Time frame: Through study completion, an average of 12 weeks
Mood state
Time frame: Through study completion, an average of 12 weeks
Adverse effects
Time frame: Through study completion, an average of 12 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 May 2026.
- Individual participant dataSharing planned: Yes
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Caffeine + Resistance exercise in people with Caffeine and Resistance Training, run by Alberto Pérez-López at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 6 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean velocity at different %1RM (time frame: Through study completion, an average of 12 weeks). The study lists 9 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 May 2026.