Anomia (Word-Finding Impairment)NCT06619756
Anomia Treatment Predictors
A study testing Phonomotor Treatment (PMT) and Phonological Components Analysis (PCA) in people with Anomia (Word-Finding Impairment) and Aphasia, run by State University of New York at Buffalo at 1 site in United States.
Trial summary
The goal of this clinical trial is to identify predictors of response to phonological-focused anomia treatment in people with aphasia. The main question it aims to answer is who responds to which type of anomia treatment. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Anomia (Word-Finding Impairment), Aphasia
- What is being tested?
- Phonomotor Treatment (PMT) and Phonological Components Analysis (PCA)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 2 participants
- Where
- 1 siteUnited States
- Study dates
- 18 Sep 2024to 1 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Chronic aphasia (6+ months)
- Anomia
- Sufficient auditory comprehension to follow task instructions
- Phonologic impairment
Who cannot join
- Progressive neurological illness or disease, including dementia
- Chronic medical illness that interferes with adherence to testing schedule
- Severe, uncorrected vision or hearing impairment that interferes with task completion
- Moderate-severe apraxia of speech or dysarthria that interferes with task completion
Trial locations and contacts
1 site in 1 country.
United States1 site
UB Audiology and Speech-Language Pathology Clinic
Buffalo, New York, 14214
About this study
Official title: Predictors of Phonological-focused Anomia Treatment
The goal of this clinical trial is to identify predictors of response to phonological-focused anomia treatment in people with aphasia. The main question it aims to answer is who responds to which type of anomia treatment. Researchers will compare Phonomotor Treatment and Phonological Components Analysis to see which treatment is more beneficial, and for whom. Participants will engage in both treatments over several months.
Read the detailed description
Participants will complete screening and characterization testing to determine eligibility for the study. Each treatment will be administered twice a week, for 10-15 sessions. Pre-treatment and post-treatment testing will also occur for each treatment. There will be a period of no treatment in between the first and second treatment blocks.
- Conditions
- Anomia (Word-Finding Impairment), Aphasia
- Being tested
- Phonomotor Treatment (PMT), Phonological Components Analysis (PCA)
- Keywords
- anomia treatment, aphasia treatment
- Medical subject headings
- Anomia, Aphasia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Phonomotor Treatment (PMT)Behavioural
Anomia treatment focuses on improving word-finding abilities. This intervention targets the phonology of words to improve word-finding.
Phonological Components Analysis (PCA)Behavioural
Anomia treatment focuses on improving word-finding abilities. This intervention targets the phonology of words to improve word-finding.
| Study group | Role | What they receive |
|---|---|---|
| PMT | Experimental | Phonomotor Treatment (PMT) will be administered. This treatment improves anomia by training the sound sequences of words. This is a multimodal treatment approach that includes listening, producing, visualizing, and describing sounds and sound sequences. The participant practices the sound sequence tasks with the clinician. Receives: Behavioral: Phonomotor Treatment (PMT) |
| PCA | Experimental | Phonological Components Analysis (PCA) will be administered. This treatment improves anomia by identifying phonological features of words. A picture is presented. The participant provides features of the picture name: the first sound of the word, the final sound of the word, the number of syllables of the word, another word that starts with the same sound, and another words that rhymes with the word. The participant attempts to produce the word independently and by repeating after the clinician. Receives: Behavioral: Phonological Components Analysis (PCA) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Naming of Trained Words
Picture naming of trained words
Measured: Pre-treatment and Immediately post-treatment
Secondary outcomes (3)
Naming of Untrained Words
Picture naming of untrained words
Measured: Pre-treatment and Immediately post-treatment
Standardized Assessment of Phonology in Aphasia (SAPA)
The SAPA assesses phonological processing abilities, including oral reading, rhyme judgments, minimal pair judgments, lexical decision, blending, and parsing.
Measured: Pre-treatment and Immediately post-treatment
Philadelphia Naming Test
The short-form of the Philadelphia Naming Test is a picture naming test of items not seen during treatment.
Measured: Pre-treatment and Immediately post-treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Oct 2024
- Study start18 Sep 2024
- Primary completion1 Oct 2025
- Study completion1 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Anomia (Word-Finding Impairment)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 2 participants (actual)
Sponsor and investigators
- Lead sponsor
- State University of New York at Buffalo
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nichol Castro, State University of New York at Buffalo
- Investigators
- Nichol Castro, PhD, Principal investigator, SUNY at Buffalo
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06619756
- Sponsor's protocol ID
- STUDY00008623
- Status last verified
- Nov 2025
- First submitted
- 27 Sep 2024
- Last updated
- 12 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Sample size is low increasing risk of identification of individuals.
Study at a glance
From the registry record, last updated by the sponsor on 12 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Predictors of Phonological-focused Anomia Treatment
- ClinicalTrials.gov ID
- NCT06619756
- Acronym / sponsor ID
- STUDY00008623
- Conditions
- Anomia (Word-Finding Impairment), Aphasia
- Keywords
- anomia treatment, aphasia treatment
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 2 participants (actual)
- Lead sponsor
- State University of New York at BuffaloUniversity, hospital or other
- Study start
- 18 Sep 2024 (actual)
- Primary completion
- 1 Oct 2025 (actual)
- Study completion
- 1 Oct 2025 (actual)
- First posted
- 1 Oct 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to identify predictors of response to phonological-focused anomia treatment in people with aphasia. The main question it aims to answer is who responds to which type of anomia treatment. Researchers will compare Phonomotor Treatment and Phonological Components Analysis to see which treatment is more beneficial, and for whom. Participants will engage in both treatments over several months.
Detailed description
Participants will complete screening and characterization testing to determine eligibility for the study. Each treatment will be administered twice a week, for 10-15 sessions. Pre-treatment and post-treatment testing will also occur for each treatment. There will be a period of no treatment in between the first and second treatment blocks.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| PMT | Experimental | Behavioral: Phonomotor Treatment (PMT)Phonomotor Treatment (PMT) will be administered. This treatment improves anomia by training the sound sequences of words. This is a multimodal treatment approach that includes listening, producing, visualizing, and describing sounds and sound sequences. The participant practices the sound sequence tasks with the clinician. |
| PCA | Experimental | Behavioral: Phonological Components Analysis (PCA)Phonological Components Analysis (PCA) will be administered. This treatment improves anomia by identifying phonological features of words. A picture is presented. The participant provides features of the picture name: the first sound of the word, the final sound of the word, the number of syllables of the word, another word that starts with the same sound, and another words that rhymes with the word. The participant attempts to produce the word independently and by repeating after the clinician. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Chronic aphasia (6+ months)
- Anomia
- Sufficient auditory comprehension to follow task instructions
- Phonologic impairment
Key exclusion criteria (4 listed)
- Progressive neurological illness or disease, including dementia
- Chronic medical illness that interferes with adherence to testing schedule
- Severe, uncorrected vision or hearing impairment that interferes with task completion
- Moderate-severe apraxia of speech or dysarthria that interferes with task completion
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Phonomotor Treatment (PMT)Anomia treatment focuses on improving word-finding abilities. This intervention targets the phonology of words to improve word-finding. | Behavioural | PMT |
| Phonological Components Analysis (PCA)Anomia treatment focuses on improving word-finding abilities. This intervention targets the phonology of words to improve word-finding. | Behavioural | PCA |
Primary outcome
Naming of Trained Words
Time frame: Pre-treatment and Immediately post-treatment
Picture naming of trained words
3 secondary outcomes
Naming of Untrained Words
Time frame: Pre-treatment and Immediately post-treatment
Standardized Assessment of Phonology in Aphasia (SAPA)
Time frame: Pre-treatment and Immediately post-treatment
Philadelphia Naming Test
Time frame: Pre-treatment and Immediately post-treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Nov 2025.
- Individual participant dataSharing planned: No. Sample size is low increasing risk of identification of individuals.
Related trials for Anomia (Word-Finding Impairment)
Enrolling by invitation
Criterion-learning Naming Treatment For Addressing Comprehension Deficits in Aphasia
Aphasia
Not yet recruiting
Effects of Semantic Context on Criterion-learning Naming Treatment in Aphasia
Aphasia
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Nichol Castro, PhD principal investigator
SUNY at Buffalo
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Phonomotor Treatment (PMT) and Phonological Components Analysis (PCA) in people with Anomia (Word-Finding Impairment) and Aphasia, run by State University of New York at Buffalo at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Naming of Trained Words (time frame: Pre-treatment and Immediately post-treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Nov 2025.