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DengueNCT06648603

Citizen Action for Sustainable Dengue Control in Sub-Saharan Africa

A study testing Community-based larval source management, Enhanced Aedes adults trapping (BG-GAT) and Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT) in people with Dengue, run by Swiss Tropical & Public Health Institute at 1 site in Côte d’Ivoire.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This project focuses on addressing arboviral outbreaks in Ivory Coast by involving local communities in the sustainable control of Aedes mosquitoes, utilizing scientific advice and environmental interventions. Read more about this study

Who is it for?
Any ageHealthy volunteers can take part
Conditions the study is for
Dengue
What is being tested?
Community-based larval source management, Enhanced Aedes adults trapping (BG-GAT) and Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT)
Could I receive a placebo?
No, everyone receives an active treatment
How many people
40 participants
Where
1 siteCôte d’Ivoire
Study dates
15 Jul 2023to 30 Sep 2024
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages Any age
  • All sexes
  • Healthy volunteers accepted
  • Child, Adult, Older adult

Who may be able to join

  • Geographical location: households must be located within the designated clusters in the two districts involved in the trial.
  • Participation in cluster arms: households must belong to a cluster that is assigned to one of the four arms (1. Control, 2. Community-based larval source management, 3 Enhanced Aedes adults trapping (BG-GAT), 4. Enhanced Aedes adults trapping (BG-GAT) + Community-based larval source management).
  • Willingness to participate: households agreed to allow researchers to place mosquito traps and conduct larval and adult mosquito surveys.
  • Socio-Environmental Data: households must agree and provide consent to participate to the socio-environmental questionnaire.

Who cannot join

  • Outside of trial clusters: households located outside the designated clusters in the two districts were excluded.
  • Refusal to participate: households that do not consent to mosquito trap placement or surveys
  • Inaccessibility: households that are not accessible for regular visits or data collection (e.g., due to relocation or difficult terrain).

Trial locations and contacts

1 site in 1 country.

Côte d’Ivoire1 site

  • Centre Suisse de Recherches Scientifiques en Côte d'Ivoire

    Abidjan

Other trials in Côte d’Ivoire

About this study

This project focuses on addressing arboviral outbreaks in Ivory Coast by involving local communities in the sustainable control of Aedes mosquitoes, utilizing scientific advice and environmental interventions. It will evaluate the impact of a participatory strategy on decreasing mosquito populations and the risk of virus transmission, aiming to provide insights for policy development on disease prevention.

Read the detailed description

This project targets the growing threat of Aedes mosquito-borne diseases such as dengue in Africa, focusing on the Anono and Gbagba communities in Abidjan, Ivory Coast, by transitioning from traditional control approaches to a community-driven strategy. It focuses on educating and involving communities in the design of sustainable mosquito management measures, such as breeding site eradication and adult mosquito capturing, with scientific experts guiding the efforts. The approach will entail conducting sociocultural surveys and interactive workshops while also encouraging local participation and multi-sectoral collaboration. A randomized controlled trial (RCT) will test this effectiveness of this novel integrated community-based participatory intervention approach in reducing the transmission of Aedes mosquito and other arboviruses. This effort seeks to develop a scalable model for arboviral disease control, promote community resilience, and inform policy recommendations for better public health outcomes in resource-constrained urban settings.

Conditions
Dengue
Being tested
Community-based larval source management, Enhanced Aedes adults trapping (BG-GAT), Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT)
Keywords
Aedes Aegypti, Vector control, Community based intervention, Participatory research, Dengue, Africa, Ivory Coast
Medical subject headings
Dengue

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Community-based larval source managementBehavioural

    This project will foster active engagement with community stakeholders, including healthcare workers, community leaders, and other key informants, through participatory meetings aimed at co-creating and developing larval source reduction measures tailored to community's needs. This method emphasizes a participatory framework, ensuring that interventions are both community-informed and culturally relevant.

  • Enhanced Aedes adults trapping (BG-GAT)Device

    Furthermore, the project intends to determine whether the addition of cost-effective, gravid female mosquito-targeting traps, specifically two Biogents Gravid Aedes Traps (BG-GAT) per household, can improve the overall success of these community-based intervention.

  • Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT)Combination product

    The community-based interventions and the BG-GAT deployment will be evaluated in combination to assess their individual and synergistic effects on vector control. This dual strategy combines local participation and practical, evidence-based solutions to address mosquito-borne illness transmission.

Study groups in NCT06648603
Study groupRoleWhat they receive
ControlNo interventionNon-intervened control arm: no community-based larval source management (LSM) or BG-GAT intervention
Community-based larval source managementExperimentalLSM intervention arm: Aedes larval source reduction carried out by trained and supervised local community members
Receives: Behavioral: Community-based larval source management
Enhanced Aedes adults trapping (BG-GAT)ExperimentalBG-GAT intervention arm: Aedes adult mass trapping by BG-GAT set up and maintained by trained and supervised local community members
Receives: Device: Enhanced Aedes adults trapping (BG-GAT)
Community-based larval source management + Enhanced Aedes adults trapping (BG-GAT)ExperimentalCombined LSM and BG-GAT intervention arm: simultaneous Aedes larval source reduction and Aedes adult mass trapping by BG-GAT carried out by trained and supervised local community members
Receives: Combination Product: Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT)

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Aedes aegypti mean number per trap per day

    Biting rate is the mean number of Aedes females per trap and per day. The proportion of unfed, fed, half-gravid and gravid females will be estimated.

    Measured: Continuously during months 1-4 (baseline) and months 5-17 (trial)

Secondary outcomes (7)

  1. House index

    House index: proportion of houses with at least one larva

    Measured: Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)

  2. Pupal indices: pupae per person index, pupa index and pupae per hectare index

    Pupae per person index: number of pupae per person Pupa index: number of pupae per house Pupae per hectare index: number of pupae per ha

    Measured: Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)

  3. Adults: parity rate

    The parity rate (PR) (proposition of parous females) will be calculated to estimate vector longevity.

    Measured: Continuously during months 1-4 (baseline) and months 5-17 (trial)

  4. Knowledge, attitudes, and practices on Dengue prevention among the population of Cocody-Bingerville

    A Knowledge, Attitudes, and Practices (KAP) study will be conducted to assess the communities' understanding, attitudes, practices, and beliefs related to dengue. This will be done using a structured questionnaire developed specifically for this trial. The questionnaire comprises both multiple-choice and open-ended questions, allowing for a comprehensive assessment of: 1) Knowledge: Understanding of dengue transmission, symptoms, and prevention, 2) Attitudes: Perceptions of dengue risk and confidence in prevention methods, 3) Practices: Reported behaviors to prevent dengue, such as mosquito control measures. This structured tool will be used at both baseline and endline to measure changes and assess the effectiveness of the intervention."

    Measured: Before (month 1) the start of the trial and at the end of the trial (month 12)

  5. Mapping and describe Aedes aegypti breeding sites, focusing on their geographic and ecological characteristics. This mapping will be used to enhance targeted larval control efforts in these areas.

    The geographic survey will collect household and environmental data, including demographic details, public space quality, water provision, sanitation access, and waste management practices. It will map housing conditions, examining building types, construction materials, and key features like water storage and solid waste management. The survey will also assess local built environments to inform interventions for improving living conditions and controlling mosquito breeding sites.

    Measured: Before (month 1) the start of the trial and at the end of the trial (month 12)

  6. Container index

    Proportion of positive containers

    Measured: before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)

  7. Breteau index

    Number of positive containers per 100 houses

    Measured: Before (month 1), twice during (month 4, 8) and once at the end of the trial (month 12)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted18 Oct 2024
  2. Study start15 Jul 2023
  3. Primary completion31 Jul 2024
  4. Study completion30 Sep 2024

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Factorial
Model description
Cluster randomized trial with 2x2 factorial design - 40 clusters, 10 clusters per study arm (4 arms)
Masking
Single blind
Who is masked
Outcomes assessor
Enrolment
40 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06648603
Sponsor's protocol ID
C21047
Status last verified
Dec 2023
First submitted
1 Jul 2024
Last updated
22 Oct 2024
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing Community-based larval source management, Enhanced Aedes adults trapping (BG-GAT) and Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT) in people with Dengue, run by Swiss Tropical & Public Health Institute at 1 site in Côte d’Ivoire.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 22 Oct 2024. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Côte d’Ivoire. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Aedes aegypti mean number per trap per day (time frame: Continuously during months 1-4 (baseline) and months 5-17 (trial)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06648603.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Oct 2024.

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