Dentin SensitivityNCT06651827
Clinical Evaluation of the Effectiveness of the Er:Cr:YSGG Laser in Reducing Dentin Sensitivity
A study testing Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatment in people with Dentin Sensitivity, run by Can Tho University of Medicine and Pharmacy at 1 site in Vietnam.
Trial summary
This study aims to evaluate the clinical effectiveness of the Er:Cr laser in reducing dentin hypersensitivity (DH), a common dental condition characterized by sharp pain in response to thermal, mechanical, chemical, or osmotic stimuli. Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Dentin Sensitivity
- What is being tested?
- Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatment
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteVietnam
- Study dates
- 15 Jun 2023to 15 Jun 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patients >18 years old
- Express a desire for treatment for their dentin hypersensitivity
- Only sensitive teeth without indications for restorative procedures were considered eligible
- Informed consent was obtained from all participants
Who cannot join
- Patients with underlying systemic conditions or those taking medications that could affect the study outcomes, such as analgesics, anti-inflammatory drugs, or sedatives within 72 hours prior to enrollment
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Clinical Evaluation of the Effectiveness of the Er:Cr:YSGG Laser in Reducing Dentin Sensitivity: A Cross-Sectional Study
This study aims to evaluate the clinical effectiveness of the Er:Cr laser in reducing dentin hypersensitivity (DH), a common dental condition characterized by sharp pain in response to thermal, mechanical, chemical, or osmotic stimuli.
Read the detailed description
Dentin Hypersensitivity is one of the common and uncomfortable clinical issues for patients, characterized by sharp pain when the dentinal tubules are stimulated by thermal, mechanical, chemical, or osmotic agents. This sensitivity often appears in the canine and premolar areas, particularly in the cervical third of the tooth surface. The main cause of DH is dentin exposure, which occurs when the enamel or cementum covering the root surface is lost, usually due to factors such as improper brushing techniques, erosion-induced abrasion, or harmful habits like bruxism. Dentin exposure can also occur due to periodontal disease, gingival recession, or periodontal interventions, such as root planing. One of the most widely accepted theories explaining the mechanism of DH is the hydrodynamic theory proposed by Brännström in 1984. According to this theory, when the dentinal tubules are exposed, pressure changes in the surrounding tissue cause fluid movement within the tubules, stimulating mechanoreceptors in the pulpal nerves, resulting in sharp pain. The diagnosis and treatment of DH are complex due to its multifactorial nature, requiring thorough examination to rule out other oral pathologies and ensure the health of the pulp and gingiva.
Various treatment methods for DH have been proposed in the literature, ranging from modifying brushing habits, guiding patients on diet, occlusal adjustment, to using desensitizing agents such as potassium nitrate, potassium oxalate, and calcium phosphate. Some approaches also involve using bonding systems, adhesive materials, or even lasers to occlude the dentinal tubules and reduce sensitivity. In recent years, the use of dental lasers as an alternative treatment for DH has gained significant attention from researchers. Commonly used lasers include high-power lasers such as Nd:YAG, Er:YAG, Er,Cr:YSGG… as well as low-power lasers in photobiomodulation therapy. The Er,Cr:YSGG laser is of particular interest due to their operation at a wavelength of 2780 nm, which is highly absorbed by water. This allows for the evaporation of fluid in the dentinal tubules, leaving insoluble salts that help seal the tubules and reduce sensitivity symptoms. According to a study by Yilmaz et al. (2011), the Er,Cr:YSGG laser not only provides rapid relief but also maintains its effect for up to three months without causing significant side effects.
Due to the subjective nature of DH, assessing the level of sensitivity is often challenging. However, measurement tools such as the Visual Analog Scale VAS or Yeaple pressure probe have been used in studies to provide more reliable measurement results. The objective of this study is to evaluate the effectiveness of the Er,Cr:YSGG laser in the treatment of DH.
- Conditions
- Dentin Sensitivity
- Being tested
- Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatment
- Keywords
- Dentin hypersensitivity, Er,Cr:YSSG laser, Yeaple Probe, Visual Analog Scale
- Medical subject headings
- Dentin Sensitivity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatmentDiagnostic test
Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatment. The effectiveness of the treatment was assessed at baseline, 30 minutes, 1 week, and 1 month post-treatment using the Visual Analog Scale (VAS) and Yeaple Probe scores.
| Study group | Role | What they receive |
|---|---|---|
| Dentin sensitivity was measured before and after treatment | Experimental | Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatment Receives: Diagnostic Test: Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatment |
What is being measured
The primary outcome is the main question the study is designed to answer.
The objective of this study is to evaluate the effectiveness of the Er,Cr:YSGG laser in the treatment of Dentin Sensitivity
The objective of this study is to evaluate the effectiveness of Dentin Sensitivity using the Yeaple Probe
Measured: Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before of the Er,Cr:YSGG laser in the and after treatment.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Oct 2024
- Study start15 Jun 2023
- Primary completion1 Jun 2024
- Study completion15 Jun 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Dentin SensitivityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- Can Tho University of Medicine and Pharmacy
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Quang Xuan Vo, Principal investigator, Can Tho University of Medicine and Pharmacy
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06651827
- Sponsor's protocol ID
- Vo Xuan Quang
- Status last verified
- Jun 2023
- First submitted
- 19 Oct 2024
- Last updated
- 30 Oct 2024
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Haneet RK, Vandana LK. Prevalence of dentinal hypersensitivity and study of associated factors: a cross-sectional study based on the general dental population of Davangere, Karnataka, India. Int Dent J. 2016 Feb;66(1):49-57. doi: 10.1111/idj.12206. Epub 2015 Nov 19.
PubMed 26582076Yilmaz N, Baltaci E, Baygin O, Tuzuner T, Ozkaya S, Canakci A. Effect of the usage of Er,Cr:YSGG laser with and without different remineralization agents on the enamel erosion of primary teeth. Lasers Med Sci. 2020 Sep;35(7):1607-1620. doi: 10.1007/s10103-020-03015-0. Epub 2020 May 29.
PubMed 32472426
Study at a glance
From the registry record, last updated by the sponsor on 30 Oct 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Evaluation of the Effectiveness of the Er:Cr:YSGG Laser in Reducing Dentin Sensitivity: A Cross-Sectional Study
- ClinicalTrials.gov ID
- NCT06651827
- Acronym / sponsor ID
- Vo Xuan Quang
- Conditions
- Dentin Sensitivity
- Keywords
- Dentin hypersensitivity, Er,Cr:YSSG laser, Yeaple Probe, Visual Analog Scale
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- Can Tho University of Medicine and PharmacyUniversity, hospital or other
- Study start
- 15 Jun 2023 (actual)
- Primary completion
- 1 Jun 2024 (actual)
- Study completion
- 15 Jun 2024 (actual)
- First posted
- 22 Oct 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to evaluate the clinical effectiveness of the Er:Cr laser in reducing dentin hypersensitivity (DH), a common dental condition characterized by sharp pain in response to thermal, mechanical, chemical, or osmotic stimuli.
Detailed description
Dentin Hypersensitivity is one of the common and uncomfortable clinical issues for patients, characterized by sharp pain when the dentinal tubules are stimulated by thermal, mechanical, chemical, or osmotic agents. This sensitivity often appears in the canine and premolar areas, particularly in the cervical third of the tooth surface. The main cause of DH is dentin exposure, which occurs when the enamel or cementum covering the root surface is lost, usually due to factors such as improper brushing techniques, erosion-induced abrasion, or harmful habits like bruxism. Dentin exposure can also occur due to periodontal disease, gingival recession, or periodontal interventions, such as root planing. One of the most widely accepted theories explaining the mechanism of DH is the hydrodynamic theory proposed by Brännström in 1984. According to this theory, when the dentinal tubules are exposed, pressure changes in the surrounding tissue cause fluid movement within the tubules, stimulating mechanoreceptors in the pulpal nerves, resulting in sharp pain. The diagnosis and treatment of DH are complex due to its multifactorial nature, requiring thorough examination to rule out other oral pathologies and ensure the health of the pulp and gingiva.
Various treatment methods for DH have been proposed in the literature, ranging from modifying brushing habits, guiding patients on diet, occlusal adjustment, to using desensitizing agents such as potassium nitrate, potassium oxalate, and calcium phosphate. Some approaches also involve using bonding systems, adhesive materials, or even lasers to occlude the dentinal tubules and reduce sensitivity. In recent years, the use of dental lasers as an alternative treatment for DH has gained significant attention from researchers. Commonly used lasers include high-power lasers such as Nd:YAG, Er:YAG, Er,Cr:YSGG… as well as low-power lasers in photobiomodulation therapy. The Er,Cr:YSGG laser is of particular interest due to their operation at a wavelength of 2780 nm, which is highly absorbed by water. This allows for the evaporation of fluid in the dentinal tubules, leaving insoluble salts that help seal the tubules and reduce sensitivity symptoms. According to a study by Yilmaz et al. (2011), the Er,Cr:YSGG laser not only provides rapid relief but also maintains its effect for up to three months without causing significant side effects.
Due to the subjective nature of DH, assessing the level of sensitivity is often challenging. However, measurement tools such as the Visual Analog Scale VAS or Yeaple pressure probe have been used in studies to provide more reliable measurement results. The objective of this study is to evaluate the effectiveness of the Er,Cr:YSGG laser in the treatment of DH.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Dentin sensitivity was measured before and after treatment | Experimental | Diagnostic Test: Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatmentDentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatment |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Patients >18 years old
- Express a desire for treatment for their dentin hypersensitivity
- Only sensitive teeth without indications for restorative procedures were considered eligible
- Informed consent was obtained from all participants
Key exclusion criteria (1 listed)
- Patients with underlying systemic conditions or those taking medications that could affect the study outcomes, such as analgesics, anti-inflammatory drugs, or sedatives within 72 hours prior to enrollment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatmentDentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatment. The effectiveness of the treatment was assessed at baseline, 30 minutes, 1 week, and 1 month post-treatment using the Visual Analog Scale (VAS) and Yeaple Probe scores. | Diagnostic test | Dentin sensitivity was measured before and after treatment |
Primary outcome
The objective of this study is to evaluate the effectiveness of the Er,Cr:YSGG laser in the treatment of Dentin Sensitivity
Time frame: Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before of the Er,Cr:YSGG laser in the and after treatment.
The objective of this study is to evaluate the effectiveness of Dentin Sensitivity using the Yeaple Probe
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Oct 2024.
- Results publication: PubMed 26582076Haneet RK, Vandana LK. Prevalence of dentinal hypersensitivity and study of associated factors: a cross-sectional study based on the general dental population of Davangere, Karnataka, India. Int Dent J. 2016 Feb;66(1):49-57. doi: 10.1111/idj.12206. Epub 2015 Nov 19.
- Results publication: PubMed 32472426Yilmaz N, Baltaci E, Baygin O, Tuzuner T, Ozkaya S, Canakci A. Effect of the usage of Er,Cr:YSGG laser with and without different remineralization agents on the enamel erosion of primary teeth. Lasers Med Sci. 2020 Sep;35(7):1607-1620. doi: 10.1007/s10103-020-03015-0. Epub 2020 May 29.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Quang Xuan Vo principal investigator
Can Tho University of Medicine and Pharmacy
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before and after treatment in people with Dentin Sensitivity, run by Can Tho University of Medicine and Pharmacy at 1 site in Vietnam.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Oct 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Vietnam. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The objective of this study is to evaluate the effectiveness of the Er,Cr:YSGG laser in the treatment of Dentin Sensitivity (time frame: Dentin sensitivity was measured using the Yeaple Probe and air stimulation tests before of the Er,Cr:YSGG laser in the and after treatment.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06651827, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Oct 2024.