Cairo UniversityNCT06653543
Effect of Mulligan on Cervical Radiculopathy
A study testing Mulligan mobilization with arm movement and conventional therapy of cevical radiculopathy in people with Cairo University, run by Cairo University at 1 site in Egypt.
Trial summary
The goal of this clinical trial is to investigate the effect of Mulligan mobilization with arm movement on nerve conduction velocity in patients with unilateral cervical radiculopathy. The main questions it aims to answer are : 1. Read more about this study
- Who is it for?
- Ages 20 to 60 years
- Conditions the study is for
- Cairo University
- What is being tested?
- Mulligan mobilization with arm movement and conventional therapy of cevical radiculopathy
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 40 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jan 2025to 10 Aug 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- • diagnosed with cervical radiculopathy .
- Age group between 20-60 years
- Unilateral radiating pain through the course of median nerve .
- Subject having positive upper limb tension test (ULTT 1)
- either gender male and female
- Subjects who can understand the instructions and are willing to participate in the study.
Who cannot join
- • History of trauma, dislocation and subluxation of upper extremity
- Rheumatoid Arthritis
- Malignancy
- Spinal canal stenosis .
- Cervical instability/Spondylolisthesis
- VBI (Vertebral-Basillar Insufficiency)
Show all 12Show fewer
- Referred pain in patients with cardiac ischemia
- Cervical or thoracic spine surgeries .
- systemic causes like diabetic neuropathy .
- recent fracture or surgery in and around the shoulder .
- carpal tunnel syndrome .
- thoracic outlet syndrome .
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Kafr El-Sheikh university
Kafr El-Sheikh Governorate, Kafr el-Sheikh Governorate, 33516
university, 047 3109590, tawfiq.algazar_a010@pt.kfs.edu.eg
About this study
Official title: Effect of Mulligan Mobilization With Arm Movement on Nerve Conduction Velocity in Patients With Unilateral Cervical Radiculopathy
The goal of this clinical trial is to investigate the effect of Mulligan mobilization with arm movement on nerve conduction velocity in patients with unilateral cervical radiculopathy. The main questions it aims to answer are :
- Is there a statistical significant effect of mobilization with arm movement on NCV velocity in treatment of cervical radiculopathy ?
- Is there a statistical significant effect of mobilization with arm movement on pain level in treatment of cervical radiculopathy ?
- Is there a statistical significant effect of mobilization with arm movement on cervical ROM in treatment of cervical radiculopathy ?
- Is there a statistical significant effect of mobilization with arm movement on neck disability level in treatment of cervical radiculopathy ?
The course of treatment involves 6 sessions over the course of 3 weeks participants will be divided into 2 groups : Control group : recieves only Conventional treatment Experimental group : recieves Conventional treatment and Mulligan mobilization with arm movement .
Read the detailed description
the aim of our study is to examine the effect of Mulligan mobilization with arm movement on cervical radiculopathy using nerve conduction studies , in addition to the original measures of previous studies (pain level, cervical ROM and neck disability scale) .
Delimitations :
Inclusion Criteria
Individuals will be enrolled into the study if they are :
- diagnosed with cervical radiculopathy .
- Age group between 20-60 years
- Unilateral radiating pain through the course of median nerve .
- Subject having positive upper limb tension test (ULTT 1)
- either gender male and female
- Subjects who can understand the instructions and are willing to participate in the study.
Exclusion Criteria .
- History of trauma, dislocation and subluxation of upper extremity
- Rheumatoid Arthritis
- Malignancy
- Spinal canal stenosis .
- Cervical instability/Spondylolisthesis
- VBI (Vertebral-Basillar Insufficiency)
- Referred pain in patients with cardiac ischemia
- Cervical or thoracic spine surgeries
- systemic causes like diabetic neuropathy.
- recent fracture or surgery in and around the shoulder
- carpal tunnel syndrome .
- thoracic outlet syndrome .
Outcome measure would include:
- The primary outcome measure will be NCV velocity, for the median nerve (latency, amplitude, Duration , F-wave and nerve conduction velocity of motor nerve action potentials and sensory nerve action potentials (SNAPs)) .
- Secondary outcome measures will include:
- Pain intensity, assessed using the Visual Analog Scale (VAS) .
- Functional disability, evaluated using the Neck Disability Index (NDI) .
- Cervical range of motion, measured using a CROM goniometer to assess flexion, extension, lateral flexion, and rotation.
- The course of treatment involves 6 sessions over the course of 3 weeks .
- pre-treatment for both groups :
- affected nerve conduction velocity will be measured using nerve conduction study .
- neck disability level will be measured using neck disability index .
- cervical ROM measurement will be taken in all directions using CROM goniometer .
- pain will be assessed using Visual analog scale . participants will be divided into 2 groups :
Group A- Control group:
During each session : only Conventional treatment will be provided , includes : hot pack for 10 minutes, active ranges of motion (AROMs) with 3 sets of 10 repetitions and isometrics for each movement repeated 20 times with the hold of 6 to 10 seconds in each repetition.
Group B- Experimental group- Mulligan mobilization group:
- During each session :
- Conventional treatment will be provided .
- Mulligan mobilization will be applied in the form of : sustained passive accessory joint mobilization to a specific spinal vertebra level while simultaneously guiding the patient through an active, pain-free movement pattern involving the affected limb :
- Patient position : Sitting upright on chair
- Therapist position : Standing behind the patient .
- Hand placement : Approach the desired level of spinous process from medial aspect of the thumb of one hand, which may be reinforced by the index finger of the other hand.
- Mobilization Pure transverse glide is performed from affected to unaffected side. While the glide is sustained, patient performs the offending movements (flexion/abduction/horizontal adduction/horizontal abduction)
- Conditions
- Cairo University
- Being tested
- Mulligan mobilization with arm movement, conventional therapy of cevical radiculopathy
- Keywords
- mobilization, Mulligan, cervical, radiculopathy
- Medical subject headings
- Radiculopathy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mulligan mobilization with arm movementOther
mulligan mobilization applied on cervical spine with arm movement
conventional therapy of cevical radiculopathyOther
hot pack for 10 minutes, active ranges of motion (AROMs) with 3 sets of 10 repetitions and isometrics for each movement repeated 20 times with the hold of 6 to 10 seconds in each repetition
| Study group | Role | What they receive |
|---|---|---|
| mulligan group | Experimental | 20 participants recieving conventional therapy in addition to mulligan mobilization with arm movement Receives: Other: Mulligan mobilization with arm movement; Other: conventional therapy of cevical radiculopathy |
| control group | Sham comparator | control group that revieves only the conventional therapy Receives: Other: conventional therapy of cevical radiculopathy |
What is being measured
The primary outcome is the main question the study is designed to answer.
median nerve conduction study
using nerve conduction studies to measure the median nerve (latency, amplitude, Duration , F-wave and nerve conduction velocity of motor nerve action potentials and sensory nerve action potentials ) .
Measured: 2 weeks
Secondary outcomes (3)
cervical range of motion
using cervical CROM device to measure the cervical ROM in all 3 planes
Measured: 2 weeks
pain
using visual analogue scale for the pain intensity .. where no pain or discomfort(0) , while the severest pain (10) .. the more the pain , the more the points on the scale
Measured: 2 weeks
neck disability level
using neck disability index questionnaire consists of 10 items, where each item is scored on a scale of 0 to 5, with 0 indicating no disability and 5 indicating complete disability
- The total score ranges from 0 to 50.
- Higher scores indicate greater disability and impairment, while lower scores indicate less disability.
Measured: 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Oct 2024
- Study start1 Jan 2025
- Primary completion30 Mar 2025
- Study completion10 Aug 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cairo UniversityStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tawfik Mohamed Tawfik Elgazar, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06653543
- Sponsor's protocol ID
- P.T.REC/012/005110
- Status last verified
- Apr 2025
- First submitted
- 1 Sep 2024
- Last updated
- 27 Apr 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Mulligan Mobilization With Arm Movement on Nerve Conduction Velocity in Patients With Unilateral Cervical Radiculopathy
- ClinicalTrials.gov ID
- NCT06653543
- Acronym / sponsor ID
- P.T.REC/012/005110
- Conditions
- Cairo University
- Keywords
- mobilization, Mulligan, cervical, radiculopathy
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Jan 2025 (actual)
- Primary completion
- 30 Mar 2025 (actual)
- Study completion
- 10 Aug 2025 (estimated)
- First posted
- 22 Oct 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to investigate the effect of Mulligan mobilization with arm movement on nerve conduction velocity in patients with unilateral cervical radiculopathy. The main questions it aims to answer are :
- Is there a statistical significant effect of mobilization with arm movement on NCV velocity in treatment of cervical radiculopathy ?
- Is there a statistical significant effect of mobilization with arm movement on pain level in treatment of cervical radiculopathy ?
- Is there a statistical significant effect of mobilization with arm movement on cervical ROM in treatment of cervical radiculopathy ?
- Is there a statistical significant effect of mobilization with arm movement on neck disability level in treatment of cervical radiculopathy ?
The course of treatment involves 6 sessions over the course of 3 weeks participants will be divided into 2 groups : Control group : recieves only Conventional treatment Experimental group : recieves Conventional treatment and Mulligan mobilization with arm movement .
Detailed description
the aim of our study is to examine the effect of Mulligan mobilization with arm movement on cervical radiculopathy using nerve conduction studies , in addition to the original measures of previous studies (pain level, cervical ROM and neck disability scale) .
Delimitations :
Inclusion Criteria
Individuals will be enrolled into the study if they are :
- diagnosed with cervical radiculopathy .
- Age group between 20-60 years
- Unilateral radiating pain through the course of median nerve .
- Subject having positive upper limb tension test (ULTT 1)
- either gender male and female
- Subjects who can understand the instructions and are willing to participate in the study.
Exclusion Criteria .
- History of trauma, dislocation and subluxation of upper extremity
- Rheumatoid Arthritis
- Malignancy
- Spinal canal stenosis .
- Cervical instability/Spondylolisthesis
- VBI (Vertebral-Basillar Insufficiency)
- Referred pain in patients with cardiac ischemia
- Cervical or thoracic spine surgeries
- systemic causes like diabetic neuropathy.
- recent fracture or surgery in and around the shoulder
- carpal tunnel syndrome .
- thoracic outlet syndrome .
Outcome measure would include:
- The primary outcome measure will be NCV velocity, for the median nerve (latency, amplitude, Duration , F-wave and nerve conduction velocity of motor nerve action potentials and sensory nerve action potentials (SNAPs)) .
- Secondary outcome measures will include:
- Pain intensity, assessed using the Visual Analog Scale (VAS) .
- Functional disability, evaluated using the Neck Disability Index (NDI) .
- Cervical range of motion, measured using a CROM goniometer to assess flexion, extension, lateral flexion, and rotation.
- The course of treatment involves 6 sessions over the course of 3 weeks .
- pre-treatment for both groups :
- affected nerve conduction velocity will be measured using nerve conduction study .
- neck disability level will be measured using neck disability index .
- cervical ROM measurement will be taken in all directions using CROM goniometer .
- pain will be assessed using Visual analog scale . participants will be divided into 2 groups :
Group A- Control group:
During each session : only Conventional treatment will be provided , includes : hot pack for 10 minutes, active ranges of motion (AROMs) with 3 sets of 10 repetitions and isometrics for each movement repeated 20 times with the hold of 6 to 10 seconds in each repetition.
Group B- Experimental group- Mulligan mobilization group:
- During each session :
- Conventional treatment will be provided .
- Mulligan mobilization will be applied in the form of : sustained passive accessory joint mobilization to a specific spinal vertebra level while simultaneously guiding the patient through an active, pain-free movement pattern involving the affected limb :
- Patient position : Sitting upright on chair
- Therapist position : Standing behind the patient .
- Hand placement : Approach the desired level of spinous process from medial aspect of the thumb of one hand, which may be reinforced by the index finger of the other hand.
- Mobilization Pure transverse glide is performed from affected to unaffected side. While the glide is sustained, patient performs the offending movements (flexion/abduction/horizontal adduction/horizontal abduction)
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| mulligan group | Experimental | Other: Mulligan mobilization with arm movement, Other: conventional therapy of cevical radiculopathy20 participants recieving conventional therapy in addition to mulligan mobilization with arm movement |
| control group | Sham comparator | Other: conventional therapy of cevical radiculopathycontrol group that revieves only the conventional therapy |
Who may qualify
- Ages
- 20 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- • diagnosed with cervical radiculopathy .
Key exclusion criteria (12 listed)
- • History of trauma, dislocation and subluxation of upper extremity
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mulligan mobilization with arm movementmulligan mobilization applied on cervical spine with arm movement | Other | mulligan group |
| conventional therapy of cevical radiculopathyhot pack for 10 minutes, active ranges of motion (AROMs) with 3 sets of 10 repetitions and isometrics for each movement repeated 20 times with the hold of 6 to 10 seconds in each repetition | Other | control group, mulligan group |
Primary outcome
median nerve conduction study
Time frame: 2 weeks
using nerve conduction studies to measure the median nerve (latency, amplitude, Duration , F-wave and nerve conduction velocity of motor nerve action potentials and sensory nerve action potentials ) .
3 secondary outcomes
cervical range of motion
Time frame: 2 weeks
pain
Time frame: 2 weeks
neck disability level
Time frame: 2 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Apr 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mulligan mobilization with arm movement and conventional therapy of cevical radiculopathy in people with Cairo University, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Elgazar (201013863820, tawfiq.algazar_a010@pt.kfs.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
median nerve conduction study (time frame: 2 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Apr 2025.