Chronic Ankle Instability,CANCT06663371
The Impact of IntegBasic Physical Fitness Rated Neuromuscular Training Intervention on the of Military Personnel
A study testing Basic Physical Fitness and Traditional Physical Training in people with Chronic Ankle Instability,CA and Basic Physical Fitness, run by Yang Liu at 1 site in China.
Trial summary
Objective: The study aims to evaluate the efficacy of an 8-week integrated neuromuscular training intervention on the fundamental physical fitness parameters of military personnel, encompassing strength, velocity, agility, and equilibrium. Read more about this study
- Who is it for?
- Ages 18 to 24 years
- Conditions the study is for
- Chronic Ankle Instability,CA, Basic Physical Fitness
- What is being tested?
- Basic Physical Fitness and Traditional Physical Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 24 participants
- Where
- 1 siteChina
- Study dates
- 8 Nov 2024to 17 Apr 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 24 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Age between 18-24 years old
- Students with corresponding military status
- Meeting the diagnostic criteria for functional movement screen assessment
- No history of psychological or psychiatric disorders, and not participating in other physical training during the experimental period
- Capable of cooperating to complete the corresponding training and testing, and will not withdraw from the experiment without cause
Who cannot join
- Major sports injuries within the past 2 years, including fractures, ligament tears, muscle or tendon ruptures, and recurrent dislocations of joints
- Patients with cardiovascular and cerebrovascular diseases and related internal organ conditions
- Failure to pass the functional movement screen test
- Individuals with injuries or discomfort in other areas
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Impact of Integrated Neuromuscular Training Intervention on the Basic Physical Fitness of Military Personnel
Objective: The study aims to evaluate the efficacy of an 8-week integrated neuromuscular training intervention on the fundamental physical fitness parameters of military personnel, encompassing strength, velocity, agility, and equilibrium.
Methodology: The research randomly allocated 20 military students from the National University of Defense Technology into two cohorts, utilizing an experimental methodology with longitudinal assessments at the onset, midpoint, and conclusion of the intervention to quantitatively assess the influence of the integrated neuromuscular training on velocity and agility. Participants in both the experimental and control groups were evaluated one week prior to the intervention, at the fourth week, and one week post-intervention. Statistical analysis involved a two-factor repeated measures ANOVA to compare measures across the three time points, while paired-sample t-tests were applied for pre-post comparisons. The experimental group engaged in an 8-week integrated neuromuscular training regimen, consisting of three 90-minute sessions per week, culminating in a total of 24 sessions. Concurrently, the control group adhered to a conventional physical training schedule, also structured around three 90-minute sessions per week, over the same 24-session period, thereby ensuring parity in total training duration and frequency between the experimental and control groups.
- Being tested
- Basic Physical Fitness, Traditional Physical Training
- Keywords
- Integrated Neuromuscular Training, Military Population, Basic Physical Fitness
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Basic Physical FitnessBehavioural
Also called Speed, Strength, Balance, Agility
The single module training paradigm followed a circuit-style format, with each training module consisting of 6 to 8 distinct exercise movements. Taking the INT training intervention on Mondays as an example, the training protocol involved completing one major module (e.g., plyometric exercises) before transitioning to another module (e.g., core stability exercises). Specific exercise methods, such as box jumps, were performed until all sets were completed before moving on to the next exercise (e.g., continuous depth jumps).
Traditional Physical TrainingBehavioural
Also called Speed, Strength
In the fundamental strength training, a circuit training modality is employed, with each training segment comprising 5 to 7 exercise movements. For instance, a series of squat exercises is performed initially, followed by upper body strength training such as bench presses; each movement must be completed with the specified number of sets and repetitions before proceeding to the next exercise. Explosiveness training enhances the rapid contraction capabilities of the muscles through a series of jumping and throwing movements, while flexibility exercises improve the range of motion of muscles and joints through a combination of static and dynamic stretching.
| Study group | Role | What they receive |
|---|---|---|
| Integrated Neuromuscular Training | Experimental | Integrative Neuromuscular Training (INT) is an interdisciplinary training paradigm that amalgamates cutting-edge concepts and practices from the realms of athletic training, physical therapy, biomechanics, and neuroscience. The genesis of INT dates back to the late twentieth century to the early twenty-first century, a period marked by a burgeoning understanding of motor control and neuromuscular coordination. Experts in the fields of sports science and rehabilitation began to explore a training modality designed to holistically enhance athletic performance while concurrently reducing the risk of injury.
The central tenet of INT is to optimize the coordination of the neuromuscular system and the synergistic action among muscle groups, thereby deepening functional movement training and integrating specific training components. These components include, but are not limited to, strength, balance, velocity, agility, fatigue resistance, and plyometric training. This methodology is not sol Receives: Behavioral: Basic Physical Fitness |
| Traditional Physical Training | Placebo comparator | Traditional Physical Training (TPT) involves a set of exercises with limited variation and fixed movement paths, conducted under stable conditions. This method primarily enhances muscle strength and endurance but often falls short in integrating with specific sports requirements and developing athletes' specialized skills.TPT emphasizes basic athletic attributes like strength, speed, and flexibility, which are vital for competition. Yet, it tends to focus on bulking up muscles and isolating body parts, potentially leading to higher injury risks and suboptimal performance.The concept of TPT is conservative, drawing on traditional sports training without fully embracing modern sports science and rehabilitation. However, as our understanding of motor control and neuromuscular coordination advances, modern training is becoming more holistic and scientific, prioritizing specialized movements, balance, and multi-joint coordination to boost the effectiveness of strength training. Receives: Behavioral: Traditional Physical Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Vertical-Jump Test
Vertical-Jump Test: The testing equipment used is the Swiss Myotest explosiveness testing device. Before the start of the test, participants completed familiarization exercises, jogging, stretching, and other routine warm-up activities. The best score out of three attempts was recorded. According to previous research, the test-retest reliability of the vertical jump test under the experimental conditions of this study is 0.993.
Measured: 8 weeks
Balance Test
Balance Test: The Y-balance test (YBT) was used for measurement, following the testing patterns from studies by Plisky et al. and Xu Fei et al. . Specifically, the participant stands on the Y-balance test device with one leg, barefoot, and the other leg's foot is used to slowly push the test board to the furthest distance in three directions: anterior (A), posteromedial (PM), and posterolateral (PL). The sequence is first with the right leg supporting and then with the left leg supporting. Each direction is measured three times, and the maximum distance is taken for analysis. During the test, participants are required to keep their feet stationary and their hands off the anterior superior iliac spine. After the test, the composite score of the YBT for both legs is calculated based on the distances in the three directions for both the left and right legs, which is used to evaluate the participant's balance ability. The calculation formula is [(A + PM + PL) / (3 × lower limb leng
Measured: 8 weeks
Maximum Strength (1RM, 1 Repetition Maximum)
Maximum Strength (1RM, 1 Repetition Maximum): Before the official test, participants are required to perform familiarization exercises without weights, adhering to the standard techniques for the squat and bench press movements. Subsequently, an indirect test for maximum strength is conducted . The calculation formula by Brzycki et al. for 1RM is used: 1RM = weight repeated / (1.0278 - 0.0278 × number of repetitions). For the squat test, participants are instructed to maintain a fixed foot stance and toe angle, with heels always in contact with the ground, and the thighs should be parallel to or slightly below the ground level during each squat, with knees not extending beyond the toes . For the bench press test, participants are required to ensure that the barbell touches the chest before pressing the arms upward until they are fully extended. Research by Kravitz et al. indicates that the 1RM test has a high degree of accuracy.
Measured: 8 weeks
100m Sprint Test
100m Sprint Test: Participants undergo two trials of the 100m sprint test. Prior to the official test, they all engage in 20 minutes of regular warm-up activities, including light jogging and stretching. They are instructed to use a standing start and to exert their maximum effort; upon hearing the start signal, they begin running. There is a 10-minute rest period between the two trials. The test is timed by professional referees with a precision of 0.01 seconds. To ensure consistency, the best performance out of the two trials is recorded.
Measured: 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Oct 2024
- Study start8 Nov 2024
- Primary completion12 Mar 2025
- Study completion17 Apr 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Chronic Ankle Instability,CAStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- There is no specific relevant model to refer to for use.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Yang Liu
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Yang Liu, Wuhan Sports University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06663371
- Sponsor's protocol ID
- Basic Physical Fitness
- Status last verified
- May 2026
- First submitted
- 22 Oct 2024
- Last updated
- 2 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: It involves personal privacy.
Publications
Jiang Y, Liu P, Xiao Z, Kang J, Chen N, Cheng Z, Xiang X, Li Z, Yan J. Effects of an 8-week integrated neuromuscular training on lower limb functional asymmetry and balance in military personnel: a randomized controlled trial. BMC Sports Sci Med Rehabil. 2026 May 23;18(1):321. doi: 10.1186/s13102-026-01760-3.
PubMed 42177576Liu P, Liu Y, Hao X, Cheng N, Kang J, Xiao Z, He P, Yan J. The impact of an 8-week integrated neuromuscular training on strength, speed, and agility in military personnel: a randomized controlled trial. BMC Sports Sci Med Rehabil. 2025 May 22;17(1):127. doi: 10.1186/s13102-025-01172-9.
PubMed 40405304
Study at a glance
From the registry record, last updated by the sponsor on 2 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact of Integrated Neuromuscular Training Intervention on the Basic Physical Fitness of Military Personnel
- ClinicalTrials.gov ID
- NCT06663371
- Acronym / sponsor ID
- Basic Physical Fitness
- Keywords
- Integrated Neuromuscular Training, Military Population, Basic Physical Fitness
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Yang LiuUniversity, hospital or other
- Study start
- 8 Nov 2024 (actual)
- Primary completion
- 12 Mar 2025 (actual)
- Study completion
- 17 Apr 2025 (actual)
- First posted
- 29 Oct 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Objective: The study aims to evaluate the efficacy of an 8-week integrated neuromuscular training intervention on the fundamental physical fitness parameters of military personnel, encompassing strength, velocity, agility, and equilibrium.
Methodology: The research randomly allocated 20 military students from the National University of Defense Technology into two cohorts, utilizing an experimental methodology with longitudinal assessments at the onset, midpoint, and conclusion of the intervention to quantitatively assess the influence of the integrated neuromuscular training on velocity and agility. Participants in both the experimental and control groups were evaluated one week prior to the intervention, at the fourth week, and one week post-intervention. Statistical analysis involved a two-factor repeated measures ANOVA to compare measures across the three time points, while paired-sample t-tests were applied for pre-post comparisons. The experimental group engaged in an 8-week integrated neuromuscular training regimen, consisting of three 90-minute sessions per week, culminating in a total of 24 sessions. Concurrently, the control group adhered to a conventional physical training schedule, also structured around three 90-minute sessions per week, over the same 24-session period, thereby ensuring parity in total training duration and frequency between the experimental and control groups.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- There is no specific relevant model to refer to for use.
| Arm | Type | Receives |
|---|---|---|
| Integrated Neuromuscular Training | Experimental | Behavioral: Basic Physical FitnessIntegrative Neuromuscular Training (INT) is an interdisciplinary training paradigm that amalgamates cutting-edge concepts and practices from the realms of athletic training, physical therapy, biomechanics, and neuroscience. The genesis of INT dates back to the late twentieth century to the early twenty-first century, a period marked by a burgeoning understanding of motor control and neuromuscular coordination. Experts in the fields of sports science and rehabilitation began to explore a training modality designed to holistically enhance athletic performance while concurrently reducing the risk of injury. The central tenet of INT is to optimize the coordination of the neuromuscular system and the synergistic action among muscle groups, thereby deepening functional movement training and integrating specific training components. These components include, but are not limited to, strength, balance, velocity, agility, fatigue resistance, and plyometric training. This methodology is not sol |
| Traditional Physical Training | Placebo comparator | Behavioral: Traditional Physical TrainingTraditional Physical Training (TPT) involves a set of exercises with limited variation and fixed movement paths, conducted under stable conditions. This method primarily enhances muscle strength and endurance but often falls short in integrating with specific sports requirements and developing athletes' specialized skills.TPT emphasizes basic athletic attributes like strength, speed, and flexibility, which are vital for competition. Yet, it tends to focus on bulking up muscles and isolating body parts, potentially leading to higher injury risks and suboptimal performance.The concept of TPT is conservative, drawing on traditional sports training without fully embracing modern sports science and rehabilitation. However, as our understanding of motor control and neuromuscular coordination advances, modern training is becoming more holistic and scientific, prioritizing specialized movements, balance, and multi-joint coordination to boost the effectiveness of strength training. |
Who may qualify
- Ages
- 18 to 24 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Age between 18-24 years old
- Students with corresponding military status
- Meeting the diagnostic criteria for functional movement screen assessment
- No history of psychological or psychiatric disorders, and not participating in other physical training during the experimental period
- Capable of cooperating to complete the corresponding training and testing, and will not withdraw from the experiment without cause
Key exclusion criteria (4 listed)
- Major sports injuries within the past 2 years, including fractures, ligament tears, muscle or tendon ruptures, and recurrent dislocations of joints
- Patients with cardiovascular and cerebrovascular diseases and related internal organ conditions
- Failure to pass the functional movement screen test
- Individuals with injuries or discomfort in other areas
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Basic Physical FitnessAlso: Speed, Strength, Balance, AgilityThe single module training paradigm followed a circuit-style format, with each training module consisting of 6 to 8 distinct exercise movements. Taking the INT training intervention on Mondays as an example, the training protocol involved completing one major module (e.g., plyometric exercises) before transitioning to another module (e.g., core stability exercises). Specific exercise methods, such as box jumps, were performed until all sets were completed before moving on to the next exercise (e.g., continuous depth jumps). | Behavioural | Integrated Neuromuscular Training |
| Traditional Physical TrainingAlso: Speed, StrengthIn the fundamental strength training, a circuit training modality is employed, with each training segment comprising 5 to 7 exercise movements. For instance, a series of squat exercises is performed initially, followed by upper body strength training such as bench presses; each movement must be completed with the specified number of sets and repetitions before proceeding to the next exercise. Explosiveness training enhances the rapid contraction capabilities of the muscles through a series of jumping and throwing movements, while flexibility exercises improve the range of motion of muscles and joints through a combination of static and dynamic stretching. | Behavioural | Traditional Physical Training |
Primary outcome
Vertical-Jump Test
Time frame: 8 weeks
Vertical-Jump Test: The testing equipment used is the Swiss Myotest explosiveness testing device. Before the start of the test, participants completed familiarization exercises, jogging, stretching, and other routine warm-up activities. The best score out of three attempts was recorded. According to previous research, the test-retest reliability of the vertical jump test under the experimental conditions of this study is 0.993.
Balance Test
Time frame: 8 weeks
Balance Test: The Y-balance test (YBT) was used for measurement, following the testing patterns from studies by Plisky et al. and Xu Fei et al. . Specifically, the participant stands on the Y-balance test device with one leg, barefoot, and the other leg's foot is used to slowly push the test board to the furthest distance in three directions: anterior (A), posteromedial (PM), and posterolateral (PL). The sequence is first with the right leg supporting and then with the left leg supporting. Each direction is measured three times, and the maximum distance is taken for analysis. During the test, participants are required to keep their feet stationary and their hands off the anterior superior iliac spine. After the test, the composite score of the YBT for both legs is calculated based on the distances in the three directions for both the left and right legs, which is used to evaluate the participant's balance ability. The calculation formula is [(A + PM + PL) / (3 × lower limb leng
Maximum Strength (1RM, 1 Repetition Maximum)
Time frame: 8 weeks
Maximum Strength (1RM, 1 Repetition Maximum): Before the official test, participants are required to perform familiarization exercises without weights, adhering to the standard techniques for the squat and bench press movements. Subsequently, an indirect test for maximum strength is conducted . The calculation formula by Brzycki et al. for 1RM is used: 1RM = weight repeated / (1.0278 - 0.0278 × number of repetitions). For the squat test, participants are instructed to maintain a fixed foot stance and toe angle, with heels always in contact with the ground, and the thighs should be parallel to or slightly below the ground level during each squat, with knees not extending beyond the toes . For the bench press test, participants are required to ensure that the barbell touches the chest before pressing the arms upward until they are fully extended. Research by Kravitz et al. indicates that the 1RM test has a high degree of accuracy.
100m Sprint Test
Time frame: 8 weeks
100m Sprint Test: Participants undergo two trials of the 100m sprint test. Prior to the official test, they all engage in 20 minutes of regular warm-up activities, including light jogging and stretching. They are instructed to use a standing start and to exert their maximum effort; upon hearing the start signal, they begin running. There is a 10-minute rest period between the two trials. The test is timed by professional referees with a precision of 0.01 seconds. To ensure consistency, the best performance out of the two trials is recorded.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jun 2026.
- Derived from this study: PubMed 42177576Jiang Y, Liu P, Xiao Z, Kang J, Chen N, Cheng Z, Xiang X, Li Z, Yan J. Effects of an 8-week integrated neuromuscular training on lower limb functional asymmetry and balance in military personnel: a randomized controlled trial. BMC Sports Sci Med Rehabil. 2026 May 23;18(1):321. doi: 10.1186/s13102-026-01760-3.
- Derived from this study: PubMed 40405304Liu P, Liu Y, Hao X, Cheng N, Kang J, Xiao Z, He P, Yan J. The impact of an 8-week integrated neuromuscular training on strength, speed, and agility in military personnel: a randomized controlled trial. BMC Sports Sci Med Rehabil. 2025 May 22;17(1):127. doi: 10.1186/s13102-025-01172-9.
- Individual participant dataSharing planned: No. It involves personal privacy.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Basic Physical Fitness and Traditional Physical Training in people with Chronic Ankle Instability,CA and Basic Physical Fitness, run by Yang Liu at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Vertical-Jump Test (time frame: 8 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06663371, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jun 2026.