Major Depressive Disorder (MDD)ADEMNCT06663423
Impact of Anxiety and Depression on Implicit and Explicit Memory Performance
An observational study of Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD), run by Islamic Azad University, Sanandaj at 1 site in Iran.
Trial summary
This study examines the effect of anxiety and depression on memory processes, focusing on implicit and explicit memory. Implicit memory involves unconscious recall, such as recognizing familiar words without effort, while explicit memory requires conscious recollection of specific information. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Memory Bias
- How many people
- 27 participants
- Where
- 1 siteIran
- Study dates
- 10 Aug 2024to 30 Sep 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: A sample of individuals from Tehran Institute of Psychiatry and Shahid Esmaili Clinic, including patients with depressive disorder, generalized anxiety disorder, and a control group of healthy individuals with no history of emotional disorders.
Who may be able to join
- Adults aged 18 years or older
- Individuals diagnosed with major depressive disorder (Group 1)
- Individuals diagnosed with generalized anxiety disorder (Group 2)
- Healthy individuals with no history of emotional disorders (Group 3)
Who cannot join
- History of neurological disorders
- Visual impairments
- Substance abuse or drug addiction
- Psychiatric hospitalizations unrelated to primary diagnosis (for Groups 1 and 2)
Trial locations and contacts
1 site in 1 country.
Iran1 site
Tehran Institute of Psychiatry and/or Shahid Esmaili Clinic.
Tehran, Tehran Province, 14176
About this study
Official title: Cohort Study on the Differential Impact of Anxiety and Depression on Implicit and Explicit Memory Performance
This study examines the effect of anxiety and depression on memory processes, focusing on implicit and explicit memory. Implicit memory involves unconscious recall, such as recognizing familiar words without effort, while explicit memory requires conscious recollection of specific information. The study aims to investigate whether individuals with depression and anxiety show differences in these types of memory, which may contribute to biases related to their emotional states.
Participants were divided into three groups: individuals with depressive disorder, individuals with generalized anxiety disorder, and a control group with no emotional disorders. Each group was assessed using tasks designed to measure both implicit and explicit memory performance. The goal is to enhance understanding of memory biases in individuals with depression and anxiety, potentially supporting more targeted interventions.
Read the detailed description
This cohort study is designed to explore potential memory biases in individuals with depressive and anxiety disorders compared to a control group. The study includes 27 participants divided into three groups: nine individuals diagnosed with major depressive disorder, nine with generalized anxiety disorder, and nine control subjects with no history of emotional disorders. All participants were matched by age and education level.
Participants completed standardized tasks and assessments, including the Spielberger State-Trait Anxiety Inventory and various memory tasks such as word decoding and recognition memory tasks. These tasks aim to evaluate mood-congruent biases in memory recall. Data collection will focus on analyzing any distinct memory processing patterns in depression and anxiety to improve psychological treatment approaches.
- Conditions
- Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Memory Bias, Implicit Memory, Explicit Memory
- Keywords
- Anxiety, Depression, Cognitive Bias, Memory Processing, Emotional Influence on Memory, Word Recognition Task, Mood-Congruent Memory, Psychological Disorders
- Medical subject headings
- Depressive Disorder, Major, Generalized Anxiety Disorder, Anxiety Disorders, Depression, Mental Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Group 1 | Depressive Disorder group - 9 participants. | |
| Group 2 | Generalized Anxiety Disorder group - 9 participants. | |
| Group 3 | Control group - 9 participants. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Explicit Memory Bias
The primary outcome is to assess explicit memory bias by measuring word recognition in participants with depressive disorder, generalized anxiety disorder, and a control group. Word recognition accuracy and response times are evaluated to determine mood-congruent biases specific to each group.
Measured: At a single time point during the experimental session, approximately 1 day
Secondary outcomes (1)
Implicit Memory Bias
Secondary outcome is to assess implicit memory bias using a tachistoscopic word recognition task, measuring participants' ability to identify emotionally congruent words (e.g., words associated with depression, anxiety, and neutral words) without conscious awareness.
Measured: At a single time point during the experimental session, approximately 1 hour
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Oct 2024
- Study start10 Aug 2024
- Primary completion30 Aug 2024
- Study completion30 Sep 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Major Depressive Disorder (MDD)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 27 participants (actual)
Sponsor and investigators
- Lead sponsor
- Islamic Azad University, Sanandaj
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Shaghayegh Radmehr, Islamic Azad University, Sanandaj
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06663423
- Sponsor's protocol ID
- SDU-MEMORY-2024
- Acronym
- ADEM
- Status last verified
- Oct 2024
- First submitted
- 25 Oct 2024
- Last updated
- 31 Oct 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 31 Oct 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cohort Study on the Differential Impact of Anxiety and Depression on Implicit and Explicit Memory Performance
- ClinicalTrials.gov ID
- NCT06663423
- Acronym / sponsor ID
- ADEM / SDU-MEMORY-2024
- Conditions
- Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Memory Bias, Implicit Memory, Explicit Memory
- Keywords
- Anxiety, Depression, Cognitive Bias, Memory Processing, Emotional Influence on Memory, Word Recognition Task, Mood-Congruent Memory, Psychological Disorders
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 27 participants (actual)
- Lead sponsor
- Islamic Azad University, SanandajUniversity, hospital or other
- Study start
- 10 Aug 2024 (actual)
- Primary completion
- 30 Aug 2024 (actual)
- Study completion
- 30 Sep 2024 (actual)
- First posted
- 29 Oct 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study examines the effect of anxiety and depression on memory processes, focusing on implicit and explicit memory. Implicit memory involves unconscious recall, such as recognizing familiar words without effort, while explicit memory requires conscious recollection of specific information. The study aims to investigate whether individuals with depression and anxiety show differences in these types of memory, which may contribute to biases related to their emotional states.
Participants were divided into three groups: individuals with depressive disorder, individuals with generalized anxiety disorder, and a control group with no emotional disorders. Each group was assessed using tasks designed to measure both implicit and explicit memory performance. The goal is to enhance understanding of memory biases in individuals with depression and anxiety, potentially supporting more targeted interventions.
Detailed description
This cohort study is designed to explore potential memory biases in individuals with depressive and anxiety disorders compared to a control group. The study includes 27 participants divided into three groups: nine individuals diagnosed with major depressive disorder, nine with generalized anxiety disorder, and nine control subjects with no history of emotional disorders. All participants were matched by age and education level.
Participants completed standardized tasks and assessments, including the Spielberger State-Trait Anxiety Inventory and various memory tasks such as word decoding and recognition memory tasks. These tasks aim to evaluate mood-congruent biases in memory recall. Data collection will focus on analyzing any distinct memory processing patterns in depression and anxiety to improve psychological treatment approaches.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Group 1 | – | –Depressive Disorder group - 9 participants. |
| Group 2 | – | –Generalized Anxiety Disorder group - 9 participants. |
| Group 3 | – | –Control group - 9 participants. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- A sample of individuals from Tehran Institute of Psychiatry and Shahid Esmaili Clinic, including patients with depressive disorder, generalized anxiety disorder, and a control group of healthy individuals with no history of emotional disorders.
Key inclusion criteria (4 listed)
- Adults aged 18 years or older
- Individuals diagnosed with major depressive disorder (Group 1)
- Individuals diagnosed with generalized anxiety disorder (Group 2)
- Healthy individuals with no history of emotional disorders (Group 3)
Key exclusion criteria (4 listed)
- History of neurological disorders
- Visual impairments
- Substance abuse or drug addiction
- Psychiatric hospitalizations unrelated to primary diagnosis (for Groups 1 and 2)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Explicit Memory Bias
Time frame: At a single time point during the experimental session, approximately 1 day
The primary outcome is to assess explicit memory bias by measuring word recognition in participants with depressive disorder, generalized anxiety disorder, and a control group. Word recognition accuracy and response times are evaluated to determine mood-congruent biases specific to each group.
1 secondary outcome
Implicit Memory Bias
Time frame: At a single time point during the experimental session, approximately 1 hour
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Oct 2024.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD), run by Islamic Azad University, Sanandaj at 1 site in Iran.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 31 Oct 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Iran. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Explicit Memory Bias (time frame: At a single time point during the experimental session, approximately 1 day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Oct 2024.