Vascular FunctionNCT06664281
Effects of SIT Combined with Remote Ischemic Preconditioning on Vascular Function in Young Women with Masked Obesity
A study testing SIT and SIT combined RIPC in people with Vascular Function, run by Beijing Sport University at 1 site in China.
Trial summary
Comparison of the effects of combined Sprint Interval Training (SIT) with Remote Ischemic Preconditioning (RIPC) and SIT on vascular function in young women with masked obesity. Read more about this study
- Who is it for?
- Ages 18 to 30 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Vascular Function
- What is being tested?
- SIT and SIT combined RIPC
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 siteChina
- Study dates
- 28 Feb 2023to 30 Dec 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Females aged between 18 and 30 years;
- BMI within the normal range (18.5～24.9 kg/m²), BF% > 30%;
- Participants with no clinically diagnosed contraindications for exercise, in good health, and not engaged in regular exercise, as determined by the health and physical activity questionnaire (based on the American College of Sports Medicine's guidelines for exercise testing and prescription).
Who cannot join
- History of cardiovascular diseases, including coronary heart disease, stroke, or peripheral arterial disease diagnosed through vascular imaging techniques;
- Currently participating in other intervention studies, including dietary, nutritional, or psychological education programs;
- Those with regular professional training;
- Musculoskeletal disorders that make long-term exercise interventions unsuitable.
Trial locations and contacts
1 site in 1 country.
China1 site
School of Sports Medicine and Rehabilitation, Beijing Sport University
Beijing
About this study
Official title: Effects of Sprint Interval Training Combined with Remote Ischemic Preconditioning on Vascular Function in Young Women with Masked Obesity
Comparison of the effects of combined Sprint Interval Training (SIT) with Remote Ischemic Preconditioning (RIPC) and SIT on vascular function in young women with masked obesity.
Read the detailed description
This is a randomized clinical trial of single-blind with 3 arms (control group, SIT group and SIT with RIPC group), in which a pre-treatment-posttest design has been used.
- Conditions
- Vascular Function
- Being tested
- SIT, SIT combined RIPC
- Keywords
- Sprint Interval Training, Masked Obesity, Young Women, Ischemic Preconditioning, Vascular Function
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
SITBehavioural
sprint interval training
SIT combined RIPCBehavioural
sprint interval training combined with remote ischemic preconditioning
| Study group | Role | What they receive |
|---|---|---|
| sprint interval training group | Active comparator | Not described Receives: Behavioral: SIT |
| sprint interval training combined with remote ischemic preconditioning group | Active comparator | Not described Receives: Behavioral: SIT combined RIPC |
| Control group | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Intima-Media Thickness (IMT)
Changes in Intima media thickness before and after intervention.
Measured: 8 weeks
Flow-Mediated Dilation (FMD)
Changes in Flow-mediated dilation before and after Intervention. Brachial artery flow-mediated dilation (FMD) was measured by the UNEXEF high-resolution ultrasound vascular endothelial function analyzer.
Measured: 8 weeks
Secondary outcomes (5)
Body Composition Indicator
Changes in Body composition indicators before and after Intervention. Including body fat percentage (BF%).
Measured: 8 weeks
Human Morphometric i Indicators
Changes in Human morphometric indicators before and after Intervention. Including height, weight, waist circumference, hip circumference, and body mass index (BMI). BMI was calculated based on the measured height and weight using the formula: BMI = weight/height² (kg/m²).
Measured: 8 weeks
Blood Pressure (BP)
Changes in blood pressure before and after intervention. Including systolic and diastolic blood pressure.
Measured: 8 weeks
Nitric Oxide (NO)
Changes in concentration of nitric oxide before and after Intervention.
Measured: 8 weeks
Maximum Oxygen Uptake (VO2max)
Changes in maximum oxygen uptake before and after Intervention.
Measured: 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Oct 2024
- Study start28 Feb 2023
- Primary completion30 Oct 2023
- Study completion30 Dec 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Vascular FunctionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 44 participants (actual)
Sponsor and investigators
- Lead sponsor
- Beijing Sport University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06664281
- Sponsor's protocol ID
- ESITCRIPVFYWMO
- Status last verified
- Sep 2024
- First submitted
- 24 Oct 2024
- Last updated
- 29 Oct 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Ji Y, Yang L, Zhang P. Effects of sprint interval training combined with remote ischaemic preconditioning on vascular function in young women with masked obesity. Eur J Appl Physiol. 2026 Feb;126(2):1165-1174. doi: 10.1007/s00421-025-05970-4. Epub 2025 Sep 22.
PubMed 40982049
Study at a glance
From the registry record, last updated by the sponsor on 29 Oct 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Sprint Interval Training Combined with Remote Ischemic Preconditioning on Vascular Function in Young Women with Masked Obesity
- ClinicalTrials.gov ID
- NCT06664281
- Acronym / sponsor ID
- ESITCRIPVFYWMO
- Conditions
- Vascular Function
- Keywords
- Sprint Interval Training, Masked Obesity, Young Women, Ischemic Preconditioning, Vascular Function
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44 participants (actual)
- Lead sponsor
- Beijing Sport UniversityUniversity, hospital or other
- Study start
- 28 Feb 2023 (actual)
- Primary completion
- 30 Oct 2023 (actual)
- Study completion
- 30 Dec 2023 (actual)
- First posted
- 29 Oct 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Comparison of the effects of combined Sprint Interval Training (SIT) with Remote Ischemic Preconditioning (RIPC) and SIT on vascular function in young women with masked obesity.
Detailed description
This is a randomized clinical trial of single-blind with 3 arms (control group, SIT group and SIT with RIPC group), in which a pre-treatment-posttest design has been used.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| sprint interval training group | Active comparator | Behavioral: SIT |
| sprint interval training combined with remote ischemic preconditioning group | Active comparator | Behavioral: SIT combined RIPC |
| Control group | No intervention | – |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Females aged between 18 and 30 years;
- BMI within the normal range (18.5～24.9 kg/m²), BF% > 30%;
- Participants with no clinically diagnosed contraindications for exercise, in good health, and not engaged in regular exercise, as determined by the health and physical activity questionnaire (based on the American College of Sports Medicine's guidelines for exercise testing and prescription).
Key exclusion criteria (4 listed)
- History of cardiovascular diseases, including coronary heart disease, stroke, or peripheral arterial disease diagnosed through vascular imaging techniques;
- Currently participating in other intervention studies, including dietary, nutritional, or psychological education programs;
- Those with regular professional training;
- Musculoskeletal disorders that make long-term exercise interventions unsuitable.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| SITsprint interval training | Behavioural | sprint interval training group |
| SIT combined RIPCsprint interval training combined with remote ischemic preconditioning | Behavioural | sprint interval training combined with remote ischemic preconditioning group |
Primary outcome
Intima-Media Thickness (IMT)
Time frame: 8 weeks
Changes in Intima media thickness before and after intervention.
Flow-Mediated Dilation (FMD)
Time frame: 8 weeks
Changes in Flow-mediated dilation before and after Intervention. Brachial artery flow-mediated dilation (FMD) was measured by the UNEXEF high-resolution ultrasound vascular endothelial function analyzer.
5 secondary outcomes
Body Composition Indicator
Time frame: 8 weeks
Human Morphometric i Indicators
Time frame: 8 weeks
Blood Pressure (BP)
Time frame: 8 weeks
Nitric Oxide (NO)
Time frame: 8 weeks
Maximum Oxygen Uptake (VO2max)
Time frame: 8 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Oct 2024.
- Derived from this study: PubMed 40982049Ji Y, Yang L, Zhang P. Effects of sprint interval training combined with remote ischaemic preconditioning on vascular function in young women with masked obesity. Eur J Appl Physiol. 2026 Feb;126(2):1165-1174. doi: 10.1007/s00421-025-05970-4. Epub 2025 Sep 22.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing SIT and SIT combined RIPC in people with Vascular Function, run by Beijing Sport University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Oct 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Intima-Media Thickness (IMT) (time frame: 8 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06664281, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Oct 2024.