Health-Related BehaviorNCT06678386
Alteration of Sweet Taste Perception After Reduction of Sweet Food and Beverage Consumption.
A study testing 50% sugar reduction in people with Health-Related Behavior, run by Mahidol University at 1 site in Thailand.
Trial summary
The goal of this clinical trial is to determine whether reducing sugar intake by 50% for 12 weeks can change sweet taste perception in healthy adults and its consequences. The main questions it aims to answer are: Does sweet intensity change after reducing daily sugar intake by 50% for 12 weeks? How does sweet… Read more about this study
- Who is it for?
- Ages 18 to 59 yearsHealthy volunteers can take part
- Conditions the study is for
- Health-Related Behavior
- What is being tested?
- 50% sugar reduction
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 58 participants
- Where
- 1 siteThailand
- Study dates
- 1 Oct 2024to 31 Jul 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 59 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- People with a fasting blood sugar level below 126 mg/dL or an HbA1C below 6.5% in the past 6 months, who are not currently being treated for diabetes.
- People who score 10 or more points on the sweet food consumption behavior questionnaire.
- People who are able to communicate in the Thai language.
- People who are able to chat and use video calls via the Line application.
- People who agree to modify their diet and beverages according to the recommendations of a dietitian.
- People who agree to undergo sweet taste testing, complete a food record, and fill out a questionnaire.
Who cannot join
- People with uncontrolled chronic conditions who have had changes in their treatment within the past 3 months.
- People with a history of severe illness in the past 6 months.
- People who regularly use medication, excluding contraceptives and vitamins.
- Pregnant women.
- People who have experienced a weight change of at least 10% over the past 3 months.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Thailand1 site
Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkoknoi, Bangkok, 10700
About this study
Official title: Alteration of Sweet Taste Perception After 50% Reduction of Sweet Food and Beverage Consumption for 12 Weeks, Compared With Unmodified Diet.
The goal of this clinical trial is to determine whether reducing sugar intake by 50% for 12 weeks can change sweet taste perception in healthy adults and its consequences. The main questions it aims to answer are:
- Does sweet intensity change after reducing daily sugar intake by 50% for 12 weeks?
- How does sweet intensity change after completing dietary modification for 8 weeks?
- Does individual daily sugar intake change after completing dietary modification for 8 weeks?
Read more
Researchers will compare reducing daily sugar intake by 50% for 12 weeks to an unmodified diet to see if sugar reduction can change sweet intensity.
Participants will:
- Reduce daily sugar intake by 50% or maintain an unmodified diet for 12 weeks.
- Visit the clinic three times for anthropometric measurements, sweet perception tests, and to complete questionnaires.
- Keep a diet record for a total of 15 days during the research period.
- Conditions
- Health-Related Behavior
- Being tested
- 50% sugar reduction
- Keywords
- sweet taste perception, sugar reduction, dietary behavior, dietary modification, sweet intensity
- Medical subject headings
- Health Behavior
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
50% sugar reductionBehavioural
Participants were advised by a dietitian to reduce their daily caloric intake from sugars by 50% for 12 weeks.
| Study group | Role | What they receive |
|---|---|---|
| 50% sugar reduction | Experimental | Participants were advised by a dietitian to reduce their daily caloric intake from sugars by 50% for 12 weeks. Receives: Behavioral: 50% sugar reduction |
| unmodified diet | No intervention | Participants maintained an unmodified diet. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Sweet intensity change from baseline after 12 weeks of the intervention.
Percentage of participants whose sweet intensity has increased after reducing daily sugar intake by 50% for 12 weeks, compared to those with an unmodified diet.
Measured: 16 weeks from baseline (12 weeks after the start of the intervention)
Secondary outcomes (2)
Sweet intensity change from baseline after completing the intervention for 8 weeks.
Percentage of participants whose sweet intensity increased after completing dietary modification for 8 weeks, compared to those with an unmodified diet.
Measured: 24 weeks from baseline
Changes in sugar consumption behavior from baseline
The average daily caloric intake from sugars after completing dietary modification for 8 weeks, compared to before the dietary change.
Measured: 24 weeks from baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Nov 2024
- Study start1 Oct 2024
- Primary completion31 Mar 2025 (estimated)
- Study completion31 Jul 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Health-Related BehaviorStudies of the same condition, open and under way.
- More trials run by Mahidol UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Investigator
- Enrolment
- 58 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mahidol University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06678386
- Sponsor's protocol ID
- 233/2567 (IRB1)
- Status last verified
- Nov 2024
- First submitted
- 6 Nov 2024
- Last updated
- 7 Nov 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 7 Nov 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Alteration of Sweet Taste Perception After 50% Reduction of Sweet Food and Beverage Consumption for 12 Weeks, Compared With Unmodified Diet.
- ClinicalTrials.gov ID
- NCT06678386
- Acronym / sponsor ID
- 233/2567 (IRB1)
- Conditions
- Health-Related Behavior
- Keywords
- sweet taste perception, sugar reduction, dietary behavior, dietary modification, sweet intensity
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 58 participants (estimated)
- Lead sponsor
- Mahidol UniversityUniversity, hospital or other
- Study start
- 1 Oct 2024 (actual)
- Primary completion
- 31 Mar 2025 (estimated)
- Study completion
- 31 Jul 2025 (estimated)
- First posted
- 7 Nov 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to determine whether reducing sugar intake by 50% for 12 weeks can change sweet taste perception in healthy adults and its consequences. The main questions it aims to answer are:
- Does sweet intensity change after reducing daily sugar intake by 50% for 12 weeks?
- How does sweet intensity change after completing dietary modification for 8 weeks?
- Does individual daily sugar intake change after completing dietary modification for 8 weeks?
Researchers will compare reducing daily sugar intake by 50% for 12 weeks to an unmodified diet to see if sugar reduction can change sweet intensity.
Participants will:
- Reduce daily sugar intake by 50% or maintain an unmodified diet for 12 weeks.
- Visit the clinic three times for anthropometric measurements, sweet perception tests, and to complete questionnaires.
- Keep a diet record for a total of 15 days during the research period.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| 50% sugar reduction | Experimental | Behavioral: 50% sugar reductionParticipants were advised by a dietitian to reduce their daily caloric intake from sugars by 50% for 12 weeks. |
| unmodified diet | No intervention | –Participants maintained an unmodified diet. |
Who may qualify
- Ages
- 18 to 59 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- People with a fasting blood sugar level below 126 mg/dL or an HbA1C below 6.5% in the past 6 months, who are not currently being treated for diabetes.
- People who score 10 or more points on the sweet food consumption behavior questionnaire.
- People who are able to communicate in the Thai language.
- People who are able to chat and use video calls via the Line application.
- People who agree to modify their diet and beverages according to the recommendations of a dietitian.
Key exclusion criteria (5 listed)
- People with uncontrolled chronic conditions who have had changes in their treatment within the past 3 months.
- People with a history of severe illness in the past 6 months.
- People who regularly use medication, excluding contraceptives and vitamins.
- Pregnant women.
- People who have experienced a weight change of at least 10% over the past 3 months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 50% sugar reductionParticipants were advised by a dietitian to reduce their daily caloric intake from sugars by 50% for 12 weeks. | Behavioural | 50% sugar reduction |
Primary outcome
Sweet intensity change from baseline after 12 weeks of the intervention.
Time frame: 16 weeks from baseline (12 weeks after the start of the intervention)
Percentage of participants whose sweet intensity has increased after reducing daily sugar intake by 50% for 12 weeks, compared to those with an unmodified diet.
2 secondary outcomes
Sweet intensity change from baseline after completing the intervention for 8 weeks.
Time frame: 24 weeks from baseline
Changes in sugar consumption behavior from baseline
Time frame: 24 weeks from baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Nov 2024.
- Individual participant dataSharing planned: Undecided
Related trials for Health-Related Behavior
Not yet recruitingObservational study
Validation of the Healthcare Relationship Assessment Scale (ERA) in Health Sciences Students.
Health Adult Subjects, Communication
Recruiting
Trial Phase: Syndemic Adapted Medly Uganda
Mental Health
Not yet recruiting
Feasibility of a Web-based Single-session Intervention Combined With Ecological Momentary Assessment and Intervention for Patients With Complex Posttraumatic Stress Disorder Awaiting Inpatient Treatment
PTSD - Post Traumatic Stress Disorder, Depression
Not yet recruiting
Deaf CBT-TS to Reduce Suicide Risk
Depression - Major Depressive Disorder, Anxiety
RecruitingObservational study
Brain Function and Psychological Changes Related to Cell Therapy for Autoimmune Hemolytic Anemia
CAR T-cell Therapy, Autoimmune Hemolytic Anemia
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing 50% sugar reduction in people with Health-Related Behavior, run by Mahidol University at 1 site in Thailand.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 7 Nov 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Thailand. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Sweet intensity change from baseline after 12 weeks of the intervention. (time frame: 16 weeks from baseline (12 weeks after the start of the intervention)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Nov 2024.