Healthy ControlNCT06688526
Auditory Stimulation Effect on Brain Oscillations and Sleep Dependent Learning
A study testing Quiet Sounds in people with Healthy Control, run by Massachusetts General Hospital at 1 site in United States.
Trial summary
The investigators are testing the impact of quiet sounds played during sleep on brain oscillations and memory. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Control
- What is being tested?
- Quiet Sounds
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 0 participants
- Where
- 1 siteUnited States
- Study dates
- 13 Nov 2024to 30 Jun 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Exclusion Criteria: History of neurological disease, psychiatric disease, sleep apnea or sleep disorder.
- -
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country.
United States1 site
Athinoula A. Martinos Center Biomedical Imaging
Charlestown, Massachusetts, 02129
About this study
The investigators are testing the impact of quiet sounds played during sleep on brain oscillations and memory.
Read the detailed description
Participants will undergo two visits with a memory task and nap. During one of the visits, quiet sounds will be played timed with sleep oscillations. During the other visit, no sounds will be played. Brain oscillations and memory will be measured at each visit.
- Conditions
- Healthy Control
- Being tested
- Quiet Sounds, Sham Sounds
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Quiet SoundsOther
Quiet sounds are played during sleep
Sham SoundsOther
No sounds are played during sleep
| Study group | Role | What they receive |
|---|---|---|
| Auditory Stimulation | Active comparator | Quiet sounds are played during sleep Receives: Other: Quiet Sounds |
| Sham Stimulation | Sham comparator | Volume is set to zero. Receives: Other: Sham Sounds |
What is being measured
The primary outcome is the main question the study is designed to answer.
Sleep spindle rate
Sleep spindles are prominent thalamocortical brain oscillations seen on EEG during sleep that have been mechanistically linked to sleep-dependent memory consolidation. The sleep spindle rate over the course of the nap will be assessed using an automated spindle detector applied to the collected EEG sleep data.
Measured: 90 minutes
Secondary outcomes (1)
Memory consolidation
The motor sequence task (MST), a validated probe of memory consolidation, will be used to measure sleep-dependent memory consolidation. Participants will trained on MST before the nap opportunity and tested on MST after the nap opportunity to reliably measure memory consolidation.
Measured: 90 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Nov 2024
- Study start13 Nov 2024
- Primary completion30 Jun 2025
- Study completion30 Jun 2025
Why it stopped: Subjects were never enrolled and PI moved
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy ControlStudies of the same condition, open and under way.
- More trials run by Massachusetts General HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- Massachusetts General Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Catherine Chu, MD, Massachusetts General Hospital
- Investigators
- Catherine Chu, MD, Principal investigator, Massachusetts General Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06688526
- Sponsor's protocol ID
- 2024P002714
- Status last verified
- Jun 2026
- First submitted
- 25 Oct 2024
- Last updated
- 30 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Deidentified data will be shared upon request to the study PI
Study at a glance
From the registry record, last updated by the sponsor on 30 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Auditory Stimulation Effect on Brain Oscillations and Sleep Dependent Learning
- ClinicalTrials.gov ID
- NCT06688526
- Acronym / sponsor ID
- 2024P002714
- Conditions
- Healthy Control
- Study type
- Interventional
- Recruitment status
- WithdrawnReason stopped: Subjects were never enrolled and PI moved
- Enrolment
- 0 participants (actual)
- Lead sponsor
- Massachusetts General HospitalUniversity, hospital or other
- Study start
- 13 Nov 2024 (actual)
- Primary completion
- 30 Jun 2025 (actual)
- Study completion
- 30 Jun 2025 (actual)
- First posted
- 14 Nov 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The investigators are testing the impact of quiet sounds played during sleep on brain oscillations and memory.
Detailed description
Participants will undergo two visits with a memory task and nap. During one of the visits, quiet sounds will be played timed with sleep oscillations. During the other visit, no sounds will be played. Brain oscillations and memory will be measured at each visit.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Auditory Stimulation | Active comparator | Other: Quiet SoundsQuiet sounds are played during sleep |
| Sham Stimulation | Sham comparator | Other: Sham SoundsVolume is set to zero. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Exclusion Criteria: History of neurological disease, psychiatric disease, sleep apnea or sleep disorder.
- -
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Quiet SoundsQuiet sounds are played during sleep | Other | Auditory Stimulation |
| Sham SoundsNo sounds are played during sleep | Other | Sham Stimulation |
Primary outcome
Sleep spindle rate
Time frame: 90 minutes
Sleep spindles are prominent thalamocortical brain oscillations seen on EEG during sleep that have been mechanistically linked to sleep-dependent memory consolidation. The sleep spindle rate over the course of the nap will be assessed using an automated spindle detector applied to the collected EEG sleep data.
1 secondary outcome
Memory consolidation
Time frame: 90 minutes
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jun 2026.
- Individual participant dataSharing planned: Yes. Deidentified data will be shared upon request to the study PI
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Catherine Chu, MD principal investigator
Massachusetts General Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Quiet Sounds in people with Healthy Control, run by Massachusetts General Hospital at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 30 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Sleep spindle rate (time frame: 90 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jun 2026; AzTrials last refreshed its copy on 28 Oct 2026.