Collagen SupplementationNCT06689761
Influence of Specific Collagen Peptides on Training-Induced Metabolic and Biomechanical Adaptations of Skeletal Muscle
A study testing ColCT, ColET and PlaCT in people with Collagen Supplementation, run by University of Vienna at 1 site in Austria.
Trial summary
This study investigates whether taking daily collagen peptides, combined with long-term endurance or concurrent training can enhance running economy through muscle and/or tendon adaptations. Read more about this study
- Who is it for?
- Ages 18 to 40 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Collagen Supplementation
- What is being tested?
- ColCT, ColET and PlaCT
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 60 participants
- Where
- 1 siteAustria
- Study dates
- 13 Nov 2024to 30 May 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male gender Age 18-40 years No subjective symptoms during physical exertion BMI of 18.5 to 26 Stable weight and dietary habits No extensive strength/endurance training (less than 3 hours per week) No contraindications to physical exertion according to ACSM guidelines No contraindications to supplemental nutrition or ergogenic supplements
Who cannot join
- Contraindications to physical activity (e.g., chronic heart disease, arrhythmia, heart valve disease, arthritis, etc.; general exclusion criteria according to ACSM 2009; intolerance/aversion to animal protein) Arterial hypertension (systolic BP > 200 mmHg and/or diastolic BP > 105 mmHg) at rest Insulin-dependent diabetes mellitus (IDDM) Liver and/or kidney disease that excludes a high protein load
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Austria1 site
Centre for Sport Science and University Sports, Department of Sport and Human Movement Science
Vienna, State of Vienna, 1150
About this study
This study investigates whether taking daily collagen peptides, combined with long-term endurance or concurrent training can enhance running economy through muscle and/or tendon adaptations.
Read the detailed description
An adequate and high-quality intake of proteins and amino acids is crucial for synthesizing the body's own connective tissue-like structures, such as muscles, tendons, ligaments, and bones. Various metabolic and hormonal processes are regulated or influenced by proteins. It is undisputed that measurable improvements are only possible through the combination of training and protein intake. Simply increasing protein intake without physical activity cannot be expected to result in structural or metabolic adaptations.
In recent years, interest in regular collagen intake in sports nutrition, particularly in connection with moderate to intense physical activity, has increased. Since collagen and its peptides are primarily found in force-transmitting structures such as tendons, studies have been conducted to examine how tendons adapt to collagen peptide supplementation. Studies by Jerger et al. (2022 \& 2023) have shown that both the patellar and Achilles tendons adapt to collagen supplementation, as evidenced by an increased cross-sectional area compared to a non-caloric placebo. This increase allows tendons to withstand greater forces, making them more resilient and thus playing an important role in injury prevention. These results were achieved with a dose of 5g of collagen combined with three months of strength training.
Additionally, multi-month collagen peptide supplementation combined with concurrent training (strength and endurance training in one session) led to improved endurance performance. Both running distance and speed at the aerobic and anaerobic thresholds significantly increased compared to a placebo group with a daily intake of 15g of collagen over three months (Jerger et al. 2023, Jendricke et al. 2020).
Based on these results, the question arises as to whether regularly supplemented collagen peptides, combined with pure endurance training, lead to similar metabolic and/or tendon-specific adaptations. Therefore, the aim of this proposed study is to investigate both metabolic and specific (morphological, mechanical, and material) properties of the Achilles and patellar tendons to determine the mechanism through which the so-called "running economy" develops in connection with collagen peptides. The results will be compared to those of concurrent training, which has already shown metabolic adaptations as described above.
- Conditions
- Collagen Supplementation
- Being tested
- ColCT, ColET, PlaCT, PlaET
- Keywords
- Running economy, collagen supplementation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ColCTDietary supplement
Dietary Supplement: Collagen Participants ingest 15 grams of specific collagen peptides daily
ColETDietary supplement
Dietary Supplement: Collagen Participants ingest 15 grams of specific collagen peptides daily
PlaCTDietary supplement
Dietary Supplement: Placebo. Participants ingest 15 grams of placebo daily
PlaETDietary supplement
Dietary Supplement: Placebo. Participants ingest 15 grams of placebo daily
| Study group | Role | What they receive |
|---|---|---|
| ColCT | Experimental | Dietary Supplement: Collagen Participants ingest 15 grams specific collagen peptides daily
+ Concurrent training 12 weeks, 3x/week Receives: Dietary Supplement: ColCT |
| PlaCT | Placebo comparator | Dietary Supplement: Placebo Participants ingest 15 grams of a placebo daily
+ Concurrent training 12 weeks, 3x/week Receives: Dietary Supplement: PlaCT |
| ColET | Experimental | Dietary Supplement: Collagen Participants ingest 15 grams specific collagen peptides daily
+ Endurance training 12 weeks, 3x/week Receives: Dietary Supplement: ColET |
| PlaET | Placebo comparator | Dietary Supplement: Collagen Participants ingest 15 grams of placebo daily
+ Endurance training 12 weeks, 3x/week Receives: Dietary Supplement: PlaET |
What is being measured
The primary outcome is the main question the study is designed to answer.
One-hour time trial performance
Participants run an hour on the track outside as far as possible
Measured: Baseline and after 12 weeks
Achilles tendon cross sectional-area
Ultrasound
Measured: Baseline and after 12 weeks
Achilles and Patellar tendon Stiffness
Ultrasound + isokinetic dynamometer
Measured: Baseline and after 12 weeks
VO2max
treadmill with spirometry
Measured: Baseline and after 12 weeks
Secondary outcomes (5)
Body composition
Fat mass, fat-free mass, extracellular mass, body cell mass, skeletal muscle mass. Measured by bioelectrical impedance analysis
Measured: Baseline and after 12 weeks
Achilles tendon stress, strain, Young's modulus
Ultrasound + isokinetic dynamometer
Measured: Baseline and after 12 weeks
Patellar tendon strain
Ultrasound + isokinetic dynamometer
Measured: Baseline and after 12 weeks
RER, VT1, VT2, LTP1, LTP2, HFrel., FATox.
treadmill with spirometry and blood (lactate) collection.
Measured: Baseline and after 12 weeks
Achilles tendon echointensity
Ultrasound
Measured: Baseline and after 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Nov 2024
- Study start13 Nov 2024
- Primary completion1 May 2025 (estimated)
- Study completion30 May 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Collagen SupplementationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Vienna
- Sponsor type
- University, hospital or other
- Collaborators
- Collagen Research Institute
- Responsible party
- Principal investigator, Kevin Bischof, University of Vienna
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06689761
- Sponsor's protocol ID
- 01177
- Status last verified
- Nov 2024
- First submitted
- 12 Nov 2024
- Last updated
- 14 Nov 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Nov 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Influence of Specific Collagen Peptides on Training-Induced Metabolic and Biomechanical Adaptations of Skeletal Muscle
- ClinicalTrials.gov ID
- NCT06689761
- Acronym / sponsor ID
- 01177
- Conditions
- Collagen Supplementation
- Keywords
- Running economy, collagen supplementation
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- University of ViennaUniversity, hospital or other
- Collaborators
- Collagen Research Institute
- Study start
- 13 Nov 2024 (actual)
- Primary completion
- 1 May 2025 (estimated)
- Study completion
- 30 May 2025 (estimated)
- First posted
- 14 Nov 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates whether taking daily collagen peptides, combined with long-term endurance or concurrent training can enhance running economy through muscle and/or tendon adaptations.
Detailed description
An adequate and high-quality intake of proteins and amino acids is crucial for synthesizing the body's own connective tissue-like structures, such as muscles, tendons, ligaments, and bones. Various metabolic and hormonal processes are regulated or influenced by proteins. It is undisputed that measurable improvements are only possible through the combination of training and protein intake. Simply increasing protein intake without physical activity cannot be expected to result in structural or metabolic adaptations.
In recent years, interest in regular collagen intake in sports nutrition, particularly in connection with moderate to intense physical activity, has increased. Since collagen and its peptides are primarily found in force-transmitting structures such as tendons, studies have been conducted to examine how tendons adapt to collagen peptide supplementation. Studies by Jerger et al. (2022 \& 2023) have shown that both the patellar and Achilles tendons adapt to collagen supplementation, as evidenced by an increased cross-sectional area compared to a non-caloric placebo. This increase allows tendons to withstand greater forces, making them more resilient and thus playing an important role in injury prevention. These results were achieved with a dose of 5g of collagen combined with three months of strength training.
Additionally, multi-month collagen peptide supplementation combined with concurrent training (strength and endurance training in one session) led to improved endurance performance. Both running distance and speed at the aerobic and anaerobic thresholds significantly increased compared to a placebo group with a daily intake of 15g of collagen over three months (Jerger et al. 2023, Jendricke et al. 2020).
Based on these results, the question arises as to whether regularly supplemented collagen peptides, combined with pure endurance training, lead to similar metabolic and/or tendon-specific adaptations. Therefore, the aim of this proposed study is to investigate both metabolic and specific (morphological, mechanical, and material) properties of the Achilles and patellar tendons to determine the mechanism through which the so-called "running economy" develops in connection with collagen peptides. The results will be compared to those of concurrent training, which has already shown metabolic adaptations as described above.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| ColCT | Experimental | Dietary Supplement: ColCTDietary Supplement: Collagen Participants ingest 15 grams specific collagen peptides daily + Concurrent training 12 weeks, 3x/week |
| PlaCT | Placebo comparator | Dietary Supplement: PlaCTDietary Supplement: Placebo Participants ingest 15 grams of a placebo daily + Concurrent training 12 weeks, 3x/week |
| ColET | Experimental | Dietary Supplement: ColETDietary Supplement: Collagen Participants ingest 15 grams specific collagen peptides daily + Endurance training 12 weeks, 3x/week |
| PlaET | Placebo comparator | Dietary Supplement: PlaETDietary Supplement: Collagen Participants ingest 15 grams of placebo daily + Endurance training 12 weeks, 3x/week |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Male gender Age 18-40 years No subjective symptoms during physical exertion BMI of 18.5 to 26 Stable weight and dietary habits No extensive strength/endurance training (less than 3 hours per week) No contraindications to physical exertion according to ACSM guidelines No contraindications to supplemental nutrition or ergogenic supplements
Key exclusion criteria (1 listed)
- Contraindications to physical activity (e.g., chronic heart disease, arrhythmia, heart valve disease, arthritis, etc.; general exclusion criteria according to ACSM 2009; intolerance/aversion to animal protein) Arterial hypertension (systolic BP > 200 mmHg and/or diastolic BP > 105 mmHg) at rest Insulin-dependent diabetes mellitus (IDDM) Liver and/or kidney disease that excludes a high protein load
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ColCTDietary Supplement: Collagen Participants ingest 15 grams of specific collagen peptides daily | Dietary supplement | ColCT |
| ColETDietary Supplement: Collagen Participants ingest 15 grams of specific collagen peptides daily | Dietary supplement | ColET |
| PlaCTDietary Supplement: Placebo. Participants ingest 15 grams of placebo daily | Dietary supplement | PlaCT |
| PlaETDietary Supplement: Placebo. Participants ingest 15 grams of placebo daily | Dietary supplement | PlaET |
Primary outcome
One-hour time trial performance
Time frame: Baseline and after 12 weeks
Participants run an hour on the track outside as far as possible
Achilles tendon cross sectional-area
Time frame: Baseline and after 12 weeks
Ultrasound
Achilles and Patellar tendon Stiffness
Time frame: Baseline and after 12 weeks
Ultrasound + isokinetic dynamometer
VO2max
Time frame: Baseline and after 12 weeks
treadmill with spirometry
5 secondary outcomes
Body composition
Time frame: Baseline and after 12 weeks
Achilles tendon stress, strain, Young's modulus
Time frame: Baseline and after 12 weeks
Patellar tendon strain
Time frame: Baseline and after 12 weeks
RER, VT1, VT2, LTP1, LTP2, HFrel., FATox.
Time frame: Baseline and after 12 weeks
Achilles tendon echointensity
Time frame: Baseline and after 12 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Nov 2024.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ColCT, ColET and PlaCT in people with Collagen Supplementation, run by University of Vienna at 1 site in Austria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 14 Nov 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
One-hour time trial performance (time frame: Baseline and after 12 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Nov 2024.