Taste Thresholds in Healthy VolunteersNCT06697847
Sweet Thresholds in Healthy Volunteers Study
An observational study of Taste Thresholds in Healthy Volunteers, run by Ranvier Health Ltd at 1 site in United Kingdom.
Trial summary
The sweet threshold (concentration of sucrose in water) at which healthy participants can detect a sweet flavour will be recorded. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Taste Thresholds in Healthy Volunteers
- How many people
- 30 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 27 Nov 2024to 14 Mar 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Adults without mood questionnaires recruited by word of mouth and posters in retail establishments in England and Wales
Who may be able to join
- . Male and female adults of 18 years old and over;
- Participants without a diagnosis of major depressive disorder (MDD) / anxiety disorder;
- Participants not taking an antidepressant during the preceding 6 months
- Not suffering from significant other mental or physical illness, such as confirmed psychosis, end of life care, or any other condition assessed as significant by the Site Investigator;
- Willing and able to comply with all study-related procedures;
- Not having COVID 19 or continuing effects of COVID 19 including altered sense of taste;
- Understands the study requirements and the treatment procedures and is able to provide written informed consent.
Who cannot join
- Taking antidepressant medication currently or during the previous 6 months;
- Known or suspected hypersensitivity or intolerance to any taste testing solutions, or any of their excipients;
- A history or presence of neurological or confounding psychiatric conditions (such as stroke, traumatic brain injury, epilepsy, space occupying lesions, multiple sclerosis, Parkinson's disease, vascular dementia, transient ischemic attack, or schizophrenia);
- Patients with a diagnosis of chronic pain;
- Pregnancy or possibility pregnancy, or breastfeeding;
- Participants using supplements containing psychoactive herbs (for example St Johns Wort or 5-HTP (5-Hydroxytryptophan, also known as oxitriptan);
- Participants regularly using psychoactive stimulants (for example MDMA);
- Participants unable or unwilling to comply with study procedures.
Trial locations and contacts
1 site in 1 country.
United Kingdom1 site
Westbury Lodge, Westbury Park
Bristol, City Of Bristol, BS6 7JE
About this study
Official title: Assessing Taste Thresholds and Scores on Standardised Mood Questionnaires in Participants Without Mood Disorders
The sweet threshold (concentration of sucrose in water) at which healthy participants can detect a sweet flavour will be recorded.
Read the detailed description
The sweet threshold (concentration of sucrose in water) at which healthy participants can detect a sweet flavour will be recorded by means of application on a cotton bud to the anterior third of the tongue. Solutions will be presented in a pseudo-randomised order. Mood questionnaires will be completed (to check that participants are indeed healthy). The questionnaires used will be the Patient Health Questionnaire 9 (PHQ9), Beck's Depression Inventory (BDI) and Generalised Anxiety Disorder Questionnaire 7 (GAD-7).
This data is being collected with the intention of its use for comparison with sweet thresholds established in other populations using the same method of sweet threshold estimation.
- Conditions
- Taste Thresholds in Healthy Volunteers
- Keywords
- Taste thresholds, Healthy volunteers
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Healthy volunteers | Adults with no mood disorder and who have not been diagnosed with or had treatment for a mood disorder in the last 6 months. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Sweet taste threshold
Sweet taste threshold established by applying varying concentrations of sucrose solution to the tongue and assessing whether a sweet taste can be detected by the participant. The sweet threshold is the minimum concentration at which a participant can reliably detect the sweet flavour.
Measured: From enrolment to a final taste test 6 weeks later
Secondary outcomes (3)
Score on Becks Depression Inventory
Becks depression inventory will be completed by the participant at the first and last visit. The score will be calculated to check that the participant is free of mood disorder. The scale ranges from 1-40 and a score of less than 10 is normal. Higher scores suggest increasing degrees of depression.
Measured: From enrolment to a final questionnaire 6 weeks later
Score on Patient Health Questionnaire 9
Patient Health Questionnaire 9 will be completed by the participant at the first and last visit. The score will be calculated to check that the participant is free of mood disorder. The scale ranges from 0-27 and a score less than 5 suggests the subject is not depressed.
Measured: From enrolment to a final questionnaire 6 weeks later
Score on Generalised Anxiety Disorder scale 7
Generalised Anxiety Disorder scale 7 will be completed by the participant at the first and last visit. The score will be calculated to check that the participant is free of mood disorder. The scale ranges from 0-21. A score of less than 4 suggests minimal anxiety and increasing scores suggest greater anxiety symptoms.
Measured: From enrolment to a final questionnaire 6 weeks later
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Nov 2024
- Study start27 Nov 2024
- Primary completion31 Jan 2025
- Study completion14 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Taste Thresholds in Healthy VolunteersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ranvier Health Ltd
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06697847
- Sponsor's protocol ID
- 2Brsv1
- Status last verified
- Jun 2026
- First submitted
- 18 Nov 2024
- Last updated
- 22 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Data collected contains sensitive information and even when anonymised contains commercially sensitive information
Study at a glance
From the registry record, last updated by the sponsor on 22 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessing Taste Thresholds and Scores on Standardised Mood Questionnaires in Participants Without Mood Disorders
- ClinicalTrials.gov ID
- NCT06697847
- Acronym / sponsor ID
- 2Brsv1
- Conditions
- Taste Thresholds in Healthy Volunteers
- Keywords
- Taste thresholds, Healthy volunteers
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Ranvier Health LtdIndustry (pharma, biotech, devices)
- Study start
- 27 Nov 2024 (actual)
- Primary completion
- 31 Jan 2025 (actual)
- Study completion
- 14 Mar 2025 (actual)
- First posted
- 20 Nov 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The sweet threshold (concentration of sucrose in water) at which healthy participants can detect a sweet flavour will be recorded.
Detailed description
The sweet threshold (concentration of sucrose in water) at which healthy participants can detect a sweet flavour will be recorded by means of application on a cotton bud to the anterior third of the tongue. Solutions will be presented in a pseudo-randomised order. Mood questionnaires will be completed (to check that participants are indeed healthy). The questionnaires used will be the Patient Health Questionnaire 9 (PHQ9), Beck's Depression Inventory (BDI) and Generalised Anxiety Disorder Questionnaire 7 (GAD-7).
This data is being collected with the intention of its use for comparison with sweet thresholds established in other populations using the same method of sweet threshold estimation.
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Healthy volunteers | – | –Adults with no mood disorder and who have not been diagnosed with or had treatment for a mood disorder in the last 6 months. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Adults without mood questionnaires recruited by word of mouth and posters in retail establishments in England and Wales
Key inclusion criteria (7 listed)
- . Male and female adults of 18 years old and over;
- Participants without a diagnosis of major depressive disorder (MDD) / anxiety disorder;
- Participants not taking an antidepressant during the preceding 6 months
- Not suffering from significant other mental or physical illness, such as confirmed psychosis, end of life care, or any other condition assessed as significant by the Site Investigator;
- Willing and able to comply with all study-related procedures;
Key exclusion criteria (8 listed)
- Taking antidepressant medication currently or during the previous 6 months;
- Known or suspected hypersensitivity or intolerance to any taste testing solutions, or any of their excipients;
- A history or presence of neurological or confounding psychiatric conditions (such as stroke, traumatic brain injury, epilepsy, space occupying lesions, multiple sclerosis, Parkinson's disease, vascular dementia, transient ischemic attack, or schizophrenia);
- Patients with a diagnosis of chronic pain;
- Pregnancy or possibility pregnancy, or breastfeeding;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Sweet taste threshold
Time frame: From enrolment to a final taste test 6 weeks later
Sweet taste threshold established by applying varying concentrations of sucrose solution to the tongue and assessing whether a sweet taste can be detected by the participant. The sweet threshold is the minimum concentration at which a participant can reliably detect the sweet flavour.
3 secondary outcomes
Score on Becks Depression Inventory
Time frame: From enrolment to a final questionnaire 6 weeks later
Score on Patient Health Questionnaire 9
Time frame: From enrolment to a final questionnaire 6 weeks later
Score on Generalised Anxiety Disorder scale 7
Time frame: From enrolment to a final questionnaire 6 weeks later
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jun 2026.
- Individual participant dataSharing planned: No. Data collected contains sensitive information and even when anonymised contains commercially sensitive information
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Taste Thresholds in Healthy Volunteers, run by Ranvier Health Ltd at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Sweet taste threshold (time frame: From enrolment to a final taste test 6 weeks later). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jun 2026.