DeprescribingNCT06698770
Leveraging Behavioral Science to Improve Medicine Optimization Conversations With Older Adults
A study testing Anticipated long-term use of medication and Period re-evaluation of medication in people with Deprescribing, run by University of Michigan at 1 site in United States.
Trial summary
Our online, survey-based experiment will include 2,400 adults who are 65-years and older (n=1,200 each from United States and Australia). Each participant will be asked to give their opinions on a hypothetical patient scenario that has been developed by our diverse team in partnership with our stakeholder… Read more about this study
- Who is it for?
- Ages 65 years and olderHealthy volunteers can take part
- Conditions the study is for
- Deprescribing
- What is being tested?
- Anticipated long-term use of medication and Period re-evaluation of medication
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 2,420 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Nov 2024to 30 Jan 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- Healthy volunteers accepted
- Older adult
Who may be able to join
- 65 years and older and resides in Australia or the United States
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country.
About this study
Our online, survey-based experiment will include 2,400 adults who are 65-years and older (n=1,200 each from United States and Australia). Each participant will be asked to give their opinions on a hypothetical patient scenario that has been developed by our diverse team in partnership with our stakeholder organizations.This work is expected to significantly contribute to our understanding of how older adults make decisions about deprescribing medications.
- Conditions
- Deprescribing
- Being tested
- Anticipated long-term use of medication, Period re-evaluation of medication
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Anticipated long-term use of medicationOther
In this hypothetical scenario, the doctor anticipates that the participant will take this medication for the rest of their life.
Period re-evaluation of medicationOther
In this hypothetical scenario, the doctor anticipates that the participant will take this medication for the rest of their life but will periodically re-evaluate the benefits and risks of the medication.
| Study group | Role | What they receive |
|---|---|---|
| Start medication - Lower chance of future health problems | Experimental | Participants read a hypothetical scenario where a doctor recommends starting a new medication to lower their chances of experiencing significant health problems. Receives: Other: Anticipated long-term use of medication; Other: Period re-evaluation of medication |
| Start medication - Higher risk without medication | Experimental | Participants read a hypothetical scenario where a doctor recommends starting a new medication because they could experience a higher risk of serious health problems without it Receives: Other: Anticipated long-term use of medication; Other: Period re-evaluation of medication |
| Stop medication - Lack of benefit | Experimental | Participants read a hypothetical scenario where a doctor suggests stopping the medication due to a lack of benefit. Receives: Other: Anticipated long-term use of medication; Other: Period re-evaluation of medication |
| Stop medication - Potential for harm | Experimental | Participants read a hypothetical scenario where a doctor suggests stopping the medication due to the potential for harm. Receives: Other: Anticipated long-term use of medication; Other: Period re-evaluation of medication |
What is being measured
The primary outcome is the main question the study is designed to answer.
Preference regarding starting medication
Response to statement, "Based on what you have read so far, what would you prefer to do with this diabetes medicine?" on a 6-point Likert scale with scale anchors 1=Strongly prefer not to start medicine and 6=Strongly prefer to start medicine
Measured: 1 year
Stopping medication
Response to statement, "Based on what you have read so far, what would you prefer to do with this diabetes medicine?" on a 6-point Likert scale with scale anchors 1=Strongly prefer not to continue and 6=Strongly prefer to stop
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Nov 2024
- Study start1 Nov 2024
- Primary completion30 Jan 2025
- Study completion30 Jan 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for DeprescribingStudies of the same condition, open and under way.
- More trials run by University of MichiganThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 2,420 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Michigan
- Sponsor type
- University, hospital or other
- Collaborators
- University of Sydney
- Responsible party
- Principal investigator, Vordenberg, University of Michigan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06698770
- Sponsor's protocol ID
- HUM00259517
- Status last verified
- Nov 2024
- First submitted
- 19 Nov 2024
- Last updated
- 26 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Chaitoff A, Weir KR, Marshall VD, Vordenberg SE. Understanding Medicine Preferences of Older Adults: The Role of Messaging in a Multi-Methods Experimental Survey. Health Expect. 2025 Aug;28(4):e70366. doi: 10.1111/hex.70366.
PubMed 40767505
Study at a glance
From the registry record, last updated by the sponsor on 26 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Leveraging Behavioral Science to Improve Medicine Optimization Conversations With Older Adults
- ClinicalTrials.gov ID
- NCT06698770
- Acronym / sponsor ID
- HUM00259517
- Conditions
- Deprescribing
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 2,420 participants (actual)
- Lead sponsor
- University of MichiganUniversity, hospital or other
- Collaborators
- University of Sydney
- Study start
- 1 Nov 2024 (actual)
- Primary completion
- 30 Jan 2025 (actual)
- Study completion
- 30 Jan 2025 (actual)
- First posted
- 21 Nov 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Our online, survey-based experiment will include 2,400 adults who are 65-years and older (n=1,200 each from United States and Australia). Each participant will be asked to give their opinions on a hypothetical patient scenario that has been developed by our diverse team in partnership with our stakeholder organizations.This work is expected to significantly contribute to our understanding of how older adults make decisions about deprescribing medications.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind (participant)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Start medication - Lower chance of future health problems | Experimental | Other: Anticipated long-term use of medication, Other: Period re-evaluation of medicationParticipants read a hypothetical scenario where a doctor recommends starting a new medication to lower their chances of experiencing significant health problems. |
| Start medication - Higher risk without medication | Experimental | Other: Anticipated long-term use of medication, Other: Period re-evaluation of medicationParticipants read a hypothetical scenario where a doctor recommends starting a new medication because they could experience a higher risk of serious health problems without it |
| Stop medication - Lack of benefit | Experimental | Other: Anticipated long-term use of medication, Other: Period re-evaluation of medicationParticipants read a hypothetical scenario where a doctor suggests stopping the medication due to a lack of benefit. |
| Stop medication - Potential for harm | Experimental | Other: Anticipated long-term use of medication, Other: Period re-evaluation of medicationParticipants read a hypothetical scenario where a doctor suggests stopping the medication due to the potential for harm. |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
Key inclusion criteria (1 listed)
- 65 years and older and resides in Australia or the United States
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Anticipated long-term use of medicationIn this hypothetical scenario, the doctor anticipates that the participant will take this medication for the rest of their life. | Other | Start medication - Higher risk without medication, Start medication - Lower chance of future health problems, Stop medication - Lack of benefit, Stop medication - Potential for harm |
| Period re-evaluation of medicationIn this hypothetical scenario, the doctor anticipates that the participant will take this medication for the rest of their life but will periodically re-evaluate the benefits and risks of the medication. | Other | Start medication - Higher risk without medication, Start medication - Lower chance of future health problems, Stop medication - Lack of benefit, Stop medication - Potential for harm |
Primary outcome
Preference regarding starting medication
Time frame: 1 year
Response to statement, "Based on what you have read so far, what would you prefer to do with this diabetes medicine?" on a 6-point Likert scale with scale anchors 1=Strongly prefer not to start medicine and 6=Strongly prefer to start medicine
Stopping medication
Time frame: 1 year
Response to statement, "Based on what you have read so far, what would you prefer to do with this diabetes medicine?" on a 6-point Likert scale with scale anchors 1=Strongly prefer not to continue and 6=Strongly prefer to stop
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Sep 2025.
- Derived from this study: PubMed 40767505Chaitoff A, Weir KR, Marshall VD, Vordenberg SE. Understanding Medicine Preferences of Older Adults: The Role of Messaging in a Multi-Methods Experimental Survey. Health Expect. 2025 Aug;28(4):e70366. doi: 10.1111/hex.70366.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Anticipated long-term use of medication and Period re-evaluation of medication in people with Deprescribing, run by University of Michigan at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Preference regarding starting medication (time frame: 1 year). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06698770, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Sep 2025.