Endoscopic UltrasoundNCT06704867
High Flow Nasal Cannula Compared to Standard Oxygen for Endoscopic Ultrasound
A study testing High flow nasal cannula in people with Endoscopic Ultrasound, run by Mayo Clinic at 1 site in United States.
Trial summary
The purpose of the study is to evaluate the use of high flow nasal cannula versus standard oxygen therapy for high-risk patients undergoing endoscopy procedures. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Endoscopic Ultrasound
- What is being tested?
- High flow nasal cannula
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 200 participants
- Where
- 1 siteUnited States
- Study dates
- 14 Jul 2025to Feb 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- All patients age 18 years and older who present to Gonda 2 procedural area for Endoscopic ultrasound (EUS) with or without endoscopy (EGD)/biopsy/tissue sampling. with BMI ≥ 35 kg/m2 (BMI within the past 6 months in electronic medical records or at current procedure) who are able to consent will be approached for potential enrollment.
Who cannot join
- Need for general anesthesia for the procedure instead of the standard monitored anesthesia care.
- Patients undergoing combined procedure: Therapeutic EUS/combined procedures including EUS/ERCP, EUS/colonoscopy
- Patients on home oxygen therapy, or the diagnosis of "severe COPD"
- Patients with existing tracheostomy
- Inpatients undergoing EUS
- Inability to consent
Show all 10Show fewer
- Cognitive impairment
- Blocked nasal passages
- Trauma/previous surgery to the nasopharynx
- Irregularities of the nose, face, or airway such that HFNC cannot be properly fitted
Trial locations and contacts
1 site in 1 country.
About this study
Official title: High Flow Nasal Cannula Compared to Standard Oxygen Therapy for Endoscopic Ultrasound Procedure in High Risk Patients on Recovery Time and Procedural Conditions
The purpose of the study is to evaluate the use of high flow nasal cannula versus standard oxygen therapy for high-risk patients undergoing endoscopy procedures.
Read the detailed description
Patients with a higher BMI are at greater risk for lower oxygen levels which can delay the endoscopy procedure. This research is being conducted to find out if high risk patients will have a shorter recovery time and improved procedural conditions with a high flow nasal cannula versus standard oxygen therapy.
- Conditions
- Endoscopic Ultrasound
- Being tested
- High flow nasal cannula
- Keywords
- High Flow Nasal Cannula, High BMI, Oxygen
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High flow nasal cannulaOther
Subjects undergoing endoscopic ultrasound will receive high flow nasal cannula during the procedure
| Study group | Role | What they receive |
|---|---|---|
| Standard oxygen therapy | No intervention | Standard oxygen therapy will be initiated utilizing 2-4 liters of oxygen with a nasal cannula. |
| High Flow Nasal Cannula | Experimental | A high flow oxygen device with 100% FiO2 will be initiated prior to endoscopic ultrasound. Receives: Other: High flow nasal cannula |
What is being measured
The primary outcome is the main question the study is designed to answer.
Decrease recovery time
Time measured in minutes for participants to enter post anesthesia care until the nurse marks "ready for discharge" in the medical record.
Measured: 4 hours
Secondary outcomes (1)
Improve procedural conditions
Decreased number of times the procedure is paused or delayed.
Measured: 1 hour
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Nov 2024
- Study start14 Jul 2025
- Primary completion23 Jun 2026
- Study completionFeb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Endoscopic UltrasoundStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Care provider
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Collaborators
- Fisher and Paykel Healthcare
- Responsible party
- Principal investigator, Bhargavi Gali, M.D., Mayo Clinic
- Investigators
- Bhargavi Gali, MD, MHA, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06704867
- Sponsor's protocol ID
- 24-003924
- Status last verified
- Sep 2026
- First submitted
- 20 Nov 2024
- Last updated
- 8 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- High Flow Nasal Cannula Compared to Standard Oxygen Therapy for Endoscopic Ultrasound Procedure in High Risk Patients on Recovery Time and Procedural Conditions
- ClinicalTrials.gov ID
- NCT06704867
- Acronym / sponsor ID
- 24-003924
- Conditions
- Endoscopic Ultrasound
- Keywords
- High Flow Nasal Cannula, High BMI, Oxygen
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Collaborators
- Fisher and Paykel Healthcare
- Study start
- 14 Jul 2025 (actual)
- Primary completion
- 23 Jun 2026 (actual)
- Study completion
- Feb 2027 (estimated)
- First posted
- 26 Nov 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of the study is to evaluate the use of high flow nasal cannula versus standard oxygen therapy for high-risk patients undergoing endoscopy procedures.
Detailed description
Patients with a higher BMI are at greater risk for lower oxygen levels which can delay the endoscopy procedure. This research is being conducted to find out if high risk patients will have a shorter recovery time and improved procedural conditions with a high flow nasal cannula versus standard oxygen therapy.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (care provider)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Standard oxygen therapy | No intervention | –Standard oxygen therapy will be initiated utilizing 2-4 liters of oxygen with a nasal cannula. |
| High Flow Nasal Cannula | Experimental | Other: High flow nasal cannulaA high flow oxygen device with 100% FiO2 will be initiated prior to endoscopic ultrasound. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- All patients age 18 years and older who present to Gonda 2 procedural area for Endoscopic ultrasound (EUS) with or without endoscopy (EGD)/biopsy/tissue sampling. with BMI ≥ 35 kg/m2 (BMI within the past 6 months in electronic medical records or at current procedure) who are able to consent will be approached for potential enrollment.
Key exclusion criteria (10 listed)
- Need for general anesthesia for the procedure instead of the standard monitored anesthesia care.
- Patients undergoing combined procedure: Therapeutic EUS/combined procedures including EUS/ERCP, EUS/colonoscopy
- Patients on home oxygen therapy, or the diagnosis of "severe COPD"
- Patients with existing tracheostomy
- Inpatients undergoing EUS
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High flow nasal cannulaSubjects undergoing endoscopic ultrasound will receive high flow nasal cannula during the procedure | Other | High Flow Nasal Cannula |
Primary outcome
Decrease recovery time
Time frame: 4 hours
Time measured in minutes for participants to enter post anesthesia care until the nurse marks "ready for discharge" in the medical record.
1 secondary outcome
Improve procedural conditions
Time frame: 1 hour
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Sep 2026.
- Individual participant dataSharing planned: No
Related trials for Endoscopic Ultrasound
Recruiting
Determination of Pancreatic Steatosis Prevalence and Correlation With High-risk Cyst Features
Pancreatic Steatosis, Pancreatic Cyst
Not yet recruitingObservational study
Within-Session Repeatability of EUS-Guided Portal Pressure Gradient Measurement
Portal Hypertension, Chronic Liver Disease
Recruiting
Randomized Trial of Next Generation Fluoroscopy System vs. Conventional Fluoroscopy System in Endoscopy
Radiation Exposure
Recruiting
EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope
Pancreatic Disease, Pancreatic Cancer
RecruitingObservational study
EUS Procedures Using RIVOS™ EUS Access Device
Pancreatic Fluid Collections, Biliary Obstruction
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Bhargavi Gali, MD, MHA principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High flow nasal cannula in people with Endoscopic Ultrasound, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 8 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Decrease recovery time (time frame: 4 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Sep 2026.