Hoarding DisorderTMS-HOLANCT06712914
Rapid Non-Invasive Brain Stimulation for Hoarding Disorder
A study testing MagPro X100 by MagVenture in people with Hoarding Disorder and Hoarding, run by Stanford University at 1 site in United States.
Trial summary
This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Hoarding Disorder, Hoarding, Clutter
- What is being tested?
- MagPro X100 by MagVenture
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteUnited States
- Study dates
- 27 Mar 2026to 1 Jan 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 18-70 years
- Primary diagnosis of hoarding disorder
- Sufficient severity of hoarding symptoms
- Willing and able to understand and complete consent and study procedures
Who cannot join
- Psychiatric or medical conditions or medications that make participation unsafe
- Pregnant or nursing females
- Previous exposure to TMS or ECT
- History of any implanted device or psychosurgery
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Stanford University Medical Center
Palo Alto, California, 94305
Paula Munoz Rodriguez, PhD, 650-723-4095, clutterhelp@stanford.edu
Carolyn Rodriguez, MD, PhD
About this study
This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms.
Read the detailed description
Hoarding disorder (HD) is characterized by difficulty letting go of possessions, leading to clutter that congests living spaces and impairs daily functioning. The majority of HD patients treated with cognitive behavioral therapy for HD usually experience considerable residual symptoms. New treatments are greatly needed. This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms.
- Conditions
- Hoarding Disorder, Hoarding, Clutter
- Being tested
- MagPro X100 by MagVenture
- Keywords
- TMS, hoarding disorder, hoarding, clutter, iTBS
- Medical subject headings
- Hoarding Disorder, Hoarding, Speech Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MagPro X100 by MagVentureDevice
Participants will receive 5 session per day of TBS for 6 days (30 sessions total). Six treatment days have to occur within a 2 week period. Each session will be comprised of 1800 pulses, using a MagVenture MagPro X100.
| Study group | Role | What they receive |
|---|---|---|
| Theta-burst stimulation (TBS) | Experimental | Theta-burst stimulation (a form of transcranial magnetic stimulation) targeting the right frontal pole. Receives: Device: MagPro X100 by MagVenture |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Compulsive Acquisition Scale (CAS)
The Compulsive Acquisition Scale (CAS) is an 18-item questionnaire that measures the extent to which individuals acquire and feel compelled to acquire possessions.
The total score (sum of 18 items) ranges from 0 to 126. Total score higher than 48 shows significant difficulty with acquiring.
Measured: Change from baseline to 3 weeks after treatment starts
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Dec 2024
- Study start27 Mar 2026
- Primary completion31 Dec 2027 (estimated)
- Study completion1 Jan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hoarding DisorderStudies of the same condition, open and under way.
- More trials run by Stanford UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Stanford University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Carolyn Rodriguez, Stanford University
- Investigators
- Carolyn I Rodriguez, MD, PhD, Principal investigator, Stanford University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06712914
- Sponsor's protocol ID
- 77098
- Acronym
- TMS-HOLA
- Status last verified
- Apr 2026
- First submitted
- 27 Nov 2024
- Last updated
- 22 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Rapid Non-Invasive Brain Stimulation for Hoarding Disorder
- ClinicalTrials.gov ID
- NCT06712914
- Acronym / sponsor ID
- TMS-HOLA / 77098
- Conditions
- Hoarding Disorder, Hoarding, Clutter
- Keywords
- TMS, hoarding disorder, hoarding, clutter, iTBS
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- Stanford UniversityUniversity, hospital or other
- Study start
- 27 Mar 2026 (actual)
- Primary completion
- 31 Dec 2027 (estimated)
- Study completion
- 1 Jan 2028 (estimated)
- First posted
- 2 Dec 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms.
Detailed description
Hoarding disorder (HD) is characterized by difficulty letting go of possessions, leading to clutter that congests living spaces and impairs daily functioning. The majority of HD patients treated with cognitive behavioral therapy for HD usually experience considerable residual symptoms. New treatments are greatly needed. This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Theta-burst stimulation (TBS) | Experimental | Device: MagPro X100 by MagVentureTheta-burst stimulation (a form of transcranial magnetic stimulation) targeting the right frontal pole. |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age 18-70 years
- Primary diagnosis of hoarding disorder
- Sufficient severity of hoarding symptoms
- Willing and able to understand and complete consent and study procedures
Key exclusion criteria (4 listed)
- Psychiatric or medical conditions or medications that make participation unsafe
- Pregnant or nursing females
- Previous exposure to TMS or ECT
- History of any implanted device or psychosurgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MagPro X100 by MagVentureParticipants will receive 5 session per day of TBS for 6 days (30 sessions total). Six treatment days have to occur within a 2 week period. Each session will be comprised of 1800 pulses, using a MagVenture MagPro X100. | Device | Theta-burst stimulation (TBS) |
Primary outcome
Change in Compulsive Acquisition Scale (CAS)
Time frame: Change from baseline to 3 weeks after treatment starts
The Compulsive Acquisition Scale (CAS) is an 18-item questionnaire that measures the extent to which individuals acquire and feel compelled to acquire possessions. The total score (sum of 18 items) ranges from 0 to 126. Total score higher than 48 shows significant difficulty with acquiring.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Apr 2026.
- Rodriguez Lab WebsiteLink provided by the sponsor.
- Dr. Carolyn Rodriguez (PI) Stanford Faculty ProfileLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Carolyn I Rodriguez, MD, PhD principal investigator
Stanford University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing MagPro X100 by MagVenture in people with Hoarding Disorder and Hoarding, run by Stanford University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 22 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Paula Munoz Rodriguez, PhD (650-723-4095, clutterhelp@stanford.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Compulsive Acquisition Scale (CAS) (time frame: Change from baseline to 3 weeks after treatment starts). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Apr 2026.