Socket PreservationNCT06716736
Socket Preservation After Surgical Extraction of Impacted Lower Third Molar
A study testing socket preservation using dentine graft mixed with i-PRF, socket preservation using bone allograft and socket preservation using collagen cone in people with Socket Preservation, run by Wael Mohamed at 1 site in Egypt.
Trial summary
The aim of this study will be to evaluate socket preservation using autogenous particulate dentin in combination with liquid platelet-rich fibrin versus bone allografts and collagen cone after surgical extraction of the horizontally impacted lower third molar Read more about this study
- Who is it for?
- Ages 18 to 35 years
- Conditions the study is for
- Socket Preservation
- What is being tested?
- socket preservation using dentine graft mixed with i-PRF, socket preservation using bone allograft and socket preservation using collagen cone
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Dec 2022to 1 Apr 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Fresh extracted socket of horizontally impacted mandibular third molar
- Co-operative patients willing to complete the follow-up periods.
- Patients age from 18-35 years.
- Good oral hygiene.
Who cannot join
- Any pathological condition at the site of surgery.
- Patients with systemic diseases that contra-indicate the surgical procedure such as uncontrolled diabetes mellitus, bleeding disorders, serious osseous disorders and mental disorders.
- Smokers .
- Pregnancy.
- -
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Socket Preservation Using Autogenous Particulate Dentin in Combination With Liquid Platelet-rich Fibrin Versus Bone Allografts and Collagen Cones After Surgical Extraction of Impacted Lower Third Molar
The aim of this study will be to evaluate socket preservation using autogenous particulate dentin in combination with liquid platelet-rich fibrin versus bone allografts and collagen cone after surgical extraction of the horizontally impacted lower third molar
Read the detailed description
The aim of this study will be to evaluate socket preservation using autogenous particulate dentin in combination with liquid platelet-rich fibrin (sticky tooth) versus bone allografts and collagen cone after surgical extraction of the horizontally impacted lower third molar
- Conditions
- Socket Preservation
- Being tested
- socket preservation using dentine graft mixed with i-PRF, socket preservation using bone allograft, socket preservation using collagen cone
- Keywords
- socket preservation, dentine graft
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
socket preservation using dentine graft mixed with i-PRFBiological
surgical extraction of horizontally impacted third molar , placement of dentin graft mixed with i-PRF inside the socket , suturing
socket preservation using bone allograftBiological
surgical extraction of horizontally impacted third molar , placement of bone allograft inside the socket , suturing
socket preservation using collagen coneBiological
surgical extraction of horizontally impacted third molar , placement of collagen cone inside the socket , suturing
| Study group | Role | What they receive |
|---|---|---|
| socket preservation with dentine graft mixed with liquid platelet rich fibrin (sticky tooth) | Active comparator | socket preservation with dentine graft mixed with liquid platelet rich fibrin (sticky tooth) after surgical extraction of horizontally impacted lower wisdom Receives: Biological: socket preservation using dentine graft mixed with i-PRF |
| socket preservation with bone allograft | Active comparator | socket preservation with bone allograft after surgical extraction of horizontally impacted lower wisdom Receives: Biological: socket preservation using bone allograft |
| socket preservation with collagen cone | Active comparator | socket preservation with collagen cone after surgical extraction of horizontally impacted lower wisdom Receives: Biological: socket preservation using collagen cone |
What is being measured
The primary outcome is the main question the study is designed to answer.
bone resorption distal to second molar
by measuring bone level immediate and 3 months after extraction on CBCT
Measured: 3 months after extraction
Secondary outcomes (3)
bone density
using CBCT 3 month after extraction
Measured: 3 months after extraction
edema
by measuring distance between predetermined anatomical landmarks:
- Mandibular angle and canthus of the eye.
- Mandibular angle and corner of the mouth.
- Mandibular angle and tragus.
- Mandibular angle and pogonion.
Measured: 4 days after extraction
pain after surgical extraction
using numerical rating scale
Measured: 4 days after extraction
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Dec 2024
- Study start1 Dec 2022
- Primary completion15 Dec 2023
- Study completion1 Apr 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Socket PreservationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- Wael Mohamed
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Wael Mohamed, Mansoura University
- Investigators
- Wael M Ahmed, PHD, Principal investigator, mansoura uniersity
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06716736
- Sponsor's protocol ID
- A08061222
- Status last verified
- Nov 2024
- First submitted
- 29 Nov 2024
- Last updated
- 4 Dec 2024
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Dec 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Socket Preservation Using Autogenous Particulate Dentin in Combination With Liquid Platelet-rich Fibrin Versus Bone Allografts and Collagen Cones After Surgical Extraction of Impacted Lower Third Molar
- ClinicalTrials.gov ID
- NCT06716736
- Acronym / sponsor ID
- A08061222
- Conditions
- Socket Preservation
- Keywords
- socket preservation, dentine graft
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- Wael MohamedUniversity, hospital or other
- Study start
- 1 Dec 2022 (actual)
- Primary completion
- 15 Dec 2023 (actual)
- Study completion
- 1 Apr 2024 (actual)
- First posted
- 4 Dec 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study will be to evaluate socket preservation using autogenous particulate dentin in combination with liquid platelet-rich fibrin versus bone allografts and collagen cone after surgical extraction of the horizontally impacted lower third molar
Detailed description
The aim of this study will be to evaluate socket preservation using autogenous particulate dentin in combination with liquid platelet-rich fibrin (sticky tooth) versus bone allografts and collagen cone after surgical extraction of the horizontally impacted lower third molar
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| socket preservation with dentine graft mixed with liquid platelet rich fibrin (sticky tooth) | Active comparator | Biological: socket preservation using dentine graft mixed with i-PRFsocket preservation with dentine graft mixed with liquid platelet rich fibrin (sticky tooth) after surgical extraction of horizontally impacted lower wisdom |
| socket preservation with bone allograft | Active comparator | Biological: socket preservation using bone allograftsocket preservation with bone allograft after surgical extraction of horizontally impacted lower wisdom |
| socket preservation with collagen cone | Active comparator | Biological: socket preservation using collagen conesocket preservation with collagen cone after surgical extraction of horizontally impacted lower wisdom |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Fresh extracted socket of horizontally impacted mandibular third molar
- Co-operative patients willing to complete the follow-up periods.
- Patients age from 18-35 years.
- Good oral hygiene.
Key exclusion criteria (5 listed)
- Any pathological condition at the site of surgery.
- Patients with systemic diseases that contra-indicate the surgical procedure such as uncontrolled diabetes mellitus, bleeding disorders, serious osseous disorders and mental disorders.
- Smokers .
- Pregnancy.
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| socket preservation using dentine graft mixed with i-PRFsurgical extraction of horizontally impacted third molar , placement of dentin graft mixed with i-PRF inside the socket , suturing | Biological | socket preservation with dentine graft mixed with liquid platelet rich fibrin (sticky tooth) |
| socket preservation using bone allograftsurgical extraction of horizontally impacted third molar , placement of bone allograft inside the socket , suturing | Biological | socket preservation with bone allograft |
| socket preservation using collagen conesurgical extraction of horizontally impacted third molar , placement of collagen cone inside the socket , suturing | Biological | socket preservation with collagen cone |
Primary outcome
bone resorption distal to second molar
Time frame: 3 months after extraction
by measuring bone level immediate and 3 months after extraction on CBCT
3 secondary outcomes
bone density
Time frame: 3 months after extraction
edema
Time frame: 4 days after extraction
pain after surgical extraction
Time frame: 4 days after extraction
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Dec 2024.
- Individual participant dataSharing planned: No
Related trials for Socket Preservation
Not yet recruiting
Bone and Soft Tissue Healing After Socket Preservation With NOVAMag or Permamem Membranes
Alveolar Bone Loss, Tooth Loss / Rehabilitation
Active, not recruitingPhase 4
Application of Alloplastic Bone Graft With Polycaprolactone (PCL) Membrane and ECM-Collagen Membrane on Secondary Socket Healing in Third Molar Surgery.
Wisdom Tooth, Socket Preservation
Recruiting
Effect of Thymoquinone 0.2% Gel on Bone Density, Bone Width, and Socket Preservation After Tooth Extraction
Radiographic Evaluation, Bone Density
Not yet recruiting
Injectable Alloplastic Bone Graft for Socket Preservation: Clinical, Radiographic, and Histological Evaluation
Tooth Extraction, Socket Preservation
Not yet recruiting
Evaluating The Use of CGF Plugs in Fresh Odontectomy Socket.
Odontectomy (Tooth Extraction), Socket Preservation and Healing Following Simple, Non-surgical Extraction
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Wael M Ahmed, PHD principal investigator
mansoura uniersity
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing socket preservation using dentine graft mixed with i-PRF, socket preservation using bone allograft and socket preservation using collagen cone in people with Socket Preservation, run by Wael Mohamed at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Dec 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
bone resorption distal to second molar (time frame: 3 months after extraction). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Dec 2024; AzTrials last refreshed its copy on 31 Oct 2026.