Crowding of Anterior Mandibular TeethNCT06731465
Efficiency, Efficacy, Periodontal & Occlusal Outcomes for Aligners Versus Fixed Orthodontic Appliances in Crowded Incisor Treatment
A study testing Clear aligner therapy and Fixed pre-adjusted edgewise orthodontic appliance in people with Crowding of Anterior Mandibular Teeth, run by University of Sharjah at 1 site in United Arab Emirates.
Trial summary
The goal of this clinical trial is to compare between fixed labial braces and clear aligners for the straightening of moderately overlapped lower front teeth. The main questions it aims to answer are: Effect of treatment on gum health Which treatment achieves lower front teeth alignment faster in terms of alignment… Read more about this study
- Who is it for?
- Ages 16 to 45 years
- Conditions the study is for
- Crowding of Anterior Mandibular Teeth
- What is being tested?
- Clear aligner therapy and Fixed pre-adjusted edgewise orthodontic appliance
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteUnited Arab Emirates
- Study dates
- 16 Oct 2023to Dec 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 to 45 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Patients with moderate-severe lower crowding (Little's irregularity index 4 to 9 mm), non-extraction treatment
- Age range: 16-45 years old
- Class I malocclusion
- Full permanent dentition
- No caries or periodontal disease
Who cannot join
- Extraction cases
- Patients with craniofacial syndromes, or cleft palate
- Patients with uncontrolled medical conditions or taking medication that can interfere with orthodontic tooth movement.
- Presence of extensive dental restorations in proximity to the gingival margin
- Presence of fixed bridges/crowns or partial dentures
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United Arab Emirates1 site
University Dental Hospital Sharjah (UDHS_
Sharjah city, Emirate of Sharjah, 27272
About this study
Official title: Efficiency, Efficacy, Periodontal and Occlusal Outcomes for Clear Aligners Versus Pre-adjusted Orthodontic Appliances in Moderately Crowded Lower Incisor Treatment: A Randomized Clinical
The goal of this clinical trial is to compare between fixed labial braces and clear aligners for the straightening of moderately overlapped lower front teeth. The main questions it aims to answer are:
- Effect of treatment on gum health
- Which treatment achieves lower front teeth alignment faster in terms of alignment time and t number of visits required to the orthodontist
- How well it straightens teeth.
Read more
Participants will:
- Receive either labial braces or clear aligners as part of their orthodontic treatment.
- Come for regular follow-up visits every 4 to 6 weeks with the orthodontist till full straightening of the lower front teeth.
- Have a 3D scan of their teeth taken after their teeth are aligned along with a specialized x-ray of their head and jaw.
Read the detailed description
The study is a randomized controlled trial aimed at comparing the efficiency, efficacy, periodontal and occlusal outcomes between two orthodontic treatment options: clear aligners and traditional fixed braces for patients with moderate crowding in the lower incisors.
Pre-treatment diagnostic records including clinical examination, intraoral scans, intraoral and extraoral photographs will be obtained for each participant.
To ensure that participants in both groups have similar levels of crowding severity and comparable dental health characteristics at the start of the study, randomization will be conducted in blocks. A total of forty participants (20 in each group) will be selected according to specific criteria designed to maintain this uniformity across both treatment groups.This study follows a parallel-group design and the participants will be randomly allocated into one of the two groups included in the study:
Intervention Groups:
- Group A - Fixed Labial Braces (Master Series®, American Orthodontics): In the traditional braces group, fixed metal brackets will be bonded to the lower teeth, and archwires will be used in a specific sequence designed to bring the teeth into alignment over time.
- Group B - Clear Aligners (EON Aligner): The clear aligner group will receive custom-fitted aligners created using a digital model of each participant's teeth. These aligners are removable, requiring patient adherence to wearing them for at least 22 hours daily.
Primary Outcomes:
- Total alignment time
- Clinical measures of periodontal status
- Occlusal contact distribution
- Efficacy of clear aligners Vs fixed appliances in alignment of lower anterior teeth
Secondary Outcomes:
- Total number of scheduled routine appointments and additional emergency visits
- Missed appointment rate
- Number of refinements
- Bracket/ attachment failure rate
- Chair-side Time
- Treatment Efficiency Index
- BANA (Microbial-enzymatic N-benzoyl-DL-arginine-2-napthylamide) Score
- Immunological Assay using ELISA
- Patient's occlusal comfort level
- Changes in mandibular incisor inclination
- Changes in the mandibular arch form
Data will be analyzed using SPSS (Statistical Package for the Social Sciences) software, with statistical tests appropriate to the variable types (e.g., Mann-Whitney for group comparisons and Wilcoxon Signed-Rank test for time-related variables).
- Conditions
- Crowding of Anterior Mandibular Teeth
- Being tested
- Clear aligner therapy, Fixed pre-adjusted edgewise orthodontic appliance
- Keywords
- Clinical trial, Clear Aligners, Fixed Pre-adjusted Edgewise Orthodontic Appliance, Orthodontic Treatment, Efficiency, Efficacy, Periodontal Outcomes, Randomized Clinical Trial, Orthodontic alignment time, Occlusal outcomes
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Clear aligner therapyDevice
Also called Clear aligners, Clear aligner therapy (CAT), Eon aligner
Participants in this group will receive clear aligners (EON Aligner, Minneapolis), designed and customized based on a digital model of each patient's dental structure. Aligners will be worn for at least 22 hours daily, and patients will change to a new aligner depending on treatment progress.
Fixed pre-adjusted edgewise orthodontic applianceDevice
Also called Fixed orthodontic appliance, Fixed labial braces, Conventional braces, Edgewise appliance
Participants in this group will be treated with pre-adjusted fixed orthodontic appliances (Master Series®, American Orthodontics™, WI, USA). This system includes fixed brackets bonded on the labial surface of teeth and a sequence of progressively larger arch wires aimed at achieving alignment over time.
| Study group | Role | What they receive |
|---|---|---|
| Fixed labial braces group | Active comparator | Participants in this group will be treated with pre-adjusted fixed orthodontic appliances. Receives: Device: Fixed pre-adjusted edgewise orthodontic appliance |
| Clear aligner group | Active comparator | Participants in this group will receive clear aligners customized based on a digital model of each patient's dentition. Receives: Device: Clear aligner therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Total alignment time
The duration of treatment time (rounded to the nearest day) required to achieve full alignment of the mandibular incisors determined clinically as <1mm little's irregularity index, evaluated for both treatment groups. This information is to be extracted from participant notes into a data collection sheet designed specifically for this study.
Measured: Through alignment, an average of 6 months
Bleeding on probing
Bleeding on probing as an indicator of tissue inflammatory response to bacterial pathogensis, using the Michigan Williams probe assigned a score of 0 - 3 for each site.
Measured: Baseline, after 3 months, and after 6 months
Occlusal contact surface area
Occlusal contact surface area as measured by the T-scan device in terms of no. of pixels
Measured: Baseline, and after an average of 6 months, and after treatment an average of 1 year
Efficacy of clear aligners Vs fixed appliances in alignment of lower anterior teeth
Efficacy of clear aligners Vs fixed appliances in alignment of lower anterior teeth using Little's irregularity index
Measured: Baseline, and after an average of 6 months
Symmetry of contact distribution
Symmetry of contact distribution as measured by the T-scan device.
Measured: Baseline, and after an average of 6 months
Probing depth
The distance measured from the base of the pocket to the most apical point on the gingival margin using the Michigan Williams probe.
Measured: Baseline, after 3 months, and after 6 months
Plaque index
Plaque index to evaluate the level and rate of plaque formation on tooth surfaces
Measured: Baseline, after 3 months, and after 6 months
Gingival index
Gingival index to determine the severity of gingival inflammation with a score from 0 - 3
Measured: Baseline, after 3 months, and after 6 months
Total treatment time
The duration of treatment time (rounded to the nearest day) required to complete treatment, evaluated for both treatment groups. This information is to be extracted from participant notes into a data collection sheet designed specifically for this study.
Measured: Through treatment, an average of 1 year
Secondary outcomes (11)
Total number of scheduled routine appointments and additional emergency visits
The number of scheduled routine appointments required to achieve full mandibular incisor alignment and additional visits for emergencies as recorded in participants' notes and the data collection sheet.
Measured: Through alignment, an average of 6 months
Missed appointment rate
The number of scheduled routine appointments that the patient failed to attend during the alignment phase of treatment as recorded in both participants' notes and the data collection sheet.
Measured: Through alignment, an average of 6 months
Number of refinements
If any of the participants required a refinement scan prior to completion of leveling and alignment of the mandibular incisors, this would be recorded in both participants' notes and the data collection sheet
Measured: Through alignment, an average of 6 months
Bracket/ attachment failure rate
Adverse events i.e., bracket failure rate in Group A and attachment failure rate in Group B were recorded in both participants' notes and the data collection sheet. The patient's provider noted in the clinical chart every bracket that had bond failure during the course of the study trial period. The brackets on the molar teeth were omitted. Brackets that debonded twice or more on the same tooth were counted only once. At the end of 180 days post-bonding, the percentage of broken brackets was calculated as: number of debonded brackets divided by the total number of teeth bonded (excluding molar teeth).
Measured: Through alignment, an average of 6 months
Chair side time
The average time taken at the initial banding and bonding visit for the group A and the initial attachment bonding and aligner delivery visit for group B along with multiple routine mid-treatment appointments for both the groups during the alignment phase of treatment, as well as one emergency appointment for both measured using a digital stopwatch. The appointment times were rounded to the nearest minute with the total chair side time beginning when the patient sits on the chair and ending when they stood up to leave.
Measured: Through alignment, an average of 6 months
Treatment Efficiency Index
The treatment efficiency index calculated by measuring the average Little's irregularity index before treatment and dividing it by the average treatment time in months/ days for alignment of the mandibular incisors.
Measured: Through alignment, an average of 6 months
BANA (Microbial-enzymatic N-benzoyl-DL-arginine-2-napthylamide) Score
Microbiological index for the subgingival plaque
Measured: Baseline, after 3 months, and after 6 months
Immunological Assay using ELISA
Immunological assay cytokine IL-1Beta in the gingival crevicular fluid
Measured: Baseline, after 3 months, and after 6 months
Patient's occlusal comfort level
Patient's occlusal comfort level assessed by means of a Visual Analog Scale with a score from 0 - 10, 0 being least comfortable and 10 being most comfortable
Measured: Baseline, and after an average of 6 months, and after treatment an average of 1 year
Changes in mandibular incisor inclination
Changes in mandibular incisor inclination as measured on the lateral cephalogram
Measured: Baseline, and after an average of 6 months
Changes in the mandibular arch form
Changes in the mandibular arch form as measured on the study model
Measured: Baseline, and after an average of 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Dec 2024
- Study start16 Oct 2023
- Primary completionDec 2028 (estimated)
- Study completionDec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Crowding of Anterior Mandibular TeethStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The interventional study model used in this study is a two-arm, parallel-group, randomized controlled trial (RCT) with a 1:1 allocation ratio between two treatment arms: clear aligners and fixed braces. The study is structured to evaluate the treatment efficiency, efficacy and periodontal as well as occlusal parameters in participants treated with fixed labial braces or clear aligners for alignment of moderately crowded lower incisors. Block randomization is used to ensure an equal number of participants in each group, reducing potential imbalances in group size and baseline characteristics. Both groups will have regular progress checks every 4-6weeks, with adjustments or new aligners provided based on treatment progression.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Sharjah
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mais Medhat Sadek AbdelAzim, University of Sharjah
- Investigators
- Mais Medhat Sadek, BDS, MSc, PHD, Morth(RCSEd), Principal investigator, University of Sharjah
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06731465
- Sponsor's protocol ID
- REC-23-05-13-01-PG
- Status last verified
- Apr 2026
- First submitted
- 31 Oct 2024
- Last updated
- 11 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: All IPD collected throughout the trial
Publications
Buschang PH, Shaw SG, Ross M, Crosby D, Campbell PM. Comparative time efficiency of aligner therapy and conventional edgewise braces. Angle Orthod. 2014 May;84(3):391-6. doi: 10.2319/062113-466. Epub 2013 Nov 18.
PubMed 24749702
Study at a glance
From the registry record, last updated by the sponsor on 11 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Efficiency, Efficacy, Periodontal and Occlusal Outcomes for Clear Aligners Versus Pre-adjusted Orthodontic Appliances in Moderately Crowded Lower Incisor Treatment: A Randomized Clinical
- ClinicalTrials.gov ID
- NCT06731465
- Acronym / sponsor ID
- REC-23-05-13-01-PG
- Conditions
- Crowding of Anterior Mandibular Teeth
- Keywords
- Clinical trial, Clear Aligners, Fixed Pre-adjusted Edgewise Orthodontic Appliance, Orthodontic Treatment, Efficiency, Efficacy, Periodontal Outcomes, Randomized Clinical Trial
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- University of SharjahUniversity, hospital or other
- Study start
- 16 Oct 2023 (actual)
- Primary completion
- Dec 2028 (estimated)
- Study completion
- Dec 2028 (estimated)
- First posted
- 12 Dec 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to compare between fixed labial braces and clear aligners for the straightening of moderately overlapped lower front teeth. The main questions it aims to answer are:
- Effect of treatment on gum health
- Which treatment achieves lower front teeth alignment faster in terms of alignment time and t number of visits required to the orthodontist
- How well it straightens teeth.
Participants will:
- Receive either labial braces or clear aligners as part of their orthodontic treatment.
- Come for regular follow-up visits every 4 to 6 weeks with the orthodontist till full straightening of the lower front teeth.
- Have a 3D scan of their teeth taken after their teeth are aligned along with a specialized x-ray of their head and jaw.
Detailed description
The study is a randomized controlled trial aimed at comparing the efficiency, efficacy, periodontal and occlusal outcomes between two orthodontic treatment options: clear aligners and traditional fixed braces for patients with moderate crowding in the lower incisors.
Pre-treatment diagnostic records including clinical examination, intraoral scans, intraoral and extraoral photographs will be obtained for each participant.
To ensure that participants in both groups have similar levels of crowding severity and comparable dental health characteristics at the start of the study, randomization will be conducted in blocks. A total of forty participants (20 in each group) will be selected according to specific criteria designed to maintain this uniformity across both treatment groups.This study follows a parallel-group design and the participants will be randomly allocated into one of the two groups included in the study:
Intervention Groups:
- Group A - Fixed Labial Braces (Master Series®, American Orthodontics): In the traditional braces group, fixed metal brackets will be bonded to the lower teeth, and archwires will be used in a specific sequence designed to bring the teeth into alignment over time.
- Group B - Clear Aligners (EON Aligner): The clear aligner group will receive custom-fitted aligners created using a digital model of each participant's teeth. These aligners are removable, requiring patient adherence to wearing them for at least 22 hours daily.
Primary Outcomes:
- Total alignment time
- Clinical measures of periodontal status
- Occlusal contact distribution
- Efficacy of clear aligners Vs fixed appliances in alignment of lower anterior teeth
Secondary Outcomes:
- Total number of scheduled routine appointments and additional emergency visits
- Missed appointment rate
- Number of refinements
- Bracket/ attachment failure rate
- Chair-side Time
- Treatment Efficiency Index
- BANA (Microbial-enzymatic N-benzoyl-DL-arginine-2-napthylamide) Score
- Immunological Assay using ELISA
- Patient's occlusal comfort level
- Changes in mandibular incisor inclination
- Changes in the mandibular arch form
Data will be analyzed using SPSS (Statistical Package for the Social Sciences) software, with statistical tests appropriate to the variable types (e.g., Mann-Whitney for group comparisons and Wilcoxon Signed-Rank test for time-related variables).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- The interventional study model used in this study is a two-arm, parallel-group, randomized controlled trial (RCT) with a 1:1 allocation ratio between two treatment arms: clear aligners and fixed braces. The study is structured to evaluate the treatment efficiency, efficacy and periodontal as well as occlusal parameters in participants treated with fixed labial braces or clear aligners for alignment of moderately crowded lower incisors. Block randomization is used to ensure an equal number of participants in each group, reducing potential imbalances in group size and baseline characteristics. Both groups will have regular progress checks every 4-6weeks, with adjustments or new aligners provided based on treatment progression.
| Arm | Type | Receives |
|---|---|---|
| Fixed labial braces group | Active comparator | Device: Fixed pre-adjusted edgewise orthodontic applianceParticipants in this group will be treated with pre-adjusted fixed orthodontic appliances. |
| Clear aligner group | Active comparator | Device: Clear aligner therapyParticipants in this group will receive clear aligners customized based on a digital model of each patient's dentition. |
Who may qualify
- Ages
- 16 to 45 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (5 listed)
- Patients with moderate-severe lower crowding (Little's irregularity index 4 to 9 mm), non-extraction treatment
- Age range: 16-45 years old
- Class I malocclusion
- Full permanent dentition
- No caries or periodontal disease
Key exclusion criteria (5 listed)
- Extraction cases
- Patients with craniofacial syndromes, or cleft palate
- Patients with uncontrolled medical conditions or taking medication that can interfere with orthodontic tooth movement.
- Presence of extensive dental restorations in proximity to the gingival margin
- Presence of fixed bridges/crowns or partial dentures
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Clear aligner therapyAlso: Clear aligners, Clear aligner therapy (CAT), Eon alignerParticipants in this group will receive clear aligners (EON Aligner, Minneapolis), designed and customized based on a digital model of each patient's dental structure. Aligners will be worn for at least 22 hours daily, and patients will change to a new aligner depending on treatment progress. | Device | Clear aligner group |
| Fixed pre-adjusted edgewise orthodontic applianceAlso: Fixed orthodontic appliance, Fixed labial braces, Conventional braces, Edgewise applianceParticipants in this group will be treated with pre-adjusted fixed orthodontic appliances (Master Series®, American Orthodontics™, WI, USA). This system includes fixed brackets bonded on the labial surface of teeth and a sequence of progressively larger arch wires aimed at achieving alignment over time. | Device | Fixed labial braces group |
Primary outcome
Total alignment time
Time frame: Through alignment, an average of 6 months
The duration of treatment time (rounded to the nearest day) required to achieve full alignment of the mandibular incisors determined clinically as <1mm little's irregularity index, evaluated for both treatment groups. This information is to be extracted from participant notes into a data collection sheet designed specifically for this study.
Bleeding on probing
Time frame: Baseline, after 3 months, and after 6 months
Bleeding on probing as an indicator of tissue inflammatory response to bacterial pathogensis, using the Michigan Williams probe assigned a score of 0 - 3 for each site.
Occlusal contact surface area
Time frame: Baseline, and after an average of 6 months, and after treatment an average of 1 year
Occlusal contact surface area as measured by the T-scan device in terms of no. of pixels
Efficacy of clear aligners Vs fixed appliances in alignment of lower anterior teeth
Time frame: Baseline, and after an average of 6 months
Efficacy of clear aligners Vs fixed appliances in alignment of lower anterior teeth using Little's irregularity index
Symmetry of contact distribution
Time frame: Baseline, and after an average of 6 months
Symmetry of contact distribution as measured by the T-scan device.
Probing depth
Time frame: Baseline, after 3 months, and after 6 months
The distance measured from the base of the pocket to the most apical point on the gingival margin using the Michigan Williams probe.
Plaque index
Time frame: Baseline, after 3 months, and after 6 months
Plaque index to evaluate the level and rate of plaque formation on tooth surfaces
Gingival index
Time frame: Baseline, after 3 months, and after 6 months
Gingival index to determine the severity of gingival inflammation with a score from 0 - 3
Total treatment time
Time frame: Through treatment, an average of 1 year
The duration of treatment time (rounded to the nearest day) required to complete treatment, evaluated for both treatment groups. This information is to be extracted from participant notes into a data collection sheet designed specifically for this study.
11 secondary outcomes
Total number of scheduled routine appointments and additional emergency visits
Time frame: Through alignment, an average of 6 months
Missed appointment rate
Time frame: Through alignment, an average of 6 months
Number of refinements
Time frame: Through alignment, an average of 6 months
Bracket/ attachment failure rate
Time frame: Through alignment, an average of 6 months
Chair side time
Time frame: Through alignment, an average of 6 months
Treatment Efficiency Index
Time frame: Through alignment, an average of 6 months
BANA (Microbial-enzymatic N-benzoyl-DL-arginine-2-napthylamide) Score
Time frame: Baseline, after 3 months, and after 6 months
Immunological Assay using ELISA
Time frame: Baseline, after 3 months, and after 6 months
Patient's occlusal comfort level
Time frame: Baseline, and after an average of 6 months, and after treatment an average of 1 year
Changes in mandibular incisor inclination
Time frame: Baseline, and after an average of 6 months
Changes in the mandibular arch form
Time frame: Baseline, and after an average of 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Aug 2026.
- Results publication: PubMed 24749702Buschang PH, Shaw SG, Ross M, Crosby D, Campbell PM. Comparative time efficiency of aligner therapy and conventional edgewise braces. Angle Orthod. 2014 May;84(3):391-6. doi: 10.2319/062113-466. Epub 2013 Nov 18.
- Individual participant dataSharing planned: Yes. All IPD collected throughout the trial
Related trials for Crowding of Anterior Mandibular Teeth
Active, not recruiting
Treatment of the Mandibular Dental Crowding With and Without Corticotomy Surgery
Dental Research, Orthodontics
Not yet recruiting
Bracketless Orthodontic Treatment (3D-BOT) Versus Conventional Fixed Braces for Mild-to-Moderate Lower Front Tooth Crowding in Adults
Mild-to-Moderate Mandibular Anterior Crowding
Recruiting
Evaluating the Efficacy of Micro-Osteoperforations Technique on the Orthodontic Tooth Movement Acceleration in Moderate Mandibular Anterior Crowding Cases Treated With Clear Aligners
Crowding of Anterior Mandibular Teeth
Active, not recruiting
Effects of Laser Therapy and Vitamin D Pills on Braces Tooth Movement: A Random Controlled Study
Malocclusion of Anterior Teeth
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mais Medhat Sadek, BDS, MSc, PHD, Morth(RCSEd) principal investigator
University of Sharjah
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Clear aligner therapy and Fixed pre-adjusted edgewise orthodontic appliance in people with Crowding of Anterior Mandibular Teeth, run by University of Sharjah at 1 site in United Arab Emirates.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 11 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Arab Emirates. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Total alignment time (time frame: Through alignment, an average of 6 months). The study lists 9 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06731465, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Aug 2026.