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Cannabis DependenceCANQUITNCT06733792

A Mobile App to Reduce and/or Quit Cannabis Use

A study testing CBT-based intervention and Self-help guide in people with Cannabis Dependence, run by Alba González-Roz, PhD at 2 sites in Spain.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

This study aims to develop an App-based intervention (CANQUIT) aimed at regular cannabis users. The efficacy of this intervention will be evaluated in the short-term (1-month follow-up) and long-term (3- and 6-months follow-ups) using a sample of 120 participants. Read more about this study

Who is it for?
Ages 18 to 30 years
Conditions the study is for
Cannabis Dependence
What is being tested?
CBT-based intervention and Self-help guide
Could I receive a placebo?
No, everyone receives an active treatment
How many people
120 participants
Where
2 sitesSpain
Study dates
13 Dec 2024to Mar 2027
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 30 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Between 18 and 30 years old.
  • At least one occasion of cannabis use in the last month.
  • Access to smartphones (iOS or Android).
  • Access to Internet.

Who cannot join

  • -

Trial locations and contacts

2 sites in 1 country. Contact the study team or a site near you to ask about taking part.

Alba González-Roz, PhD, Assistant Professor contact

+34 985104189

gonzalezralba@uniovi.es

Spain2 sites, 1 recruiting

  • Faculty of Psychology, University of Oviedo

    Oviedo, Principality of Asturias, 33003

    Alba González de la Roz, PhD, +34 985 10 53 62, gonzalezralba@uniovi.es

    Recruiting

  • University of Oviedo

    Oviedo, Principality of Asturias, 33003

    Active, not recruiting

Other trials in Spain

About this study

Official title: Efficacy of a Digitalized Selective Prevention Program (App - "CANQUIT") to Reduce and/or Quit Cannabis Use

This study aims to develop an App-based intervention (CANQUIT) aimed at regular cannabis users. The efficacy of this intervention will be evaluated in the short-term (1-month follow-up) and long-term (3- and 6-months follow-ups) using a sample of 120 participants. Participants will be randomly assigned to the experimental arm (App-assisted CBT-based intervention) or the control (App-assisted self-help guide). The study will also estimate the economic impact of the intervention by considering the benefit-cost ratio (BCR) and net benefit (in €) associated with the total cost of the program. The goal is to provide evidence that can inform policy decisions regarding cannabis use and minimize the negative consequences on the physical and mental health of young adults in Spain. This study aims to offer a cost-effective prevention strategy that minimize the negative consequences on the physical and mental health of young adults in Spain.

Read the detailed description

The aim of this study is to evaluate the efficacy and cost-effectiveness in the short (1-month) and long-term (3 and 6 months) of a digitalized intervention (CANQUIT) to reduce and/or quit cannabis among young Spanish adults.

CANQUIT is a 4-week digitalized CBT-based intervention aimed at reducing or ceasing cannabis use among regular cannabis users (at least 1 occasion of cannabis use in the previous month). It is specifically tailored to young adults (18-30 years old). CANQUIT will be available to download both on Apple Store (iOS) and Play Store (Android). Upon completion of the baseline assessment, participants will be randomly assigned 2:1 to either an experimental arm (60 participants: App-assisted CBT-based intervention) or control (60 participants: App-assisted self-help guide). Participants in the experimental arm will be exposed to seven weekly modules, which include: 1) psychoeducation regarding the benefits of ceasing cannabis use, its short and long-term effects and myths associated with its consumption, 2) training in emotion regulation strategies, stimulus control (i.e., alternatives to cannabis use), 3) behavioral activation strategies, and 4) relapse prevention (i.e., assertiveness and problem-solving abilities). Participants will also register daily consumption of cannabis (number of joints) and receive weekly recommendations regarding cannabis use reduction. To ensure adherence to treatment, CANQUIT includes gamification via direct contact with a mental health professional and social interaction with others (through an online chat).

Alternatively, participants allocated to the control group will receive a self-help guide with information based on the contents of the App. This guide will be also available through the App. As in the experimental arm, participants in the control group will also complete 1-month, 3-months and 6-months follow-ups through the App.

Being tested
CBT-based intervention, Self-help guide
Keywords
Cannabis, App-based intervention, Young adults, Selective prevention, CBT, Contingency Management
Medical subject headings
Marijuana Abuse

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • CBT-based interventionBehavioural

    • 1st week: Daily self-report on cannabis and tobacco use, myths regarding cannabis use and its health consequences, motives for cannabis use reduction/quitting, psychoeducation concerning withdrawal symptomatology, therapist's recommendation (progressive reduction of cannabis use).
    • 2nd week: Daily self-report on cannabis and tobacco use, myths regarding cannabis use and its health and behavioral consequences, identification of triggers, alternatives to cannabis use, therapist's recommendation (progressive reduction of cannabis use).
    • 3rd week: Daily self-report on cannabis and tobacco use benefits from quitting cannabis, behavioral activation, diaphragmatic breathing, training in social abilities, strategies to prevent smoking, therapist's recommendation (progressive reduction of cannabis use).
    • 4th week: Daily self-report on cannabis and tobacco use (i.e., nº of joints/cigarettes), high-risk situations for relapse, lapse vs. relapse, coping strategies, relapse prevention plan.

  • Self-help guideBehavioural

    Psychoeducation on cannabis.

Study groups in NCT06733792
Study groupRoleWhat they receive
App-assisted CBT-based interventionExperimentalParticipants have access to a 4-week digitalized CBT-based intervention. Participants will have access to seven weekly modules. Modules include cannabis-related psychoeducation (i.e., benefits concerning cannabis use reduction/quitting, short- and long-term consequences, myths), training in emotional regulation strategies, stimulus control (i.e., alternatives to cannabis use), behavioral activation strategies and relapse prevention (i.e., training in assertiveness skills and problem-solving abilities).
Receives: Behavioral: CBT-based intervention
App-assisted self-help guideActive comparatorParticipants receive a self-help guide based on psychoeducation on cannabis use and its physical/mental health effects.
Receives: Behavioral: Self-help guide

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Cannabis abstinence

    • Self-reported point prevalence cannabis abstinence
    • Continuous self-reported cannabis abstinence

    Measured: 7-day point prevalence abstinence (PP) at 4-week follow-up (FU), 3-months follow-up (FU), 6-months follow-up (FU)

  2. Cannabis reduction

    • Self-reported reduction in quantity of cannabis used on a weekly basis (daily joints, number of hashish/marijuana joints, grams)
    • Decreases in self-reported past-month frequency of cannabis use (i.e., once, less than one per week, once/twice per week, 3-4 times a week, 5-6 times a week, every day).

    Measured: 4 weeks follow-up (FU), 3 months follow-up (FU), 6 months follow-up (FU)

  3. Acceptability

    Client Satisfaction Questionnaire-8 (CSQ-8). The CSQ-8 is an 8-item questionnaire that evaluates the level of satisfaction with the treatment received by the participants. Scores range between 8-32, with higher scores indicating higher levels of satisfaction.

    Measured: 4-week follow-up (FU)

Secondary outcomes (3)

  1. Changes in legal and illegal substance use

    Self-reported past-month legal and illegal substance use (alcohol, tobacco, cocaine, heroine, amphetamine, ecstasies, hallucinogens, prescription drugs).

    Measured: 4 weeks follow-up (FU), 3 months follow-up (FU), 6 months follow-up (FU),

  2. Changes in cannabis-related problems

    Pre to post-intervention changes in cannabis problems as measured by the Cannabis Use Disorder Identification Test-Revised (CUDIT-R). The CUDIT-R is an 8-item screening test for measuring cannabis-related problems. Scores of 8 or more are indicative of hazardous cannabis use. Meanwhile, scores of 12 or more indicate the participant may present a cannabis use disorder.

    Measured: 4-week follow-up (FU), 3-months follow-up (FU), 6-months follow-up (FU)

  3. Improvement in risk of emotional disorders

    Reductions in the severity of symptoms of depression, anxiety, somatization as measured by the Brief Symptoms Inventory-18 (BSI-18). The BSI-18 is an 18-item assessment screening of psychological distress (somatic, anxious and depressive symptomatology). Scores range between 0-72, with higher values indicating higher risk of depression, anxiety and somatization.

    Measured: Changes in 4-week follow-up (FU), 6-months follow-up (FU)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted13 Dec 2024
  2. Study start13 Dec 2024
  3. Primary completionMar 2027 (estimated)
  4. Study completionMar 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
120 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06733792
Sponsor's protocol ID
MS-23-PNSD-1
Other IDs
2022I002
Acronym
CANQUIT
Status last verified
Mar 2025
First submitted
6 Dec 2024
Last updated
30 Mar 2025
Results posted
No
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • Derogatis, L.R. (2001). BSI 18, Brief Symptom Inventory 18: Administration, scoring and Procedure Manual. Pearson.

  • Adamson SJ, Kay-Lambkin FJ, Baker AL, Lewin TJ, Thornton L, Kelly BJ, Sellman JD. An improved brief measure of cannabis misuse: the Cannabis Use Disorders Identification Test-Revised (CUDIT-R). Drug Alcohol Depend. 2010 Jul 1;110(1-2):137-43. doi: 10.1016/j.drugalcdep.2010.02.017. Epub 2010 Mar 26.

    PubMed 20347232

  • Attkisson CC, Zwick R. The client satisfaction questionnaire. Psychometric properties and correlations with service utilization and psychotherapy outcome. Eval Program Plann. 1982;5(3):233-7. doi: 10.1016/0149-7189(82)90074-x.

    PubMed 10259963

Questions about this trial

What is this clinical trial studying?

A study testing CBT-based intervention and Self-help guide in people with Cannabis Dependence, run by Alba González-Roz, PhD at 2 sites in Spain.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 30 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 2 sites in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Alba González-Roz, PhD, Assistant Professor (+34 985104189, gonzalezralba@uniovi.es), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Cannabis abstinence (time frame: 7-day point prevalence abstinence (PP) at 4-week follow-up (FU), 3-months follow-up (FU), 6-months follow-up (FU)). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06733792, which also lists 3 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Mar 2025.

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