Ankylosing Spondylitis (AS)NCT06739369
The Relationship Between Arterial Stiffness and Pulmonary and Extrapulmonary Features in Ankylosing Spondylitis
An observational study of Ankylosing Spondylitis (AS), run by Kirsehir Ahi Evran Universitesi at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study was to investigate the relationship between arterial stiffness and pulmonary and extrapulmonary features in patients with ankylosing spondylitis. Read more about this study
- Who is it for?
- Ages 18 to 85 years
- Conditions the study is for
- Ankylosing Spondylitis (AS)
- How many people
- 25 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 6 Aug 2025to Dec 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients followed up with a diagnosis of ankylosing spondylitis will be included.
Who may be able to join
- Diagnosis of ankylosing spondylitis according to ASAS diagnostic criteria
- Being aged 18-65
- Stable medication use for at least 3 months
- Voluntary participation in the study
Who cannot join
- Having uncontrolled cardiopulmonary disease
- Being pregnant
- Having undergone recent surgery
- Presence of malignancy
- Failure to perform to assessments
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Kirsehir Ahi Evran University
Kırşehir
Merve Firat, +90 850 441 02 44, mervefirat@ahievran.edu.tr
About this study
Official title: Investigation of the Relationship Between Arterial Stiffness and Pulmonary and Extrapulmonary Features in Patients With Ankylosing Spondylitis
The aim of this study was to investigate the relationship between arterial stiffness and pulmonary and extrapulmonary features in patients with ankylosing spondylitis.
- Conditions
- Ankylosing Spondylitis (AS)
- Medical subject headings
- Spondylitis, Ankylosing
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Ankylosing spondylitis | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Arterial stiffness
It will be evaluated with brachial pulse waves.
Measured: 1st day
Respiratory muscle strength
Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) will be measured using a portable mouth pressure device.
Measured: 1st day
Respiratory muscle endurance
This will be evaluated with increased workload testing.
Measured: 1st day
Exercise capacity
Exercise capacity will be assessed with 6 minute walk test.
Measured: 1st day
Peripheral muscle strength
Hand grip strength will be assessed with a grip dynamometer.
Measured: 1st day
Muscle function
It will be evaluated with one-minute sit to stand test
Measured: 1st day
Secondary outcomes (6)
Physical activity
Physical activity level will be evaluated using International Physical Activity Questionnaire-Short form
Measured: 1st day
Forced vital capacity
Forced vital capacity (FVC) will be assessed using spirometry.
Measured: 1st day
Forced expiratory volume in one second
Forced expiratory volume in one second (FEV1) will be assessed using spirometry.
Measured: 1st day
Forced expiratory volume in one second/forced vital capacity ratio
Forced expiratory volume in one second/forced vital capacity ratio will be assessed using spirometry.
Measured: 1st day
Peak expiratory flow
Peak expiratory flow (PEF) will be assessed using spirometry.
Measured: 1st day
Forced mid-expiratory flow
Forced mid-expiratory flow (FEF25-75) will be assessed using spirometry.
Measured: 1st day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Dec 2024
- Study start6 Aug 2025
- Primary completionJan 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ankylosing Spondylitis (AS)Studies of the same condition, open and under way.
- More trials run by Kirsehir Ahi Evran UniversitesiThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 25 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Kirsehir Ahi Evran Universitesi
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Merve Firat, Kirsehir Ahi Evran Universitesi
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06739369
- Sponsor's protocol ID
- 2024-14/120
- Status last verified
- Nov 2024
- First submitted
- 27 Nov 2024
- Last updated
- 12 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of the Relationship Between Arterial Stiffness and Pulmonary and Extrapulmonary Features in Patients With Ankylosing Spondylitis
- ClinicalTrials.gov ID
- NCT06739369
- Acronym / sponsor ID
- 2024-14/120
- Conditions
- Ankylosing Spondylitis (AS)
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 25 participants (estimated)
- Lead sponsor
- Kirsehir Ahi Evran UniversitesiUniversity, hospital or other
- Study start
- 6 Aug 2025 (actual)
- Primary completion
- Jan 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 18 Dec 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study was to investigate the relationship between arterial stiffness and pulmonary and extrapulmonary features in patients with ankylosing spondylitis.
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Ankylosing spondylitis | – | – |
Who may qualify
- Ages
- 18 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients followed up with a diagnosis of ankylosing spondylitis will be included.
Key inclusion criteria (4 listed)
- Diagnosis of ankylosing spondylitis according to ASAS diagnostic criteria
- Being aged 18-65
- Stable medication use for at least 3 months
- Voluntary participation in the study
Key exclusion criteria (5 listed)
- Having uncontrolled cardiopulmonary disease
- Being pregnant
- Having undergone recent surgery
- Presence of malignancy
- Failure to perform to assessments
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Arterial stiffness
Time frame: 1st day
It will be evaluated with brachial pulse waves.
Respiratory muscle strength
Time frame: 1st day
Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) will be measured using a portable mouth pressure device.
Respiratory muscle endurance
Time frame: 1st day
This will be evaluated with increased workload testing.
Exercise capacity
Time frame: 1st day
Exercise capacity will be assessed with 6 minute walk test.
Peripheral muscle strength
Time frame: 1st day
Hand grip strength will be assessed with a grip dynamometer.
Muscle function
Time frame: 1st day
It will be evaluated with one-minute sit to stand test
6 secondary outcomes
Physical activity
Time frame: 1st day
Forced vital capacity
Time frame: 1st day
Forced expiratory volume in one second
Time frame: 1st day
Forced expiratory volume in one second/forced vital capacity ratio
Time frame: 1st day
Peak expiratory flow
Time frame: 1st day
Forced mid-expiratory flow
Time frame: 1st day
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Aug 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Ankylosing Spondylitis (AS), run by Kirsehir Ahi Evran Universitesi at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 12 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Merve Firat (+90 850 441 02 44, mervefirat@ahievran.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Arterial stiffness (time frame: 1st day). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Aug 2025.