Cerebrospinal FluidDYNA-LCS PNCT06743347
Dynamic Measurement of Cerebrospinal Fluid in Healthy Subjects: Pilot Study
A study testing MRI Contrast in people with Cerebrospinal Fluid and Healthy Subjects or Volunteers, run by Poitiers University Hospital at 1 site in France.
Trial summary
This research will enhance our knowledge and understanding of Cerebrospinal Fluid (CSF) circulation around the Central Nervous System (CNS) (brain and spinal cord). The main objective is to obtain flow velocities using Phase Contrast (PC) MRI over the entire subarachnoid space (SAS). Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Cerebrospinal Fluid, Healthy Subjects or Volunteers
- What is being tested?
- MRI Contrast
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 15 participants
- Where
- 1 siteFrance
- Study dates
- 24 Sep 2025to 17 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age ≥ 18 years at the time of agreement
- Free subject, without guardianship or curatorship or subordination
- Patients benefiting from a Social Security scheme or benefiting from it through a third party
- Informed consent signed by the patient after clear and complete information about the study
Who cannot join
- 3T MRI contraindications (pacemaker, cochlear implant, metallic splinter, etc)
- History of neurological pathology
- Previous operations involving the central nervous system (spinal surgery, neurological surgery, etc.)
- Current pathology or treatment that may interfere with the CSF or subarachnoid spaces (CSF dysregulation, disc herniation, hydrocephalus, Chiari malformation, etc.)
- Concurrent participation in another clinical research study
- Persons not covered by Social Security or not covered by Social Security through a third party
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- Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, adults under legal protection
- Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy)
- Discovery of a contraindication to 3T MRI (pacemaker, cochlear implant, metallic splinter, etc)
Trial locations and contacts
1 site in 1 country.
About this study
This research will enhance our knowledge and understanding of Cerebrospinal Fluid (CSF) circulation around the Central Nervous System (CNS) (brain and spinal cord).
The main objective is to obtain flow velocities using Phase Contrast (PC) MRI over the entire subarachnoid space (SAS). This will enable us to develop and validate a numerical model of the SAS.
- Being tested
- MRI Contrast
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MRI ContrastOther
Pass a Phase Contrast MRI. No injection required.
| Study group | Role | What they receive |
|---|---|---|
| Phase Contrast MRI | Experimental | Not described Receives: Other: MRI Contrast |
What is being measured
The primary outcome is the main question the study is designed to answer.
To evaluate the velocity displacement of CSF about 7 planes (intracranial plane, C2-C3, C5-C6, T4-T5, T10-T11, L3-L4, L5-S1)
Displacement velocities of CSF will be obtain by Phase Contrats MRI.
Measured: Time PC-MRI will be around 60min
Secondary outcomes (2)
Using morphological MRI to model a digital twin
Comparison of velocity fields for each measurement section plane
Measured: Time PC-MRI will be around 60min
To evaluate the velocity displacement of blood about 2 planes (intracranial plane, C2-C3)
Displacement velocities of blood will be obtain by Phase Contrats MRI.
Measured: Time PC-MRI will be around 60min
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Dec 2024
- Study start24 Sep 2025
- Primary completion17 Dec 2025
- Study completion17 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cerebrospinal FluidStudies of the same condition, open and under way.
- More trials run by Poitiers University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 15 participants (actual)
Sponsor and investigators
- Lead sponsor
- Poitiers University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06743347
- Sponsor's protocol ID
- 2024-A02411-46
- Acronym
- DYNA-LCS P
- Status last verified
- Jan 2026
- First submitted
- 16 Dec 2024
- Last updated
- 5 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 5 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dynamic Measurement of Cerebrospinal Fluid in Healthy Subjects: Pilot Study
- ClinicalTrials.gov ID
- NCT06743347
- Acronym / sponsor ID
- DYNA-LCS P / 2024-A02411-46
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 15 participants (actual)
- Lead sponsor
- Poitiers University HospitalUniversity, hospital or other
- Study start
- 24 Sep 2025 (actual)
- Primary completion
- 17 Dec 2025 (actual)
- Study completion
- 17 Dec 2025 (actual)
- First posted
- 19 Dec 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This research will enhance our knowledge and understanding of Cerebrospinal Fluid (CSF) circulation around the Central Nervous System (CNS) (brain and spinal cord).
The main objective is to obtain flow velocities using Phase Contrast (PC) MRI over the entire subarachnoid space (SAS). This will enable us to develop and validate a numerical model of the SAS.
Study design
- Primary purpose
- Health services research
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Phase Contrast MRI | Experimental | Other: MRI Contrast |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age ≥ 18 years at the time of agreement
- Free subject, without guardianship or curatorship or subordination
- Patients benefiting from a Social Security scheme or benefiting from it through a third party
- Informed consent signed by the patient after clear and complete information about the study
Key exclusion criteria (9 listed)
- 3T MRI contraindications (pacemaker, cochlear implant, metallic splinter, etc)
- History of neurological pathology
- Previous operations involving the central nervous system (spinal surgery, neurological surgery, etc.)
- Current pathology or treatment that may interfere with the CSF or subarachnoid spaces (CSF dysregulation, disc herniation, hydrocephalus, Chiari malformation, etc.)
- Concurrent participation in another clinical research study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MRI ContrastPass a Phase Contrast MRI. No injection required. | Other | Phase Contrast MRI |
Primary outcome
To evaluate the velocity displacement of CSF about 7 planes (intracranial plane, C2-C3, C5-C6, T4-T5, T10-T11, L3-L4, L5-S1)
Time frame: Time PC-MRI will be around 60min
Displacement velocities of CSF will be obtain by Phase Contrats MRI.
2 secondary outcomes
Using morphological MRI to model a digital twin
Time frame: Time PC-MRI will be around 60min
To evaluate the velocity displacement of blood about 2 planes (intracranial plane, C2-C3)
Time frame: Time PC-MRI will be around 60min
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Jan 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing MRI Contrast in people with Cerebrospinal Fluid and Healthy Subjects or Volunteers, run by Poitiers University Hospital at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
To evaluate the velocity displacement of CSF about 7 planes (intracranial plane, C2-C3, C5-C6, T4-T5, T10-T11, L3-L4, L5-S1) (time frame: Time PC-MRI will be around 60min). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Jan 2026.