Rheumatoid ArthritisNCT06753851
Validity and Reliability of the Six-minute Peg Board and Ring Test in Patients With Rheumatoid Arthritis
An observational study of Rheumatoid Arthritis, run by Kirsehir Ahi Evran Universitesi at 1 site in Turkey (Türkiye).
Trial summary
The aim of the study was to evaluate the validity and reliability of 6-PBRT in patients with rheumatoid arthritis and to determine the applicability of the test for this population. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Rheumatoid Arthritis
- How many people
- 40 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 26 Jan 2025to 3 Nov 2025
- How long will I take part?
- 2 Days
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Rheumatoid arthritis patients with disease remission between the ages of 18-75 and with a DAS-28 score below 2.6, who are followed up in the Rheumatology Polyclinic of the Department of Physical Medicine and Rehabilitation at Kırşehir Ahi Evran University, will be included in the study.
Who may be able to join
- Patients diagnosed with rheumatoid arthritis,
- Ages of between 18-75 years,
- Patients who volunteer to participate in the study will be included in the study.
Who cannot join
- Serious cardiopulmonary, neurological, neuromuscular, orthopedic and other systemic diseases or other diseases affecting physical functions,
- Participated in a planned exercise program in the last three months,
- Cognitive impairment that will cause difficulty in understanding and following exercise test instructions,
- Contraindications to exercise testing or exercise training according to the American Sports Medicine Association will not be included in the study.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Kırşehir Ahi Evran University, 63 / 5.000 Physical Therapy and Rehabilitation Center, Cardiopulmonary Unit
Kırşehir, Merkez, 40100
About this study
The aim of the study was to evaluate the validity and reliability of 6-PBRT in patients with rheumatoid arthritis and to determine the applicability of the test for this population.
Read the detailed description
Rheumatoid arthritis (RA) is a systemic, inflammatory disease that causes pain and joint involvement. Pain, loss of range of motion, and decreased muscle strength lead to loss of function in patients with RA. Hand grip and generalized muscle weakness in patients cause decreased upper extremity functions. A study found that the upper extremity functional capacity of RA patients was lower than that of healthy individuals. In routine evaluations of rheumatoid arthritis patients, rough and fine grip strength measurements are made, but these measurements do not provide sufficient information about upper extremity functional exercise capacity. Rehabilitation programs aim to improve upper extremity function, therefore, valid and reliable methods are needed to determine upper extremity function in RA patients and to measure the effectiveness of rehabilitation programs. The six-minute peg board and ring test (6-PBRT) is a valid, reliable, useful, practical and easy-to-apply test that evaluates upper extremity endurance without support in patients with chronic obstructive pulmonary disease and asthma and in healthy individuals (5-7). Studies have determined that the total number of rings in 6-PBRT has a positive relationship with upper extremity daily living activities in COPD and asthma patients. Six-PBRT is frequently used in the evaluation of upper extremity exercise capacity and endurance without support and in determining the effectiveness of rehabilitation programs. The validity and reliability of 6-PBRT, which is used in the evaluation of functional upper extremity exercise capacity in different diseases, has not been investigated in patients with RA. The arm ergometer test is also a gold standard method used to evaluate upper extremity exercise capacity. Therefore, it was planned to use the arm ergometer test as a criterion measure for the validity of 6-PBRT in our study. The aim of this study was to evaluate the validity and reliability of 6-PBRT in patients with rheumatoid arthritis and to determine the applicability of the test for this patient population.
- Conditions
- Rheumatoid Arthritis
- Keywords
- exercise capacity, rheumatoid arthritis, hand-grip
- Medical subject headings
- Arthritis, Rheumatoid
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Rheumatoid arthritis group | All evaluations in the study will be completed on two separate days. First, demographic information, medical history and clinical findings of the patients will be recorded. On the first day, handgrip strength, DASH questionnaire and first 6-PBRT and arm ergometer test will be performed. The first 6-PBRT will be performed on the patients at least 30 minutes before the arm ergometer test and the patients will rest between the two tests. One week later, the same expert physiotherapist who performed the evaluations will perform the second 6-PBRT on the patients for reliability analysis. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Six-minute pegboard and ring test
The six minute pegboard and ring test (6-PBRT) will be used to assess upper extremity exercise capacity.
Measured: First day and second day
Secondary outcomes (3)
Maximal symptom-limited arm ergometer test
Maximum symptom limit arm ergometer test will be used as the criterion measure for the validity of the six minute peg board and ring test.
Measured: First day
Hand-grip strength
Hand grip strength will be evaluated.
Measured: Second day.
Disabilities of the arm, shoulder and hand (DASH) questionnaire
It will be used to evaluate the upper extremity functional status of patients. Disabilities of the arm, shoulder and hand (DASH) questionnaire evaluates the functional status of the upper extremity subjectively according to the Likert scale. The scale consists of three parts. The questionnaire scores between 0 (no disability) and 100 (severe disability).
Measured: First day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Dec 2024
- Study start26 Jan 2025
- Primary completion6 Jun 2025
- Study completion3 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Rheumatoid ArthritisStudies of the same condition, open and under way.
- More trials run by Kirsehir Ahi Evran UniversitesiThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 40 participants (actual)
- Target duration
- 2 Days
Sponsor and investigators
- Lead sponsor
- Kirsehir Ahi Evran Universitesi
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Başak KAVALCI KOL, Kirsehir Ahi Evran Universitesi
- Investigators
- Başak KAVALCI KOL, PhD, PT, Principal investigator, Kirsehir Ahi Evran UniversitesiMerve FIRAT, PhD, PT, Study chair, Kirsehir Ahi Evran UniversitesiFigen TUNCAY, Prof. Dr., MD, Study chair, Kirsehir Ahi Evran Universitesi
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06753851
- Sponsor's protocol ID
- AhiEvranU524
- Status last verified
- Feb 2025
- First submitted
- 23 Dec 2024
- Last updated
- 3 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: We will not share individual participant data as we store it securely in a locked cabinet and cloud database.
Publications
Bearne LM, Coomer AF, Hurley MV. Upper limb sensorimotor function and functional performance in patients with rheumatoid arthritis. Disabil Rehabil. 2007 Jul 15;29(13):1035-9. doi: 10.1080/09638280600929128.
PubMed 17612988Takeda K, Kawasaki Y, Yoshida K, Nishida Y, Harada T, Yamaguchi K, Ito S, Hashimoto K, Matsumoto S, Yamasaki A, Igishi T, Shimizu E. The 6-minute pegboard and ring test is correlated with upper extremity activity of daily living in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2013;8:347-51. doi: 10.2147/COPD.S45081. Epub 2013 Jul 23.
PubMed 23901268Lima VP, Almeida FD, Janaudis-Ferreira T, Carmona B, Ribeiro-Samora GA, Velloso M. Reference values for the six-minute pegboard and ring test in healthy adults in Brazil. J Bras Pneumol. 2018 May-Jun;44(3):190-194. doi: 10.1590/S1806-37562017000000388.
PubMed 30043884Kavalci Kol B, Firat M, Tuncay F, Demir C. Validity and reliability of the six-minute pegboard and ring test for assessing upper limb functional capacity in patients with rheumatoid arthritis. J Back Musculoskelet Rehabil. 2026 Aug 24:10538127261476803. doi: 10.1177/10538127261476803. Online ahead of print.
PubMed 42635973
Study at a glance
From the registry record, last updated by the sponsor on 3 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Validity and Reliability of the Six-minute Peg Board and Ring Test in Patients With Rheumatoid Arthritis
- ClinicalTrials.gov ID
- NCT06753851
- Acronym / sponsor ID
- AhiEvranU524
- Conditions
- Rheumatoid Arthritis
- Keywords
- exercise capacity, rheumatoid arthritis, hand-grip
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Kirsehir Ahi Evran UniversitesiUniversity, hospital or other
- Study start
- 26 Jan 2025 (actual)
- Primary completion
- 6 Jun 2025 (actual)
- Study completion
- 3 Nov 2025 (actual)
- First posted
- 31 Dec 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the study was to evaluate the validity and reliability of 6-PBRT in patients with rheumatoid arthritis and to determine the applicability of the test for this population.
Detailed description
Rheumatoid arthritis (RA) is a systemic, inflammatory disease that causes pain and joint involvement. Pain, loss of range of motion, and decreased muscle strength lead to loss of function in patients with RA. Hand grip and generalized muscle weakness in patients cause decreased upper extremity functions. A study found that the upper extremity functional capacity of RA patients was lower than that of healthy individuals. In routine evaluations of rheumatoid arthritis patients, rough and fine grip strength measurements are made, but these measurements do not provide sufficient information about upper extremity functional exercise capacity. Rehabilitation programs aim to improve upper extremity function, therefore, valid and reliable methods are needed to determine upper extremity function in RA patients and to measure the effectiveness of rehabilitation programs. The six-minute peg board and ring test (6-PBRT) is a valid, reliable, useful, practical and easy-to-apply test that evaluates upper extremity endurance without support in patients with chronic obstructive pulmonary disease and asthma and in healthy individuals (5-7). Studies have determined that the total number of rings in 6-PBRT has a positive relationship with upper extremity daily living activities in COPD and asthma patients. Six-PBRT is frequently used in the evaluation of upper extremity exercise capacity and endurance without support and in determining the effectiveness of rehabilitation programs. The validity and reliability of 6-PBRT, which is used in the evaluation of functional upper extremity exercise capacity in different diseases, has not been investigated in patients with RA. The arm ergometer test is also a gold standard method used to evaluate upper extremity exercise capacity. Therefore, it was planned to use the arm ergometer test as a criterion measure for the validity of 6-PBRT in our study. The aim of this study was to evaluate the validity and reliability of 6-PBRT in patients with rheumatoid arthritis and to determine the applicability of the test for this patient population.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 2 Days
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Rheumatoid arthritis group | – | –All evaluations in the study will be completed on two separate days. First, demographic information, medical history and clinical findings of the patients will be recorded. On the first day, handgrip strength, DASH questionnaire and first 6-PBRT and arm ergometer test will be performed. The first 6-PBRT will be performed on the patients at least 30 minutes before the arm ergometer test and the patients will rest between the two tests. One week later, the same expert physiotherapist who performed the evaluations will perform the second 6-PBRT on the patients for reliability analysis. |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Rheumatoid arthritis patients with disease remission between the ages of 18-75 and with a DAS-28 score below 2.6, who are followed up in the Rheumatology Polyclinic of the Department of Physical Medicine and Rehabilitation at Kırşehir Ahi Evran University, will be included in the study.
Key inclusion criteria (3 listed)
- Patients diagnosed with rheumatoid arthritis,
- Ages of between 18-75 years,
- Patients who volunteer to participate in the study will be included in the study.
Key exclusion criteria (4 listed)
- Serious cardiopulmonary, neurological, neuromuscular, orthopedic and other systemic diseases or other diseases affecting physical functions,
- Participated in a planned exercise program in the last three months,
- Cognitive impairment that will cause difficulty in understanding and following exercise test instructions,
- Contraindications to exercise testing or exercise training according to the American Sports Medicine Association will not be included in the study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Six-minute pegboard and ring test
Time frame: First day and second day
The six minute pegboard and ring test (6-PBRT) will be used to assess upper extremity exercise capacity.
3 secondary outcomes
Maximal symptom-limited arm ergometer test
Time frame: First day
Hand-grip strength
Time frame: Second day.
Disabilities of the arm, shoulder and hand (DASH) questionnaire
Time frame: First day
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Dec 2025.
- Results publication: PubMed 17612988Bearne LM, Coomer AF, Hurley MV. Upper limb sensorimotor function and functional performance in patients with rheumatoid arthritis. Disabil Rehabil. 2007 Jul 15;29(13):1035-9. doi: 10.1080/09638280600929128.
- Results publication: PubMed 23901268Takeda K, Kawasaki Y, Yoshida K, Nishida Y, Harada T, Yamaguchi K, Ito S, Hashimoto K, Matsumoto S, Yamasaki A, Igishi T, Shimizu E. The 6-minute pegboard and ring test is correlated with upper extremity activity of daily living in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2013;8:347-51. doi: 10.2147/COPD.S45081. Epub 2013 Jul 23.
- Results publication: PubMed 30043884Lima VP, Almeida FD, Janaudis-Ferreira T, Carmona B, Ribeiro-Samora GA, Velloso M. Reference values for the six-minute pegboard and ring test in healthy adults in Brazil. J Bras Pneumol. 2018 May-Jun;44(3):190-194. doi: 10.1590/S1806-37562017000000388.
- Derived from this study: PubMed 42635973Kavalci Kol B, Firat M, Tuncay F, Demir C. Validity and reliability of the six-minute pegboard and ring test for assessing upper limb functional capacity in patients with rheumatoid arthritis. J Back Musculoskelet Rehabil. 2026 Aug 24:10538127261476803. doi: 10.1177/10538127261476803. Online ahead of print.
- Individual participant dataSharing planned: No. We will not share individual participant data as we store it securely in a locked cabinet and cloud database.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Başak KAVALCI KOL, PhD, PT principal investigator
Kirsehir Ahi Evran Universitesi
Merve FIRAT, PhD, PT study chair
Kirsehir Ahi Evran Universitesi
Figen TUNCAY, Prof. Dr., MD study chair
Kirsehir Ahi Evran Universitesi
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Rheumatoid Arthritis, run by Kirsehir Ahi Evran Universitesi at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Six-minute pegboard and ring test (time frame: First day and second day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06753851, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Dec 2025.