Stroke Not Otherwise SpecifiedNCT06756724
Vessel Angles and Diameters in Stroke Disease
An observational study of Stroke Not Otherwise Specified and Control Condition, run by Tokat Gaziosmanpasa University at 1 site in Turkey (Türkiye).
Trial summary
Retrospective analysis of internal carotid artery morphology on CT angiography images of patients with acute ischemic stroke. Read more about this study
- Who is it for?
- Ages 18 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Stroke Not Otherwise Specified, Control Condition
- How many people
- 128 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 25 Sep 2022to 30 Jun 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Individuals applying to the Emergency Department of Tokat Gaziosmanpasa University Medical Faculty Hospital
Who may be able to join
- Our study included 66 healthy individuals for control group. The control group consisted of individuals without any pathology or ischemia, selected from patients who underwent brain CTA for headache but showed no structural lesions. Additionally, none of the control group had a history of stroke or evidence of prior ischemic stroke on MRI.
Who cannot join
- After excluding patients with plaques in the carotid arteries (CCA and ICA), systemic vascular disease, risk factors for cardiogenic stroke, cardioembolism, ischemic stroke due to vasculitis or drug use, and other uncommon causes of stroke, 62 ischemic stroke patients were included in the study.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Tokat Gaziosmanpasa University
Tokat Province, Merkez, 60000
About this study
Official title: Morphometric Insights Into Stroke Development: Analyzing Bifurcation Angles and Diameters of Common and Internal Carotid Arteries Using Frankfurt Plane Reoriented Images
Retrospective analysis of internal carotid artery morphology on CT angiography images of patients with acute ischemic stroke.
- Conditions
- Stroke Not Otherwise Specified, Control Condition
- Keywords
- Ischemic stroke risk, Carotid artery bifurcation, Computed tomography angiography, Bifurcation angles, Vessel diameters, Carotid artery morphology
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Stroke | Individuals with acute ischemic stroke | |
| Healthy | Individuals without any intracranial pathology |
What is being measured
The primary outcome is the main question the study is designed to answer.
Internal carotid artery angle (degree measure)
The effect of angle degree change at the bifurcation point of the internal carotid artery on acute ischemic stroke
Measured: 1 week
Internal carotid artery diameter (cm)
Effect of internal carotid artery diameter (cm) on acute ischemic stroke.
Measured: 1 Week
Secondary outcomes (1)
Internal carotid artery angle and diameter
Statistical evaluation of the effects of changes in internal carotid artery diameter (cm) and angle (degree) on acute ischemic stroke using logistic regression analysis.
Measured: 1 Week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Jan 2025
- Study start25 Sep 2022
- Primary completion30 Jun 2024
- Study completion30 Jun 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Stroke Not Otherwise SpecifiedStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 128 participants (actual)
Sponsor and investigators
- Lead sponsor
- Tokat Gaziosmanpasa University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mert Nahir, Tokat Gaziosmanpasa University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06756724
- Sponsor's protocol ID
- 22-KAEK-198
- Status last verified
- Dec 2024
- First submitted
- 21 Dec 2024
- Last updated
- 3 Jan 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Study data may be sent for control upon request by the editor and referees. However, disclosing the data outside of publication under the relevant title may conflict with our institution's Ethics Committee principles.
Publications
Liu Y, Ni L, Wang C, Shi P, Yin L, Fu XY, Zhou HD. Association between internal carotid artery kinking and ischemic stroke: A population-based cross-sectional study. J Stroke Cerebrovasc Dis. 2023 Dec;32(12):107417. doi: 10.1016/j.jstrokecerebrovasdis.2023.107417. Epub 2023 Nov 2.
PubMed 37924779Apaydin M, Cetinoglu K. Carotid angle in young stroke. Clin Imaging. 2021 Feb;70:10-17. doi: 10.1016/j.clinimag.2020.10.020. Epub 2020 Oct 13.
PubMed 33120284Arora S, Chien JD, Cheng SC, Chun KA, Wintermark M. Optimal carotid artery coverage for carotid plaque CT-imaging in predicting ischemic stroke. J Neuroradiol. 2010 May;37(2):98-103. doi: 10.1016/j.neurad.2009.04.002. Epub 2009 Jul 1.
PubMed 19573923Cui Y, Lv X, Wang F, Kong J, Zhao H, Ye Z, Si C, Pan L, Liu P, Wen J. Geometry of the Carotid Artery and Its Association With Pathologic Changes in a Chinese Population. Front Physiol. 2020 Jan 21;10:1628. doi: 10.3389/fphys.2019.01628. eCollection 2019.
PubMed 32038300
Study at a glance
From the registry record, last updated by the sponsor on 3 Jan 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Morphometric Insights Into Stroke Development: Analyzing Bifurcation Angles and Diameters of Common and Internal Carotid Arteries Using Frankfurt Plane Reoriented Images
- ClinicalTrials.gov ID
- NCT06756724
- Acronym / sponsor ID
- 22-KAEK-198
- Conditions
- Stroke Not Otherwise Specified, Control Condition
- Keywords
- Ischemic stroke risk, Carotid artery bifurcation, Computed tomography angiography, Bifurcation angles, Vessel diameters, Carotid artery morphology
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 128 participants (actual)
- Lead sponsor
- Tokat Gaziosmanpasa UniversityUniversity, hospital or other
- Study start
- 25 Sep 2022 (actual)
- Primary completion
- 30 Jun 2024 (actual)
- Study completion
- 30 Jun 2024 (actual)
- First posted
- 3 Jan 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Retrospective analysis of internal carotid artery morphology on CT angiography images of patients with acute ischemic stroke.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Stroke | – | –Individuals with acute ischemic stroke |
| Healthy | – | –Individuals without any intracranial pathology |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Individuals applying to the Emergency Department of Tokat Gaziosmanpasa University Medical Faculty Hospital
Key inclusion criteria (1 listed)
- Our study included 66 healthy individuals for control group. The control group consisted of individuals without any pathology or ischemia, selected from patients who underwent brain CTA for headache but showed no structural lesions. Additionally, none of the control group had a history of stroke or evidence of prior ischemic stroke on MRI.
Key exclusion criteria (1 listed)
- After excluding patients with plaques in the carotid arteries (CCA and ICA), systemic vascular disease, risk factors for cardiogenic stroke, cardioembolism, ischemic stroke due to vasculitis or drug use, and other uncommon causes of stroke, 62 ischemic stroke patients were included in the study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Internal carotid artery angle (degree measure)
Time frame: 1 week
The effect of angle degree change at the bifurcation point of the internal carotid artery on acute ischemic stroke
Internal carotid artery diameter (cm)
Time frame: 1 Week
Effect of internal carotid artery diameter (cm) on acute ischemic stroke.
1 secondary outcome
Internal carotid artery angle and diameter
Time frame: 1 Week
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Jan 2025.
- Background: PubMed 37924779Liu Y, Ni L, Wang C, Shi P, Yin L, Fu XY, Zhou HD. Association between internal carotid artery kinking and ischemic stroke: A population-based cross-sectional study. J Stroke Cerebrovasc Dis. 2023 Dec;32(12):107417. doi: 10.1016/j.jstrokecerebrovasdis.2023.107417. Epub 2023 Nov 2.
- Background: PubMed 33120284Apaydin M, Cetinoglu K. Carotid angle in young stroke. Clin Imaging. 2021 Feb;70:10-17. doi: 10.1016/j.clinimag.2020.10.020. Epub 2020 Oct 13.
- Background: PubMed 19573923Arora S, Chien JD, Cheng SC, Chun KA, Wintermark M. Optimal carotid artery coverage for carotid plaque CT-imaging in predicting ischemic stroke. J Neuroradiol. 2010 May;37(2):98-103. doi: 10.1016/j.neurad.2009.04.002. Epub 2009 Jul 1.
- Background: PubMed 32038300Cui Y, Lv X, Wang F, Kong J, Zhao H, Ye Z, Si C, Pan L, Liu P, Wen J. Geometry of the Carotid Artery and Its Association With Pathologic Changes in a Chinese Population. Front Physiol. 2020 Jan 21;10:1628. doi: 10.3389/fphys.2019.01628. eCollection 2019.
- Individual participant dataSharing planned: No. Study data may be sent for control upon request by the editor and referees. However, disclosing the data outside of publication under the relevant title may conflict with our institution's Ethics Committee principles.
Related trials for Stroke Not Otherwise Specified
RecruitingObservational study
The Erlanger Stroke Registry (ESPro) is the Only Ongoing Prospective Population-based Stroke Registry in Germany, Started in 1994. ESPro Includes All Hospitalized and Non-hospitalized Patients With Stroke in the Community of Erlangen (120.000 Inhabitants), With a Long-life Follow-up.
Intracerebral Haemorrhage (ICH), Cerebral Infarction
Not yet recruiting
More Steps Towards an Active Life After Stroke - ActForStroke
Stroke Not Otherwise Specified
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Stroke Not Otherwise Specified and Control Condition, run by Tokat Gaziosmanpasa University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Jan 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Internal carotid artery angle (degree measure) (time frame: 1 week). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06756724, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jan 2025.