The Current Study Focuses on Investigating the Short-term Effect of BFRT on the Somatosensory System Among Healthy Young AdultsNCT06762912
The Short-term Effect of Low-load Resistance Training with Blood-flow Restriction on Somatosensory-evoked Potentials in Healthy Young Adults
A study testing Passive application of BFR cuff, Resistance exercise with BFR and Resistance exercise without BFR in people with The Current Study Focuses on Investigating the Short-term Effect of BFRT on the Somatosensory System Among Healthy Young Adults, run by University of Sharjah at 1 site in United Arab Emirates.
Trial summary
The goal of this clinical trial is to investigate the short-term effect of lower limb BFRT on the somatosensory processing and related changes in SSEP amplitude and latency. The main questions it aims to answer are: Is there an effect of short-term application of BFRT on the somatosensory system? How do different cuff… Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- The Current Study Focuses on Investigating the Short-term Effect of BFRT on the Somatosensory System Among Healthy Young Adults
- What is being tested?
- Passive application of BFR cuff, Resistance exercise with BFR and Resistance exercise without BFR
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited Arab Emirates
- Study dates
- 20 Jan 2025to 31 Jul 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Participants will be included if they are aged 18-30 years of both genders, with no history of cardiovascular problems or osteo-articular problems in the lower limbs, and if they responded negatively to all items of the Physical Activity Readiness Questionnaire (PAR-Q).
- Participants will be included if they have a body mass index (BMI) less than 25 or non-overweight individuals.
- Use of the long international physical activity questionnaire (L-IPAQ) to ensure all participants have equal physical activity levels.
Who cannot join
- Participants will be excluded if they did not meet the inclusion criteria, and if they had a history of deep vein thrombosis (DVT), congenital heart disease, varicose veins, currently pregnant, or any contraindications to exercise.
- Participants will be excluded if they were diagnosed with any neurological disease.
- Participants will be excluded if they have had any musculoskeletal injury in the past 3 months to avoid potential effect on their physical activity levels.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United Arab Emirates1 site
University of Sharjah
Sharjah city
Prof. Ibrahim Mostafa Abuamr, PhD, +97165057513, iabuamr@sharjah.ac.ae
About this study
Official title: The Short-term Effect of Low-load Resistance Training with Blood-flow Restriction on Somatosensory-evoked Potentials in Healthy Young Adults - a Randomized Crossover Trial
The goal of this clinical trial is to investigate the short-term effect of lower limb BFRT on the somatosensory processing and related changes in SSEP amplitude and latency. The main questions it aims to answer are:
- Is there an effect of short-term application of BFRT on the somatosensory system?
- How do different cuff widths affect the somatosensory system?
- How do three different cuff widths affect perceived pain? Researchers will compare 3 different cuff widths to see if different cuff widths affect the somatosensory system and perceived pain.
Read more
Participants will:
- Undergo 3 experimental sessions, sessions will be separated by 72 hours and the order of the sessions to be randomly selected.
- Perform low-load resistance training with blood flow restriction.
Read the detailed description
The current study will be conducted in the college of health sciences, physiotherapy department, in the medical campus in the University of Sharjah, Sharjah, United Arab Emirates. The study design is a Randomized Crossover Trial, which will include three groups of healthy young adults, each group will use a different cuff widths (small cuff width (5 cm), medium cuff width (12 cm), and large cuff width (18 cm)). Participants in all three groups will undergo three experimental sessions in a random order, which will include the application of a blood flow restriction cuff combined with resistance exercise, the application of a blood flow restriction cuff without resistance exercise, and traditional resistance exercise without a blood flow restriction cuff. During each session, SSEP measurements will be recorded at three time points: before, during, and after the experimental session by stimulating the tibial nerve at the ankle and measuring the SSEP amplitude and latency.
Healthy young adults aged 18-30 years of both genders will be recruited through word of mouth and through social media by sharing the study flyer. Then, they will be screened for their eligibility to participate in the current study. Participants who will meet the eligibility criteria will be asked to provide their consent after the study is explained by filling out the consent form.
Participants will be randomly assigned to one of the three groups: (1) small cuff width (5 cm), (2) medium cuff width (12 cm), and (3) large cuff width (18 cm) by using permuted block randomization method with large, random, and variable block sizes to ensure groups are balanced and selection bias is minimized.
The first experimental session will start by conducting the one repetition maximum (1-RM) test of unilateral knee extension of the dominant leg, in which the dominant side was identified by asking the participants which side they will use to kick a ball. Before conducting the 1-RM test, 5 minutes warm-up on the cycle ergometer at 75W will be done. Calibration of the dynamometer will be done before operating the machine with each participant, then the participant will be positioned on the dynamometer seat comfortably with ensuring the back is supported and the knee is aligned with the axis of rotation. The participant will be asked to complete one successful repetition of knee extension through full range of motion (ROM), with increasing load until the participant can no longer complete full knee extension ROM, 3 minutes of rest will be allowed between attempts until the 1-RM is identified. To eliminate the effect of fatigue after 1-RM test, the first experimental session will always include the application of the BFR cuff without resistance exercise.
For both experimental sessions 2 and 3, the order of exercise condition will be randomly selected, either to be (1) the application of BFR cuff with resistance exercise, or (2) resistance exercise without the application of BFR cuff to decrease the incidence of learning effect. Cuff pressure during the application of BFR will be standardized to 50% of AOP.
The resistance exercise for both experimental sessions 2 and 3 will be exactly similar and will involve four sets of isometric knee extensions at an intensity of 20% of 1-RM with repetitions of 30, 15, 15, and 15 by using the isokinetic dynamometer machine, which has a good to excellent test-retest reliability for knee extension movement with ICC value of 0.95-0.99. To minimize cognitive and neuromuscular fatigue, the experimental sessions will be separated by a minimum of three days (72 hours).
- Being tested
- Passive application of BFR cuff, Resistance exercise with BFR, Resistance exercise without BFR
- Keywords
- Blood Flow Restriction Training, Somatosensory Evoked Potentials, Neuroplasticity, Pain
- Medical subject headings
- Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Passive application of BFR cuffOther
The first experimental session will start by conducting the one repetition maximum (1-RM) test of unilateral knee extension of the dominant leg, in which the dominant side was identified by asking the participants which side they will use to kick a ball. Before conducting the 1-RM test, 5 minutes warm-up on the cycle ergometer at 75W will be done. Calibration of the dynamometer will be done before operating the machine with each participant, then the participant will be positioned on the dynamometer seat comfortably with ensuring the back is supported and the knee is aligned with the axis of rotation. The participant will be asked to complete one successful repetition of knee extension through full range of motion (ROM), with increasing load until the participant can no longer complete full knee extension ROM, 3 minutes of rest will be allowed between attempts until the 1-RM is identified.
Resistance exercise with BFROther
For both experimental sessions 2 and 3, the order of exercise condition will be randomly selected, either to be (1) the application of BFR cuff with resistance exercise, or (2) resistance exercise without the application of BFR cuff to decrease the incidence of learning effect. Cuff pressure during the application of BFR will be standardized to 50% of AOP.
The resistance exercise for both experimental sessions 2 and 3 will be exactly similar and will involve four sets of isometric knee extensions at an intensity of 20% of 1-RM with repetitions of 30, 15, 15, and 15 by using the isokinetic dynamometer machine, which has a good to excellent test-retest reliability for knee extension movement with ICC value of 0.95-0.99. To minimize cognitive and neuromuscular fatigue, the experimental sessions will be separated by a minimum of three days (72 hours).
Resistance exercise without BFROther
For both experimental sessions 2 and 3, the order of exercise condition will be randomly selected, either to be (1) the application of BFR cuff with resistance exercise, or (2) resistance exercise without the application of BFR cuff to decrease the incidence of learning effect. Cuff pressure during the application of BFR will be standardized to 50% of AOP.
The resistance exercise for both experimental sessions 2 and 3 will be exactly similar and will involve four sets of isometric knee extensions at an intensity of 20% of 1-RM with repetitions of 30, 15, 15, and 15 by using the isokinetic dynamometer machine, which has a good to excellent test-retest reliability for knee extension movement with ICC value of 0.95-0.99. To minimize cognitive and neuromuscular fatigue, the experimental sessions will be separated by a minimum of three days (72 hours).
| Study group | Role | What they receive |
|---|---|---|
| Passive application of BFR cuff | Experimental | Not described Receives: Other: Passive application of BFR cuff |
| Resistance exercise with BFR | Experimental | Not described Receives: Other: Resistance exercise with BFR |
| Resistance exercise without BFR | Experimental | Not described Receives: Other: Resistance exercise without BFR |
What is being measured
The primary outcome is the main question the study is designed to answer.
Somatosensory-evoked Potential
SSEP is a reliable, reproducible, and frequently employed to detect alterations in electrophysiological conduction within the central and peripheral nervous pathways. The assessment of SSEP will involve the placement of electrodes for tibial nerve stimulation at the ankle, which includes both stimulating and recording electrodes.
Measured: 1st Session: Before BFR cuff. During (4 times, 2 min apart). After (4 times, 5 min apart). 2nd & 3rd Sessions: Before exercise with/without BFR cuff. During (4 times, after each set, during rest period). After (4 times, 5 min apart).
Secondary outcomes (1)
Perceived Pain
Visual analogue scale (VAS) is widely used to measure the frequency or intensity of various symptoms. VAS is valid, reliable, and frequently used outcome measure to measure intensity of perceived pain. Electronic-based VAS will be used to measure the level of perceived pain after the application of different cuff widths, where there will be a 10-cm/100-mm long horizontal line, with "No pain" to be rated as 0 mm, while "Worst imaginable pain" to be rated as 100 mm and the participant is asked to draw a vertical mark on the horizontal line indicating their level of perceived pain.
Measured: Immediately after each session: - Rate perceived pain during the session (BFR cuff application and resistance exercise). - Rate if they are currently experiencing pain.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Jan 2025
- Study start20 Jan 2025 (estimated)
- Primary completion31 Jul 2025 (estimated)
- Study completion31 Jul 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (17)Papers the sponsor has linked to this study.
- Other trials for The Current Study Focuses on Investigating the Short-term Effect of BFRT on the Somatosensory System Among Healthy Young AdultsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Participants will be randomly assigned to one of the three groups: small cuff width (5 cm), medium cuff width (12 cm), and large cuff width (18 cm). Each participant in all three groups will enroll in the three experimental sessions in a random order. All experimental sessions will be provided by the same physiotherapist to minimize the inter-rater variations.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Sharjah
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Taif A. M. Omran, University of Sharjah
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06762912
- Sponsor's protocol ID
- BFRT-SSEP
- Status last verified
- Jan 2025
- First submitted
- 23 Dec 2024
- Last updated
- 8 Jan 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Yusof, N., (2019). Likert Scale vs. Visual analogue scale on vehicle seat discomfort questionnaire: a review. Malaysian Journal of Medicine and Health Sciences, 15(204).
Muzyka IM, Estephan B. Somatosensory evoked potentials. Handb Clin Neurol. 2019;160:523-540. doi: 10.1016/B978-0-444-64032-1.00035-7.
PubMed 31277874Li X, Li J, Qing L, Wang H, Ma H, Huang P. Effect of quadriceps training at different levels of blood flow restriction on quadriceps strength and thickness in the mid-term postoperative period after anterior cruciate ligament reconstruction: a randomized controlled external pilot study. BMC Musculoskelet Disord. 2023 May 8;24(1):360. doi: 10.1186/s12891-023-06483-x.
PubMed 37158913Wanner M, Probst-Hensch N, Kriemler S, Meier F, Autenrieth C, Martin BW. Validation of the long international physical activity questionnaire: Influence of age and language region. Prev Med Rep. 2016 Mar 9;3:250-6. doi: 10.1016/j.pmedr.2016.03.003. eCollection 2016 Jun.
PubMed 27419023Korakakis V, Whiteley R, Giakas G. Low load resistance training with blood flow restriction decreases anterior knee pain more than resistance training alone. A pilot randomised controlled trial. Phys Ther Sport. 2018 Nov;34:121-128. doi: 10.1016/j.ptsp.2018.09.007. Epub 2018 Sep 19.
PubMed 30268966Sousa J, Neto GR, Santos HH, Araujo JP, Silva HG, Cirilo-Sousa MS. Effects of strength training with blood flow restriction on torque, muscle activation and local muscular endurance in healthy subjects. Biol Sport. 2017 Mar;34(1):83-90. doi: 10.5114/biolsport.2017.63738. Epub 2016 Dec 1.
PubMed 28416903Shousha T, Alayat M, Moustafa I. Effects of low-level laser therapy versus soft occlusive splints on mouth opening and surface electromyography in females with temporomandibular dysfunction: A randomized-controlled study. PLoS One. 2021 Oct 1;16(10):e0258063. doi: 10.1371/journal.pone.0258063. eCollection 2021.
PubMed 34597318Alghadir AH, Anwer S, Iqbal A, Iqbal ZA. Test-retest reliability, validity, and minimum detectable change of visual analog, numerical rating, and verbal rating scales for measurement of osteoarthritic knee pain. J Pain Res. 2018 Apr 26;11:851-856. doi: 10.2147/JPR.S158847. eCollection 2018.
PubMed 29731662Cidem M, Sahin Z, Aydin T, Aysal F. Somatosensory evoked potential findings in ankylosing spondylitis. Eurasian J Med. 2014 Feb;46(1):42-6. doi: 10.5152/eajm.2013.100.
PubMed 25610293Tuominen J, Leppanen M, Jarske H, Pasanen K, Vasankari T, Parkkari J. Test-Retest Reliability of Isokinetic Ankle, Knee and Hip Strength in Physically Active Adults Using Biodex System 4 Pro. Methods Protoc. 2023 Mar 9;6(2):26. doi: 10.3390/mps6020026.
PubMed 36961046Maudrich T, Degener S, Ragert P, Kenville R. The impact of acute blood-flow-restriction resistance exercise on somatosensory-evoked potentials in healthy adults. Exp Physiol. 2024 Nov;109(11):1869-1881. doi: 10.1113/EP091911. Epub 2024 Sep 4.
PubMed 39233383Fatela P, Reis JF, Mendonca GV, Avela J, Mil-Homens P. Acute effects of exercise under different levels of blood-flow restriction on muscle activation and fatigue. Eur J Appl Physiol. 2016 May;116(5):985-95. doi: 10.1007/s00421-016-3359-1. Epub 2016 Mar 26.
PubMed 27017495Ilett MJ, Rantalainen T, Keske MA, May AK, Warmington SA. The Effects of Restriction Pressures on the Acute Responses to Blood Flow Restriction Exercise. Front Physiol. 2019 Aug 13;10:1018. doi: 10.3389/fphys.2019.01018. eCollection 2019.
PubMed 31456694van Melick N, Meddeler BM, Hoogeboom TJ, Nijhuis-van der Sanden MWG, van Cingel REH. How to determine leg dominance: The agreement between self-reported and observed performance in healthy adults. PLoS One. 2017 Dec 29;12(12):e0189876. doi: 10.1371/journal.pone.0189876. eCollection 2017.
PubMed 29287067Carter, K., Scheffold, A. L., Renteria, J., Berger, V. W., Luo, Y. A., Chipman, J. J., & Sverdlov, O. (2024). Regulatory Guidance on Randomization and the Use of Randomization Tests in Clinical Trials: A Systematic Review. Statistics in Biopharmaceutical Research, 16(4), 428-440. https://doi.org/10.1080/19466315.2023.2239521
Study at a glance
From the registry record, last updated by the sponsor on 8 Jan 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Short-term Effect of Low-load Resistance Training with Blood-flow Restriction on Somatosensory-evoked Potentials in Healthy Young Adults - a Randomized Crossover Trial
- ClinicalTrials.gov ID
- NCT06762912
- Acronym / sponsor ID
- BFRT-SSEP
- Keywords
- Blood Flow Restriction Training, Somatosensory Evoked Potentials, Neuroplasticity, Pain
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- University of SharjahUniversity, hospital or other
- Study start
- 20 Jan 2025 (estimated)
- Primary completion
- 31 Jul 2025 (estimated)
- Study completion
- 31 Jul 2025 (estimated)
- First posted
- 8 Jan 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to investigate the short-term effect of lower limb BFRT on the somatosensory processing and related changes in SSEP amplitude and latency. The main questions it aims to answer are:
- Is there an effect of short-term application of BFRT on the somatosensory system?
- How do different cuff widths affect the somatosensory system?
- How do three different cuff widths affect perceived pain? Researchers will compare 3 different cuff widths to see if different cuff widths affect the somatosensory system and perceived pain.
Participants will:
- Undergo 3 experimental sessions, sessions will be separated by 72 hours and the order of the sessions to be randomly selected.
- Perform low-load resistance training with blood flow restriction.
Detailed description
The current study will be conducted in the college of health sciences, physiotherapy department, in the medical campus in the University of Sharjah, Sharjah, United Arab Emirates. The study design is a Randomized Crossover Trial, which will include three groups of healthy young adults, each group will use a different cuff widths (small cuff width (5 cm), medium cuff width (12 cm), and large cuff width (18 cm)). Participants in all three groups will undergo three experimental sessions in a random order, which will include the application of a blood flow restriction cuff combined with resistance exercise, the application of a blood flow restriction cuff without resistance exercise, and traditional resistance exercise without a blood flow restriction cuff. During each session, SSEP measurements will be recorded at three time points: before, during, and after the experimental session by stimulating the tibial nerve at the ankle and measuring the SSEP amplitude and latency.
Healthy young adults aged 18-30 years of both genders will be recruited through word of mouth and through social media by sharing the study flyer. Then, they will be screened for their eligibility to participate in the current study. Participants who will meet the eligibility criteria will be asked to provide their consent after the study is explained by filling out the consent form.
Participants will be randomly assigned to one of the three groups: (1) small cuff width (5 cm), (2) medium cuff width (12 cm), and (3) large cuff width (18 cm) by using permuted block randomization method with large, random, and variable block sizes to ensure groups are balanced and selection bias is minimized.
The first experimental session will start by conducting the one repetition maximum (1-RM) test of unilateral knee extension of the dominant leg, in which the dominant side was identified by asking the participants which side they will use to kick a ball. Before conducting the 1-RM test, 5 minutes warm-up on the cycle ergometer at 75W will be done. Calibration of the dynamometer will be done before operating the machine with each participant, then the participant will be positioned on the dynamometer seat comfortably with ensuring the back is supported and the knee is aligned with the axis of rotation. The participant will be asked to complete one successful repetition of knee extension through full range of motion (ROM), with increasing load until the participant can no longer complete full knee extension ROM, 3 minutes of rest will be allowed between attempts until the 1-RM is identified. To eliminate the effect of fatigue after 1-RM test, the first experimental session will always include the application of the BFR cuff without resistance exercise.
For both experimental sessions 2 and 3, the order of exercise condition will be randomly selected, either to be (1) the application of BFR cuff with resistance exercise, or (2) resistance exercise without the application of BFR cuff to decrease the incidence of learning effect. Cuff pressure during the application of BFR will be standardized to 50% of AOP.
The resistance exercise for both experimental sessions 2 and 3 will be exactly similar and will involve four sets of isometric knee extensions at an intensity of 20% of 1-RM with repetitions of 30, 15, 15, and 15 by using the isokinetic dynamometer machine, which has a good to excellent test-retest reliability for knee extension movement with ICC value of 0.95-0.99. To minimize cognitive and neuromuscular fatigue, the experimental sessions will be separated by a minimum of three days (72 hours).
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 3
- Model description
- Participants will be randomly assigned to one of the three groups: small cuff width (5 cm), medium cuff width (12 cm), and large cuff width (18 cm). Each participant in all three groups will enroll in the three experimental sessions in a random order. All experimental sessions will be provided by the same physiotherapist to minimize the inter-rater variations.
| Arm | Type | Receives |
|---|---|---|
| Passive application of BFR cuff | Experimental | Other: Passive application of BFR cuff |
| Resistance exercise with BFR | Experimental | Other: Resistance exercise with BFR |
| Resistance exercise without BFR | Experimental | Other: Resistance exercise without BFR |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Participants will be included if they are aged 18-30 years of both genders, with no history of cardiovascular problems or osteo-articular problems in the lower limbs, and if they responded negatively to all items of the Physical Activity Readiness Questionnaire (PAR-Q).
- Participants will be included if they have a body mass index (BMI) less than 25 or non-overweight individuals.
- Use of the long international physical activity questionnaire (L-IPAQ) to ensure all participants have equal physical activity levels.
Key exclusion criteria (3 listed)
- Participants will be excluded if they did not meet the inclusion criteria, and if they had a history of deep vein thrombosis (DVT), congenital heart disease, varicose veins, currently pregnant, or any contraindications to exercise.
- Participants will be excluded if they were diagnosed with any neurological disease.
- Participants will be excluded if they have had any musculoskeletal injury in the past 3 months to avoid potential effect on their physical activity levels.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Passive application of BFR cuffThe first experimental session will start by conducting the one repetition maximum (1-RM) test of unilateral knee extension of the dominant leg, in which the dominant side was identified by asking the participants which side they will use to kick a ball. Before conducting the 1-RM test, 5 minutes warm-up on the cycle ergometer at 75W will be done. Calibration of the dynamometer will be done before operating the machine with each participant, then the participant will be positioned on the dynamometer seat comfortably with ensuring the back is supported and the knee is aligned with the axis of rotation. The participant will be asked to complete one successful repetition of knee extension through full range of motion (ROM), with increasing load until the participant can no longer complete full knee extension ROM, 3 minutes of rest will be allowed between attempts until the 1-RM is identified. | Other | Passive application of BFR cuff |
| Resistance exercise with BFRFor both experimental sessions 2 and 3, the order of exercise condition will be randomly selected, either to be (1) the application of BFR cuff with resistance exercise, or (2) resistance exercise without the application of BFR cuff to decrease the incidence of learning effect. Cuff pressure during the application of BFR will be standardized to 50% of AOP. The resistance exercise for both experimental sessions 2 and 3 will be exactly similar and will involve four sets of isometric knee extensions at an intensity of 20% of 1-RM with repetitions of 30, 15, 15, and 15 by using the isokinetic dynamometer machine, which has a good to excellent test-retest reliability for knee extension movement with ICC value of 0.95-0.99. To minimize cognitive and neuromuscular fatigue, the experimental sessions will be separated by a minimum of three days (72 hours). | Other | Resistance exercise with BFR |
| Resistance exercise without BFRFor both experimental sessions 2 and 3, the order of exercise condition will be randomly selected, either to be (1) the application of BFR cuff with resistance exercise, or (2) resistance exercise without the application of BFR cuff to decrease the incidence of learning effect. Cuff pressure during the application of BFR will be standardized to 50% of AOP. The resistance exercise for both experimental sessions 2 and 3 will be exactly similar and will involve four sets of isometric knee extensions at an intensity of 20% of 1-RM with repetitions of 30, 15, 15, and 15 by using the isokinetic dynamometer machine, which has a good to excellent test-retest reliability for knee extension movement with ICC value of 0.95-0.99. To minimize cognitive and neuromuscular fatigue, the experimental sessions will be separated by a minimum of three days (72 hours). | Other | Resistance exercise without BFR |
Primary outcome
Somatosensory-evoked Potential
Time frame: 1st Session: Before BFR cuff. During (4 times, 2 min apart). After (4 times, 5 min apart). 2nd & 3rd Sessions: Before exercise with/without BFR cuff. During (4 times, after each set, during rest period). After (4 times, 5 min apart).
SSEP is a reliable, reproducible, and frequently employed to detect alterations in electrophysiological conduction within the central and peripheral nervous pathways. The assessment of SSEP will involve the placement of electrodes for tibial nerve stimulation at the ankle, which includes both stimulating and recording electrodes.
1 secondary outcome
Perceived Pain
Time frame: Immediately after each session: - Rate perceived pain during the session (BFR cuff application and resistance exercise). - Rate if they are currently experiencing pain.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jan 2025.
- BackgroundYusof, N., (2019). Likert Scale vs. Visual analogue scale on vehicle seat discomfort questionnaire: a review. Malaysian Journal of Medicine and Health Sciences, 15(204).
- Background: PubMed 31277874Muzyka IM, Estephan B. Somatosensory evoked potentials. Handb Clin Neurol. 2019;160:523-540. doi: 10.1016/B978-0-444-64032-1.00035-7.
- Background: PubMed 37158913Li X, Li J, Qing L, Wang H, Ma H, Huang P. Effect of quadriceps training at different levels of blood flow restriction on quadriceps strength and thickness in the mid-term postoperative period after anterior cruciate ligament reconstruction: a randomized controlled external pilot study. BMC Musculoskelet Disord. 2023 May 8;24(1):360. doi: 10.1186/s12891-023-06483-x.
- Background: PubMed 27419023Wanner M, Probst-Hensch N, Kriemler S, Meier F, Autenrieth C, Martin BW. Validation of the long international physical activity questionnaire: Influence of age and language region. Prev Med Rep. 2016 Mar 9;3:250-6. doi: 10.1016/j.pmedr.2016.03.003. eCollection 2016 Jun.
- Background: PubMed 30268966Korakakis V, Whiteley R, Giakas G. Low load resistance training with blood flow restriction decreases anterior knee pain more than resistance training alone. A pilot randomised controlled trial. Phys Ther Sport. 2018 Nov;34:121-128. doi: 10.1016/j.ptsp.2018.09.007. Epub 2018 Sep 19.
- Background: PubMed 28416903Sousa J, Neto GR, Santos HH, Araujo JP, Silva HG, Cirilo-Sousa MS. Effects of strength training with blood flow restriction on torque, muscle activation and local muscular endurance in healthy subjects. Biol Sport. 2017 Mar;34(1):83-90. doi: 10.5114/biolsport.2017.63738. Epub 2016 Dec 1.
- Background: PubMed 34597318Shousha T, Alayat M, Moustafa I. Effects of low-level laser therapy versus soft occlusive splints on mouth opening and surface electromyography in females with temporomandibular dysfunction: A randomized-controlled study. PLoS One. 2021 Oct 1;16(10):e0258063. doi: 10.1371/journal.pone.0258063. eCollection 2021.
- Background: PubMed 29731662Alghadir AH, Anwer S, Iqbal A, Iqbal ZA. Test-retest reliability, validity, and minimum detectable change of visual analog, numerical rating, and verbal rating scales for measurement of osteoarthritic knee pain. J Pain Res. 2018 Apr 26;11:851-856. doi: 10.2147/JPR.S158847. eCollection 2018.
- Background: PubMed 25610293Cidem M, Sahin Z, Aydin T, Aysal F. Somatosensory evoked potential findings in ankylosing spondylitis. Eurasian J Med. 2014 Feb;46(1):42-6. doi: 10.5152/eajm.2013.100.
- Background: PubMed 36961046Tuominen J, Leppanen M, Jarske H, Pasanen K, Vasankari T, Parkkari J. Test-Retest Reliability of Isokinetic Ankle, Knee and Hip Strength in Physically Active Adults Using Biodex System 4 Pro. Methods Protoc. 2023 Mar 9;6(2):26. doi: 10.3390/mps6020026.
- Background: PubMed 39233383Maudrich T, Degener S, Ragert P, Kenville R. The impact of acute blood-flow-restriction resistance exercise on somatosensory-evoked potentials in healthy adults. Exp Physiol. 2024 Nov;109(11):1869-1881. doi: 10.1113/EP091911. Epub 2024 Sep 4.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Passive application of BFR cuff, Resistance exercise with BFR and Resistance exercise without BFR in people with The Current Study Focuses on Investigating the Short-term Effect of BFRT on the Somatosensory System Among Healthy Young Adults, run by University of Sharjah at 1 site in United Arab Emirates.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 8 Jan 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Arab Emirates. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Taif A. M. Omran, Master's Student (+971551610573, u23102812@sharjah.ac.ae), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Somatosensory-evoked Potential (time frame: 1st Session: Before BFR cuff. During (4 times, 2 min apart). After (4 times, 5 min apart). 2nd & 3rd Sessions: Before exercise with/without BFR cuff. During (4 times, after each set, during rest period). After (4 times, 5 min apart).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06762912, which also lists 17 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jan 2025.