Glucose Metabolism DisordersNCT06763562
Food Orders on Blood Glucose and Fuel Use at Rest
A study testing Carbohydrate-first meal and Carbohydrate-last meal in people with Glucose Metabolism Disorders and Hunger, run by Old Dominion University at 1 site in United States.
Trial summary
Consuming a carbohydrate-rich food as the final food in a meal, as compared to the first food in a meal, has been shown to reduce blood glucose levels after eating in both diabetes patients and in healthy controls. Read more about this study
- Who is it for?
- Ages 18 to 70 yearsHealthy volunteers can take part
- Conditions the study is for
- Glucose Metabolism Disorders, Hunger, Fat Burn
- What is being tested?
- Carbohydrate-first meal and Carbohydrate-last meal
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteUnited States
- Study dates
- 5 Jan 2025to 26 Nov 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- 18-70 years old
- Free from any allergy or condition that precluding consumption of edamame, butter, and rice
- Not currently pregnant
- Free of any medical conditions requiring the use of insulin
- Have no history of bariatric surgery
- Have no implanted electrical devices such as a pacemaker
Who cannot join
- Younger than 18 and older than 70 years old
- Having an allergy or condition that precludes consumption of edamame, butter, and rice
- Currently pregnant
- Any medical conditions requiring the use of insulin
- A history of bariatric surgery
- Having an implanted electrical device such as a pacemaker
Trial locations and contacts
1 site in 1 country.
United States1 site
Old Dominion University Human Performance Laboratory
Norfolk, Virginia, 23529
About this study
Official title: The Impact of Different Food Orders on Blood Glucose and Fuel Use at Rest
Consuming a carbohydrate-rich food as the final food in a meal, as compared to the first food in a meal, has been shown to reduce blood glucose levels after eating in both diabetes patients and in healthy controls. However, gaps remain in the literature in this area of research, and currently little is known about how substrate (fuel) use is impacted by altering food order. In addition, most studies to date have used a mix of meat and plant foods, while little research has focused exclusively on vegetarian foods. This randomized experiment will examine how altering the order of foods eaten in a vegetarian meal impacts blood glucose and fuel utilization at rest.
- Conditions
- Glucose Metabolism Disorders, Hunger, Fat Burn
- Being tested
- Carbohydrate-first meal, Carbohydrate-last meal
- Medical subject headings
- Glucose Metabolism Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Carbohydrate-first mealOther
Rice eaten first (150 grams), followed by edamame (150 grams) and butter (10 grams)
Carbohydrate-last mealOther
Edamame (150 grams) and butter (10 grams) eaten first, followed by rice (150 grams)
| Study group | Role | What they receive |
|---|---|---|
| Carbohydrate-first meal | Experimental | Not described Receives: Other: Carbohydrate-first meal |
| Carbohydrate-last meal | Experimental | Not described Receives: Other: Carbohydrate-last meal |
What is being measured
The primary outcome is the main question the study is designed to answer.
Respiratory exchange ratio
Ratio of carbon dioxide production and oxygen consumption for determination of fuel use
Measured: 90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)
Secondary outcomes (4)
Fat use
Fat utilization will be estimated from respiratory gas exchange
Measured: 90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)
Carbohydrate use
Carbohydrate utilization will be estimated from respiratory gas exchange
Measured: 90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)
Blood glucose
Blood glucose will be measured with fingerstick samples and a portable glucometer
Measured: 90 minutes (baseline/premeal and 30, 60, and 90 minutes postmeal)
Hunger-satiety perceptions
Hunger, appetite, satiety, and fullness on a 0-10 Likert scale
Measured: 90 minutes (baseline/premeal and 30, 60, and 90 minutes postmeal)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Jan 2025
- Study start5 Jan 2025
- Primary completion26 Nov 2025
- Study completion26 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Glucose Metabolism DisordersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Old Dominion University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Patrick Wilson, PhD, Old Dominion University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06763562
- Sponsor's protocol ID
- 24-163
- Status last verified
- Oct 2026
- First submitted
- 2 Jan 2025
- Last updated
- 16 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified IPD will be shared as supplementary material associated with the published peer-reviewed publication or through a publicly available repository (depending on the journal's preference).
Study at a glance
From the registry record, last updated by the sponsor on 16 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact of Different Food Orders on Blood Glucose and Fuel Use at Rest
- ClinicalTrials.gov ID
- NCT06763562
- Acronym / sponsor ID
- 24-163
- Conditions
- Glucose Metabolism Disorders, Hunger, Fat Burn
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Old Dominion UniversityUniversity, hospital or other
- Study start
- 5 Jan 2025 (actual)
- Primary completion
- 26 Nov 2025 (actual)
- Study completion
- 26 Nov 2025 (actual)
- First posted
- 8 Jan 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Consuming a carbohydrate-rich food as the final food in a meal, as compared to the first food in a meal, has been shown to reduce blood glucose levels after eating in both diabetes patients and in healthy controls. However, gaps remain in the literature in this area of research, and currently little is known about how substrate (fuel) use is impacted by altering food order. In addition, most studies to date have used a mix of meat and plant foods, while little research has focused exclusively on vegetarian foods. This randomized experiment will examine how altering the order of foods eaten in a vegetarian meal impacts blood glucose and fuel utilization at rest.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Carbohydrate-first meal | Experimental | Other: Carbohydrate-first meal |
| Carbohydrate-last meal | Experimental | Other: Carbohydrate-last meal |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- 18-70 years old
- Free from any allergy or condition that precluding consumption of edamame, butter, and rice
- Not currently pregnant
- Free of any medical conditions requiring the use of insulin
- Have no history of bariatric surgery
Key exclusion criteria (6 listed)
- Younger than 18 and older than 70 years old
- Having an allergy or condition that precludes consumption of edamame, butter, and rice
- Currently pregnant
- Any medical conditions requiring the use of insulin
- A history of bariatric surgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Carbohydrate-first mealRice eaten first (150 grams), followed by edamame (150 grams) and butter (10 grams) | Other | Carbohydrate-first meal |
| Carbohydrate-last mealEdamame (150 grams) and butter (10 grams) eaten first, followed by rice (150 grams) | Other | Carbohydrate-last meal |
Primary outcome
Respiratory exchange ratio
Time frame: 90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)
Ratio of carbon dioxide production and oxygen consumption for determination of fuel use
4 secondary outcomes
Fat use
Time frame: 90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)
Carbohydrate use
Time frame: 90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)
Blood glucose
Time frame: 90 minutes (baseline/premeal and 30, 60, and 90 minutes postmeal)
Hunger-satiety perceptions
Time frame: 90 minutes (baseline/premeal and 30, 60, and 90 minutes postmeal)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Oct 2026.
- Individual participant dataSharing planned: Yes. De-identified IPD will be shared as supplementary material associated with the published peer-reviewed publication or through a publicly available repository (depending on the journal's preference).
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Carbohydrate-first meal and Carbohydrate-last meal in people with Glucose Metabolism Disorders and Hunger, run by Old Dominion University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Respiratory exchange ratio (time frame: 90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Oct 2026.