Immediate Dental ImplantsNCT06773104
Autogenous Tooth Bone Graft Versus Allogeneic Bone Graft Around Dental Implant in Aesthetic Zone
A study testing immediate implant with allogenic bone graft and Allogeneic bone graft with immediate implant placement in people with Immediate Dental Implants and Thin Labial Plate of Bone Pre-extraction, run by Tanta University at 1 site in Egypt.
Trial summary
24 patienta with non restorable anterior teeth underwent extraction with immediate implant installation using bone grafts either autogenous tooth bone graft or allogenic bone graft Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement with autogenous tooth bone graft. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Immediate Dental Implants, Thin Labial Plate of Bone Pre-extraction, Hopeless Tooth in Esthetic Zone
- What is being tested?
- immediate implant with allogenic bone graft and Allogeneic bone graft with immediate implant placement
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteEgypt
- Study dates
- 25 Mar 2024to 16 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patients with non restorable maxillary anterior teeth need to be extracted.
- Thin labial plate of bone of the tooth to be extracted.
- Patients age above 20years old.
- Good oral hygiene.
- No signs of acute infection or inflammation
Who cannot join
- Prior radiation therapy.
- Soft and hard tissue pathology at the operation site.
- Any relevant systemic disease or medication that might compromise bone healing.
Trial locations and contacts
1 site in 1 country.
About this study
24 patienta with non restorable anterior teeth underwent extraction with immediate implant installation using bone grafts either autogenous tooth bone graft or allogenic bone graft Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement with autogenous tooth bone graft.
- Allogeneic bone graft group (control group): 12 patients will have immediate implant placement with allogeneic bone graft (demineralized freeze dried bone allograft - cortico cancellous).
Read the detailed description
24 patienta with non restorable anterior teeth underwent extraction with immediate implant installation randomized to two groups Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement with autogenous tooth bone graft.
- Allogeneic bone graft group (control group): 12 patients will have immediate implant placement with allogeneic bone graft (demineralized freeze dried bone allograft - cortico cancellous). preparation of autogenous tooth bone graft Any restorations, caries, cementum, periodontal ligament and pulp tissue will be removed .The tooth will be grinded using dental bone mill and bone crusher Tooth particles will be sieved to particles size 300 to 1200 microns. The sorted particles will be immersed in 70 % ethanol and 5% Peracetic acid* in a sterile container for 10 minutes to remove any soft tissue remnants, bacteria and smear layer (defatting and sterilization).
Tooth particles will be demineralized using 2% HNO3for 20 minutes to expose the dentine organic matrix.
The bacteria-free particulate dentin will be washed with phosphate buffered saline‡ twice for 5 minutes to restore the PH balance to 7.4. In the same setting, surgical procedure after atraumatic extraction immediate implant willbe inserted according to dimensions taken from CBCT and jumbing gap will be filled with bone graft according to randomization
- Conditions
- Immediate Dental Implants, Thin Labial Plate of Bone Pre-extraction, Hopeless Tooth in Esthetic Zone
- Being tested
- immediate implant with allogenic bone graft, Allogeneic bone graft with immediate implant placement
- Keywords
- autogenous tooth bone graft, allogenic bone graft, grafting the jumbing gap, immediate dental implant
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
immediate implant with allogenic bone graftProcedure or surgery
after atraumatic extraction immediate implant will be inserted with allogenic bone graft
Allogeneic bone graft with immediate implant placementProcedure or surgery
Immediate dental implant placement with grafting of the jumping gap using allogeneic bone graft (DFDBA).
| Study group | Role | What they receive |
|---|---|---|
| Autogenous tooth bone graft group | Experimental | Twelve patients receiving immediate implant placement with autogenous fresh partially demineralized dentin graft. Receives: Procedure: Allogeneic bone graft with immediate implant placement |
| Allogeneic bone graft group (control group) | Active comparator | Patients receiving immediate dental implant placement with allogeneic bone graft (DFDBA) for grafting of the jumping gap. Receives: Procedure: immediate implant with allogenic bone graft |
What is being measured
The primary outcome is the main question the study is designed to answer.
labial bone thickness
measuring thickness of labial bone labial to the implant
Measured: 6 months
marginal bone loss
Measured: 6 months
Secondary outcomes (3)
bone density around dental implant
bone density will be assessed using CBCT buccal to the implant fixtures 6 months after implant installation
Measured: 6 months
implant secondary stability
Implant stability will be assessed at the time of implant insertion and 6 months after the operation. Resonance frequency analysis (RFA) values expressed as implant stability quotient (ISQ) will be recorded by a transducer attached to the implant by a screw and a frequencyresponse analyzer (Osstell Mentor Device) with the average of 2measurements performed with the probe in 2 perpendiculardirections
Measured: 6 months
implant success
when the following clinical features arise: emerging of the fistula, the particle of the bone graft material flow out from the fistula or mucosal dehiscence, and the chronic inflammation ragarded as failure
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jan 2025
- Study start25 Mar 2024
- Primary completion16 Oct 2025
- Study completion16 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Immediate Dental ImplantsStudies of the same condition, open and under way.
- More trials run by Tanta UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- non restorable anterior teeth with thin labial plate of bone
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Tanta University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Diab Abdel Gaied Diab Ghanem Mohammed, Tanta University
- Investigators
- diab abdelgaied diab, master, Principal investigator, faculty of dentistry tanta universityRafic ramadan bedir, professor, Principal investigator, faculty of dentistry tanta universityIbrahim mohammed nowair, professor, Principal investigator, faculty of dentistry tanta universityMona samy sheta, lecturer, Principal investigator, faculty of dentistry tanta university
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06773104
- Sponsor's protocol ID
- diab123
- Status last verified
- Jan 2026
- First submitted
- 30 Dec 2024
- Last updated
- 20 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Autogenous Tooth Bone Graft Versus Allogeneic Bone Graft Around Dental Implant in Aesthetic Zone
- ClinicalTrials.gov ID
- NCT06773104
- Acronym / sponsor ID
- diab123
- Conditions
- Immediate Dental Implants, Thin Labial Plate of Bone Pre-extraction, Hopeless Tooth in Esthetic Zone
- Keywords
- autogenous tooth bone graft, allogenic bone graft, grafting the jumbing gap, immediate dental implant
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Tanta UniversityUniversity, hospital or other
- Study start
- 25 Mar 2024 (actual)
- Primary completion
- 16 Oct 2025 (actual)
- Study completion
- 16 Oct 2025 (actual)
- First posted
- 14 Jan 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
24 patienta with non restorable anterior teeth underwent extraction with immediate implant installation using bone grafts either autogenous tooth bone graft or allogenic bone graft Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement with autogenous tooth bone graft.
- Allogeneic bone graft group (control group): 12 patients will have immediate implant placement with allogeneic bone graft (demineralized freeze dried bone allograft - cortico cancellous).
Detailed description
24 patienta with non restorable anterior teeth underwent extraction with immediate implant installation randomized to two groups Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement with autogenous tooth bone graft.
- Allogeneic bone graft group (control group): 12 patients will have immediate implant placement with allogeneic bone graft (demineralized freeze dried bone allograft - cortico cancellous). preparation of autogenous tooth bone graft Any restorations, caries, cementum, periodontal ligament and pulp tissue will be removed .The tooth will be grinded using dental bone mill and bone crusher Tooth particles will be sieved to particles size 300 to 1200 microns. The sorted particles will be immersed in 70 % ethanol and 5% Peracetic acid* in a sterile container for 10 minutes to remove any soft tissue remnants, bacteria and smear layer (defatting and sterilization).
Tooth particles will be demineralized using 2% HNO3for 20 minutes to expose the dentine organic matrix.
The bacteria-free particulate dentin will be washed with phosphate buffered saline‡ twice for 5 minutes to restore the PH balance to 7.4. In the same setting, surgical procedure after atraumatic extraction immediate implant willbe inserted according to dimensions taken from CBCT and jumbing gap will be filled with bone graft according to randomization
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- non restorable anterior teeth with thin labial plate of bone
| Arm | Type | Receives |
|---|---|---|
| Autogenous tooth bone graft group | Experimental | Procedure: Allogeneic bone graft with immediate implant placementTwelve patients receiving immediate implant placement with autogenous fresh partially demineralized dentin graft. |
| Allogeneic bone graft group (control group) | Active comparator | Procedure: immediate implant with allogenic bone graftPatients receiving immediate dental implant placement with allogeneic bone graft (DFDBA) for grafting of the jumping gap. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Patients with non restorable maxillary anterior teeth need to be extracted.
- Thin labial plate of bone of the tooth to be extracted.
- Patients age above 20years old.
- Good oral hygiene.
- No signs of acute infection or inflammation
Key exclusion criteria (3 listed)
- Prior radiation therapy.
- Soft and hard tissue pathology at the operation site.
- Any relevant systemic disease or medication that might compromise bone healing.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| immediate implant with allogenic bone graftafter atraumatic extraction immediate implant will be inserted with allogenic bone graft | Procedure or surgery | Allogeneic bone graft group (control group) |
| Allogeneic bone graft with immediate implant placementImmediate dental implant placement with grafting of the jumping gap using allogeneic bone graft (DFDBA). | Procedure or surgery | Autogenous tooth bone graft group |
Primary outcome
labial bone thickness
Time frame: 6 months
measuring thickness of labial bone labial to the implant
marginal bone loss
Time frame: 6 months
3 secondary outcomes
bone density around dental implant
Time frame: 6 months
implant secondary stability
Time frame: 6 months
implant success
Time frame: 6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
diab abdelgaied diab, master principal investigator
faculty of dentistry tanta university
Rafic ramadan bedir, professor principal investigator
faculty of dentistry tanta university
Ibrahim mohammed nowair, professor principal investigator
faculty of dentistry tanta university
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing immediate implant with allogenic bone graft and Allogeneic bone graft with immediate implant placement in people with Immediate Dental Implants and Thin Labial Plate of Bone Pre-extraction, run by Tanta University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
labial bone thickness (time frame: 6 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jan 2026.