Clinical and Laboratory Profile of Myasthenia Gravis in Children At Sohag University Hospitals

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

• Ages 1 month to 16 years
• All sexes
• No healthy volunteers
• Child

Study population: Patients: Patients diagnosed with myasthenia gravis at the pediatric out patient clinic by clinical charactristics ,nerve study and laboratory data will be elligable for the study.

Trial locations and contacts

3 sites in 1 country.

About this study

Conditions

Myasthenia Gravis in Children

Being tested

All patients in this study were subjected to the followings: (A) Clinical history focusing on: Sociodemographic data: age, gender , residence,and degree of consanguinity. Full neurodevelopmental his, EMG ,rNST,Ach R antibodies & thyroid function

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

• All patients in this study were subjected to the followings: (A) Clinical history focusing on: Sociodemographic data: age, gender , residence,and degree of consanguinity. Full neurodevelopmental hisDiagnostic test

  Thorough clinical examination:

  1. General examination including general look, vital signs and anthropometric measurements.
  2. Scale system include gross motor function and muscle power(Quantitative Myasthenia Gravis Scale) [36] 3. detailed neurological examination including motor ,sensory and reflexes. (C) Investigations:
  3. Electrophysiological testing: EMG : is especially useful in diagnosis of seronegative MG and congenital myasthenic syndromes. NCS: including repetitive nerve stimulation test (r NST)
  4. laboratory studies:

  • Serology. Detection of antibodies to the AChR supports the diagnosis of JMG. In young children where AChR antibodies are negative this can lead to difficulty in differentiating from CMS.
  • Thyroid function tests :

  1. Imaging:

  • CT chest: Although thymoma in children is rare, the thymus must be imaged once JMG has been diagnosed.

  1. molecular studies (when possible).

• EMG ,rNST,Ach R antibodies & thyroid functionDiagnostic test

  1. Investigations:
  2. Electrophysiological testing: EMG : is especially useful in diagnosis of seronegative MG and congenital myasthenic syndromes. NCS: including repetitive nerve stimulation test (r NST)
  3. laboratory studies:

  • Serology. Detection of antibodies to the AChR supports the diagnosis of JMG. In young children where AChR antibodies are negative this can lead to difficulty in differentiating from CMS.
  • Thyroid function tests :

  1. Imaging:

  • CT chest: Although thymoma in children is rare, the thymus must be imaged once JMG has been diagnosed.

  1. molecular studies (when possible).

What is being measured

The primary outcome is the main question the study is designed to answer.

1. Clinical and laboratory profile of patients with myasthenia gravis at Sohag Neurology Outpatient clinic of pediatric department

   All patients with myasthenia gravis in this study focusing on clinical and laboratory profile at Sohag Neurology outpatient clinic.

   Measured: Follow up for 6 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1. First posted14 Jan 2025
2. Study start1 Feb 2025 (estimated)
3. Primary completion1 May 2025 (estimated)
4. Study completion1 Aug 2025 (estimated)

Resources

• Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
• Other trials for Myasthenia Gravis in ChildrenStudies of the same condition, open and under way.
• More trials run by Sohag UniversityThe sponsor's other registered studies.
• What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.