PerformanceCROSSCAPSNCT06784271
Effect of Acute Phenylcapsaicin Intake on Trained Cross-Training Athletes
A study testing Phenylcapsaicin in people with Performance, run by Universidad de Granada at 1 site in Spain.
Trial summary
The aim of this study is to investigate the effect of acute phenylcapsaicin intake during a cross-training session on perceived exertion, performance, and recovery in cross-training athletes. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Performance
- What is being tested?
- Phenylcapsaicin
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 50 participants
- Where
- 1 siteSpain
- Study dates
- 2 Dec 2024to 28 Feb 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age: 18-35 years.
- Body mass index: 18.5-30 kg/m2.
- Ability to understand the instructions, objectives, and study protocol.
- Minimum of 3 years of experience in crosstraining, with at least 6 hours of weekly training over the past 3 months.
- Resident on the island of Tenerife.
Who cannot join
- History of a significant adverse cardiovascular event, renal insufficiency, cirrhosis, eating disorder, weight control surgical intervention, or type 2 diabetes mellitus.
- Any chronic pathology in which the intake of nutritional supplements, especially pungent components, is not recommended.
- Any condition that, in the investigator's judgment, would impair the ability to participate in the study or represent a personal risk to the participant.
- Use of medications that may affect the study results.
- Unstable body weight for 3 months prior to the start of the study (> 4 kg loss or gain in weight).
- Active tobacco abuse or illicit drug use, or history of treatment for alcohol abuse.
- On a special diet or prescribed for other reasons (e.g., celiac disease).
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Acute Phenylcapsaicin Intake on Trained Cross-Training Athletes: a Randomized, Placebo-Controlled Crossover Study
The aim of this study is to investigate the effect of acute phenylcapsaicin intake during a cross-training session on perceived exertion, performance, and recovery in cross-training athletes.
Read the detailed description
Capsaicin appears to enhance athletic performance by reducing perceived effort, increasing mechanical performance (e.g., total volume load), and decreasing muscle damage. Given the close relationship between the metabolic and physiological responses of cross-training and supplementation with Phenylcapsaicin (PC), it could be expected that consuming capsaicin during cross-training would have a favorable impact on perceived effort, recovery, and performance.
25 women and 24 men trained in CrossFit consumed either Phenylcapsaicin (PC) or a placebo during a CrossFit class, which consisted of a 16-minute weightlifting segment and a 15-minute WOD. Both the Rating of Perceived Exertion (RPE) and the Perceived Recovery Status scale (RPS) were administered at the beginning of the session and at the end of each segment of the CrossFit session. DOMS was assessed using a visual analog scale at 24 and 48 hours after the CrossFit session.
- Conditions
- Performance
- Being tested
- Phenylcapsaicin, Placebo
- Keywords
- Phenylcapsaicin, performance, concurrent exercise, nutrition, recovery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PhenylcapsaicinDietary supplement
2.5mg of Phenylcapsaicin
PlaceboDietary supplement
Placebo
| Study group | Role | What they receive |
|---|---|---|
| Phenylcapsaicin | Experimental | 2.5 mg of Phenylcapsaicin Receives: Dietary Supplement: Phenylcapsaicin |
| Placebo | Placebo comparator | Preparation of colorants, sweeteners, aromas, and acidulants Receives: Dietary Supplement: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Performance
Performance measured through the countermovement jump
Measured: 60min
Performance
Deep squat test at 70% of repetition maximum
Measured: 60min
Secondary outcomes (7)
Heart rate
Heart rate will be measured with the Polar H10 heart rate monitor
Measured: 60min
Subjective fatigue throughe the RPE scale
Rate of perceived exertion scale
Measured: 60min
Recovery
Perceived Recovery Status Scale (RPS)
Measured: 60min
Delayed-onset muscle soreness (DOMS)
Delayed-onset muscle soreness (DOMS) scale (0-10 arbitrary units)
Measured: 60min
Capillar lactate levels
Capillar lactate levels
Measured: 60min
Performance: Weight used in the crosstraining session
Weight used in the crosstraining session
Measured: 60min
Performance: Time performed in the crosstraining session
Time performed in the crosstraining session
Measured: 60min
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jan 2025
- Study start2 Dec 2024
- Primary completion28 Feb 2025 (estimated)
- Study completion28 Feb 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PerformanceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Universidad de Granada
- Sponsor type
- University, hospital or other
- Collaborators
- Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
- Responsible party
- Principal investigator, Lucas Jurado-Fasoli, Universidad de Granada
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06784271
- Sponsor's protocol ID
- CROSSCAPS
- Acronym
- CROSSCAPS
- Status last verified
- Jan 2025
- First submitted
- 14 Jan 2025
- Last updated
- 20 Jan 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 20 Jan 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Acute Phenylcapsaicin Intake on Trained Cross-Training Athletes: a Randomized, Placebo-Controlled Crossover Study
- ClinicalTrials.gov ID
- NCT06784271
- Acronym / sponsor ID
- CROSSCAPS / CROSSCAPS
- Conditions
- Performance
- Keywords
- Phenylcapsaicin, performance, concurrent exercise, nutrition, recovery
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Universidad de GranadaUniversity, hospital or other
- Collaborators
- Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
- Study start
- 2 Dec 2024 (actual)
- Primary completion
- 28 Feb 2025 (estimated)
- Study completion
- 28 Feb 2025 (estimated)
- First posted
- 20 Jan 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to investigate the effect of acute phenylcapsaicin intake during a cross-training session on perceived exertion, performance, and recovery in cross-training athletes.
Detailed description
Capsaicin appears to enhance athletic performance by reducing perceived effort, increasing mechanical performance (e.g., total volume load), and decreasing muscle damage. Given the close relationship between the metabolic and physiological responses of cross-training and supplementation with Phenylcapsaicin (PC), it could be expected that consuming capsaicin during cross-training would have a favorable impact on perceived effort, recovery, and performance.
25 women and 24 men trained in CrossFit consumed either Phenylcapsaicin (PC) or a placebo during a CrossFit class, which consisted of a 16-minute weightlifting segment and a 15-minute WOD. Both the Rating of Perceived Exertion (RPE) and the Perceived Recovery Status scale (RPS) were administered at the beginning of the session and at the end of each segment of the CrossFit session. DOMS was assessed using a visual analog scale at 24 and 48 hours after the CrossFit session.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Phenylcapsaicin | Experimental | Dietary Supplement: Phenylcapsaicin2.5 mg of Phenylcapsaicin |
| Placebo | Placebo comparator | Dietary Supplement: PlaceboPreparation of colorants, sweeteners, aromas, and acidulants |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Age: 18-35 years.
- Body mass index: 18.5-30 kg/m2.
- Ability to understand the instructions, objectives, and study protocol.
- Minimum of 3 years of experience in crosstraining, with at least 6 hours of weekly training over the past 3 months.
- Resident on the island of Tenerife.
Key exclusion criteria (7 listed)
- History of a significant adverse cardiovascular event, renal insufficiency, cirrhosis, eating disorder, weight control surgical intervention, or type 2 diabetes mellitus.
- Any chronic pathology in which the intake of nutritional supplements, especially pungent components, is not recommended.
- Any condition that, in the investigator's judgment, would impair the ability to participate in the study or represent a personal risk to the participant.
- Use of medications that may affect the study results.
- Unstable body weight for 3 months prior to the start of the study (> 4 kg loss or gain in weight).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Phenylcapsaicin2.5mg of Phenylcapsaicin | Dietary supplement | Phenylcapsaicin |
| PlaceboPlacebo | Dietary supplement | Placebo |
Primary outcome
Performance
Time frame: 60min
Performance measured through the countermovement jump
Performance
Time frame: 60min
Deep squat test at 70% of repetition maximum
7 secondary outcomes
Heart rate
Time frame: 60min
Subjective fatigue throughe the RPE scale
Time frame: 60min
Recovery
Time frame: 60min
Delayed-onset muscle soreness (DOMS)
Time frame: 60min
Capillar lactate levels
Time frame: 60min
Performance: Weight used in the crosstraining session
Time frame: 60min
Performance: Time performed in the crosstraining session
Time frame: 60min
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jan 2025.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Phenylcapsaicin in people with Performance, run by Universidad de Granada at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 20 Jan 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Performance (time frame: 60min). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jan 2025.