Parkinson DiseaseNCT06803212
Investigation of Dual-Task Exercise's Effect in Parkinson's Disease
A study testing Conventional Physiotherapy Program and Dual-Task Interference in people with Parkinson Disease, run by Emre Şenocak at 1 site in Turkey (Türkiye).
Trial summary
This study was conducted to investigate the effects of dual-task training on upper extremity motor functions in patients with Parkinson's disease. A total of 32 patients participated in the study. Patients were divided into two groups by randomization. Read more about this study
- Who is it for?
- Ages 50 to 85 years
- Conditions the study is for
- Parkinson Disease
- What is being tested?
- Conventional Physiotherapy Program and Dual-Task Interference
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 28 Jun 2024to 30 Dec 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients aged 50-85 years with a diagnosis of Stage 1-3 Parkinson's disease, based on the Hoehn \& Yahr Scale
- Patients had to have no issues with performing basic mathematical operations, - A Mini-Mental State Examination (MMSE) score above 24 points,
- Regular medication use for at least 4 weeks (for patients who were prescribed medical treatment),
- No comorbid neurological, neuromuscular, or orthopedic diseases
Who cannot join
- Patients with vision or hearing impairments,
- Moderate-to-severe fluctuations in tremor or dyskinesia,
- Having deep brain stimulator implants, or sensory loss in the upper extremities.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Dual-Task Interference on Upper Extremity Motor Experience With Parkinson's Disease
This study was conducted to investigate the effects of dual-task training on upper extremity motor functions in patients with Parkinson's disease. A total of 32 patients participated in the study. Patients were divided into two groups by randomization. One group received only conventional physiotherapy applications, while the other group performed dual-task exercises in addition. Dual-task exercises were performed while conventional treatment was applied. The treatment program was applied as 60x5x6 min/day/week.
Conventional treatment was determined according to the individual needs of the patients, including the lower and upper extremities. Dual-task interventions included performing such as counting backward, word recall, and reading words backward.
Assessments were repeated twice: Baseline and after a 30-session. "Demographic Information", "Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)", "Box and Block Test" and "Parkinson Disease Questionnaire (PDQ-39) were used as assessment tools.
- Conditions
- Parkinson Disease
- Being tested
- Conventional Physiotherapy Program, Dual-Task Interference
- Medical subject headings
- Parkinson Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Conventional Physiotherapy ProgramOther
The patients' conventional physiotherapy program included stretching, strengthening, balance, and coordination exercises according to their individual needs
Dual-Task InterferenceOther
This intervention consisted of counting backward, reading words backward, and remembering word exercises.
| Study group | Role | What they receive |
|---|---|---|
| Conventional Therapy | Active comparator | This group were performed just conventional physiotherapy. Receives: Other: Conventional Physiotherapy Program |
| Dual-Task Interference | Experimental | Dual-task exercises were applied during conventional physiotherapy practices. Receives: Other: Conventional Physiotherapy Program; Other: Dual-Task Interference |
What is being measured
The primary outcome is the main question the study is designed to answer.
Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS):
The scale consists of four separate domains. The first section includes non-motor experiences in daily life (13 items), the second section includes motor experiences in daily life (13 items), the third section involves motor examination (33 items), and the last section addresses motor complications (6 items). The scale contains 65 individual items in total. Items are generally scored between 0-4, with some Yes/No items. The domains of the scale directly related to the upper extremities, including eating, dressing, cleaning, writing, rigidity, finger movements, hand movements, pronation and supination of the hand, postural tremor in the hands, kinetic tremor in the hands, resting tremor, and tremor persistence, were used in this study (Figure 1). The MDS-UPDRS scoring was performed while patients were in the "ON" state.
Measured: Baseline of the study
Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS):
The scale consists of four separate domains. The first section includes non-motor experiences in daily life (13 items), the second section includes motor experiences in daily life (13 items), the third section involves motor examination (33 items), and the last section addresses motor complications (6 items). The scale contains 65 individual items in total. Items are generally scored between 0-4, with some Yes/No items. The domains of the scale directly related to the upper extremities, including eating, dressing, cleaning, writing, rigidity, finger movements, hand movements, pronation and supination of the hand, postural tremor in the hands, kinetic tremor in the hands, resting tremor, and tremor persistence, were used in this study (Figure 1). The MDS-UPDRS scoring was performed while patients were in the "ON" state.
Measured: End of the 30th physiotherapy session
Secondary outcomes (5)
Box Block Test (BBT)
The BBT consists of a panel and two boxes, one containing 150 wooden blocks. The patient is asked to transfer blocks from one box to another within 60 seconds, one block at a time, using only one hand. The test is repeated with both hands. The number of blocks moved provides the total score. A higher score indicates better manual dexterity.
Measured: Baseline of the study
Box Block Test (BBT)
The BBT consists of a panel and two boxes, one containing 150 wooden blocks. The patient is asked to transfer blocks from one box to another within 60 seconds, one block at a time, using only one hand. The test is repeated with both hands. The number of blocks moved provides the total score. A higher score indicates better manual dexterity.
Measured: End of the 30th physiotherapy session
Parkinson's Disease Questionnaire - 39 (PDQ-39)
This licensed tool assesses the quality of life associated with Parkinson's disease with a total of 39 items. Each item is scored between 0-4, with higher scores indicating poor quality of life. Responses are converted into hundredths for scoring, and the total score ranges from 0 to 100 points.
Measured: Baseline of the study
Parkinson's Disease Questionnaire - 39 (PDQ-39)
This licensed tool assesses the quality of life associated with Parkinson's disease with a total of 39 items. Each item is scored between 0-4, with higher scores indicating poor quality of life. Responses are converted into hundredths for scoring, and the total score ranges from 0 to 100 points.
Measured: End of the 30th physiotherapy session
Demographic Data Form
This form was developed by the investigators and included age, body mass index, disease duration, sex, dominant limb, education level, presence of freezing, presence of tremor, MMSE score, total daily dose of levodopa, and Hoehn \& Yahr Staging.
Measured: Baseline of the study
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Jan 2025
- Study start28 Jun 2024
- Primary completion30 Dec 2024
- Study completion30 Dec 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Parkinson DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- None (open label)
- Enrolment
- 32 participants (actual)
Sponsor and investigators
- Lead sponsor
- Emre Şenocak
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Emre Şenocak, Karadeniz Technical University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06803212
- Sponsor's protocol ID
- 2024/109
- Status last verified
- Jan 2025
- First submitted
- 27 Jan 2025
- Last updated
- 31 Jan 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Senocak E, Karaca S, Akturk A. Effect of dual-task interference on upper extremity motor experience with Parkinson's disease motor effect of dual-task in Parkinson's disease. BMC Neurol. 2025 Oct 22;25(1):436. doi: 10.1186/s12883-025-04462-4.
PubMed 41126101
Study at a glance
From the registry record, last updated by the sponsor on 31 Jan 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Dual-Task Interference on Upper Extremity Motor Experience With Parkinson's Disease
- ClinicalTrials.gov ID
- NCT06803212
- Acronym / sponsor ID
- 2024/109
- Conditions
- Parkinson Disease
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 32 participants (actual)
- Lead sponsor
- Emre ŞenocakUniversity, hospital or other
- Study start
- 28 Jun 2024 (actual)
- Primary completion
- 30 Dec 2024 (actual)
- Study completion
- 30 Dec 2024 (actual)
- First posted
- 31 Jan 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study was conducted to investigate the effects of dual-task training on upper extremity motor functions in patients with Parkinson's disease. A total of 32 patients participated in the study. Patients were divided into two groups by randomization. One group received only conventional physiotherapy applications, while the other group performed dual-task exercises in addition. Dual-task exercises were performed while conventional treatment was applied. The treatment program was applied as 60x5x6 min/day/week.
Conventional treatment was determined according to the individual needs of the patients, including the lower and upper extremities. Dual-task interventions included performing such as counting backward, word recall, and reading words backward.
Assessments were repeated twice: Baseline and after a 30-session. "Demographic Information", "Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)", "Box and Block Test" and "Parkinson Disease Questionnaire (PDQ-39) were used as assessment tools.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Conventional Therapy | Active comparator | Other: Conventional Physiotherapy ProgramThis group were performed just conventional physiotherapy. |
| Dual-Task Interference | Experimental | Other: Conventional Physiotherapy Program, Other: Dual-Task InterferenceDual-task exercises were applied during conventional physiotherapy practices. |
Who may qualify
- Ages
- 50 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patients aged 50-85 years with a diagnosis of Stage 1-3 Parkinson's disease, based on the Hoehn \& Yahr Scale
- Patients had to have no issues with performing basic mathematical operations, - A Mini-Mental State Examination (MMSE) score above 24 points,
- Regular medication use for at least 4 weeks (for patients who were prescribed medical treatment),
- No comorbid neurological, neuromuscular, or orthopedic diseases
Key exclusion criteria (3 listed)
- Patients with vision or hearing impairments,
- Moderate-to-severe fluctuations in tremor or dyskinesia,
- Having deep brain stimulator implants, or sensory loss in the upper extremities.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Conventional Physiotherapy ProgramThe patients' conventional physiotherapy program included stretching, strengthening, balance, and coordination exercises according to their individual needs | Other | Conventional Therapy, Dual-Task Interference |
| Dual-Task InterferenceThis intervention consisted of counting backward, reading words backward, and remembering word exercises. | Other | Dual-Task Interference |
Primary outcome
Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS):
Time frame: Baseline of the study
The scale consists of four separate domains. The first section includes non-motor experiences in daily life (13 items), the second section includes motor experiences in daily life (13 items), the third section involves motor examination (33 items), and the last section addresses motor complications (6 items). The scale contains 65 individual items in total. Items are generally scored between 0-4, with some Yes/No items. The domains of the scale directly related to the upper extremities, including eating, dressing, cleaning, writing, rigidity, finger movements, hand movements, pronation and supination of the hand, postural tremor in the hands, kinetic tremor in the hands, resting tremor, and tremor persistence, were used in this study (Figure 1). The MDS-UPDRS scoring was performed while patients were in the "ON" state.
Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS):
Time frame: End of the 30th physiotherapy session
The scale consists of four separate domains. The first section includes non-motor experiences in daily life (13 items), the second section includes motor experiences in daily life (13 items), the third section involves motor examination (33 items), and the last section addresses motor complications (6 items). The scale contains 65 individual items in total. Items are generally scored between 0-4, with some Yes/No items. The domains of the scale directly related to the upper extremities, including eating, dressing, cleaning, writing, rigidity, finger movements, hand movements, pronation and supination of the hand, postural tremor in the hands, kinetic tremor in the hands, resting tremor, and tremor persistence, were used in this study (Figure 1). The MDS-UPDRS scoring was performed while patients were in the "ON" state.
5 secondary outcomes
Box Block Test (BBT)
Time frame: Baseline of the study
Box Block Test (BBT)
Time frame: End of the 30th physiotherapy session
Parkinson's Disease Questionnaire - 39 (PDQ-39)
Time frame: Baseline of the study
Parkinson's Disease Questionnaire - 39 (PDQ-39)
Time frame: End of the 30th physiotherapy session
Demographic Data Form
Time frame: Baseline of the study
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jan 2025.
- Derived from this study: PubMed 41126101Senocak E, Karaca S, Akturk A. Effect of dual-task interference on upper extremity motor experience with Parkinson's disease motor effect of dual-task in Parkinson's disease. BMC Neurol. 2025 Oct 22;25(1):436. doi: 10.1186/s12883-025-04462-4.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Conventional Physiotherapy Program and Dual-Task Interference in people with Parkinson Disease, run by Emre Şenocak at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 31 Jan 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Movement Disorder Society (MDS)-Unified Parkinson's Disease Rating Scale (MDS-UPDRS): (time frame: Baseline of the study). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06803212, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jan 2025.