Cardiac Arrest (CA)VENT-IHCANCT06809309
The Ventilation During In-hospital Cardiac Arrest Study
An observational study of Cardiac Arrest (CA) and In-Hospital Cardiac Arrest, run by University of Aarhus at 11 sites in 2 countries.
Trial summary
The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest (CA), In-Hospital Cardiac Arrest, Heart Arrest
- What is being tested?
- Positive pressure ventilation during cardiopulmonary resuscitation
- How many people
- 900 participants
- Where
- 11 sitesin 2 countries
- Study dates
- 1 Feb 2025to Jun 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients receiving ventilation with a bag-valve-mask (BVM) or advanced airway during cardiopulmonary resuscitation for in-hospital cardiac arrest.
Who may be able to join
- In-hospital cardiac arrest
- Age ≥ 18 years
- >1minute of recorded ventilation data
Who cannot join
- Documented do-not-attempt cardiopulmonary resuscitation order
- Invasive mechanical circulatory support at the time of the cardiac arrest
Trial locations and contacts
11 sites in 2 countries. Contact the study team or a site near you to ask about taking part.
11 sites in 2 countries
Denmark10 sites, 10 recruiting
- Recruiting
Hospital of Southern Jutland - Aabenraa
Aabenraa
Rajesh Prabhakar Bhavsar, +45 79 97 00 00, rajesh.prabhakar.bhavsar@rsyd.dk
- Recruiting
Aalborg University Hospital
Aalborg, 9000
Thomas L Klitgaard, +45 97 66 00 00, tlk@rn.dk
Steen Kåre Stokbro Fagerberg, +45 97 66 00 00, s.fagerberg@rn.dk
- Recruiting
Aarhus University Hospital
Aarhus, 8200
Kristian Krogh, +45 7845 0000, krikrogh@rm.dk
- Recruiting
Hospital of Southwest Jutland - Esbjerg
Esbjerg, 6700
Peter Kuhne Qvist, +45 7918 2000, Peter.Joachim.Kuhne-Qvist@rsyd.dk
- Recruiting
Gødstrup Hospital
Gødstrup, 7400
Peter Carøe Lind, +45 7843 0000, pecali@clin.au.dk
- Recruiting
North Denmark Region Hospital - Hjørring
Hjørring, 9800
Cecilie Overgaard Nielsen, +45 97 64 00 00, cenie@rn.dk
- Recruiting
Horsens Regional Hospital
Horsens, 8700
Lisa F Irion, +45 7842 5000, LISIRI@rm.dk
- Recruiting
Odense University Hospital
Odense, 5000
Stine Thorhauge Zwisler, +45 66 11 33 33, stine.zwisler@rsyd.dk
Nicole Brahe, +45 66 11 33 33, nicole.brahe@rsyd.dk
- Recruiting
Randers Regional Hospital
Randers, 8930
Carsten Poulsen, +45 78 42 00 00, carspoul@rm.dk
- Recruiting
Viborg Regional Hospital
Viborg, 8800
Hans K S Brødløs, +45 78 44 00 00, Hans.Kristian.Sangill.Broedloes@Viborg.RM.dk
Norway1 site, 1 recruiting
- Recruiting
St. Olavs Hospital, Trondheim University Hospital
Trondheim, 7006
Eirik Skogvoll, +4772573000, eirik.skogvoll@ntnu.no
Catrine Hem, +4772573000, Catrine.Hem@stolav.no
About this study
Official title: The Ventilation During In-Hospital Cardiac Arrest (VENT-IHCA) Study
The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients.
The main questions it aims to answer are:
What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC?
Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.
- Being tested
- Positive pressure ventilation during cardiopulmonary resuscitation
- Keywords
- prospective observational study, ventilation, manual ventilation, cardiac arrest, in-hospital cardiac arrest (IHCA), bag-valve-mask (BVM), tidal volume, ventilation rate, intra-arrest ventilation, cardiopulmonary ventilation (CPR), resuscitation, adult
- Medical subject headings
- Heart Arrest, Respiratory Aspiration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Positive pressure ventilation during cardiopulmonary resuscitationOther
Also called manual ventilation, artificial ventilation, intra-arrest ventilation, bag-valve-mask ventilation
The primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation.
Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded.
| Study group | Role | What they receive |
|---|---|---|
| Study cohort | Adult patients (≥18 years) with in-hospital cardiac arrest receiving cardiopulmonary resuscitation.
Groups will be defined based on observed distribution of ventilation parameters (ventilation rate, tidal volume and minute ventilation). Receives: Other: Positive pressure ventilation during cardiopulmonary resuscitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Fraction of patients with return of spontaneous circulation (ROSC)
ROSC is defined as sustained spontaneous circulation with no need for chest compressions for at least 20 minutes.
Measured: ROSC is assessed immediately following cardiopulmonary resuscitation.
Secondary outcomes (1)
Fraction of patients surviving until day 30
Patient survival for at least 30 days following cardiac arrest.
Measured: Assessed at day 30 after cardiac arrest.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Feb 2025
- Study start1 Feb 2025
- Primary completionApr 2027 (estimated)
- Study completionJun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- More trials run by University of AarhusThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 900 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Aarhus
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Johannes Wittig, MD, Principal investigator, Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, DenmarkKasper G Lauridsen, MD, PhD, Principal investigator, Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark;
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06809309
- Sponsor's protocol ID
- VENT-IHCA
- Other IDs
- 1-16-02-301-24, 2022-0367531
- Acronym
- VENT-IHCA
- Status last verified
- Mar 2026
- First submitted
- 20 Jan 2025
- Last updated
- 30 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The investigators are not permitted to share IPD.
Study at a glance
From the registry record, last updated by the sponsor on 30 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Ventilation During In-Hospital Cardiac Arrest (VENT-IHCA) Study
- ClinicalTrials.gov ID
- NCT06809309
- Acronym / sponsor ID
- VENT-IHCA / VENT-IHCA
- Keywords
- prospective observational study, ventilation, manual ventilation, cardiac arrest, in-hospital cardiac arrest (IHCA), bag-valve-mask (BVM), tidal volume, ventilation rate
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 900 participants (estimated)
- Lead sponsor
- University of AarhusUniversity, hospital or other
- Study start
- 1 Feb 2025 (actual)
- Primary completion
- Apr 2027 (estimated)
- Study completion
- Jun 2027 (estimated)
- First posted
- 5 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients.
The main questions it aims to answer are:
What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC?
Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Study cohort | – | Other: Positive pressure ventilation during cardiopulmonary resuscitationAdult patients (≥18 years) with in-hospital cardiac arrest receiving cardiopulmonary resuscitation. Groups will be defined based on observed distribution of ventilation parameters (ventilation rate, tidal volume and minute ventilation). |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients receiving ventilation with a bag-valve-mask (BVM) or advanced airway during cardiopulmonary resuscitation for in-hospital cardiac arrest.
Key inclusion criteria (3 listed)
- In-hospital cardiac arrest
- Age ≥ 18 years
- >1minute of recorded ventilation data
Key exclusion criteria (2 listed)
- Documented do-not-attempt cardiopulmonary resuscitation order
- Invasive mechanical circulatory support at the time of the cardiac arrest
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Positive pressure ventilation during cardiopulmonary resuscitationAlso: manual ventilation, artificial ventilation, intra-arrest ventilation, bag-valve-mask ventilationThe primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation. Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded. | Other | Study cohort |
Primary outcome
Fraction of patients with return of spontaneous circulation (ROSC)
Time frame: ROSC is assessed immediately following cardiopulmonary resuscitation.
ROSC is defined as sustained spontaneous circulation with no need for chest compressions for at least 20 minutes.
1 secondary outcome
Fraction of patients surviving until day 30
Time frame: Assessed at day 30 after cardiac arrest.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Mar 2026.
- Individual participant dataSharing planned: No. The investigators are not permitted to share IPD.
Related trials for Cardiac Arrest (CA)
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The VENTOR Clinical Study
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Johannes Wittig, MD principal investigator
Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark
Kasper G Lauridsen, MD, PhD principal investigator
Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark;
11 sites in 2 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiac Arrest (CA) and In-Hospital Cardiac Arrest, run by University of Aarhus at 11 sites in 2 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 30 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 11 sites in Denmark, Norway. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Johannes Wittig, MD (+45 78 42 00 00, johannes.wittig@clin.au.dk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Fraction of patients with return of spontaneous circulation (ROSC) (time frame: ROSC is assessed immediately following cardiopulmonary resuscitation.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Mar 2026; AzTrials last refreshed its copy on 3 Nov 2026.