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Cardiovascular DiseasesNCT06812624

The Effect Of Perioperative Results On Mortality In Coronary Artery Bypass Surgery

An observational study of Cardiovascular Diseases and Cardiovascular Complication, run by Istanbul University - Cerrahpasa at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

Coronary artery bypass grafting (CABG) is one of the most common heart surgeries. Most patients are elderly with comorbidities that affect morbidity and mortality rates. Even in developed countries mortality rate is 1.9-5.3%. Read more about this study

Who is it for?
Ages 18 years and older
How many people
485 participants
Where
1 siteTurkey (Türkiye)
Study dates
15 Dec 2024to 15 Dec 2025
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: Over 18 year of age, all isolated coronary artery bypass surgery between January 1, 2020 and July 31, 2024 at IUC Cardiology Institute hospital

Who may be able to join

  • All isolated coronary artery bypass surgery between January 1, 2020 and July 31, 2024 at IUC Cardiology Institute hospital

Who cannot join

  • All surgical procedures other than isolated coronary artery bypass surgery and patients under the age of 18 were excluded

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site
  • Istanbul University-Cerrahpaşa

    Istanbul

Other trials in Turkey (Türkiye)

About this study

Official title: The Effect Of Perioperative Results On Mortality In Coronary Artery Bypass Surgery: Risk Assessment With Fuzzy Logic

Coronary artery bypass grafting (CABG) is one of the most common heart surgeries. Most patients are elderly with comorbidities that affect morbidity and mortality rates. Even in developed countries mortality rate is 1.9-5.3%. Determination of perioperative risk factors and creating protocols to take precautions accordingly may reduce mortality in patients.

In CABG patients, due to the surgical burden combined with existing comorbidities, it is important for physicians to evaluate the risk status and predict the mortality rates. For this purpose, various scoring systems have been developed.

Read more

Fuzzy logic method allows partially membership, so that a glass that is neither full nor empty can be numerically expressed as being partially full but also partially empty. This feature is similar to the reasoning structure of the human brain that uses linguistic tools. In this way, in cases where there is no precise mathematical model and where the existence of imprecise and uncertain information is natural, such as medical applications, in order to solve the problem, fuzzy easily allows linguistic expressions containing the knowledge, experience and intuition of expert to transforme into the model created for the solution. In decision making process, fuzzy logic provides ability to use linguistic expressions, including experts' intuition. Thus, decisions can be made even with approximate data and uncertainty. For this reason, fuzzy logic is used in a wide range of research from engineering to medicine.

The records of patients who underwent CABG surgery in Istanbul University-Cerrahpaşa Cardiology Institute between January 1, 2020 and July 31, 2024 will be examined.

Preoperative major risk factors diabetes, pulmonary, neurological, kidney and liver disease with preoperative minor risk factors age, weight and smoking will be recorded. Perioperative risk factors; duration of artificial circulation, number of vessels bypassed, and number of blood products used will be recorded. Our primary aim is to create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in CABG surgery. Secondly we aimed to investigate the effect of perioperative risk factors on postoperative complications

Read the detailed description

Coronary artery bypass grafting (CABG) is one of the most common heart surgeries. Most patients are elderly with comorbidities such as diabetes mellitus and renal diseases. Tehese risk factors affect morbidity and mortality rates. Even in developed countries mortality rate in CABG patients is between 1.9-5.3%. Identifying perioperative risk factors and taking precautions by creating protocols can decrease mortality in patients. Experienced surgical and anesthesia teams, evidence-based practices, and advances in pharmacology and technology can increase survival.

Risk assessment is important in determining the treatment plans of patients who will be operated on, providing patient education for the postoperative period, providing insight into prognosis, and determining health care quality standards.

In CABG patients, due to the surgical burden combined with existing comorbidities, it is important for physicians to evaluate the risk status and predict the mortality rates. For this purpose low and high risk studies have been conducted and various scoring systems have been developed. European System for Cardiac Operative Risk Evaluation-II (EUROSCORE-II) is a scoring system that was created specifically for cardiac surgery patients and is widely used all over the world, predicting mortality through preoperative evaluation. EUROSCORE-II scoring may be low in older patients (over 70 years of age). A scoring system with higher predictive power is aimed by making modifications to EUROSCORE-II or comparisons with other scoring systems.

In 1965, Zadeh first introduced Fuzzy, which is the basis of the fuzzy logic procedure Fuzzy logic method allows partially membership, so that a glass that is neither full nor empty can be numerically expressed as being partially full but also partially empty. This feature is similar to the reasoning structure of the human brain that uses linguistic tools. In this way, in cases where there is no precise mathematical model and where the existence of imprecise and uncertain information is natural, such as medical applications, in order to solve the problem, fuzzy easily allows linguistic expressions containing the knowledge, experience and intuition of expert to transforme into the model created for the solution. In decision making process, fuzzy logic provides ability to use linguistic expressions, including experts' intuition. Thus, decisions can be made even with approximate data and uncertainty. For this reason, fuzzy logic is used in a wide range of research from engineering to medicine.

The records of patients who underwent isolated CABG surgery in Istanbul University-Cerrahpaşa Cardiology Institute between January 1, 2020 and July 31, 2024 will be included.

Diabetes mellitus, pulmonary, neurological, kidney and liver disease will be recorded as preoperative major risk factors. Age, weight and smoking will be recorded as preoperative minor risk factors. Duration of artificial circulation, number of vessels bypassed, and number of blood products used will be recorded as perioperative risk factors.

The effect of preoperative risk factors on mortality has been investigated in many studies. Our primary aim is to create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in isolated CABG surgery.

Being tested
There is no intervention in this study.
Keywords
Fuzzy logic, mortality, coronary artery surgery, risk assessment, risk scoring system, complications
Medical subject headings
Cardiovascular Diseases

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • There is no intervention in this study.Other

    This study is planned as a retrospective cross sectional study. Only the information of the patients will be used.

Study groups in NCT06812624
Study groupRoleWhat they receive
coronary artery bypass surgery groupAll patients over the age of 18 who underwent isolated coronary artery bypass surgery at the IUC Cardiology Institute hospital between January 1, 2020 and July 31, 2024 will be included in the study.
Receives: Other: There is no intervention in this study.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Risk assessment with fuzzy logic

    Create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in CABG operations.

    Measured: 4 months

Secondary outcomes (1)
  1. Perioperative risk factors

    Investigate the effects of artificial circulation time, number of bypassed vessels, and how many bags of blood products were used as perioperative risk factors on postoperative complications.

    Measured: 4 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted6 Feb 2025
  2. Study start15 Dec 2024
  3. Primary completion15 Dec 2025
  4. Study completion15 Dec 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Cross-sectional
Enrolment
485 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06812624
Sponsor's protocol ID
112
Status last verified
Jan 2025
First submitted
2 Feb 2025
Last updated
24 Feb 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

An observational study of Cardiovascular Diseases and Cardiovascular Complication, run by Istanbul University - Cerrahpasa at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 24 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Risk assessment with fuzzy logic (time frame: 4 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Feb 2026.

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