Cardiovascular DiseasesNCT06812624
The Effect Of Perioperative Results On Mortality In Coronary Artery Bypass Surgery
An observational study of Cardiovascular Diseases and Cardiovascular Complication, run by Istanbul University - Cerrahpasa at 1 site in Turkey (Türkiye).
Trial summary
Coronary artery bypass grafting (CABG) is one of the most common heart surgeries. Most patients are elderly with comorbidities that affect morbidity and mortality rates. Even in developed countries mortality rate is 1.9-5.3%. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiovascular Diseases, Cardiovascular Complication, Anesthesia
- How many people
- 485 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Dec 2024to 15 Dec 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Over 18 year of age, all isolated coronary artery bypass surgery between January 1, 2020 and July 31, 2024 at IUC Cardiology Institute hospital
Who may be able to join
- All isolated coronary artery bypass surgery between January 1, 2020 and July 31, 2024 at IUC Cardiology Institute hospital
Who cannot join
- All surgical procedures other than isolated coronary artery bypass surgery and patients under the age of 18 were excluded
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect Of Perioperative Results On Mortality In Coronary Artery Bypass Surgery: Risk Assessment With Fuzzy Logic
Coronary artery bypass grafting (CABG) is one of the most common heart surgeries. Most patients are elderly with comorbidities that affect morbidity and mortality rates. Even in developed countries mortality rate is 1.9-5.3%. Determination of perioperative risk factors and creating protocols to take precautions accordingly may reduce mortality in patients.
In CABG patients, due to the surgical burden combined with existing comorbidities, it is important for physicians to evaluate the risk status and predict the mortality rates. For this purpose, various scoring systems have been developed.
Read more
Fuzzy logic method allows partially membership, so that a glass that is neither full nor empty can be numerically expressed as being partially full but also partially empty. This feature is similar to the reasoning structure of the human brain that uses linguistic tools. In this way, in cases where there is no precise mathematical model and where the existence of imprecise and uncertain information is natural, such as medical applications, in order to solve the problem, fuzzy easily allows linguistic expressions containing the knowledge, experience and intuition of expert to transforme into the model created for the solution. In decision making process, fuzzy logic provides ability to use linguistic expressions, including experts' intuition. Thus, decisions can be made even with approximate data and uncertainty. For this reason, fuzzy logic is used in a wide range of research from engineering to medicine.
The records of patients who underwent CABG surgery in Istanbul University-Cerrahpaşa Cardiology Institute between January 1, 2020 and July 31, 2024 will be examined.
Preoperative major risk factors diabetes, pulmonary, neurological, kidney and liver disease with preoperative minor risk factors age, weight and smoking will be recorded. Perioperative risk factors; duration of artificial circulation, number of vessels bypassed, and number of blood products used will be recorded. Our primary aim is to create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in CABG surgery. Secondly we aimed to investigate the effect of perioperative risk factors on postoperative complications
Read the detailed description
Coronary artery bypass grafting (CABG) is one of the most common heart surgeries. Most patients are elderly with comorbidities such as diabetes mellitus and renal diseases. Tehese risk factors affect morbidity and mortality rates. Even in developed countries mortality rate in CABG patients is between 1.9-5.3%. Identifying perioperative risk factors and taking precautions by creating protocols can decrease mortality in patients. Experienced surgical and anesthesia teams, evidence-based practices, and advances in pharmacology and technology can increase survival.
Risk assessment is important in determining the treatment plans of patients who will be operated on, providing patient education for the postoperative period, providing insight into prognosis, and determining health care quality standards.
In CABG patients, due to the surgical burden combined with existing comorbidities, it is important for physicians to evaluate the risk status and predict the mortality rates. For this purpose low and high risk studies have been conducted and various scoring systems have been developed. European System for Cardiac Operative Risk Evaluation-II (EUROSCORE-II) is a scoring system that was created specifically for cardiac surgery patients and is widely used all over the world, predicting mortality through preoperative evaluation. EUROSCORE-II scoring may be low in older patients (over 70 years of age). A scoring system with higher predictive power is aimed by making modifications to EUROSCORE-II or comparisons with other scoring systems.
In 1965, Zadeh first introduced Fuzzy, which is the basis of the fuzzy logic procedure Fuzzy logic method allows partially membership, so that a glass that is neither full nor empty can be numerically expressed as being partially full but also partially empty. This feature is similar to the reasoning structure of the human brain that uses linguistic tools. In this way, in cases where there is no precise mathematical model and where the existence of imprecise and uncertain information is natural, such as medical applications, in order to solve the problem, fuzzy easily allows linguistic expressions containing the knowledge, experience and intuition of expert to transforme into the model created for the solution. In decision making process, fuzzy logic provides ability to use linguistic expressions, including experts' intuition. Thus, decisions can be made even with approximate data and uncertainty. For this reason, fuzzy logic is used in a wide range of research from engineering to medicine.
The records of patients who underwent isolated CABG surgery in Istanbul University-Cerrahpaşa Cardiology Institute between January 1, 2020 and July 31, 2024 will be included.
Diabetes mellitus, pulmonary, neurological, kidney and liver disease will be recorded as preoperative major risk factors. Age, weight and smoking will be recorded as preoperative minor risk factors. Duration of artificial circulation, number of vessels bypassed, and number of blood products used will be recorded as perioperative risk factors.
The effect of preoperative risk factors on mortality has been investigated in many studies. Our primary aim is to create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in isolated CABG surgery.
- Being tested
- There is no intervention in this study.
- Keywords
- Fuzzy logic, mortality, coronary artery surgery, risk assessment, risk scoring system, complications
- Medical subject headings
- Cardiovascular Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
There is no intervention in this study.Other
This study is planned as a retrospective cross sectional study. Only the information of the patients will be used.
| Study group | Role | What they receive |
|---|---|---|
| coronary artery bypass surgery group | All patients over the age of 18 who underwent isolated coronary artery bypass surgery at the IUC Cardiology Institute hospital between January 1, 2020 and July 31, 2024 will be included in the study. Receives: Other: There is no intervention in this study. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Risk assessment with fuzzy logic
Create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in CABG operations.
Measured: 4 months
Secondary outcomes (1)
Perioperative risk factors
Investigate the effects of artificial circulation time, number of bypassed vessels, and how many bags of blood products were used as perioperative risk factors on postoperative complications.
Measured: 4 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Feb 2025
- Study start15 Dec 2024
- Primary completion15 Dec 2025
- Study completion15 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiovascular DiseasesStudies of the same condition, open and under way.
- More trials run by Istanbul University - CerrahpasaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 485 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul University - Cerrahpasa
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Kerem Erkalp, MD, Prof, Istanbul University - Cerrahpasa
- Investigators
- Kerem Erkalp, Study chair, Istanbul University - Cerrahpasa
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06812624
- Sponsor's protocol ID
- 112
- Status last verified
- Jan 2025
- First submitted
- 2 Feb 2025
- Last updated
- 24 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect Of Perioperative Results On Mortality In Coronary Artery Bypass Surgery: Risk Assessment With Fuzzy Logic
- ClinicalTrials.gov ID
- NCT06812624
- Acronym / sponsor ID
- 112
- Keywords
- Fuzzy logic, mortality, coronary artery surgery, risk assessment, risk scoring system, complications
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 485 participants (actual)
- Lead sponsor
- Istanbul University - CerrahpasaUniversity, hospital or other
- Study start
- 15 Dec 2024 (actual)
- Primary completion
- 15 Dec 2025 (actual)
- Study completion
- 15 Dec 2025 (actual)
- First posted
- 6 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Coronary artery bypass grafting (CABG) is one of the most common heart surgeries. Most patients are elderly with comorbidities that affect morbidity and mortality rates. Even in developed countries mortality rate is 1.9-5.3%. Determination of perioperative risk factors and creating protocols to take precautions accordingly may reduce mortality in patients.
In CABG patients, due to the surgical burden combined with existing comorbidities, it is important for physicians to evaluate the risk status and predict the mortality rates. For this purpose, various scoring systems have been developed.
Fuzzy logic method allows partially membership, so that a glass that is neither full nor empty can be numerically expressed as being partially full but also partially empty. This feature is similar to the reasoning structure of the human brain that uses linguistic tools. In this way, in cases where there is no precise mathematical model and where the existence of imprecise and uncertain information is natural, such as medical applications, in order to solve the problem, fuzzy easily allows linguistic expressions containing the knowledge, experience and intuition of expert to transforme into the model created for the solution. In decision making process, fuzzy logic provides ability to use linguistic expressions, including experts' intuition. Thus, decisions can be made even with approximate data and uncertainty. For this reason, fuzzy logic is used in a wide range of research from engineering to medicine.
The records of patients who underwent CABG surgery in Istanbul University-Cerrahpaşa Cardiology Institute between January 1, 2020 and July 31, 2024 will be examined.
Preoperative major risk factors diabetes, pulmonary, neurological, kidney and liver disease with preoperative minor risk factors age, weight and smoking will be recorded. Perioperative risk factors; duration of artificial circulation, number of vessels bypassed, and number of blood products used will be recorded. Our primary aim is to create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in CABG surgery. Secondly we aimed to investigate the effect of perioperative risk factors on postoperative complications
Detailed description
Coronary artery bypass grafting (CABG) is one of the most common heart surgeries. Most patients are elderly with comorbidities such as diabetes mellitus and renal diseases. Tehese risk factors affect morbidity and mortality rates. Even in developed countries mortality rate in CABG patients is between 1.9-5.3%. Identifying perioperative risk factors and taking precautions by creating protocols can decrease mortality in patients. Experienced surgical and anesthesia teams, evidence-based practices, and advances in pharmacology and technology can increase survival.
Risk assessment is important in determining the treatment plans of patients who will be operated on, providing patient education for the postoperative period, providing insight into prognosis, and determining health care quality standards.
In CABG patients, due to the surgical burden combined with existing comorbidities, it is important for physicians to evaluate the risk status and predict the mortality rates. For this purpose low and high risk studies have been conducted and various scoring systems have been developed. European System for Cardiac Operative Risk Evaluation-II (EUROSCORE-II) is a scoring system that was created specifically for cardiac surgery patients and is widely used all over the world, predicting mortality through preoperative evaluation. EUROSCORE-II scoring may be low in older patients (over 70 years of age). A scoring system with higher predictive power is aimed by making modifications to EUROSCORE-II or comparisons with other scoring systems.
In 1965, Zadeh first introduced Fuzzy, which is the basis of the fuzzy logic procedure Fuzzy logic method allows partially membership, so that a glass that is neither full nor empty can be numerically expressed as being partially full but also partially empty. This feature is similar to the reasoning structure of the human brain that uses linguistic tools. In this way, in cases where there is no precise mathematical model and where the existence of imprecise and uncertain information is natural, such as medical applications, in order to solve the problem, fuzzy easily allows linguistic expressions containing the knowledge, experience and intuition of expert to transforme into the model created for the solution. In decision making process, fuzzy logic provides ability to use linguistic expressions, including experts' intuition. Thus, decisions can be made even with approximate data and uncertainty. For this reason, fuzzy logic is used in a wide range of research from engineering to medicine.
The records of patients who underwent isolated CABG surgery in Istanbul University-Cerrahpaşa Cardiology Institute between January 1, 2020 and July 31, 2024 will be included.
Diabetes mellitus, pulmonary, neurological, kidney and liver disease will be recorded as preoperative major risk factors. Age, weight and smoking will be recorded as preoperative minor risk factors. Duration of artificial circulation, number of vessels bypassed, and number of blood products used will be recorded as perioperative risk factors.
The effect of preoperative risk factors on mortality has been investigated in many studies. Our primary aim is to create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in isolated CABG surgery.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| coronary artery bypass surgery group | – | Other: There is no intervention in this study.All patients over the age of 18 who underwent isolated coronary artery bypass surgery at the IUC Cardiology Institute hospital between January 1, 2020 and July 31, 2024 will be included in the study. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Over 18 year of age, all isolated coronary artery bypass surgery between January 1, 2020 and July 31, 2024 at IUC Cardiology Institute hospital
Key inclusion criteria (1 listed)
- All isolated coronary artery bypass surgery between January 1, 2020 and July 31, 2024 at IUC Cardiology Institute hospital
Key exclusion criteria (1 listed)
- All surgical procedures other than isolated coronary artery bypass surgery and patients under the age of 18 were excluded
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| There is no intervention in this study.This study is planned as a retrospective cross sectional study. Only the information of the patients will be used. | Other | coronary artery bypass surgery group |
Primary outcome
Risk assessment with fuzzy logic
Time frame: 4 months
Create a fuzzy logic-based perioperative risk classification model to identify high-risk patients in CABG operations.
1 secondary outcome
Perioperative risk factors
Time frame: 4 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Kerem Erkalp study chair
Istanbul University - Cerrahpasa
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiovascular Diseases and Cardiovascular Complication, run by Istanbul University - Cerrahpasa at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Risk assessment with fuzzy logic (time frame: 4 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Feb 2026.