Cardiac Arrest (CA)LUCASVPNCT06824961
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
A study testing 5-second ventilation pause duration during mechanical CPR and 3-second ventilation pause duration during mechanical CPR in people with Cardiac Arrest (CA), run by Amsterdam UMC, location VUmc at 2 sites in Netherlands.
Trial summary
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest compression pause after 30 compressions to facilitate caregivers in providing two ventilations. Read more about this study
- Who is it for?
- Ages 16 years and older
- Conditions the study is for
- Cardiac Arrest (CA)
- What is being tested?
- 5-second ventilation pause duration during mechanical CPR and 3-second ventilation pause duration during mechanical CPR
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 692 participants
- Where
- 2 sitesNetherlands
- Study dates
- 15 Jan 2026to Jul 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Adults (≥16 years of age)
- OHCA patients with an attempt at cardiopulmonary resuscitation (CPR) by ambulance personnel
- LUCAS® 3.1 has been used during the resuscitation attempt
Who cannot join
- Missing ambulance run report, missing or unclear impedance signal (measurement of resistance across the thorax), making it impossible to assess the number of ventilation pauses
- Absence of a minimum of 3 assessable pauses intended for ventilation after connecting the LUCAS®
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Netherlands2 sites, 2 recruiting
- Recruiting
Ambulance Amsterdam
Amsterdam, North Holland, 1075LB
Durk S Linzel, MD, +31686897621, dlinzel@ambulanceamsterdam.nl
Ed Bleijenberg, ebleijenberg@ambulanceamsterdam.nl
- Recruiting
Regionale Ambulance Voorziening Kennemerland - Ambulancezorg GGD Kennemerland
Haarlem, North Holland, 2015CK
Monique Theunissen, +31624920614, m.theunissen@wittekruis.nl
Anja Radstok, a.radstok@wittekruis.nl
About this study
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest compression pause after 30 compressions to facilitate caregivers in providing two ventilations. With this standard setting, research has shown that in less than half of ventilation pauses during CPR, those two ventilations are given. Increasing the ventilation pause duration to 5 seconds instead of 3 seconds is also an option following current guideline recommendations, and aligns with measured ventilation pause duration in manual CPR. Increasing pause duration to 5 seconds could result in an increased ventilation success rate. This multicenter randomized controlled trial will randomize LUCAS® mechanical compression devices to a standard setting of 3- or 5-second compression pauses. The main outcome will be the percentage of ventilation pauses in which two ventilations are successfully given. Secondary outcomes include the restoration of spontaneous circulation (ROSC), and the difference in (neurologically intact) survival. No study has been performed to evaluate this effect yet.
- Conditions
- Cardiac Arrest (CA)
- Being tested
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Keywords
- Advanced life support, Basic life support, Cardiac arrest, Cardiopulmonary resuscitation, CPR, ALS, BLS, Out-of-hospital cardiac arrest, OHCA, Mechanical chest compression devices, Mechanical CPR, Ventilation
- Medical subject headings
- Heart Arrest, Out-of-Hospital Cardiac Arrest, Respiratory Aspiration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
5-second ventilation pause duration during mechanical CPROther
The intervention is a 5-second lasting ventilation pause during mechanical CPR
3-second ventilation pause duration during mechanical CPROther
The intervention is a 3-second lasting ventilation pause during mechanical CPR
| Study group | Role | What they receive |
|---|---|---|
| Intervention - 5-second ventilation pause | Experimental | Patients in this group will have ventilation pauses lasting 5 seconds in between cardiac compressions given by mechanical CPR Receives: Other: 5-second ventilation pause duration during mechanical CPR |
| Control - 3-second ventilation pauses | Active comparator | Patients in this group will have ventilation pauses lasting the standard 3 seconds in between cardiac compressions given by mechanical CPR Receives: Other: 3-second ventilation pause duration during mechanical CPR |
What is being measured
The primary outcome is the main question the study is designed to answer.
Percentage of ventilation pauses in which two ventilations are given
The difference in percentage of ventilation pauses in which two ventilations are given between the intervention and control group
Measured: From enrollment to end of mechanically assisted CPR by ambulance nurses (approximate maximum timeframe of 3 hours)
Secondary outcomes (12)
Return of spontaneous circulation (ROSC)
The difference in percentage of participants with and without ROSC
Measured: From enrollment to end of cardiac arrest treatment (approximate maximum timeframe of 5 hours)
Cerebral performance score (CPC score) at hospital discharge (CPC 1-2 vs. 3-4)
The difference in percentage of participants with a CPC of 1-2 (good neurological recovery) vs. 3-4 (poor neurological recovery) at hospital discharge
CPC score system:
- Normal (good cerebral performance)
- Moderate disability (disabled but independent)
- Severe disability (conscious but disabled and dependent)
- Unconscious (coma or vegetative state)
Measured: From enrollment to hospital discharge (approximate maximum timeframe of 3 months)
Survival to hospital discharge
The difference in percentage of participants with and without survival to hospital discharge
Measured: From enrollment to hospital discharge (approximate maximum timeframe of 3 months)
30-day survival
The difference in percentage of participants with and without survival at 30 days after the cardiac arrest
Measured: From enrollment to 30 days after cardiac arrest
Number of rhythm checks per five minutes, expected
The difference in the number of rhythm checks per five minutes performed with and without pausing the mechanical compression device, compared to the expected number of rhythm checks in that time frame (once every two minutes) between groups
Measured: From enrollment to prehospital termination of CPR or handover at hospital by ambulance nurses (approximate maximum timeframe of 3 hours)
Number of rhythm checks per five minutes, observed
The difference in the number of rhythm checks per five minutes performed with and without pausing the mechanical compression device, compared to the observed number of rhythm checks in that time frame (once every two minutes) between groups
Measured: From enrollment to prehospital termination of CPR or handover at hospital by ambulance nurses (approximate maximum of 3 hours)
Average tidal volume (ml)
Difference in average tidal volumes (ml) between groups
Measured: From enrollment to end of intra-arrest ambulance monitor registration or flow/pressure measurements (approximate maximum timeframe of 3 hours)
Average minute volume (ml/min)
Difference in average minute volumes (ml/min) between groups
Measured: From enrollment to end of intra-arrest ambulance monitor registration or flow/pressure measurements (approximate maximum timeframe of 3 hours)
Average respiratory rate (rate per minute)
Difference in average respiratory rate (rate per minute) between groups
Measured: From enrollment to end of intra-arrest ambulance monitor registration or flow/pressure measurements (approximate maximum timeframe of 3 hours)
Average airway pressure (cmH2O)
Difference average airway pressures (cmH2O) between groups
Measured: From enrollment to end of intra-arrest ambulance monitor registration or flow/pressure measurements (approximate maximum timeframe of 3 hours)
Chest compression fraction (CCF)
Difference in chest compression fraction (CCF) between groups
Measured: From enrollment to end of intra-arrest registration of ambulance monitor (approximate maximum timeframe of 3 hours)
Subjective experience of ambulance nurses with the mechanical CPR device and it's ventilation pause settings
Exploratory anonymous questionnaire of subjective experience of ambulance nurses with the mechanical CPR device (the LUCAS) and it's ventilation pause settings during the resuscitation.
Measured: After the last inclusion of the study, with an approximate time frame of 1-2 months to respond to the anonymous survey
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Feb 2025
- Study start15 Jan 2026
- Primary completion15 Jan 2027 (estimated)
- Study completionJul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Multicenter, single blinded (patients), randomized controlled trial
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 692 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Amsterdam UMC, location VUmc
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Prof. Dr. Patrick Schober, Amsterdam UMC, location VUmc
- Investigators
- Patrick Schober, MD, PhD, Principal investigator, Amsterdam UMC
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06824961
- Sponsor's protocol ID
- LUCASVP
- Acronym
- LUCASVP
- Status last verified
- Aug 2026
- First submitted
- 21 Jan 2025
- Last updated
- 21 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 21 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
- ClinicalTrials.gov ID
- NCT06824961
- Acronym / sponsor ID
- LUCASVP / LUCASVP
- Conditions
- Cardiac Arrest (CA)
- Keywords
- Advanced life support, Basic life support, Cardiac arrest, Cardiopulmonary resuscitation, CPR, ALS, BLS, Out-of-hospital cardiac arrest
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 692 participants (estimated)
- Lead sponsor
- Amsterdam UMC, location VUmcUniversity, hospital or other
- Study start
- 15 Jan 2026 (actual)
- Primary completion
- 15 Jan 2027 (estimated)
- Study completion
- Jul 2027 (estimated)
- First posted
- 13 Feb 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest compression pause after 30 compressions to facilitate caregivers in providing two ventilations. With this standard setting, research has shown that in less than half of ventilation pauses during CPR, those two ventilations are given. Increasing the ventilation pause duration to 5 seconds instead of 3 seconds is also an option following current guideline recommendations, and aligns with measured ventilation pause duration in manual CPR. Increasing pause duration to 5 seconds could result in an increased ventilation success rate. This multicenter randomized controlled trial will randomize LUCAS® mechanical compression devices to a standard setting of 3- or 5-second compression pauses. The main outcome will be the percentage of ventilation pauses in which two ventilations are successfully given. Secondary outcomes include the restoration of spontaneous circulation (ROSC), and the difference in (neurologically intact) survival. No study has been performed to evaluate this effect yet.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- Multicenter, single blinded (patients), randomized controlled trial
| Arm | Type | Receives |
|---|---|---|
| Intervention - 5-second ventilation pause | Experimental | Other: 5-second ventilation pause duration during mechanical CPRPatients in this group will have ventilation pauses lasting 5 seconds in between cardiac compressions given by mechanical CPR |
| Control - 3-second ventilation pauses | Active comparator | Other: 3-second ventilation pause duration during mechanical CPRPatients in this group will have ventilation pauses lasting the standard 3 seconds in between cardiac compressions given by mechanical CPR |
Who may qualify
- Ages
- 16 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (3 listed)
- Adults (≥16 years of age)
- OHCA patients with an attempt at cardiopulmonary resuscitation (CPR) by ambulance personnel
- LUCAS® 3.1 has been used during the resuscitation attempt
Key exclusion criteria (2 listed)
- Missing ambulance run report, missing or unclear impedance signal (measurement of resistance across the thorax), making it impossible to assess the number of ventilation pauses
- Absence of a minimum of 3 assessable pauses intended for ventilation after connecting the LUCAS®
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 5-second ventilation pause duration during mechanical CPRThe intervention is a 5-second lasting ventilation pause during mechanical CPR | Other | Intervention - 5-second ventilation pause |
| 3-second ventilation pause duration during mechanical CPRThe intervention is a 3-second lasting ventilation pause during mechanical CPR | Other | Control - 3-second ventilation pauses |
Primary outcome
Percentage of ventilation pauses in which two ventilations are given
Time frame: From enrollment to end of mechanically assisted CPR by ambulance nurses (approximate maximum timeframe of 3 hours)
The difference in percentage of ventilation pauses in which two ventilations are given between the intervention and control group
12 secondary outcomes
Return of spontaneous circulation (ROSC)
Time frame: From enrollment to end of cardiac arrest treatment (approximate maximum timeframe of 5 hours)
Cerebral performance score (CPC score) at hospital discharge (CPC 1-2 vs. 3-4)
Time frame: From enrollment to hospital discharge (approximate maximum timeframe of 3 months)
Survival to hospital discharge
Time frame: From enrollment to hospital discharge (approximate maximum timeframe of 3 months)
30-day survival
Time frame: From enrollment to 30 days after cardiac arrest
Number of rhythm checks per five minutes, expected
Time frame: From enrollment to prehospital termination of CPR or handover at hospital by ambulance nurses (approximate maximum timeframe of 3 hours)
Number of rhythm checks per five minutes, observed
Time frame: From enrollment to prehospital termination of CPR or handover at hospital by ambulance nurses (approximate maximum of 3 hours)
Average tidal volume (ml)
Time frame: From enrollment to end of intra-arrest ambulance monitor registration or flow/pressure measurements (approximate maximum timeframe of 3 hours)
Average minute volume (ml/min)
Time frame: From enrollment to end of intra-arrest ambulance monitor registration or flow/pressure measurements (approximate maximum timeframe of 3 hours)
Average respiratory rate (rate per minute)
Time frame: From enrollment to end of intra-arrest ambulance monitor registration or flow/pressure measurements (approximate maximum timeframe of 3 hours)
Average airway pressure (cmH2O)
Time frame: From enrollment to end of intra-arrest ambulance monitor registration or flow/pressure measurements (approximate maximum timeframe of 3 hours)
Chest compression fraction (CCF)
Time frame: From enrollment to end of intra-arrest registration of ambulance monitor (approximate maximum timeframe of 3 hours)
Subjective experience of ambulance nurses with the mechanical CPR device and it's ventilation pause settings
Time frame: After the last inclusion of the study, with an approximate time frame of 1-2 months to respond to the anonymous survey
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Aug 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Patrick Schober, MD, PhD principal investigator
Amsterdam UMC
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing 5-second ventilation pause duration during mechanical CPR and 3-second ventilation pause duration during mechanical CPR in people with Cardiac Arrest (CA), run by Amsterdam UMC, location VUmc at 2 sites in Netherlands.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Netherlands. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Lotte C Doeleman, MD (+31205665969, l.c.doeleman@amsterdamumc.nl), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Percentage of ventilation pauses in which two ventilations are given (time frame: From enrollment to end of mechanically assisted CPR by ambulance nurses (approximate maximum timeframe of 3 hours)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Aug 2026.